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Matches 1 - 50 out of 7,928

Document Document Title
WO/2020/164217A1
Disclosed is a process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly productio...  
WO/2020/161362A1
The disclosure provides a process for the preparation of 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.  
WO/2020/148641A1
The present invention relates to a process for preparation of 2-Amino-5-hydroxypropiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).  
WO/2019/195761A3
Methods of treating presbyopia or cataract in a subject in need thereof are provided, The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation of high molecul...  
WO/2020/137921A1
The present invention provides an actinic light sensitive or radiation sensitive resin composition, a resist film, a pattern forming method, and an electronic device production method, wherein the actinic light sensitive or radiation sen...  
WO/2020/102529A1
A method comprising co-administering to a subject having cancer, suspected of having cancer, or at risk of developing cancer: a therapeutically effective amount of at least one compound (a) selected from (a)(i) a nitroalkene fatty acid, ...  
WO/2020/084094A1
The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromati...  
WO/2020/050368A1
The purpose of the present invention is to provide: a method for preparing a Vilsmeier reagent, that can be carried out safely, easily, and at a low cost; and a method for producing an aromatic aldehyde or an aromatic ketone, a carboxyli...  
WO/2020/047182A1
The present invention relates to compositions of pibrentasvir, drug products thereof, and processes and intermediates for the preparation thereof. This invention relates to the drug product, active drug substance, intermediates, and proc...  
WO/2020/040614A1
The present invention provides: a preparation method for a (3R,5R)-7-[2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-[(4-hydr oxymethylphenylamino)carbonyl]-pyrrrol-1-yl]-3,5-dihydroxy heptanoic acid hemicalcium salt; an intermediate used ther...  
WO/2020/029762A1
A preparation method for a fused tricyclic γ-amino acid derivative and an intermediate thereof, and a method for preparing an intermediate of the fused tricyclic γ-amino acid derivative. The fused tricyclic γ-amino acid derivative has...  
WO/2020/028396A1
The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-d...  
WO/2020/011626A1
The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula ...  
WO/2020/010900A1
The present invention provides a use of a compound shown in Formula I/II in a drug for preventing, treating, or alleviating pain.  
WO/2019/242010A1
Provided is a compound or a salt thereof as a linking chain. The compound or a salt thereof can be loaded onto a solid-phase resin for solid-phase synthesis of a polypeptide drug, thereby improving the synthetic yield of the polypeptide ...  
WO/2019/230653A1
The present invention provides a compound represented by formula (I): [symbols in the formula are as described in the specification].  
WO/2019/191363A3
Disclosed herein are improved methods for the preparation of oseltamivir, and intermediates useful thereto.  
WO/2019/199621A4
The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are through.macrophage migration inhibitory factor (MIF) or immunoglubin G (I...  
WO/2019/216415A1
The present disclosure addresses the problem of providing a production method for a novel fluoromethyl derivative. The problem is solved by a production method that is for a fluorinated organic compound represented by formula (1) [in the...  
WO/2019/213545A1
The present disclosure provides processes for the preparation of cerdulatinib, which is of formula (I): Formula (I) or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates usef...  
WO/2019/199621A1
The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are through.macrophage migration inhibitory factor (MIF) or immunoglubin G (I...  
WO/2019/174974A1
The invention relates to a fertilizer composition comprising a) zeolitic imidazolate framework ZIF-8; and b) a fertilizer selected from liquid or solid ammonium-containing inorganic fertilizers, liquid or solid organic fertilizers, and u...  
WO/2019/174977A1
The invention relates to a composition comprising a) zeolitic imidazolate framework ZIF-8; and b) Compounds of formula (I) or a stereoisomer, salt, tautomer or N-oxide thereof, wherein the variables have a meaning as defined in the main ...  
WO/2019/172184A1
Provided is a metal imide complex which has a stable structure and is able to be easily synthesized, while being capable of efficiently oxidizing various substrates. A metal imide complex which contains a metal and an imide that serves a...  
