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Matches 1 - 50 out of 5,227

Document Document Title
WO/2018/068733A1
The present invention provides a method for preparing nintedanib. The method of the present invention is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw mater...  
WO/2018/033866A1
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...  
WO/2018/025295A1
The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present inventi...  
WO/2017/212059A1
The present invention relates to a new process of manufacturing of caged cyclofen-OH and derivatives thereof, of formula (I) or salts thereof, wherein n, R1, R1 ', R2, and R3 are as defined in the claims.  
WO/2017/195619A1
The purpose of the present invention to provide a method for producing a nitrobenzene compound represented by general formula (1), which is economically preferable, and suitable for industrialization. The present invention pertains to a ...  
WO/2017/156688A1
Disclosed in the present invention is a preparation method for a nitroolefin derivative, the method comprising the following steps: adding an ethylene compound, sodium nitrite, manganese dioxide and 2,2,6,6-tetramethylpiperidinyloxy to a...  
WO/2017/142028A1
A metal-supported macromolecule and a use thereof as a catalyst, said metal-supported macromolecule being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is bond...  
WO/2017/114058A1
The present invention discloses a method for preparing an optically active carbonyl compound, comprising the following steps: subjecting an α,β-unsaturated aldehyde or an α,β-unsaturated ketone to an asymmetric hydrogenation catalyze...  
WO/2017/100985A1
Disclosed is a method for preparing 2,2-dihalo-1,3-dicarbonyl derivatives. The method is applicable in a broad range of 1,3-dicarbonyl derivatives, which have various types of readily available raw materials. The method is utilized to pr...  
WO/2017/090569A1
This catalyst contains neodymium, sodium, and a ligand which is a compound represented by structural formula (1), wherein the neodymium and the ligand form a complex at a molar ratio of 1 : 2 (neodymium : ligand).  
WO/2017/089492A1
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...  
WO/2017/051856A1
A method for producing a specific enantiomer in a larger amount than the other enantiomer, said method comprising reacting a reaction substrate in the presence of cellulose nanofiber or a derivative thereof and a catalyst so as to improv...  
WO/2017/046118A1
The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are...  
WO2017008832A1
Polymer supported fluorinated compound of formula I, wherein the meaning for each R1 is as disclosed in the description. These compounds are useful as catalysts, particularly in Michael addition reactions under continuous flow.  
WO/2017/005606A1
The invention discloses a method for the preparation of carboxylic acid chlorides starting from methyl ketones with a sulfur chloride and a chlorinating reagent.  
WO/2017/005907A1
The invention relates to zeolitic adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium and sodium. These adsorbents are applicable in the separation of fractions of aromatic C8 isomers, especially xylenes.  
WO/2017/005908A1
The invention relates to zeolitic adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium and sodium. These adsorbents are applicable in the separation of fractions of aromatic C8 isomers, especially xylenes.  
WO/2016/198921A1
A process for removing impurities from crude nitrated aromatic products obtained during the nitration of aromatic compounds. The nitrated aromatic products (1) are purified by treatment with ammonia washing (102) followed by caustic wash...  
WO/2016/173960A1
The invention relates to an optimized synthesis of pregabalin and additional 4-aminobutane acids using an improved method for producing conjugated nitroalkenes. This is achieved by a nitro-aldol reaction of an aliphatic aldehyde with a n...  
WO/2016/140358A1
The purpose of the present invention is to provide a catalyst composite body which has an excellent reducing action. The above-described problem is able to be solved by a catalyst composite body according to the present invention, which ...  
WO/2016/127723A1
The present invention relates to the field of organic compound synthesis. Disclosed are salicylic acid trans-(β)-farnesene analogues, and a preparation method therefor and uses thereof. The compound is obtained by: mixing salicylic acid...  
WO/2016/128147A1
Disclosed is an apparatus for producing polyethylene glycol dinitrate. The apparatus includes providing continuously an acid composition and a glycol composition to a reaction apparatus; reacting the acid composition and the glycol compo...  
WO/2016/128924A1
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new c...  
WO/2016/127492A1
A tetra-phenolic compound/tetra-functionality epoxy resin, a preparation method and application thereof. The tetra-phenolic compound is obtained by reacting p-hydroxybenzaldehyde with an alkyl bromide, and then reacting the product there...  
