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Matches 501 - 550 out of 3,838

Document Document Title
WO/1997/000848A1
A process for the preparation of an ester, especially fluorinated esters R1O.OC-CFR2-CO.OR3.R1 and R3 are each independently selected from alkyl, cycloalkyl and aryl. R2 is selected from hydrogen, alkyl, cycloalkyl. The method includes t...  
WO/1996/037454A1
The object of the invention is a method for preparing 3-carboxy-4-hydroxybenzaldehydes and derivatives thereof from phenol compounds bearing formyl and/or hydroxymethyl groups in positions 2 and 4. Another object of the invention is the ...  
WO/1996/036587A1
A solvent free process for the nitration of an aromatic compound using an aluminosilicate catalyst which has been treated with nitric acid and an acid anhydride. The process enables nitrated aromatic compounds to be produced in high yiel...  
WO/1996/034848A1
The invention relates to novel derivatives of acetylsalicylic acid with an NO3 structure. They are therapeutically effective either as intact active agent molecule or after dissociation (NO release). The invention also relates to process...  
WO/1996/023770A1
The present invention provides processes having practical utility for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)...  
WO/1996/023754A1
This invention relates to a method for preparing difluoromethyl ethers, thiols and amines without using chlorofluorocarbon gases. The intermediates prepared by this method can be used to make certain compounds which act as PDE IV inhibit...  
WO/1996/021638A1
A compound of formula (I), or a salt thereof, or a solvate thereof, wherein: R1 is an alkyl group or a substituted or unsubstituted phenyl group; R2 and R3 each independently represent hydrogen or alkyl; and either: RA represents T1 wher...  
WO/1996/019288A1
Porous microcomposites have been prepared from perfluorinated ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and are useful as catalysts for olefin isomeriza...  
WO/1996/015090A1
A nonsolvent process of synthesizing bis(2,2-dinitropropyl)formal (BDNPF) is disclosed. In the process, 2,2-dinitropropanol (DNPOH) is reacted at low temperature with a formaldehyde source in the presence of a protic acid catalyst, such ...  
WO/1996/015091A1
A nonsolvent process of synthesizing bis(2,2-dinitropropyl)acetal (BDNPA) is disclosed. In the process, 2,2-dinitropropanol (DNPOH) is reacted at low temperature with an acetaldehyde source in the presence of an acid catalyst, such as a ...  
WO/1996/010561A1
2-aroylcyclohexandiones have general formula (I), in which X, Y stand for O or S; Ar stands for phenyl or heteroaryl with 1 to 4 substituents; or two adjacent carbon atoms of the phenyl or heteroaryl ring may also be bridged by a chain; ...  
WO/1996/010004A1
A process for the purification of 2,6-diisopropylphenol (Propofol) by transformation of the crude Propofol into its ester with a carboxylic or sulphonic acid, crystallization and hydrolysis, is described.  
WO/1996/010010A1
A method for preparing a compound of formula (I), wherein R1 and R2, which are the same or different, are a hydrogen atom or an alkyl or alkoxy radical, or R1 and R2, taken together with the carbon atom to which they are attached, form a...  
WO/1996/009274A1
The invention provides a method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde by reacting 3-ethoxy-4-hydroxy-5-nitrobenzaldehyde with a reagent comprising zinc chloride, water and hydrogen chloride.  
WO/1996/003356A1
A method of iodinating and/or brominating and/or chlorinating an aromatic compound which comprises the steps of reacting an iodinating agent and/or brominating agent and/or chlorinating agent with the aromatic compound in the presence of...  
WO/1996/002515A1
The disclosure herein relates to the title compounds of formula (I) and salts and esters thereof, wherein X is halogen, C1-6 polyhaloalkyl, C6-10 aryloxy, C1-6 alkoxy or alkylsulfonyl, C4-10 tert-alkyl, NO2 or CN; n is 0-4 and Z is an (u...  
WO/1996/002491A1
Photoreactive compounds are synthesized from 2,5- or 2,6-dinitrobenzyl groups. Also disclosed are methods of synthesizing reactive monomers containing 2,5- or 2,6-dinitrobenzyl groups.  
WO/1995/025085A1
4, 6-Dinitroresorcinol is prepared by reacting resorcinol with concentrated nitric acid that is substantially free of suboxides of nitric acid. It has been found that greater than 60 percent yields of the desired product can be obtained ...  
WO/1995/019222A1
Porous microcomposites have been prepared from "NAFION" ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and exhibit extremely high catalytic activity.  
WO/1995/017372A1
The present invention relates to a method of cleaving arylethers such as arylethers represented by formula (I), wherein R is hydrogen, C1-C6 alkyl, cycloalkyl, phenyl, substituted phenyl or CH=CH2; each A is independently NO2, hydroxy, h...  
WO/1995/016649A1
According to the present invention there is provided a process for the selective introduction of one or more fluorine atoms into a disubstituted aromatic compound in an acid medium with fluorine gas characterised in that the acid medium ...  
WO/1995/009831A1
The present invention refers to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, 6-methoxy-2-naphthylacetic aci...  
WO/1995/007896A1
Novel hydroxy ethyl azolyl derivatives of formula (I), in which: X is hydrogen, halogen, alkyl with 1 to 4 carbon atoms or alkoxy with 1 to 4 carbon atoms; Z is halogen, alkyl with 1 to 4 carbon atoms, halogen alkyl with 1 to 4 carbon at...  
WO/1995/007253A1
This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III...  
WO/1995/003033A1
An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if nee...  
WO/1995/000467A1
Substituted phenethanol ethers are prepared by the etherification of corresponding substituted phenethyl alcohols with an aliphatic primary alcohol. The etherification is carried out by reacting a substituted phenethyl alcohol with an al...  
