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WO/2009/004914A1 |
Disclosed are: a PET probe compound having an alkoxy group substituted by a fluorine and a hydroxy group, which is useful for the early diagnosis of a conformational disease; a pharmaceutical composition for the treatment and/or preventi...
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WO/2009/001046A2 |
This invention pertains generally to the field of radiochemical synthesis, and more specifically to methods of preparing [11C]methoxy-radiolabelled 2,3',4,5' -tetramethoxystilbene (TMS) from an unlabelled hydroxy precursor of 2,3',4,5' -...
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WO/2008/155339A2 |
The invention provides a method for radiofluorination of biological vectors such as peptides comprising reaction of a compound of formula (II): or a salt thereof with a source of [18F]-fluoride, to give a compound of formula (I): or a sa...
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WO/2008/146316A1 |
A procedure for the preparation of the radioactive tracer 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) comprises the following steps: a) preparation of anhydrous [18F]F- fluoride; b) labelling of a precursor, for example 3-N-Boc-1-[5'- 0-...
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WO/2008/140859A1 |
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disor...
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WO/2008/141021A1 |
This invention relates to novel substituted tetrahydrotriazolopyrazines of formula (I) and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compo...
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WO/2008/140616A2 |
A microscale solution for conducting [18F] fluoride phase transfer and subsequent radiosysnthesis of 2- [18F] FDG that eliminates the azeotropic drying process. [18F] fluoride phase transfer is performed using an inexpensive disposable m...
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WO/2008/137474A1 |
This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the us...
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WO/2008/128306A1 |
The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified...
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WO/2008/130924A2 |
The present disclosure provides methods of making isotopically-labeled glycans or a mixture of glycans (e.g., a glycan preparation) via reductive amination. Such methods are useful, for example, in the determination of the relative amoun...
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WO/2008/125613A1 |
The present invention is directed towards a new method of synthesis of 18F-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18 [F] fluoride, a...
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WO/2008/125617A2 |
The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within ...
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WO/2008/124651A2 |
The present invention relates to novel radioactively labeled bioreducible tracers of Formula (I) useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triaz...
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WO/2008/122010A1 |
This invention relates to novel calcimimetic compounds, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use o...
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WO/2008/110757A1 |
The present invention relates to a process for separating a target radiolabelled compound from an impurity, apparatus for performing such a process and a removable cassette for use in such apparatus. Also provided are methods for using t...
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WO/2008/101305A1 |
The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, characterised in that the eluting solution is a low water content, preferably <...
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WO/2008/101069A1 |
The present invention relates generally to synthesis of radioactive material, such as a tritiated polymer, and an apparatus for generating electrical current from the nuclear decay process of a radioactive material. In one embodiment, th...
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WO/2008/099203A2 |
Reactions of isotopically enriched samples of elements selected from phosphorus, sulfur, selenium and/or tellurium involving the addition of atoms of the isotope to organic or inorganic molecules comprising use of an ionic liquid as a re...
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WO/2008/078589A1 |
[PROBLEMS] To provide a process for producing a labeled precursor which is useful for the production of an amino acid compound labeled with a radioactive fluorine. [MEANS FOR SOLVING PROBLEMS] In the reaction process for introducing a le...
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WO/2008/075043A1 |
The present invention relates to methods of synthesising radiolabelled compounds, to the precursors useful in such methods and to the radiolabelled compounds obtainable by such methods. More particularly, the present invention relate to ...
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WO/2008/066158A1 |
Disclosed is a method for deuterating an alkane wherein deuteration effectively proceeds under relatively mild conditions (at low temperature/low pressure). Specifically disclosed is a method for deuterating an alkane wherein an alkane a...
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WO/2008/052788A1 |
The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, derivatives thereof of the formula (I) and uses thereof are described.
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WO/2008/029734A1 |
A process for producing a radioactive fluorine labeled compound, including the step (S10) of heating a mixture containing [18F] fluoride ions, a phase-transfer catalyst, potassium ions and water in a reactor vessel to thereby evaporate o...
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WO/2008/023251A2 |
The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Methods for in vivo imaging uses of the PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and...
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WO/2008/023780A1 |
It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a...
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WO/2008/015391A1 |
The invention relates to methods and apparatus for purifying a radiolabelled compound. The method comprises (i) passing a crude reaction mixture comprising the desired radiolabelled compound and one or more contaminants in a solvent thro...
