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WO2004052883A3 |
In a process comprising synthesizing pyranes including [R-(R*,R*)]-N-[3-[1 [5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-p
yran-3- yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises t...
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WO/2004/110586A1 |
The invention relates to chiral separation chromatographic and electrophoretic techniques. The aim of said invention is to obtain chiral stationary and mobile phases comprising an oligonucleotide which is specifically selected by a SELEX...
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WO/2004/096873A1 |
An optically active acetylene polymer represented by the following formula (I), produced by polymerizing an optically active 1-(dimethyl(10-pinanyl)silyl)-1-propyne and having a weight-average molecular weight of 10,000 to 1,000,000; a f...
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WO2000063175A3 |
The invention relates to a novel process for the preparation of certain pharmaceutically active pyridyl compounds.
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WO/2004/089871A1 |
A method for producing trans-2-[(&agr -methylbenzyl)amino] cyclopentanol being highly pure as a diastereoisomer, which comprises reacting a mixture of two diastereoisomers of trans-2-[(&agr -methylbenzyl)amino]cyclopentanol represented b...
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WO2003022784A9 |
The invention relates to a method for determining the enantiomer ratio of trimethylcyclopentene derivatives of structure (I), wherein Z is an alkyl radical having 1 - 10 C atoms, can be saturated or olefinically unsaturated, straight-cha...
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WO2003037840A8 |
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, a...
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WO2002072514A8 |
This invention provides methods and catalysts systems for catalyzing enantioselective oxidation reactions, including cyclization reactions and enantioselective oxidation reactions of secondary alcohols and other similarly reactive organi...
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WO2003003804A3 |
The invention relates to a process for the preparation of (R, R)-phenylisoserine and its derivatives. The process according to the invention includes the following steps : - reacting a 3-phenylglycidic acid salt with ammonia to yield the...
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WO/2004/052883A2 |
In a process comprising synthesizing pyranes including [R-(R*,R*)]-N-[3-[1 [5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-p
yran-3- yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises t...
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WO2004026247A3 |
Diketo- and pyridine-containing chiral crown ligands having at least two chiral bulky groups attached to two different chiral carbon atoms of the crown that are covalently bonded to or coated on suitable solid supports, and further coate...
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WO/2004/046714A1 |
A method for preparing a separating agent for an optical isomer, which comprises a step of contacting a dope of an optically active polymeric compound with a porous carrier, to allow the porous carrier to carry the optically active polym...
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WO/2004/043908A1 |
A process for interconverting a mixture of cis-trans erythro-threo isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are usefull intermediates in the synthesis of cis isomers of benzamide...
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WO2004014959A3 |
The invention relates to novel cyclodextrin derivatives which are characterised in that at least one of the hydrogen atoms borne by the carbon atoms in position 3 and/or 5 and/or 6 of the glucopyranoside units (or glucose) contained in t...
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WO2004005220A3 |
The invention concerns a method for resolving a racemic to obtain its optically active isomer characterized in that it consists in reacting, with diprogulic acid or one of its salt, a racemic of general formula (I), wherein: Ar is a hete...
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WO2004006829A3 |
The invention relates to a method of separating enantiomers R(-)- and S(+)-5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenz
enesulphonamide. The inventive method consists in: (a) reacting a mixture of the aforementioned enantiomer...
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WO/2004/026247A2 |
Diketo- and pyridine-containing chiral crown ligands having at least two chiral bulky groups attached to two different chiral carbon atoms of the crown that are covalently bonded to or coated on suitable solid supports, and further coate...
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WO/2004/026469A1 |
A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Bronsted acid, with a salt...
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WO/2004/020429A1 |
A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and a chiral or prochiral cyclic substrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible t...
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WO/2004/014959A2 |
The invention relates to novel cyclodextrin derivatives which are characterised in that at least one of the hydrogen atoms borne by the carbon atoms in position 3 and/or 5 and/or 6 of the glucopyranoside units (or glucose) contained in t...
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WO/2004/014821A1 |
The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram invol...
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WO/2004/013081A1 |
Process for the preparation of primary amines of formula (I): on enclosed where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): (formula see on enclosed paper version) where R1 and R...
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WO/2004/006829A2 |
The invention relates to a method of separating enantiomers R(-)- and S(+)-5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenz
enesulphonamide. The inventive method consists in: (a) reacting a mixture of the aforementioned enantiomer...
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WO/2004/005220A2 |
The invention concerns a method for resolving a racemic to obtain its optically active isomer characterized in that it consists in reacting, with diprogulic acid or one of its salt, a racemic of general formula (I), wherein: Ar is a hete...
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WO/2004/002924A1 |
A process and intermediates for producing 3-amino nitriles. The process involves resolving an enantiomeric mixture of chiral 3-amino nitriles in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. ...
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WO/2004/000761A1 |
A method of separating the enantiomers of a chiral compound from a mixture, the mixture including a first and second enantiomer, by introducing the mixture into a fluid flow leading to a separation means which changes the distribution of...
