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WO/2009/145280A1 |
An apparatus for producing a mono(lower alkyl)monoalkanolamine provided with a reaction/distillation column (12) into which a material mixture (11) consisting of a mono(lower alkyl)amine (AA: starting material I) and an alkylene oxide (A...
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WO/2009/144848A1 |
Disclosed are a method and an apparatus for producing a mono-lower-alkyl monoalkanol amine. The apparatus comprises: a reaction column (12) into which a mixed starting material (11) comprising a mono-lower-alkyl amine (AA: a starting mat...
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WO/2009/144517A1 |
The present invention relates to a process for the preparation of cyclohexanol derivatives of the general formula (I), wherein R stands for a hydrogen atom or a methyl group, in a one-step process from a cyano compound of the general for...
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WO/2009/141833A2 |
The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and...
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WO/2009/138235A1 |
The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solven...
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WO/2009/138234A1 |
The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solven...
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WO/2009/133052A1 |
The present invention relates to a compound of formula (I), including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptab...
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WO/2009/122303A2 |
Provided herein is a novel raantlelate sail of fesoterodine, process for the preparation, pharmaceutics!! compositions, and method of treating thereof. Provided also herein are solid state forms of fesoterodine mandelate, process for the...
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WO/2009/118758A2 |
Crystalline Form V of O-desmethylvenlafaxine succinate, wherein the crystalline form exhibits an X-Ray Powder Diffraction pattern having characteristic peaks expressed in degrees 2θ ( ±0.2° 2θ ) at 12.15, 13.17, 14.67, 15.8, 19.69, 2...
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WO/2009/118474A1 |
The invention relates to a method for preparing a combretastatin (A): formula (I) in the form of a base or of an addition salt with an acid, which comprises coupling, in the presence of a base and of T3P, the salt of the (Z)-amino compou...
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WO/2009/115534A1 |
The present invention relates to improved processes for the production of 2-amino-2-[2-(4- C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.
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WO/2009/114685A2 |
Salts of O-desmethylvenlafaxine, their polymorphic forms, and processes for their preparation.
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WO/2009/106335A1 |
The present invention relates to a method for the production of 6- dimethyl amino methyl-1-(3-hydroxy- or 3-C1C4-alkoxy phenyl)-cyclohexane-1,3-diols from 6-dimethyl amino methyl-1-hydroxy-1-(3-hydroxy- or 3-C1C4-alkoxy phenyl)-cyclohexa...
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WO/2009/106386A1 |
The invention relates to a process for preparing optically active α-aminoacetals by resolution of a racemic mixture or of a mixture of enantiomers via the formation of diastereoisomeric salts, and also novel intermediates in the form of...
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WO/2009/106336A1 |
The invention relates to a method for the production of (1R,3R,6R)-6-dimethyl amino methyl-1-(3- methoxy phenyl)cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethyl amino methyl-1-(3-methoxy phenyl)cyclohexane-1,3-diol, or mixtures thereof.
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WO/2009/104961A2 |
The present invention relates to a process for the preparation of a dichloropropanol product, wherein the dichloropropanol product comprises a mixture of 1,2-dichloropropan-3-ol and 1,3-dichloropropan-2-ol, said process comprising the st...
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WO/2009/102043A1 |
Disclosed is a method for producing an optically active 4-amino-3-(3,4-dichlorophenyl)butan-1-ol, wherein an optically active 3-(3,4-dichlorophenyl)-4-nitrobutanal is obtained by reacting 3-(3,4-dichlorophenyl)acrylaldehyde with nitromet...
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WO/2009/090669A2 |
A novel process for the selective reduction of halonitroarenes in general and halonitroaromatic arenes in particular, without the hydrogenolysis of the C-Cl (where, X represents F-, Cl-, Br- and I) and the C-O-C bonds, in the presence of...
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WO/2009/090791A1 |
A process for continuously producing a quaternary salt of a dialkylaminoalkyl (meth)acrylate by reacting a dialkylaminoalkyl (meth)acrylate with a gaseous quaternizing agent in an aqueous solution of a quaternary salt of a dialkylaminoal...
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WO/2009/087804A1 |
The object is to provide a process for continuously producing a dialkylaminoalkyl (meth)acrylate by utilizing a transesterification reaction while preventing the production of N,N'-dimethylpiperazine as a by-product. In the process, a st...
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WO/2009/084038A2 |
The present invention relates to an industrially advantageous process for the preparation of O- desmethyl-venlafaxine, a venlafaxine metabolite, and pharmaceutically acceptable salts thereof by demethylating venlafaxine or salts using an...
