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WO/2015/170688A1 |
Provided is a metal-supported catalyst comprising a porous coordination polymer as a carrier (a metal-supported porous coordination polymer catalyst), said catalyst having an excellent catalytic activity and being applicable to various k...
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WO/2015/166827A1 |
A method for producing an optically active anti-1,2-nitroalkanol compound, the method including a supplying step for continuously supplying an aldehyde compound and a C2 or higher nitroalkane compound to a reaction container, a reaction ...
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WO/2015/159905A1 |
A compound represented by formula (1) (wherein X represents a chlorine atom, a bromine atom or an iodine atom) can be produced by: a step wherein a compound represented by formula (2) (wherein R1a represents an alkyl group having 1-6 car...
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WO/2015/159904A1 |
A compound represented by formula (1) can be produced by: a step wherein a compound represented by formula (2) is reacted with a compound represented by formula (3), thereby obtaining a compound represented by formula (4); a step wherein...
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WO/2015/157239A1 |
The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs linked together by functionalized or multivariate BTB-based linking ligands. The disclosure further provides for the use of these MOFs in vari...
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WO/2015/151068A1 |
Novel synthetic analogues of 3-iodothyronamine of formula (I), pharmaceutical compositions containing the same, and medical uses thereof are described.
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WO/2015/129592A1 |
Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3) (in the formula, X represents a chlorine atom, bromine atom, or iodine atom) and hydrogen in the presence of a heterogeneous transition metal...
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WO/2015/129630A1 |
[Problem] To provide a novel method for producing (S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluoro
but-3-yne-2-ol. [Solution] An alkynyl ketone represented by belowmentioned formula (1) is reacted with (trifluoromethyl) trime...
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WO/2015/129813A1 |
The present invention provides: a deuteration method that is both cost effective and has an excellent deuteration rate; a method for selectively replacing a leaving group of an aromatic compound with deuterium; and a deuteration catalyst...
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WO/2015/131200A1 |
Small molecule xanthine oxidase inhibitors, speifically substituted benzaldehydes including dihydroxy and trihydroxy benzaldehydes having therapeutic utility in the treatment of gout and hyperuricemia are provided. Pharmaceutical composi...
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WO/2015/106443A1 |
Provided are preparation and application of a biphenyl compound. Using 2-nitroarylethylene and substituted 1,3-butadiene as raw materials to obtain a 2-aminobiphenyl compound, a 2-nitrobiphenyl compound or a mixture thereof in one step. ...
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WO/2015/098717A1 |
A nitro compound represented by formula (1) which is a raw material for producing a compound represented by formula (7) can be produced by reacting at least one type selected from the group consisting of a compound represented by formula...
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WO/2015/090122A1 |
The present invention relates to a phenyl benzyl ether derivative and a preparation method and use thereof, and a part of the compound act as an A beta plaque imaging agent after being radioactively nuclide labelled, and the phenyl benzy...
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WO/2015/091463A1 |
A compound of Formula (1) wherein R1 represents hydrogen, halo, a C1-C4 alkyl group, a C1-C4 alkylhalide group, a C1-C4 alkoxy-C2-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group or a C3- C7 cyclo alkyl group; R2 represents F...
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WO/2015/081827A1 |
Disclosed is a method for synthesizing a α-aryl, heteroaryl or alkenyl-α,α-2-fluoro allyl structure by palladium catalysis. Specifically, in the method of the present invention, a compound of formula A and a compound of formula B synt...
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WO/2015/059185A1 |
A process for scrubbing a crude mixture which is obtained in the nitration of toluene after separating off the nitrating acid and comprises dinitrotoluene, nitric acid, nitrogen oxides and sulfuric acid, which comprises two scrubbing ste...
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WO/2015/032706A1 |
A process for the preparation of dintrotoluene which comprises (a) nitrating toluene with a nitrating acid, wherein said nitrating acid is a mixture of nitric acid and sulfuric acid, in one or more nitration steps, and separating the nit...
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WO/2015/034820A1 |
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowin...
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WO/2015/027773A1 |
The present invention relates to an application of dimethylaminopyridine (DMAP) hydrochloride serving as recyclable catalyst in an acylation reaction (as represented by equation I). The application comprises: dissolving DMAP into a nonpo...
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WO/2015/011729A1 |
The invention discloses a process for continuous flow of liquid phase nitration of alkyl benzene compounds in micromixer and tubular reactors with better control on the product profile which comprises reacting alkyl benzene compounds wit...
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WO/2015/012069A1 |
A separating material superior to conventional separating materials, and a separation method are provided, with which 1, 3-butadiene is selectively separated and recovered from a mixed gas including 1, 3-butadiene and C4 hydrocarbons oth...
