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WO/2010/101118A1 |
Use is made of a microreactor which comprises a substrate having, formed therein, one passage having a cross section with a width and a depth of 1 mm or less each, the passage having a starting-material injection opening and a first reag...
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WO/2010/088901A1 |
The application describes a method for purifying the reaction mixture in manufacturing radiolabeled compounds, in particular 18F-labeled compounds, in particular radiopharmaceuticals, by semi-preparative or preparative liquid chromatogra...
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WO/2010/072342A2 |
The invention pertains to a method for eluting a radionuclide-label or a radionuclide-labeled compound using a solid phase extraction resin, to a device for performing such a method, and to a computer program for controlling such a device.
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WO/2010/065755A1 |
This invention relates to novel substituted pyridinones, their deuterium-modified derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of...
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WO/2010/063403A2 |
The invention relates to the compounds suitable for radiolabeling with a chelator free radioisotope and radiolabeled compounds of the general Formula (I). Said compounds are ornithine or lysine derivatives.
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WO/2010/060694A1 |
The present invention relates to 18F radiochemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety of 18F-label...
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WO/2009/141090A9 |
The present invention relates to fluorinated glutamic acid (glutamate) and glutamine derivatives wherein the fluorine atom is 19F. The glutamic acid (glutamate) and glutamine derivatives are compound(s) of general Formula I, which encomp...
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WO/2010/033511A1 |
This invention relates to novel 2-amino-3-hydroxypropanoic acid derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions...
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WO/2010/021719A1 |
A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat sour...
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WO/2010/020901A1 |
The invention provides a liquid composition for an electrowetting device/liquid lens, and a method of manufacturing the liquid composition. The method of manufacturing comprises: replacing (21) a type of atom, which is included in an ini...
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WO/2010/019560A1 |
This invention relates to deuterated derivatives of donezepil and its metabolites as well as pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such...
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WO/2010/018218A2 |
The present invention provides an improved method for fluoridation of an iodonium salt wherein a solution of the iodonium salt comprising a free radical trap is stored before the reaction is carried out. The method of the invention may b...
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WO/2010/015387A1 |
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such co...
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WO/2010/015340A1 |
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such co...
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WO/2010/007363A2 |
The invention relates to a process for producing a fluorine-labelled compound, the process comprising: (a) treating a compound of formula (I) wherein R1, R2 and the C(H) group to which R1 and R2 are bonded together form a moiety to be la...
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WO/2010/008522A2 |
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically su...
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WO/2010/003548A1 |
The present invention relates to novel processes for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET). The invention also comprises radiopharmaceutical kits using these processes.
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WO/2010/000409A2 |
The present invention relates to novel perfluorinated precursors for the production of F- 18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The inventi...
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WO/2009/156543A1 |
The invention relates to deuterated vitamin D compounds and to a method for the preparation and synthesis of a class of vitamin D compounds that can be isotopically substituted. These compounds can be used as internal standards in method...
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WO/2009/158010A1 |
This invention relates to novel prostacyclin analogs and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel prostacyclin analogs that are derivatives of treprostinil. This invention also provides...
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WO/2009/155309A1 |
This invention relates to novel substituted cyanopyrrolidines, their derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such composi...
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WO/2009/143985A1 |
New molecule 5-Hydroxy- 1 -(4-hydroxy-3-[124I]iodo-5-methoxyphenyl)-7-(4- hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one, obtainable through three different processes of chemical synthesis, all of the same importance, and all starting f...
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WO/2009/141091A1 |
The invention relates to compounds and the synthesis of [F-18] labelled L-glutamic acid, [F-18] labelled L-glutamate, to their derivatives according to formula (I) and to their uses.
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WO/2009/141079A1 |
The invention relates to compounds and the synthesis of [F-18] labelled L-glutamic acid and [F- 18] labelled L-glutamate, to their derivatives according to formula (I) and to the uses thereof.
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WO/2009/139634A1 |
The invention is directed to radiolabelled MMP selective compounds, a processes for the preparation thereof, and uses thereof. The derivatives of the invention have formula (I) wherein Y represents O, CH2, (CH2)2, S, NH, or C(=O)NH; X re...
