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JP2003183216A |
To provide a method for producing a short-chain 4-6C α- hydroxycarboxylic acid in high purity and high optical purity.The method for the production of an α-hydroxycarboxylic acid expressed by formula (I) (R1 is an alkyl; and R2 is a 2-...
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JP3422858B2 |
PURPOSE: To obtain a new optical resolving agent, comprising an optically active polyacetylene derivative having a specific structure and having excellent optical resolving ability and the possibility of extending the range of the object...
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JP2003519675A |
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed wh...
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JP3418984B2 |
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves: (i) forming a salt solution comprising said racemic mixture of a C1 to...
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JP2003171327A |
To provide a method for producing an optically active 1,1-bi-2-naphthol from a 2-naphthol by simple operation in a high yield by using an optically active compound which is industrially readily obtainable and inexpensive.This method for ...
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JP2003146995A |
To provide a method of purification for a non-natural 1-phosphorylated sugar derivative expressed by general formula (1).This method of purification for the non-natural 1-phosphorylated sugar derivative preferentially crystallizes a dias...
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JP2003137835A |
To provide a method for producing (R)-3-hydroxy-3-(2-phenylethyl) hexanoic acid, by which the (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a medicine raw material can efficiently be produced from racemic 3- hydroxy-3-(2-phenyle...
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JP2003137838A |
To provide a method for stereoselectively producing a 2,3-substituted succinic acid derivative, by which the 2,3-substituted succinic acid derivative useful as an intermediate for synthesizing useful substances such as a matrix metallopr...
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JP2003516378A |
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegene...
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JP2003515578A |
The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the ...
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JP3403469B2 |
PURPOSE: To provide a polymer of an optically active norbornene derivative having optical rotatory power and useful as a resolution agent for optical isomer and geometric isomer. CONSTITUTION: A polymer of an optically active norbornene ...
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JP3400105B2 |
PURPOSE: To obtain a compound which is useful as a reagent for optical resolution, particularly for optical resolution of DL-amino acids. CONSTITUTION: This compound is expressed by the formula (R is a lower alkyl; at least two of R1-R5 ...
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JP2003513927A |
This invention relates to the compound of Formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, which is an inhibitor of cysteine proteases, particularly cathepsin K, and is useful in the treatment of diseases in...
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JP2003513971A |
This invention relates to the compound of Formula (I): or a pharmaceutically acceptable salt, hydrate or solvate thereof, which is an inhibitor of cysteine proteases, particularly cathepsin K, and is useful in the treatment of diseases i...
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JP2003513928A |
This invention relates to the compound of Formula (I) or a pharmaceutical acceptable salt, hydrate or solvate thereof, which is an inhibitor of cystein proteases, particularly cathepsin K, and is useful in the treatment of diseases in wh...
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JP2003513891A |
Compounds of formula (I) and pharmaceutically acceptable salts and esters thereof are active as inhibitors of hepatitis C virus NS3 protease. Consequently they are potentially useful in the treatment and prevention of hepatitis C virus i...
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JP2003104186A |
To provide an acceleration slip control device for four-wheel drive vehicle, capable of preventing the shortage of braking torque and sufficiently conducting slip control when brake control is carried out for suppressing acceleration sli...
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JP2003105072A |
To provide an optically active polyester which can be easily synthesized from a low-cost raw material under mild conditions, into which substituent groups can be easily introduced, and of which the physical properties can be easily desig...
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JP2003095991A |
To provide a method for producing optically active 3,3,3-trifluoro-2- hydroxy-2-methylpropionic acid as a raw material of pharmaceuticals, agrochemicals, or the like.This method for producing the optically active 3,3,3-trifluoro-2- hydro...
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JP2003081926A |
To obtain a compound and excellent inhibitory action on PDE (phosphodiesterase) IV with a weak adverse effect.(-)-3-[3-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yloxy]-4- methoxyanilino]-2-methyl-2-cyclopenten-1-one, it hydrate, solvate or a medic...
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JP2003510180A |
(57) [Summary] The present invention relates to catalysts for asymmetric transfer hydrogenation based on transition metal compounds and nitrogen-containing optically opportunistic ligands. The present invention also relates to various me...
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JP2003073401A |
To provide a polysaccharide derivative which can be chemically bound to a carrier, is excellent in asymmetry identification ability and can produce a separating agent excellent in chemical resistance and durability with a convenient proc...
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JP2003073306A |
To recover an extracting agent for an optical resolution in good efficiency.This process comprising an optical resolution process of feeding (A) the extracting agent for the optical resolution and (B) a diluent from an upper stage of an ...
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JP2003073307A |
To efficiently resolve optically active substances.This method for optical resolution includes a process for optical resolution for inserting an extraction agent for optical resolution and a diluent to the upper stage of a distillation c...