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WO/2009/084039A2 |
The present invention relates to an improved, process for large scale production of 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol (O- desmethylvenlafaxine) or its pharmaceutically acceptable salts with increased yield and minimal i...
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WO/2009/080505A1 |
The invention relates to a method for producing (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent reworking.
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WO/2009/080514A1 |
Disclosed is a method for producing an amine by reacting a primary or secondary alcohol, aldehyde, and/or ketone with hydrogen and a nitrogen compound selected from among the group comprising ammonia and primary and secondary amines in t...
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WO/2009/080506A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group including ammonia, primary and secondary amines, i...
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WO/2009/080508A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group including ammonia, primary and secondary amines, i...
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WO/2009/080655A1 |
The present invention relates to a process for the preparation of phenethyl tertiary amine derivatives by hydrogenation of phenylacetonitriles. More particularly, the present invention relates to a one pot two step process for the prepar...
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WO/2009/080507A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group including ammonia, primary and secondary amines, i...
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WO/2009/080515A1 |
Disclosed is a method for producing an amine by reacting a primary or secondary alcohol, aldehyde, and/or ketone with hydrogen and a nitrogen compound selected from among the group comprising ammonia and primary and secondary amines in t...
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WO/2009/080510A1 |
Disclosed is a method for producing an amine by reacting a primary or secondary alcohol, aldehyde, and/or ketone with hydrogen and a nitrogen compound selected from among the group comprising ammonia and primary and secondary amines in t...
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WO/2009/080509A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group including ammonia, primary and secondary amines, i...
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WO/2009/073066A1 |
The present invention describes processes for the preparation of O- desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
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WO/2009/070311A2 |
Provided are crystalline forms of O-desmethylvenlafaxine fumarate, methods for their preparation, and pharmaceutical compositions thereof.
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WO/2009/065783A1 |
Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(=O)HR1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group -P(...
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WO/2009/065784A1 |
Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group -P(R)2; in which R is in each case...
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WO/2009/062377A1 |
A method of resolution of an important chemical intermediate, 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, comprises the following steps: reacted its two enantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane with d...
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WO/2009/060050A2 |
The present invention relates to the use of a bi-functional catalyst for the one-step preparation of para-am inophenol, said catalyst comprising a mixture of a hydrogenation noble metal and a zirconium sulfate. The present invention also...
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WO/2009/060282A2 |
Described are novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, an...
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WO/2009/053731A1 |
The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV), comprising the reaction of venlafaxine, or a salt thereof, with a thiol reagent such as a dithiol, an aminothiol or an...
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WO/2009/047905A1 |
Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically discl...
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WO/2009/041000A1 |
The object is to provide an aliphatic amine alkylene oxide adduct which shows a good color when used as a detergent, and which has a sufficiently sharp molecular weight distribution, high purity, and a low odor. Thus, disclosed is an ali...
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WO/2009/041470A1 |
Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a h...
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WO/2009/034434A2 |
The present invention provides a novel process for the preparation of O-desmethyl venlafaxine from venlafaxine or its salt. Venlafaxine or its salt is O-demethylated to provide O- desmethylvenlafaxine in high yield and purity by reacting...
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WO/2009/035535A2 |
The present invention provides for a crystalline polymorph of Carvedilol phosphate salt and a process for making the same.
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WO/2009/017056A1 |
Disclosed is a compound containing a structure represented by the general formula (1) below (including the structure of a residue obtained by removing at least one hydrogen atom from the structure represented by the general formula (1) b...
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WO/2009/014829A2 |
Biocompatible polymers having polymer backbones with at least one pendant reactive secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-open...
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WO/2009/012039A2 |
The present invention provides for crystalline forms of 2-amino-5-(2,2- dimethylpropionyl)-4-{[5-(N,N'-(2-ethoxycarbonylprop-2-yl)ph
osphonamido] furan-2-yl}thiazole and compositions thereof including pharmaceutical compositions. The pre...
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WO/2009/010990A2 |
The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms- A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine...
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WO/2007/109791A9 |
The present invention relates to processes for preparation of alkoxylated alkyl amines or alkoxylated alkyl ether amines with peaked distribution, surfactants comprising alkoxylated alkyl amines or alkoxylated alkyl ether amines with pea...
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WO/2009/004593A2 |
The invention relates to efficient and cost effective processes for the preparation of pure (-)- epinephrine. More particularly, it relates to processes for the resolution of racemic epinephrine.
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