WO/1994/019310A1
The present invention provides a process for the nitration of aromatic substrates. In one process, an aromatic substrate is reacted with a silicate, optionally modified with a metal nitrate, in the presence of an acid anhydride and an or...  
WO/1994/014981A1
Novel compositions and methods of treating viral infections, including AIDS virus or human and/or animals carrying or infected with the AIDS virus or having antibodies to the AIDS virus are disclosed. A representative composition is show...  
WO/1994/012463A1
Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation.  
WO/1994/006751A1
Process for preparing dinitrotoluene by reacting toluene with concentrated nitric acid. The process reacts toluene with a large excess of concentrated nitric acid at selected conditions to produce a product which has substantially reduce...  
WO/1994/001436A1
The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof; wherein R50 is hydrogen or C1-4 alkyl, A51 is oxygen, sulphur or a group of the formula -NR52- wherein R52 is hydrogen or C1-4 alkyl; A50 com...  
WO/1994/001391A1
A process for the preparation of halonitroalkanes, e.g. bromonitromethane, is disclosed in which a nitroalkane is reacted with an alkali metal base or an alkaline earth metal base, and the resulting nitroalkane salt is halogenated to for...  
WO/1993/025503A1
This invention relates to a process for nitrating toluene to produce dinitrotoluene characterized by a liquid phase nitration characterized in that reaction of anhydrous nitric acid with toluene in a reactor at a reaction temperature of ...  
WO/1993/025512A1
Described is a method of preparing 5-alkoxy-2,4-dinitroalkylbenzene compounds of general formula (I), in which R?1¿ is C¿1?-C¿4? alkyl and R is C¿1?-C¿6? alkyl, C¿2?-C¿4? hydroxyalkyl or C¿3?-C¿4? dihydroxyalkyl. The method call...  
WO/1993/024443A1
A process for preparing N-aliphatic substituted p-phenylenediamine intermediates is provided which comprises contacting an aliphatic amine or substituted aliphatic amine derivative and nitrobenzene in the presence of a suitable solvent s...  
WO/1993/023352A1
The invention relates to a new nitration system, comprising dinitrogen pentoxide dissolved in liquid sulphur dioxide. The invention also relates to a process for nitrating aromatic compounds, where the nitration agent used is dinitrogen ...  
WO/1993/021144A1
A method for forming cascade polymers specifically utilizing the amine monomer of formula (I). The monomer is made by initially reacting nitromethane and CH2=CHCO2-TBu by nucleophilic addition to form the triester nitrotrialkanoate of fo...  
WO/1993/019034A1
Production of chlorine-substituted olefine compounds of formula (I), wherein: R?1¿ represents a C-organic rest; R?2¿ represents -CN, -CO-R?3¿, -CO-S-R?3¿, -CO-O-R?3¿, -CO-N(R?4¿, R?5¿); R?3¿ represents a C-organic rest; R?4¿, R?...  
WO/1993/009077A2
A process for the preparation of 2-chloro-4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid as well as synthetic intermediates useful in and prepared according thereto, comprising reacting a nitrobenzene having formula (II), where...  
WO/1993/002030A1
A novel method for preparing 2-phenyl substituted-1,3-propanediols, useful intermediates in the synthesis of pharmaceutical preparations is disclosed.  
WO/1993/000080A1
The invention concerns novel pharmaceutical compositions containing as an active ingredient a 2-benzoyl-1,3-cyclohexanedione which is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD). The compositions are valuable in...  
WO/1993/000323A1
A method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde by reacting 4-hydroxy-3-methoxy-5-nitrobenzaldehyde with a strong nucleophilic agent which may be created by reacting an aromatic mercapto compound with a strong organic o...  
WO/1992/011227A1
In a method for continuous nitration of a nitrable aromatic compound, which forms an azeotrope with water, by treating with nitric acid in the presence of nitrating acids, the reaction is carried out with a molar ratio of nitric acid to ...  
WO/1992/011228A1
Described herein is a continuous one pot process for the production of dinitrotoluene by: a) reacting toluene with concentrated nitric acid to produce a product mixture containing dinitrotoluene, unreacted nitric acid and water; b) then ...  
WO/1992/011229A1
A process for preparing bromonitro-alcohols, dibromonitro-alcohols and mixtures thereof in which bromo- and/or dibromonitromethane is reacted with a C¿1?-C¿3? aldehyde in aqueous solution at an acid pH, preferably between about 4.0 and...  
WO/1992/005141A1
According to a process for producing isomer-free 2,3-difluor-6-nitrophenol, 2,3,4-trifluornitrobenzol is reacted with an aqueous solution of alkali metal or alkaline earth metal hydroxide in the absence of organic solvent, at temperature...  
WO/1992/004313A1
A process for producing aromatic nitro compound which comprises nitrating an aromatic compound by blowing oxygen or air containing a nitrogen oxide and ozone into a solution or suspension thereof in an organohalogen solvent. The use of t...  
WO/1992/001666A1
Described herein is a process for separating an acid impurity from a solution containing acid and a nitro substituted aromatic compound by contacting the solution with at least one molten nitrate salt.  
WO/1992/000270A1
Process for producing chlorofluoronitro benzenes and difluoronitro benzenes in which an excess of dichloronitro benzenes is heated to no more than 200 °C with an alkaline metal fluoride with a total water content of some 0.2 to 2.5 % wt...  
WO/1991/016286A1
A process is disclosed for producing $g(a)-fluorostyrol from fluorolefines. A halogen aromate (1) is converted into a $g(a)-fluorostyrol (III) with a fluorine substituted ethylene (II) in the presence of a palladium catalyzer. R may repr...  

Matches 501 - 550 out of 3,838