WO/2016/125185A2
The present invention provides the process for the preparation of 4-substituted-1- (trifluoromethoxy) benzene compounds..  
WO/2016/125185A3
The present invention provides the process for the preparation of 4-substituted-1- (trifluoromethoxy) benzene compounds..  
WO/2016/118450A1
The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an...  
WO/2016/114310A1
The purpose of the present invention is to provide a novel method for producing a nitro compound that is a precursor compound of a diamine compound, which is a raw material for a polyimide and/or polyamic acid used in a liquid crystal al...  
WO/2016/095684A1
The present invention provides a himbacine analogue and a method for preparing an intermediate thereof, and particularly provides a new method for preparing a compound A, a compound 4, a compound D and a compound C. In the solution for p...  
WO/2016/086722A1
Disclosed is a preparation method for an isoxazole compound and an intermediate thereof, the method comprising: a compound (I), as the starting material, is subjected to a substitution reaction with a compound (II) in the presence of a b...  
WO/2016/086710A1
Disclosed is a carboxylic acid preparation method. The method is characterized in that: a compound (II) reacts in the presence of hydrogen peroxide and a base to produce a target product (I) represented by the following equation: R1 is a...  
WO/2016/082780A1
The present invention relates to α-asary-laldehyde ester, a preparation method therefor, and an application thereof. The chemical structure of the related α-asary-laldehyde ester is represented by formula I. A related application is an...  
WO/2016/079759A4
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, effic...  
WO/2016/079138A1
A method for continuously producing a product (A1) by way of at least two coupled-together chemical reactions (C1, C2), wherein at least two input substances (E1, E2) are fed to a first chemical reaction (C1), wherein a plurality of inte...  
WO/2016/079759A9
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, effic...  
WO/2016/079759A1
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, effic...  
WO/2016/058881A2
The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula (II), wherein R1 is hydrogen, fluoro or chlo...  
WO/2016/058882A1
The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro;...  
WO/2016/058881A3
A process for the preparation of a compound of formula (I) wherein R1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the ...  
WO/2016/050759A1
The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric acid and subsequently separating a sulfuric-acid-containing aqueous phase tha...  
WO/2016/045415A1
A method for asymmetrically catalyzed synthesis of a γ-nitropyrazole amide compound, where a nitroalkene and an α,β-unsaturated pyrazole amide are employed as raw materials, a complex formed by a chiral amine oxide and a rare earth me...  
WO/2016/015479A1
The present invention relates to the fields of organic synthesis and pharmaceutical chemistry, and specifically relates to a β-elemene 13-position derivative (I) or (II), wherein R1 and R2 are defined in the description. Also disclosed ...  
WO/2016/005070A1
The present invention relates to a method for purifying raw dinitrotoluenes resulting from dinitration of toluene in the presence of a nitric acid/sulfuric acid/nitrating acid mixture, and a device or plant for performing the method, and...  
WO/2015/197521A1
The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulfuric acid under adiabatic conditions, not the entire production plant being shut down during a ...  
WO/2015/197522A1
The invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical composition. The invention further relates to plants for performing such method...  
WO/2015/189374A1
The invention relates to a method for producing aryl carboxylic acid esters and heteroaryl carboxylic acid esters Ar-COOR', wherein an aryl diazonium salt or heteroaryl diazonium salt Ar-N2+-X- at least partially dissolved in an alcohol ...  
WO/2015/189862A4
Described herein is the general synthesis of chiral amine from vinyl nitro compounds using Josiphos catalyst. The process is applied to develop a novel route to Sitagliptin (a DPP-IV inhibitor).  
WO/2015/189068A1
The present invention relates to the preparation of β-substituted γ-amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a β-substituted γ-nitro dicarboxylic a...  
WO/2015/189862A1
Described herein is the general synthesis of chiral amine from vinyl nitro compounds using Josiphos catalyst. The process is applied to develop a novel route to Sitagliptin (a DPP-IV inhibitor).  
WO/2015/184229A1
A method for preparing 3-methyl-2-nitrobenzoic acid is disclosed wherein 1, 3 -dimethyl-2-nitrobenzene is combined with an oxidation catalayst in the presence of an oxygen source and an initiator, provided that less than 99% of the 1,3 -...  

Matches 1 - 50 out of 5,227