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WO/2015/012067A1 |
A separating material superior to conventional separating materials, and a separation method are provided, with which 1, 3-butadiene is selectively separated and recovered from a mixed gas including 1, 3-butadiene and C4 hydrocarbons oth...
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WO/2015/005298A1 |
The purpose of the present invention is to provide a high purity optically active bicyclic γ-amino acid derivative. The means for accomplishing this purpose is a method for producing a compound represented by general formula (VII), or a...
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WO/2015/003988A1 |
The present invention relates to a process for preparing aliskiren and, more particularly, to an improved method for synthesizing a β-amino alcohol or a lactone analog thereof via the corresponding nitro derivatives of formula (Ia) or (...
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WO/2014/208296A1 |
The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general...
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WO/2014/202765A1 |
The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present inve...
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WO/2014/202031A1 |
The present invention relates to a method for high-selectivity co-production of adipic acid and nitrocyclohexane, utilizing an oxynitride NOx as an oxidant and nitrating agent to transform in one step with high selectivity cyclohexane to...
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WO/2014/198880A1 |
The invention provides a compound of formula (I) wherein R2-R10 represent different meanings, and pharmaceutically acceptable salts thereof. The invention also provides synthetic procedures for preparing the compounds of formula (I), pha...
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WO/2014/195973A2 |
The present invention discloses an improved process for the liquid phase nitration of aromatic compounds catalyzed by WO3 supported on mesoporous silica support, at low temperature, with high conversion and selectivity.
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WO/2014/196542A1 |
In the present invention, in an optically active compound production method that uses a column reactor, the column reactor is produced by filling asymmetric catalyst particles in a column for the column reactor, and a compound to be reac...
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WO/2014/195972A1 |
A regioselective N-Heterocyclic Carbene (NHC) catalyzed one step process for high yield synthesis of α-acyloxy carbonyl compounds is disclosed.
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WO/2014/195896A1 |
The present disclosure relates to compounds of Formula (I) and process of obtaining the same. Said compounds of Formula (I) is employed in the syntheses of pyrroloquinoline quinone (PQQ), 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-...
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WO/2014/180678A1 |
The invention relates to a method for producing nitroalkanes by reacting at least one alkane with at least one nitrating agent in the gas phase, wherein the nitration is carried out in a microstructured reaction zone having parallel chan...
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WO/2014/177517A1 |
It relates to a preparation process of 2'-(benzyloxy)-3'-nitro-1,1'-biphenyl-3- carboxylic acid or a salt thereof comprising reacting 2-(benzyloxy)-1-bromo- 3-nitrobenzene with a either 3-carboxyphenylboronic acid or a salt thereof or a ...
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WO/2014/167481A1 |
The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.
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WO/2014/164667A1 |
Compounds and methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a compound as described herein. The methods are use...
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WO/2014/152752A1 |
Provided are methods for synthesizing compounds, including chiral kynurenine compounds. The methods are suitable for large-scale manufacture and produce the chiral kynurenines compounds in high chemical purity and high chiral purity.
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WO/2014/138053A1 |
In one aspect, the invention relates to compounds having the formula: (I) where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In anoth...
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WO/2014/126008A1 |
A catalyst which is obtained by mixing a compound represented by structural formula (1), a nitroalkane compound, a neodymium-containing compound, a sodium-containing compound and a carbon structure.
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WO/2014/103947A1 |
The present invention provides: a halogenated aniline represented by formula (I) (wherein X1 and X2 independently represent a chlorine atom, a bromine atom or a iodine atom); a method for producing the halogenated aniline; and others.
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WO/2014/094270A1 |
Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream (1) and a nitric acid comprising second stream (2) into a first re...
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WO/2014/089385A2 |
The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise ...
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WO/2014/081697A2 |
The present invention relates to novel anthelmintic compounds of formula (I) wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic...
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WO/2014/073003A1 |
The present invention relates to the single-step process for the synthesis of aryl olefin compounds of Formula (1) by reacting aryl aldehydes with alkyl aldehydes in presence of malononitrile and acid or base or salt, optionally in prese...
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WO/2014/069555A1 |
Provided is a compound that exhibits an excellent melanogenesis-inhibiting effect (skin-lightening effect), exhibits an excellent antimicrobial effect, excels in terms of temporal stability and the like, and is suitable for use as an ing...
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WO/2014/066713A1 |
A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.
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WO/2014/066712A1 |
A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.
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WO/2014/058078A1 |
Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compou...
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WO/2014/038579A1 |
This fluorine-containing compound is characterized by being represented by general formula (1) (in general formula (1): X represents a halogen or an alkoxy group; R1 represents a C3-10 branched-chain or cyclic alkyl group; Rf1 and Rf2 re...
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WO/2014/037307A1 |
Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.
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