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WO/2013/117586A1 |
The present invention mainly relates to an accelerating admixture for hydraulic compositions including, in an aqueous solution: the product of the reaction of an alkanolamine with a concentrated strong acid; sulfate anions; and alkali or...
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WO/2013/113946A2 |
The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising treating a compound of formula (II) with a chiral a...
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WO/2013/111823A1 |
[Problem] To provide a method for producing a sphingoid base-containing extract, and a functional food or pharmaceutical composition containing the resulting extract. [Solution] This method for producing a sphingoid base-containing extra...
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WO/2013/104564A1 |
The present invention relates to a beta-amino acid ester, obtainable by the reaction of a di-acrylate of the general formula (I) with a diamine of the general formula (II), wherein R1 and R2 are organic groups containing no Zerewitinoff-...
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WO/2013/105109A1 |
Disclosed herein is a process for the preparation of the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol comprising a) reacting compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan
-3-ol with a mixture o...
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WO/2013/054273A9 |
The present invention provides a process for the preparation of agomelatine and its intermediate compounds. The invention also provides intermediate compounds of agomelatine represented by Formula IV, Formula V and Formula VIII.
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WO/2013/098575A1 |
A continuous process for the production of choline hydroxide includes reacting ethylene oxide, trimethylamine, and water in a reaction zone to form a reaction mixture and extracting heat from the reaction mixture. Subsequently, phase sep...
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WO/2013/101361A1 |
Methods for making sulfide scavenging compositions are provided. The method comprises reacting at least one secondary amine with at least one aldehyde and solvent in the presence of a catalyst to form a reaction composition, wherein a re...
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WO/2013/095875A1 |
An improved process for making ethoxylated amine compounds such as ethanolamines. The improvement comprises the addition of an acid to the amine compound prior to the addition of ethylene oxide to a reactor wherein the ethoxylated amine ...
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WO/2013/089002A1 |
[Problem] To provide an inexpensive and simple method for producing a diphenylamine compound, the method being capable of solving the problems of the prior art including decrease in reactivity, limits to substituents, high temperature, h...
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WO/2013/090161A1 |
A process for the synthesis of a salt of tapentadol.
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WO/2013/080095A1 |
The present invention provides a process for the preparation of agomelatine and its intermediate compounds. The invention also provides an intermediate compound of agomelatine represented by Formula (V).
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WO/2013/079815A1 |
The invention concerns an improved method for synthesising bis[3-(N,N-dialkylamino)propyl]ethers from acrylonitrile, comprising the following reactions: • - a first addition reaction of a water molecule and an acrylonitrile molecule to...
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WO/2013/075671A1 |
Disclosed are crystals of acid salts and the acid salts of dapoxetine and preparation methods therefor. The crystals are crystals of methanesulfonate, nitrate, and hydrobromide of dapoxetine, and crystals of gentisate, orotate, cyclamate...
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WO/2013/075669A1 |
Disclosed are a crystal of dapoxetine hydrochloride and an amorphous dapoxetine hydrochloride. Also disclosed is a preparation method for both. The stability of the crystal of the present invention is greater than that of the polymorph o...
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WO/2013/075670A1 |
Disclosed are acid salts of dapoxetine hydrochloride and preparation methods therefor. Specifically, disclosed are a dapoxetine succinate crystal and a preparation method therefor, an amorphous dapoxetine succinate crystal and a preparat...
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WO/2013/077855A1 |
A method for the stabilization of an aqueous choline hydroxide solution includes optionally, adding a first stabilizer of a dithionite salt or a dialkylhydroxylamine to an aqueous solution containing reactants that will produce an aqueou...
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WO/2013/076190A1 |
A method for the stabilization of an aqueous choline hydroxide solution includes, optionally adding a first stabilizer of a dithionite salt and/or a dialkylhydroxylamine to an aqueous solution containing reactants that will produce an aq...
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WO/2013/072289A1 |
The present invention relates to a process for producing a supported tin-containing catalyst, characterized in that a solution (L) containing tin nitrate and at least one complexing agent is applied to the support, where the solution (L)...
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WO/2013/059191A1 |
An online monitoring and controlling system is used for monitoring and controlling sulfur content in heat stable salts or in a flue gas stream. The system comprises valves, sensors and analyzers that are operated by a valve flow and cont...
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WO/2013/058241A1 |
The present invention makes it possible to produce (R)-2-amino-2-ethylhexanol, which is useful as a pharmaceutical intermediate, easily and efficiently without complicated procedures. (R)-2-amino-2-ethylhexanol is produced by asymmetrica...
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WO/2013/053940A1 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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WO/2013/053941A1 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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WO/2013/048279A1 |
The invention entitled "Method for the selective production of N-methyl-para-anisidine" relates to chemical technology processes and, more specifically, to methods for the catalytic alkylation of aromatic amines and nitro compounds. The ...