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WO/2009/139633A1 |
The invention is directed to radiolabelled MMP selective compounds, a processes for the preparation thereof, and uses thereof. The derivatives of the invention have formula (I) wherein Y represents O, CH2, (CH2)2, S, NH, or C(=O)NH; X re...
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WO/2009/127372A1 |
The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group...
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WO/2009/126844A2 |
This invention relates to novel derivatives of tolterodine, 5-hydroxymethyl tolterodine, fesoterodine and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and th...
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WO/2009/114809A1 |
Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.
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WO/2009/102498A1 |
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherei...
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WO/2009/096555A1 |
Disclosed is a method for producing a compound having a deuterated aromatic ring or heterocyclic ring, wherein an aromatic ring or heterocyclic ring is heated in the presence of heavy water, a transition metal and a metal which generates...
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WO/2009/087066A2 |
The invention relates to a method for preparing a 2-fluoro-purine derivative marked with the 18F radioisotope that comprises the step of fluorinating a 2-nitro-purine derivative. The invention also relates to a 2-fluoro-purine derivative...
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WO/2009/080192A1 |
Method of examining the authenticity of plant protection agents. A method of identifying a plant protection agent, where a) at least one relative ratio between two stable isotopes of a chemical element is determined in a reference sample...
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WO/2009/080561A1 |
Provided herein are methods for introducing flĪ
orine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive teminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the ...
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WO/2009/079413A2 |
A method including isotope labeling of a newly synthesized protein in a sufficient quantity such that a newly synthesized protein spectra and the pre-existing protein spectra are sufficiently separated. A further method including determi...
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WO/2009/077386A1 |
Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula (j), wherein m is from 1 to 5 and X is halo, with Z2 wherein Z is tritium or deuterium, in the presence of a catalyst, to form a compo...
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WO/2009/078396A1 |
The object is to provide a method for improving the yield in the radioactive fluorination in the process for producing a radioactive-fluorine-labeled organic compound. Provided is a method for labeling a compound represented by the formu...
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WO/2009/065789A1 |
The invention relates to a method for detecting marking materials in liquids, wherein (a) one or more, identical or different marking materials are provided in the liquid, (b) a deuteration agent is brought into contact with the liquid, ...
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WO/2009/057528A1 |
Disclosed is a kit for use in the production of a molecular probe for PET drug screening for the purpose of producing a compound containing a short-lived radionuclide for PET applications. Specifically disclosed is a kit comprising a com...
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WO/2009/052970A2 |
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such co...
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WO/2009/054964A1 |
This invention relates to novel alpha-aminoamide derivatives, their pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such ...
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WO/2009/055006A1 |
This invention relates to novel compounds that are hydroxyethylamino sulfonamide derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel hydroxyethylamino sulfonamide derivatives that...
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WO/2009/035959A2 |
The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
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WO/2009/032723A1 |
The invention relates to a synthetic strategy of using perfluoro crown ethers and other macrocycles to bind to [18F]-labelled fluorination reactions. The optional use of implementing perfluoro kryptofix 2.2.2 in this process is also disc...
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WO/2009/032843A2 |
Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula (I), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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WO/2009/029633A1 |
The invention relates to new processes for preparation of 18F-labelled alkylation reagents that can be used in the alkylation of amines that are suitable for use in labelling of Positron Emission Tomography (PET) radiotracers. (I)
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WO/2009/018280A2 |
Disclosed herein are substituted indole cysteinyl leukotriene receptor modulators of Formula (I), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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WO/2009/014203A1 |
Disclosed is a method for producing (1,3,5/2,4,6)-1-fluoro-2,3,4,5,6-cyclohexanepentol, which comprises a step (A) for producing a compound represented by the general formula (II) below by reacting a compound represented by the general f...
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WO/2009/015048A2 |
Methods and apparatus enable radiosynthesis of radiolabeled compounds using electrochemical trapping and release. The trapping and release of radioactive isotopes all occur inside a microreactor, a vial or similar device, thus eliminatin...
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WO/2009/005069A1 |
[PROBLEMS] To provide a method of efficiently deuterating a substrate with the use of a ruthenium catalyst. [MEANS FOR SOLVING PROBLEMS] The method of deuteration is characterized in that a compound having hydroxyl, an optionally substit...
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