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WO/2008/011033A2 |
Isotopically labeled alpha-keto acids and esters are disclosed herein. Also disclosed are methods of synthesizing isotopically labeled alpha-keto acids and esters.
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WO/2008/001098A1 |
A method of electrochemically separating [18F] fluoride from [18O] water comprising a device that encompasses two or more electrodes, wherein said device allows entry and exit of solutions within a chamber wherein an electric field is ap...
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WO/2007/147838A1 |
Compounds of formula (I) and salts and solvates thereof, which are radiolabeled ligands for the glycine 1 transporter, are provided: wherein R1 is a radiolabeled group incorporating or consisting of a radionuclide selected from 3H, 11C, ...
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WO/2007/147454A1 |
This invention regards a new molecule: the Cu-64ASP (copper- 64asparaginase; [64CU]asparaginase), which, used in the PET diagnostic methodology, allows a double in “vivo” use: the diagnostic and radiotherapeutical ones.
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WO/2007/139923A1 |
Provided herein are substituted aminoglycidyl compounds of Formula (1), processes of preparation, and pharmaceutical compositions thereof and methods of their use for treating, preventing, or ameliorating one or more symptoms of a social...
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WO/2007/138408A1 |
The present invention relates to new 11C/18F-labeled inhibitor compounds for over-expressed GSK-3 prepared from the GMP synthesis method. The present invention provides novel11C/18F inhibitor compounds for over-expressed GSK-3 that are s...
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WO/2007/135541A1 |
A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for pre...
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WO/2007/132689A1 |
[PROBLEMS] To provide a process for production of [18F]FACBC, which can reduce the amount of an impurity produced during the process. [MEANS FOR SOLVING PROBLEMS] A process for production of a radioactive fluorine-labeled organic compoun...
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WO/2007/122488A2 |
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in pa...
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WO/2007/109292A2 |
Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular c...
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WO/2007/099934A1 |
A combination of aliphatic amino acids labeled with stable isotope for realizing of an analysis of the conformation of protein of high molecular weight, especially molecular weight as high as exceeding 60 kDa. There is provided a combina...
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WO/2007/096194A1 |
A radio-labeled isoxazole derivative of formula I, wherein R1 represents H, N-{11C]alkyl-piperazinyl, N-[11C]alkyl-piperazinyl-alkyl, N-[3H]alkyl- piperazinyl, N-methyl-piperazinyl or N-[3H]alkyl-piperazinyl-alkyl. R2 represents H, alkox...
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WO/2007/093450A2 |
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine derivatives as well as physiologically acc...
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WO/2007/088670A1 |
A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound ha...
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WO/2007/074383A1 |
The present invention provides novel 18F-labeled phenoxyphenyl N-benzyl alkanamid derivative compounds that are suitable for use as an in vivo imaging agent. A pharmaceutical comprising the compound and a kit for the preparation of the p...
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WO/2007/067074A1 |
The invention relates to new processes for preparation of 18F-fluoroalkyl halides suitable for use in labelling of Positron Emission Tomography (PET) radiotracers. The process of preparation comprises the step of reacting a 18F-fluoroacy...
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WO/2007/066089A2 |
The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in s...
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WO/2007/063824A1 |
[PROBLEMS] To provide a novel amino acid organic compound that can be used as a labeled precursor compound of [18F]FACBC and other radioactive halogen labeled amino acid compounds, and that ensures freedom from methanol residue in the pr...
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WO/2007/062119A1 |
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generali...
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WO/2007/060517A1 |
Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with 18F using one-step syntheses are provided. Analogues labeled with the 18F using the one-step synthesis method are also provided. Ad...
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WO/2007/046258A1 |
[PROBLEMS] To provide a method of rapid alkene compound methylation which is applicable to the preparation of a PET tracer and which enables an alkene compound to be rapidly methylated through cross coupling between SP2 (alkenyl) and SP3...
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WO/2007/044001A1 |
A method of labeling amino acid-containing compounds and derivatives thereof with a halide moiety comprises reacting a nucleophilic moiety on such compounds with a halogenated electrophilic compound. Radioactive halide-labeled amino acid...
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WO/2007/036785A2 |
A potent and selective ligand for peripheral benzodiazepine receptor (PBR), N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamid
e or DAA1106 and eight structurally related analogues were labelled with 11C at carbonyl position of...
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WO/2007/026216A1 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and ph...
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