Document |
Document Title |
WO/2002/096857A1 |
The present invention relates to a novel retinoid derivative compound represented by the formula I. Wherein X,R?1¿, R?2¿ and R?3¿ are as defined herein or pharmaceutically acceptable salts thereof. Also, the present invention relates ...
|
WO/2002/096849A1 |
The invention relates to a method for the catalytic oxidation of alkyl-aromatic compounds of formula (I): Ar-C(H)¿n?-R, to obtain the corresponding aromatic aldehydes and ketones. In said formula, Ar represents an optionally substituted...
|
WO/2002/096901A2 |
The invention relates to 1,3-dihydroxybenzene derivatives of general formula (I) or (Ia), or the physiologically acceptable, water-soluble salts thereof, R'1 representing a substituted pyridyl group, a pyrimidyl group, or a radical of fo...
|
WO/2002/092608A2 |
The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comp...
|
WO/2002/092226A1 |
The invention concerns novel catalysts for aromatic nucleophilic substitution. Said catalysts are compounds of the general formula (I), wherein: R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, and R¿6?, identical or different, are selected among hyd...
|
WO/2002/092547A1 |
The invention relates to a method for producing ketones by reacting boric acid derivatives with carboxylic acid anhydrides in the presence of a transition metal catalyst. The carboxylic acid anhydrides can either be used in isolated form...
|
WO/2002/090315A1 |
In a process for preparing 1,5-diaminonaphthalenes by using an o-alkylnitrobenzene compound and a vinyl compound as the starting materials through a 4-(2-nitrobenzene)propane compound and a 5-nitro-1-tetralone compound, an aromatic nitro...
|
WO/2002/081420A1 |
A compound which has cytokine production inhibitory activity and is useful for the treatment of diseases in which cytokine participates. The compound is represented by the following general formula (I) [wherein A represents an optionally...
|
WO/2002/081434A1 |
The invention relates to derivatives of benzoylcyclohexanediones of formula (I) and to their use as herbicides. In said general formula (I), R?1�, R?3� and R?4� represent different groups, L-(R?2�)�n? represents a haloalkyl and...
|
WO/2002/079126A1 |
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligan...
|
WO/2002/079339A2 |
Compositions and processes of forming chemical bonds, such as carbon-carbon and carbon-heteroatom bonds are provided. The compositions include at least one $g(a)alpha-halo carbonyl compound, and one or more transmetallation reagents. The...
|
WO/2002/072544A2 |
The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula (I), wherein Ar, and R¿6?-R¿10? are defined herein. The present invention also relates to the discovery that...
|
WO/2002/070567A1 |
A novel compound useful as a support capable of being used for solid-phase reactions under acidic conditions and under such conditions that sulfoxide groups are reduced. The compound is, for example, 4-hydroxymethyl-3-nitrophenoxyethylpo...
|
WO/2002/066416A1 |
To more efficiently provide CPT, which is a starting compound for irinotecan hydrochloride and various camptothecin derivatives, by a practically usable total synthesis, a means whereby 2'-amino-5'-hydroxypropiophenone corresponding to t...
|
WO/2002/064547A2 |
Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula (I) wherein: R?1¿, R?2¿, and R?3¿ independently are hydrogen, halo, hydroxy, C¿1?-C¿6? alkyl, C¿1?-C¿6? alkoxy, C¿2?-C¿6? alkenyl, C¿2?-C¿6? alkynyl, ...
|
WO/2002/064080A2 |
Compounds are provided that bind allosterically to the catalytic domain of MMP-13 and comprise a hydrophobic group, first and second hydrogen bond acceptors and at least one, and preferably both, of a third hydrogen bond acceptor and a s...
|
WO/2002/064881A1 |
The invention relates to a process for protecting reduction-sensitive dyes in the course of dyeing or printing fiber materials with dyes using a compound of the formula or a mixture thereof (formula see on enclosed paper version) where t...
|
WO/2002/058139A2 |
Novel uses of diamondoid-containing materials in the field of microelectronics are disclosed. Embodiments include, but are not limited to, thermally conductive films in integrated circuit packaging, low-k dielectric layers in integrated ...
|
WO/2002/056880A1 |
Triphenylmethane derivatives of the formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac ...
|
WO/2002/057203A1 |
Disclosed are compositions comprising C¿26?H¿30? hexamantane, referred to herein as peri-condensed hexamantane, fully condensed hexamantane, and cyclohexamantane. These enriched cyclohexamantane compositions comprise at least 5 percent...
|
WO/2002/057201A2 |
Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as are intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.
|
WO/2002/057202A1 |
Higher diamondoids ranging from tetramantanes through undecamantanes are disclosed in isolated and enriched forms. Methods for obtaining these higher diamondoids are disclosed, as well.
|
WO/2002/057199A1 |
The invention relates to a process for carrying out a homogeneously catalyzed C-C coupling reaction between an optionally substituted (hetero)aromatic bromide compound and a second reactant, which is chosen from the group of olefins in w...