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JP2003509403A |
The invention relates to cyclopropane carboxylic acid amides of general formula (I), wherein the substituents have the following meaning: R<1> represents substituted or unsubstituted C1-C6 alkyl or C2-C6 alkenyl groups, R<2> represents h...
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JP2003508378A |
The present invention provides a compound having the formula (I) or (II): wherein R<1> is selected from halogen and organic moieties; R<2> and R<3> are independently selected from hydrogen and organic moieties having a mass greater than ...
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JP2003055295A |
To provide a method for simply, efficiently and profitably producing an optically active 2-benzylsuccinic acid having an optical purity sufficient for being supplied for practical uses as a synthetic intermediate for medicines or the lik...
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JP2003507452A |
The invention relates to 1,3-disubstituted-3-oxopropane-1-sulfonic acids and sulfonates and enantiomerically inriched forms thereof. The invention further relates to the use of these enantiomerically inriched compounds to resolve mixture...
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JP3378273B2 |
PURPOSE: To obtain the subject compound having high optical purity useful as an intermediate for medicines in high yield by treating d-2-exo-norborny hydrogenphthalate with a specific optically active amine having positive optical rotato...
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JP2003040807A |
To provide a method for producing an optically active substance in high purity from a mixture of optically active substances of 4-amino-2- methylbutane-1-ol. Optically active 4-amino-2-methylbutane-1-ol is produced by optically resolving...
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JP2003040806A |
To provide a method for separating an isomeric mixture, especially an optical isomeric mixture objectively, continuously and efficiently. This method for separating the isomeric mixture is to use several isomer-separating columns filled ...
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JP2003034683A |
To provide a production method in which optically active 2- methylpiperazine of high optical purity is produced from 2-methylpiperazine by means of optical resolution in a high yield and at a low cost. In the optical resolution of optica...
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JP2003502322A |
A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.
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JP2003501344A |
Methods of preparing, and compositions comprising, derivatives of (+)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depr...
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JP3366289B2 |
The present invention concerns a process for the preparation of a compound of formula 1 or a salt thereof characterised in that the process comprises a) hydroboration of a compound of formula 2 in which formulae A is arylene; R<1> is -C*...
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JP2002363136A |
To make an efficient optical resolution of an optically active substance. The objective method for efficiently producing an optically active substance comprises the optical resolution step of charging an extractive distillation column wi...
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JP3358281B2 |
PURPOSE: To simply and industrially obtain an optical isomer of jasmine lactone by reacting (±)-(Z)-5-hydroxy-7-decenoic acid with a specific reagent for optical resolution and dehydrating the reactional product. CONSTITUTION: This opti...
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JP2002542153A |
[Chemical 1] The present invention relates to a method for producing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by. In structural formula (I), R is an amine protecting group, and R1 Is an amino acid side chain, a...
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JP2002348279A |
To provide optically active pyridylketone derivatives represented by general formula (2) which have neuron differentiation-promoting activity or neuroprotective activity. The present invention is completed by finding that a diastereomer ...
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JP2002350413A |
To provide a separation column having stable frit producible easily with excellent reproducibility, and a separation method of an optical isomer by using the column. This separation column is characterized by having the frit acquired by ...
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JP2002348257A |
To provide an industrially advantageous method for producing 3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid which is an effective intermediate for an optically active medicine and an optically active agrochemical. A method for optical...
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JP2002541235A |
The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone.
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JP2002540090A |
The present invention relates to a method of industrial-scale purification of lactic acid, the method including the steps of:(a) reduced-pressure distillation of a concentrated lactic acid solution having a total acid content of at least...
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JP2002332263A |
To provide a method for purifying (2R)-4-amino-2-methylbutan-1-ol in high efficiency.The method for the efficient purification of (2R)-4-amino-2- methylbutan-1-ol comprises the crystallization of a salt of (2R)-4-amino-2- methylbutan-1-o...
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JP3349086B2 |
To provide the subject compound useful as an intermediate for synthesizing medicinal compounds in a high purity and in a high yield by crystallizing the compound from a solution containing the optically active compound, the other optical...
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JP2002539086A |
A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals ca...
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JP2002326971A |
To provide an advantageous method of production for an optically active chrysanthemumic acid.This method of production for the optically active chrysanthemumic acid reacts an optically active organic amine to the chrysanthemumic acid hav...
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JP2002326982A |
To provide an economical and efficient method for producing a specific N-carbamate type protected benzenesulfonamide derivative which is suitable for industrial production, the specific benzenesulfonamide derivative and its salt derived ...
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JP3342482B2 |
A novel polysaccharide derivative prepared by replacing part or the whole of the hydroxyl or amino groups of a polysaccharide by two or more different substituents, and a separating agent and a separator both containing this derivative. ...
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JP3343256B2 |
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary ...
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