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WO2003079002A3 |
The invention relates to novel polymeric composite chiral stationary phases of brush type suitable for the separation and/or the purification of enantiomers of organic and organometallic compounds. The invention further relates to method...
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WO2003011846B1 |
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5
-isobenzofurancarbaldoxime, O-substitute...
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WO2003011846A3 |
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5
-isobenzofurancarbaldoxime, O-substitute...
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WO2003085000A9 |
The invention concerns crosslinked polysaccharide derivatives on a support or not, insoluble in organic solvents with high dissolving power such as boiling chloroform, ethyl acetate or acetone. Said derivatives can be used as chiral stat...
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WO2003050062A3 |
Methods for production of chirally pure alpha -amino acids and N-sulfonyl alpha -amino acids are described. An aldehyde and a cyanide salt are reacted with an alpha -methylbenzylamine to afford a product. The product reacts with a strong...
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WO/2003/091185A1 |
A separating agent for an optical isomer, characterized in that a carrier having a polymerizable functional group, a polymerizable polysaccharide derivative which is a polysaccharide derivative having a polymerizable functional group, an...
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WO/2003/087808A1 |
A packing that is suitable for fractionation by simulated moving bed chromatography, ensuring high productivity. In particular, an optical isomer separation packing for simulated moving bed chromatography wherein a polysaccharide derivat...
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WO/2003/085000A1 |
The invention concerns crosslinked polysaccharide derivatives on a support or not, insoluble in organic solvents with high dissolving power such as boiling chloroform, ethyl acetate or acetone. Said derivatives can be used as chiral stat...
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WO/2003/079002A2 |
The invention relates to novel polymeric composite chiral stationary phases of brush type suitable for the separation and/or the purification of enantiomers of organic and organometallic compounds. The invention further relates to method...
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WO/2003/070961A1 |
The invention provides chimeric cannulae polypeptides and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one as...
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WO/2003/068728A1 |
A process for production of optically active N-acetyl -β-phenylalanine through optical resolution of N-acetyl-β- phenylalanine by preferential crystallization. According to this process, not only optically active N-acetyl-β-phenyl- al...
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WO/2003/068727A1 |
A process which comprises reacting an N-acyl-β- phenylalanine derivative with a specific reagent for optical resolution to form diastereomeric salts, subjecting the diastereomeric salts to optical resolution, removing the reagent from e...
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WO/2003/066873A1 |
The present invention relates to the use of insect esterases or lipases, or mutants thereof, as catalysts in biotransformation processes. The present invention may have application in any process involving hydrolysis, esterification, tra...
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WO2002092562A3 |
The present invention provides multiphasic systems comprising at least one chiral selector and an achiral phase transfer catalyst, wherein said system can be used to effect enantioselective reactions or asymmetric induction reactions.
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WO/2003/062225A1 |
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by R...
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WO/2003/062203A1 |
A novel process for preparing 3−[(4S)−5−oxo−2−(trifluoromethyl)−1,4,5,6,7,8−
hexahydroquinolin−4−yl]benzonitrile, pharmaceutical compositions containing the compound and methods of treatment using the same.
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WO/2003/059846A1 |
The present invention provides the use of highly homogeneous serum albumin as a chiral selector, preferably immobilised, such as in enantioselective chromatography. The present invention also provides an enantioselective chromatography c...
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WO/2003/059512A1 |
The invention concerns a catalyst immobilized on silica for heterogeneous catalysis, in the form of silica particles of average grain size distribution ranging between 15 $g(m)m and 2 mm comprising a ligand bound to the particles by a co...
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WO/2003/055831A1 |
Process for modifying the relative ratios of the components of a liquid starting mixture of specific diastereoisomers, containing at least two asymmetric carbon atoms comprising contacting said liquid mixture with a Lewis acid compound c...
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WO/2003/051852A1 |
An intermediate represented by the general formula (I): (I) (wherein R1 represents propyl, 2−propenyl, or 2−propinyl and R2 represents C4−8 alkyl)&semi a process for producing the intermediate&semi and a process for producing from ...
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WO/2003/051861A1 |
The invention relates to a method for the preparation of escitalopram by cyanation of optically active intermediates of the formulas (III) and (II) below, and the preparation of such intermediates by optical resolution.
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WO/2003/050062A2 |
Methods for production of chirally pure $g(a)-amino acids and N-sulfonyl $g(a)-amino acids are described. An aldehyde and a cyanide salt are reacted with an $g(a)-methylbenzylamine to afford a product. The product reacts with a strong ac...
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WO/2003/048080A1 |
Methods for the separation of chaotropic and kosmotropic enantiomers within a racemic mixture are provided. Such methods comprise differentially partitioning the enantiomers into stabilized microdomains of low density water and high dens...
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WO2002088149A3 |
The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the des...
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