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Matches 1 - 50 out of 1,923

Document Document Title
WO/2018/008311A1
[Problem] To provide 11C-labelled O6-benzylguanine with which PET images can be obtained, and a production method therefor. [Solution] This 11C-labelled O6-benzylguanine is characterized by being represented by chemical formula (a). The ...  
WO/2018/005625A1
The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue overexpressing PSMA. The compounds are of Formula (I) or a pharmace...  
WO/2017/210302A1
Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.  
WO/2017/206801A1
Disclosed are a class of diarylsulfide derivatives, a preparation method therefor, and the use thereof as a serotonin transporter-targeted imaging agent, belonging to the field of radiopharmaceutical chemistry. The diarylsulfide derivati...  
WO/2017/202206A1
The present invention discloses a substituted quinoline compound as shown in formula (I), a pharmaceutical composition comprising said compound or a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotopic va...  
WO/2017/181918A1
The present invention discloses a substituted phthalazone, wherein the substituted phthalazone is a compound represented by formula (I). The invention further discloses a pharmaceutical composition comprising the compound, or a crystalli...  
WO/2017/180492A1
A system, and method, for quantitatively mapping of mitochondrial membrane potential of a tissue in a subject is provided. In some aspects, the provided method includes administering to the subject a detectably effective amount of a trac...  
WO/2017/180589A1
The present disclosure provides compounds of Formula I and/or Formula II, or pharmaceutically acceptable salts thereof: wherein D is deuterium and each deuterium has deuterium enrichment of no less than about 10%, compositions containing...  
WO/2017/157137A1
Provided in the present invention is a new type acyclic nucleoside analogue and a pharmaceutical composition thereof, wherein the new type nucleoside analogue is the compound as shown by formula (I), or a crystal form, a pharmaceutically...  
WO/2017/152677A1
The present invention relates to a cholanic acid compound for preventing or treating FXR-mediated diseases. Specifically, disclosed are a cholanic acid compound represented by formula (I) and a pharmaceutical composition containing the c...  
WO/2017/144639A1
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.  
WO/2017/140183A1
Provided are substituted steroids and a use thereof. In particular, the substituted steroids of the present invention are steroids as shown by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer,...  
WO/2017/133337A1
The present invention provides a substituted benzimidazolone compound and a composition comprising the same. The present invention discloses a substituted benzimidazolone compound represented by formula (I) and a pharmaceutical compositi...  
WO/2017/134098A1
The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising ...  
WO/2017/117070A1
The invention provides novel chemical compounds useful for treating cancer or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.  
WO/2017/103179A1
The present invention relates to novel, radiolabeled mGluR2/3 ligands, selective versus other mGlu receptors which are useful for imaging and quantifying the metabotropic glutamate receptor mGlu2 and 3 in tissues, using positron-emission...  
WO/2017/103182A1
The present invention relates to novel, radiolabelled mGluR2/3 ligands, selective 5 versus other mGlu receptors, which are useful for imaging and quantifying the metabotropic glutamate receptors mGlu2 and 3 in tissues, using positron-emi...  
WO/2017/090354A1
[Problem] To provide an aromatic compound methylation method, in which a reaction substrate that serves as a raw material can be synthesized easily, and which can be employed as a method for producing a [11C]-labeled tracer for PET use. ...  
WO/2017/089492A1
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...  
WO/2017/087207A1
The invention provides novel chemical compounds useful for treating various hematologic malignancies and inflammatory and autoimmune diseases or a related disease or disorder thereof, and pharmaceutical composition and methods of prepara...  
WO/2017/076879A1
Radiotracer compositions comprising a radiotracer compound comprising [18F]SO3F-, [18F]PF6 - or [18F]PO2F2 -, methods of synthesising such radiotracer compounds, kits for synthesising such compounds, and the use of such compounds in a di...  
WO/2017/079003A1
The invention provides novel chemical compounds useful for treating various blood cancers, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.  
WO/2017/078928A1
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subje...  
WO/2017/072200A1
The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their ...  
WO/2017/070752A1
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly af...  
WO/2017/065899A1
Described are deuterated chlorokynurenines and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of modulating N-methyl-D-aspartate (NMDA) receptor activity, methods of treating disorders, inclu...  
WO/2017/055859A1
The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions co...  
WO/2017/055860A1
The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions co...  
WO/2017/050259A1
Provided are prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.  
WO/2017/029820A1
The present invention relates to: a radioactive halogen-labeled pyrido[1,2-a]benzimidazole derivative compound represented by a specific general formula or a salt thereof; or a radioactive medicine comprising the compound or the salt.  
WO/2017/019804A3
Compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein A, J, R1, R2, R3, R4, R5, R6, R7, R9, X, m and n are as described herein, compositions thereof, and ...  
WO/2017/007790A9
The present invention relates to compounds according to Formula (I) or Formula (II), which are potential bone imaging agents and therapeutic agents for treating bone tumors and metastases. Certain compounds labeled with 68Ga displayed ex...  
WO/2017/006931A1
The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain u...  
WO/2017/007790A1
The present invention relates to compounds according to Formula (I) or Formula (II), which are potential bone imaging agents and therapeutic agents for treating bone tumors and metastases. Certain compounds labeled with 68Ga displayed ex...  
WO/2016/201128A1
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also pro...  
WO/2016/201125A1
This disclosure relates to radioiodinated compounds useful as bioconjugation reagents, and intermediates for making radioiodinated bioconjugation reagents.  
WO/2016/198374A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2016/192586A1
Provided are a deuterium-substituted dehydrophenylahistin-like compound, preparation method thereof and use in a preparation of antitumor drugs. The deuterium-substituted dehydrophenylahistin-like compound has a structure of general form...  
WO/2016/194586A1
A radioactively labeled compound production device (100) is a production device for producing a radioactively labeled compound by introducing a radioactive isotope into a non-radioactively labeled precursor compound. The production devic...  
WO/2016/184980A1
The invention relates to a method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method comprises carrying out a first synthesis run comprising the steps of: a) providing water contai...  
WO/2016/176572A1
Disclosed are boron mimics of amino acids which are compounds, salts, solvates, or stereoisomers of the Formula (I): wherein A, R.1, R2, and R3 are defined herein, and processes for the preparation of the compounds, salts, solvates, or s...  
WO/2016/160945A1
This invention relates to novel, deuterated forms of VX-661 and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of t...  
WO/2016/153054A1
Provided are an efficient method for producing a nitrogen-containing compound or salt thereof to be used in the production of a treatment agent for diseases involving an integrin. Also provided is a production intermediate of the same. A...  
WO/2016/151295A1
The present invention relates to a process for producing an organic compound comprising an 18F atom, which process comprises treating a precursor organic compound comprising a –CY2X group with: (i) [18F] fluoride; and (ii) an activator...  
WO/2016/145156A1
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as...  
WO/2016/142702A1
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide ...  
WO/2016/140118A1
A radioactive iodine labeled pyrido[1,2-a]benzoimidazole derivative compound represented by a definite general formula or a salt thereof, or a radioactive medicine comprising the same.  
WO/2016/124508A1
The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of...  
WO/2016/116875A1
Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging...  
WO/2016/105547A1
This invention relates to novel deuterated pyrimidinedione derivatives of Formula (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such c...  

Matches 1 - 50 out of 1,923