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WO/2013/045786A1 |
The present invention relates to the manufacture of dialkylaminoalkyl (meth)acrylate, in particular N,N-dimethylaminoethyl acrylate, by transesterification reaction of an alkyl (meth)acrylate with an amino alcohol, and the subject matter...
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WO/2013/048280A1 |
The invention entitled "Method for the selective production of N-methyl-para-phenetidine" relates to chemical technology processes and, more specifically, to methods for the catalytic alkylation of aromatic amines and nitro compounds. Th...
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WO/2013/040869A1 |
Provided is a method for preparing aryl polyoxyalkyl quaternary ammonium compound, comprising: 1) reaction of phenol with dihalopolyalkylene ether in the presence of a phase-transfer catalyst to give an aryl polyoxyalkyl halide; 2) react...
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WO/2013/026773A1 |
This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalan...
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WO/2013/017937A1 |
The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof.
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WO/2013/012777A2 |
A process for making a tertiary aminoalcohol compound is disclosed. The process comprises using an excess amount of a carbonyl compound in a condensation step between the carbonyl compound and a nitroalkane in the presence of a catalytic...
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WO/2013/008247A1 |
The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also...
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WO/2013/004026A1 |
The present invention provides a process for preparing ethanolamine hydrochloride and the co-product ethanolamine. In the present process, ammonium chloride is used as a raw material for an addition reaction with EO; an appropriate formu...
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WO/2012/177674A1 |
The present application relates to molecules comprising one or more beta-hydroxyamine moieties, for example, aminosilicones and compositions such as consumer products comprising such molecules, as well as processes for making and using s...
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WO/2012/176928A1 |
Provided is a novel method that can produce an amino alcohol compound (2). A method for producing an amino alcohol compound represented by the formula (2): wherein R1, R2, and R3 each independently represent an alkyl group optionally hav...
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WO/2012/176927A1 |
Provided is a novel method that can produce an amino alcohol compound (2). A method for producing an amino alcohol compound represented by the formula (2): wherein R1, R2, and R3 each independently represent an alkyl group optionally hav...
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WO/2012/177419A1 |
Disclosed are processes and apparatuses for producing a reaction product and enabling the reaction product to be removed from a reactor operating at an elevated pressure, while simultaneously maintaining the gas pressure and retaining th...
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WO/2012/171377A1 |
Disclosed is a crystal form A of asiatic acid trometamol salt, showing main peaks at diffraction angle (2θ) of 5.98, 6.87, 9.12, 10.38, 12.00, 12.47, 12.93, 13.42, 14.72, 15.10, 17.01 and 18.14 degree, and minor peaks at diffraction ang...
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WO/2012/168359A1 |
The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations w...
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WO/2012/146978A2 |
Disclosed herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R))-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, in hig...
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WO/2012/136121A1 |
An amino phenylpropanoid compound, or a geometric isomer thereof, or a pharmaceutically acceptable salt or hydrate thereof as represented by Formula I, a preparation method therefor, and a pharmaceutical composition containing the compou...
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WO/2012/137047A1 |
The present invention relates to an improved process for the preparation of Fesoterodine and pharmaceutically acceptable salts thereof. The present invention particularly relates to a process for the preparation of fesoterodine and pharm...
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WO/2012/133182A1 |
The objective of the present invention is to provide a polyether compound which is useful as a curing agent and the like, a curing agent which uses the compound, and a method for producing the compound. A polyether compound of the presen...
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WO/2012/126363A1 |
Disclosed are an amorphous asiatic tromethamine salt and the preparation method thereof. The method comprises the steps of: (1) dissolving asiatic acid in an organic solvent; (2) mixing with tromethamine; (3) stirring and salifying the s...
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WO/2012/119928A1 |
The invention relates to a method for producing alkanol amines which comprise a primary amino group (-NH2) and a hydroxyl group (-OH), by alcohol amination of diols comprising two hydroxyl groups (-OH), using ammonia, and elimination of ...
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WO/2012/120003A1 |
The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
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WO/2012/119927A1 |
The invention relates to a method for producing primary amines comprising at least one functional group of formula (-CH2-NH2), by alcohol amination of educts which comprise at least one functional group of formula (–CH2-OH), using ammo...
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WO/2012/118441A1 |
The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding α-acyloxy sulfides.
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WO/2012/113475A1 |
The present invention relates to a chemocatalytic liquid-phase process for the direct single-stage amination of alcohols to primary amines using ammonia in high yields by means of a catalyst system containing at least one transition meta...
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WO/2012/113860A2 |
The invention relates to a compound of formula (1): where R1 through R8, which can be identical or different from each other, each are selected from of the group comprising hydrogen and the radical -(CH2)k-X, where k is a whole number fr...
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WO/2012/111856A1 |
The present invention provides a novel process for producing 2-amino-3-butene-1-ol compound. A process for producing 2-amino-3-butene-1-ol compound of the following formula (2) comprising a step of reacting an alkenylimide compound of th...
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