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JP2006016314A |
To provide a method for producing an optically active amide compound by using a racemic 2-pyridyl-2-hydroxyacetic acid.The optically active amide compound expressed by formula (2) (R1 is a (substituted)alkyl or the like; R2, R3, R4, R5 a...
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JP2006501174A |
The invention relates to acutumine and compounds thereof and also to compounds of formula (I): wherein R1 and R2 each represent hydrogen or together form an additional bond, R3 represents hydrogen or alkoxy, R5 represents hydrogen or chl...
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JP2006008606A |
To provide an optical resolution method for producing an optically active isoflavan derivative.The method for the optical resolution of an isoflavan derivative comprises the optical resolution of an enantiomer mixture of an isoflavan der...
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JP2006501182A |
The present invention relates to heterocyclic derivatives of formula (I)
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JP3733634B2 |
To provide a new method for producing an optically active oxepine derivative useful as an antiallergic medicine. This method for producing an optically active oxepine derivative is to react an optically active sulfonic acid with the race...
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JP2006500407A |
The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the ...
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JP2005538838A |
A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Brønsted acid, with a sal...
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JP2005343835A |
To provide a simple method for preparation of an optically active 2, 5-2 substituted pyrrolidine compound in high purity.The invention relates to the method for preparation of mixture of three kind of diastereomers represented by formula...
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JP3716376B2 |
To obtain a reagent for optical resolution capable of producing an optically active 3-aminopyrrolidine derivative useful as a synthetic raw material for medicines and agrochemicals in high optical purity and yield by chemically modifying...
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JP2005533094A |
The process for separating the R(-)- and S(+)-5-Ä2-ÄÄ2-(2-ethoxyphenoxy)ethylÜaminoÜpropylÜ-2-m
ethoxybenzene-sulfonamide enantiomers comprises (a) reacting a mixture of said enantiomers with an optically active organic acid to for...
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JP2005298334A |
To provide a manufacturing method capable of obtaining a compound represented by formula (V) which is highly useful as a drug and high in both chemical yield and optical purity.The novel intermediate compound is represented by formula (I...
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JP2005531633A |
A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. ...
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JP2005281215A |
To provide a new optical resolution reagent which is optically higher in stability.The optical resolution reagent consisting of an optically active spiro compound is shown by formula (1) in which R1, R2, R3 and R4 are the same or differe...
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JP3704731B2 |
PURPOSE: To efficiently obtain the subject compound useful as an intermediate for medicines and agrochemicals in a large amount by subjecting a 3- hydroxyhexanoic acid ester of a racemic modification to asymmetric hydrolysis using a porc...
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JP3706160B2 |
PURPOSE: To industrially advantageously obtain an optically active diazabicycloheptene derivative having excellent potassium channel opening action and useful as an agent, etc., for treating hypertension. CONSTITUTION: A racemic modifica...
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JP3699115B2 |
PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed ...
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JP3696930B2 |
PURPOSE: To obtain a large amount of an optically active material economically and generally by performing the optical resolution of a mixture of optical isomers with a simple device and an operation and by a new method of using a temper...
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JP2005247811A |
To provide a method for simply producing (R)-(-)-5-[2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl]-
2-methoxybenzenesulfonamide hydrochloride salt and an intermediate for the same at a reduced cost.This method for producing the optical...
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JP3694923B2 |
PURPOSE: To readily and efficiently obtain the subject compound in high optical purity by using an organic solvent as a solvent and a prescribed carboxylic acid as a reagent for optical resolution, useful as an intermediate for a fungici...
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JP3683129B2 |
To obtain an optically active alcohol of high optical purity that is gentle to the ecosystem and permits reduction in the reaction cost by applying ovalbumin originating from egg, particularly from egg white of chicken egg to the organic...
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JP3684332B2 |
A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula (I) or (XIV) or a pharmaceutically acceptable salt thereof.
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JP2005194254A |
To provide a method for searching an optical resolution factors easily from a result of calculation performed by a quantum chemical calculation of differences in physicochemical properties affecting the separation of optical isomers cont...
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JP2005520813A |
Process for preparing 3-[(4S)-5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquino
lin-4-yl]benzonitrile, pharmaceutical compositions containing the compound and methods of treatment using the same.
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JP2005176758A |
To provide a method capable of economically synthesizing 4-oxochroman-2-carboxylic acid derivative (II) or (III) in short steps and enabling the industrial production.The method for producing the 4-oxochroman-2-carboxylic acid derivative...
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JPWO2003074470A1 |
In the present invention, tert-leucine and the following general formula (1) [in the formula, R1 and R2 each independently represent a hydrogen atom, an alkyl group or a halogen atom in a solvent. However, compounds in which both R1 and ...
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JP3665976B2 |
To obtain an optically active 2-piperazinecarboxylic acid derivative useful as an intermediate for medicines, etc., in a high optical purity and in a high yield by employing the chemically modified derivative of an inexpensively availabl...
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JP2005518338A |
The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is perf...
