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Matches 1 - 50 out of 349

Document Document Title
WO/2018/179808A1
Provided is a method for producing alkyl nitrite by bringing an aqueous solution containing nitric acid and an alkanol into contact with a gas containing nitrogen monoxide to generate alkyl nitrite, wherein the reaction temperature is 60...  
WO/2018/096504A1
Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 a...  
WO/2017/097969A1
Described is a method for preparing a salt consisting of cations of an arene-transition metal sandwich complex and anions of a Brönsted acid.  
WO/2017/079721A1
Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.  
WO/2017/046118A1
The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are...  
WO/2016/128147A1
Disclosed is an apparatus for producing polyethylene glycol dinitrate. The apparatus includes providing continuously an acid composition and a glycol composition to a reaction apparatus; reacting the acid composition and the glycol compo...  
WO/2015/155234A1
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.  
WO/2015/134703A1
A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 ...  
WO/2015/044177A1
The present invention refers to compounds of formula: (formula A), wherein R1 is selected from (formula I), (formula II), (formula (III), (formula IV), (formula V), or (formula B), and wherein R2, R3, R4 and R5 are as defined in the clai...  
WO/2015/022110A1
The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which...  
WO/2015/001499A3
The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amoun...  
WO/2014/170262A1
The present invention relates to nitric oxide donor compounds having a quinone based structure of formula (I), wherein R1 to R6, m, n and p are as defined in claim 1, to processes for their preparation and to their use in the treatment o...  
WO/2014/169976A1
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role...  
WO/2014/111957A1
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the prep...  
WO/2014/086065A1
Provided is a method for producing an alkyl nitrate, using a centrifugal extraction device as a separator for the esterification reaction, feeding a mixed acid solution containing sulfuric acid and nitric acid from a heavy phase inlet of...  
WO/2013/150840A1
A method for producing a nitrous acid ester whereby nitric oxide, oxygen, and an alcohol are reacted to produce a nitrous acid ester, the method for producing a nitrous acid ester including: a step for supplying the bottoms liquid from t...  
WO/2013/060673A1
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role...  
WO/2012/152438A1
The present invention relates to a one-step process for the synthesis of nitric acid esters or 15N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).  
WO/2011/132171A1
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups ...  
WO/2011/120695A1
Organic nitrates are prepared from mono-, di- or polyhydric alcohols by (i) simultaneously feeding a first continuous-flow microreactor unit with (a) concentrated nitric acid, (b) acetic anhydride, (c) optionally, a catalytic amount of a...  
WO/2011/101245A1
The invention relates to nitrooxyderivatives of Gamma- aminobutyric acid analogs (GABA analogs) for treating neuropathic pain and in particular diabetic neuropathy. The invention also relates to pharmaceutical formulation comprising such...  
WO/2011/098839A3
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di...  
WO/2011/098839A2
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di...  
WO/2011/058162A1
This invention relates to a new process for preparing 4-nitro-oxy-methyl- benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in aceton...  
WO/2011/032936A1
The present invention relates to the novel compounds of the formula (I), as well as to their manufacture and use and compositions comprising them. The invention also relates to a change in oxidation reactions of hydrocarbons admixed to t...  
WO/2011/033392A3
The invention relates to a nitration method having the following principles: a phosgene species is converted with two equivalent silver nitrates into a double-mixed anhydride of carbonic acid and nitric acid, known here as carbonic acid ...  
WO/2011/012400A2
The present invention relates to a novel nitric oxide releasing naproxen derivative, its use for the treatment of diseases associated with pain and inflammation. This NO releasing naproxen derivative shows a surprisingly improved gastroi...  
WO/2011/012400A3
The invention relates to a nitric oxide releasing naproxen derivative of formula (I) and its use for the treatment of diseases associated with pain and inflammation. This NO releasing naproxen derivative shows a surprisingly improved gas...  
WO/2010/134679A3
Disclosed is a novel bicycloheptane-based compound. A cetane number improver containing the bicycloheptane-based compound and diesel fuel containing the cetane number improver are also provided. This cetane number improver has lower toxi...  
WO/2010/134679A2
Disclosed is a novel bicycloheptane-based compound. A cetane number improver containing the bicycloheptane-based compound and diesel fuel containing the cetane number improver are also provided. This cetane number improver has lower toxi...  
WO/2010/096320A3
The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain susceptible to hydrolytic degradation and w...  
WO/2009/153668A2
The present invention relates to a method for purifying naproxcinod comprising the steps of : a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or tw...  
WO/2009/153668A3
The present invention relates to a method for purifying naproxcinod comprising the steps of : a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or tw...  
WO/2009/153670A2
Antibodies against various domains of laminin-332 are discussed herein. The antibodies reduce the adhesion and matrix binding properties of laminin-332, inhibiting tumor growth and metastasis in vivo. Pharmaceutical compositions and meth...  
WO/2009/149053A2
Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6...  
WO/2009/149053A3
Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6...  
WO/2009/127398A2
A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, a...  
WO/2009/127398A3
A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, a...  
WO/2009/089493A2
The present invention is directed to methods and compositions which include nitrate amino acid chelates that can increase the metabolic activity or metal concentration in animals and that can increase metabolic activity and nitrogen cont...  
WO/2009/080755A1
A process for the continuous production of a compound of Formula (II), HO-R1-ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formu...  
WO/2009/049961A2
The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.  
WO/2009/049961A3
The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.  
WO/2009/046992A1
The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy resid...  
WO/2009/007230A1
The present invention relates to nitrooxyderivative of antioxidant compounds of formula (I) and pharmaceutically acceptable salts or stereoisomers thereof for the treatment of chronic pain, in particular chronic neuropathic pain. The inv...  
WO/2009/004990A1
It is intended to provide a prostaglandin F2α receptor agonist (FP receptor agonist), which comprises a biphenyl derivative represented by the following general formula (I) (wherein m represents an integer of 0 to 2; n represents an int...  
WO/2009/000723A1
The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.  
WO/2008/157537A2
Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutic...  
WO/2008/157537A3
Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutic...  
WO/2008/128832A1
Non-peptidic renin inhibitors nitroderivatives of general formula (I) : A1- (Xa-ONO2) j wherein A1 is selected from the group consisting offormula (Ia), (Ib), (Ic), Id), (Ie) and (If). They can be employed for treating or preventing card...  
WO/2008/113863A2
The present invention relates to nitrosated derivatives of 2,5- dihydroxybenzene compounds that are useful in the preparation of medicinal products for the treatment of different diseases. The diseases in question are, in particular: (a)...  

Matches 1 - 50 out of 349