|
WO/2002/055486A2 |
The invention relates to novel triazene compounds, the use thereof and novel alkylation methods. Said triazene compounds have the general formula, X-Y-Z-N=N-NH-R, where X = an insoluble support material, Y = an atom, or group of atoms, f...
|
WO/2002/055475A1 |
A process for producing 4,6-dinitroresorcinol, characterized by reacting a 1,3-dihalo-4,6-dinitrobenzene with a base in an aqueous medium in the presence of a metal catalyst to hydrolyze it and then acidifying. By the process, high-purit...
|
WO/2002/053545A1 |
The present invention provides a process for producing aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite ion and holodimethylsulfonium halide generated $i(in situ) from hydrobromic acid/DMSO or hydriodic...
|
WO/2002/051792A1 |
The invention relates to a method for the production of 1,5-naphthalenediamine and the intermediates obtained in the course of said synthesis, 4-(2-nitrophenyl)-butyronitrile, 5-nitro-3,4-dihydro-1(2H)-naphthylimine, 5-nitroso-1-naphthyl...
|
WO/2002/050007A2 |
The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbene...
|
WO/2002/048073A1 |
The invention relates to a method for producing compounds having at least one -CF¿2?-O bridge per molecule, according to which: a) an acid is added to at least one ketene dithioketal; b) the obtained bis(alkylthio)carbenium salt is reac...
|
WO/2002/048089A1 |
A process for producing a mononitrated aromatic ether compound represented by the general formula (2) (2) (wherein Z is oxygen, etc.; X is hydrogen, etc.; and R?1¿ and R?2¿ may be the same or different and each is optionally substitute...
|
WO/2002/048081A1 |
The invention relates to liquid crystalline compounds of formula (I) wherein R?1¿, R?2¿, A?1¿, A?2¿, A?3¿, A?4¿, Z?1¿, Z?2¿, a, b and c have the designations cited in claim 1. The invention also relates to liquid crystalline medi...
|
WO/2002/044144A2 |
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.
|
WO/2002/044121A1 |
Compounds of Formula I wherein R¿1? is CH¿2?CO¿2?K, CH¿2?CO¿2?H or CH¿2?CONH¿2? and R¿2? is where Hal is a halogen, preferably F or Br, and L is H or a halogen, preferably Br and Formula II are described. The compounds are useful...
|
WO/2002/044145A1 |
There is provided a compound of formula (I) wherein R?a¿, R?1¿, R?2¿, Y and R?3¿ have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are use...
|
WO/2002/043648A2 |
This invention relates to novel compounds of formula I that are liver selective glucocorticoid receptor antagonists, methods of preparing the compounds and methods for the use of the compounds in the regulation of metabolism and lowering...
|
WO/2002/041984A2 |
Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal comp...
|
WO/2002/042248A2 |
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
|
WO/2002/040459A1 |
There is described a process for the preparation of compounds of formula (I) in which R is hydrogen, optionally substituted alkyl, optionally substituted alkenyl optionally substituted cycloalkyl, optionally substituted phenyl or optiona...
|
WO/2002/036538A1 |
A process for producing an esterificated condensate, wherein a monomeric ester or thioester, or a polyester or polythioester is produced by carrying out a direct condensation reaction from a carboxylic acid and an equimolar amount of an ...
|
WO/2002/036671A1 |
A vulcanization accelerator giving a vulcanizable fluororubber composition which can be effectively prevented from scorching during storage and in a pretreatment for vulcanization, has a high vulcanization rate in actual vulcanization to...
|
WO/2002/034740A1 |
The invention relates to a method for producing cyclic carboxylic orthoester fluorides, comprising the following steps: a) reacting at least one bis(alkylthio)carbenium salt in the presence of at least one base with at least one organic ...
|
WO/2002/030865A2 |
A process for the nitration of an aromatic compound, wherein the aromatic compound is admixed with a nitrating agent in the presence of an ionic liquid is described. The method for the nitration of aromatic compounds in (e.g. neutral) io...
|
WO/2002/026701A2 |
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...
|
WO/2002/022551A1 |
Compounds of formula (I') wherein A, R¿1? to R¿3? and t are as defined in claims, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
|
WO/2002/022694A1 |
Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising two nitrogen donor atoms independently su...
|
WO/2002/014254A1 |
A process in which an olefin is oxidatively decomposed to produce the corresponding carbonyl compound. It is a simple efficient process in which a harmful substance such as ozone is not used and the reaction can be conducted in an aqueou...
|
WO/2002/011883A1 |
The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure (I), wherein R', R' and R'' are organic groups having 1-15 carbon atoms, n = 1-5, and m = 0-4. The present inv...
|
WO/2002/008189A1 |
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral ...
|
WO/2002/008228A2 |
Methods are provided for making certain 6,7-dihaol-1,5-dihydroimidazo [2,1-b]quinazolin-2(3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-di...
|
WO/2002/006228A1 |
A process for producing 5-fluorooxyindole, represented by the formula (3) characterized by comprising (A) a first step in which a 2-(5-fluoro-2-nitrophenyl)malonic diester represented by the general formula (1) (wherein R?1¿ and R?2¿ m...
|