WO/2019/168269A1
The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using ...  
WO/2019/159596A1
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...  
WO/2019/154728A1
The present invention relates to processes for preparation of 1 -nitrobenzene-2- alkyloxycarbonyl-5-carboxylic acid. In particular, the present invention relates to preparation of 1 -nitrobenzene-2-alkyloxycarbonyl-5-carboxylic acid by p...  
WO/2019/130046A1
Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.  
WO/2019/108773A1
The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFκB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and makes them par...  
WO/2019/100021A1
A construct comprising a dermal extracellular matrix gel, polymer fibers, and microparticles containing a nitro oleic acid agent.  
WO/2019/069961A1
Provided is a compound represented by general formula (I-1). (In the formula, A denotes an atomic group having an antioxidant function, B denotes a photo-releasable group, and k denotes an integer between 1 and 10.) Also provided is a co...  
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2018/237344A1
Disclosed herein are methods and compounds for treating a cancer is characterized with an elevated expression of thioredoxin reductase (TrxR) or an elevated expression of peroxiredoxin (PRDX). In some embodiments, also disclosed herein a...  
WO/2018/140435A9
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.  
WO/2018/162986A3
Fluorescence quenching nitrodiarylethene analogs are useful in oligonucleotide conjugates and probes. These analogs, whose absorption spectra are substantially blue-shifted relatively to emission spectra of common fluorophores (such as f...  
WO/2018/187542A1
Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a ran...  
WO/2018/162427A1
The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulphuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied ...  
WO/2018/149813A1
The present invention relates to a process for preparing substituted 2-nitrobiphenyls via Suzuki coupling using a palladium catalyst with specific phosphorus ligands and a solvent mixture containing water and an organic solvent which is ...  
WO/2018/141642A1
The present invention relates to an improved process for the preparation of 2-chloro-4-fluoro-5-nitrobenzotrichloride. The present invention further relates to a process for the purification of 2-chloro-4-fluoro-5-nitrobenzotrichloride, ...  
WO/2018/141451A1
The invention relates to a method for preferably adiabatic nitriding of nitrable aromatic organic compounds (aromates) and to a corresponding system, in particular a production plant (nitration plant) for carrying out said method.  
WO/2018/140435A1
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.  
WO/2018/091978A1
2-Nitro-4,5-dichloroacetanilide is an important intermediate in the dyestuff industry. In the present disclosure 2-nitro-4,5-dichloroacetanilide is prepared from 3,4-dichloroacetanilide using a nitrating agent in the presence of resultan...  
WO/2018/068733A1
The present invention provides a method for preparing nintedanib. The method of the present invention is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw mater...  
WO/2018/071166A1
A catalytic composition and process useful for the conversion of an olefin selected from the group consisting of propylene, isobutylene or mixtures thereof, to acrylonitrile, methacrylonitrile, hydrogen cyanide and acetonitrile and mixtu...  
WO/2018/035685A1
Disclosed is a process for preparing substituted biphenyls via Suzuki coupling using specific phosphorus ligands and a solvent mixture containing water, a non-polar organic solvent and a polar aprotic co-solvent.  
WO/2018/033866A1
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...  
WO/2018/025259A1
Naphthoquinone compounds that induce the formation of reactive oxygen species (ROS) are disclosed. Process of preparing the naphthoquinone compounds are also disclosed. Uses of the compounds for treating a disease or disorder are also di...  
WO/2018/025295A1
The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present inventi...  
WO/2018/022728A1
Compositions and methods are disclosed for treating subjects with cancer, particularly skin cancer.  
WO/2018/008737A1
The present invention addresses the problem of providing a compound which exerts its effect on the onset mechanism of Parkinson's disease by inhibiting the degeneration and cell death of dopamine-secreting cells, and a therapeutic or pro...  

Matches 1 - 50 out of 7,928