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JP3663643B2 |
PURPOSE: To profitably obtain the subject compound by optically resolving (RS)-1-(2,4-dichlorophenyl)ethylamine in the presence of a resolving agent comprising optically active aspartic acid which can be available in a relative low price...
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JP3659356B2 |
PURPOSE: To provide a novel compd. which is useful as an adsorbent for chromatography sepn. of an optically active polymer from a racemic body to an enantiomer. CONSTITUTION: This compd. is expressed by formula I (R is H, methyl, F; R1 i...
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JP2005516623A |
The present invention relates to the use of insect esterases or lipases, or mutants thereof, as catalysts in biotransformation processes. The present invention may have application in any process involving hydrolysis, esterification, tra...
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JP2005145842A |
To provide an oily N-alkyloxycarbonyl-S-(N-benzyloxycarbonylaminoethyl)cysteine
compound as its amine salt which is easy to handle and purify.A 1-phenylamine compound is allowed to act on the N-alkyloxycarbonyl-S-(N-benzyloxycarbonylami...
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JP2005145887A |
To provide a separation apparatus capable of simply separating two particles in the enantiomeric relation; to provide a separation method; and to provide a method for simulating the separation.The separation apparatus 1 has a circular fl...
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JP3647862B2 |
PCT No. PCT/FR94/01107 Sec. 371 Date Oct. 2, 1996 Sec. 102(e) Date Oct. 2, 1996 PCT Filed Sep. 22, 1994 PCT Pub. No. WO95/08522 PCT Pub. Date Mar. 30, 1995A method of optical enantiomer resolution by preferential crystallization involves...
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JP2005513069A |
The invention relates to a method for the preparation of escitalopram by cyanation of optically active intermediates of the formulas (III) and (II) below, and the preparation of such intermediates by optical resolution.
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JP2005104895A |
To provide an industrially feasible method for mass producing an amino alcohol compound having high optical purity.The method for preparing an optically active amino alcohol compound represented by formula (2) (wherein m is an integer of...
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JP2005104865A |
To industrially advantageously produce both optical isomers of (R) and (S) configurations of a 2-substituted amino-4-arylbutyronitrile in good yield.The method for producing an optically active 2-substituted amino-4-arylbutyronitrile or ...
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JP2005104874A |
To provide an industrially advantageous method for producing a desired optically active product at high optical purity with the use of an optical resolution agent available in large quantities at a low cost by improving the method for ma...
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JP3639599B2 |
The disclosure relates to a process for obtaining optically active L- alpha -aminocarboxylic acids from the corresponding racemic D,L, alpha -aminocarboxylic acids. The following steps are involved: (a) the D,L, alpha -aminocarboxylic ac...
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JP3638643B2 |
PURPOSE: To simply obtain the subject compound in high asymmetric selectivity by reacting 1-octen-3-ol with an acyl donor in the presence of a lipase. CONSTITUTION: 1-octen-3-ol (hereinafter referred to as matsutakeol) is reacted with an...
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JP2005509011A |
A process for the recovery of substituted tartaric acid resolving agents from resolution process liquors comprising organic solvents, wherein the substituted tartaric acid derivatives are neutralised by adding a base, extracted into an a...
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JP3635002B2 |
To provide a filler and a column for liquid chromatography, giving superior optical isomer separation relative to an object compound. In this filler for optical isomer separation for liquid chromatography, made of a polysaccharide deriva...
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JP2005507935A |
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, a...
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JP2005507863A |
Looking at the present invention from one aspect, it relates to a method for dynamically dividing a racemic mixture and a diastereomix of chiral compounds. Important elements in the method are non-racemic chiral tertiary amine-containing...
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JP2005075754A |
To provide optically active 1,2-bis(3,5-dimethylphenyl)-1,2-ethanediamine useful as an optical resolution agent or as the ligand of an asymmetric catalyst in an asymmetric synthesis reaction.This method for the optical resolution of tran...
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JP2005075758A |
To obtain a new reagent for optical resolution of an alcohol and to provide a method for efficiently producing an optically active alcohol using the reagent for optical resolution.The reagent for optical resolution of an alcohol represen...
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JP2005060231A |
To provide an advantageous method for producing an optically active 6-methoxy-naphthylglycolic acid (6-MeO-NGA) found to be useful as an optical resolving agent and to provide a method for producing an optically active arylalkylamine usi...
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JP2005053800A |
To provide a method for producing an optically active substance by an extracting distillation method, by which an extractant for optical resolution can efficiently be recovered.This method for producing the optically active substance is ...
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JP2005053917A |
To provide a method whereby an enantiomorphically enriched nitro-substituted 1-phenylethylamine is produced simply and effectively.The production method comprises the following processes: a process (A) wherein a compound of formula (III)...
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JP2005029538A |
To obtain an optically active binaphthol having high optical purity by a simple method from a racemic mixture of binaphthols.The problem is solved by producing diastereomers different in solubility by using an optically active amino acid...
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JP3615496B2 |
The present invention is directed to a process for the preparation of the D-(-)-tartrate salt of a compound of formula (I):
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