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WO/2009/005024A1 |
Disclosed is a method for producing a chiral amine, which is characterized in that an imine compound is subjected to a hydrogen transfer-type asymmetric reduction in the presence of an iridium (III) complex having a chiral proline amide ...
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WO/2009/003589A1 |
The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and g...
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WO/2008/156095A1 |
Disclosed is a method for producing an optically active trans-2-aminocyclohexanol which is characterized in that a trans-2-aminocyclohexanol in a racemic form and an optically active 2-methoxyphenyl acetic acid are reacted and then an op...
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WO/2008/151992A2 |
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino
]-8-methyl-8H- pyrid...
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WO/2008/149228A1 |
The present invention relates to the purification of (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-dipheny
lhexane (III) by making its crystalline acid addition salt, which can be used as such to produce Lopinavir /Ritonavir with ...
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WO/2008/144956A1 |
Disclosed are ambroxol compounds of formula I, their preparation processes and uses for producing apophlegmatics, antitussives or medicines having both apophlegmatic and antitussive activities. (formula I) wherein R is hydrogen, C1-C4 al...
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WO/2008/142088A1 |
The invention relates to a process for preparing α-aminoacetals substantially in racemic form, comprising a step of oxidizing optically enriched α-aminoacetals to the corresponding oximes, in the presence of a catalyst, and a step of r...
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WO/2008/140957A2 |
The present invention relates to a method for recovering N,N,N'-trimethylbisaminoethylether from a mixture with its amide and a method for separating N,N,N'- trimethylbisaminoethylether from mixtures comprising tertiary amines or tertiar...
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WO/2008/141027A2 |
A catalyst for the epoxidation of an olefin comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the quantity of the rhenium promoter deposited on the carr...
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WO/2008/132128A2 |
Process for the manufacture of UK- 427,857 ( Maraviroc ) which comprises a step wherein enantiopure (S)-3-amino-3-phenylpropan-1-ol is manufactured from a mixture of its enantiomers by crystallizing or precipitating from a solution conta...
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WO/2008/120475A1 |
Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic e...
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WO/2008/112313A2 |
Provided are processes for the preparation of amorphous O- desmethylvenlafaxine and for the preparation of crystalline forms(I), (II), (III), and (IV) of O-desmethylvenlafaxine.
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WO/2008/107797A2 |
Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of substantially pure Lercanidipine intermediate, 1,1,N- trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate. The inter...
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WO2008017278B1 |
A crystalline salt of 2-[(1R)-3-[bis(l-methylethyl)amino]-1-?henyl?ropyl]-4-methyl
-phenol with (2R,3R)-2,3-dihydroxybutanedioic acid, known under the name R-tolterodine tartarate, wherein: a) at least 90 % of all crystals are present in...
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2008/095678A1 |
Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is C1-6 alkyl or aryl-substituted C1-6 alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6 alkoxy, or salts thereof are prepared by ...
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WO/2008/092327A1 |
Provided are half-hydrated crystal of voglibose and the preparation thereof. Said half-hydrated crystal has the molecular formula of C10H21NO7 0.5H2O and the powder X-ray diffraction pattern with peaks of 2θ=9.64±0.2, 16.08±0.2, 18.34...
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WO/2008/090465A2 |
The invention relates to a process for manufacturing desvenlafaxine free base and salts or solvates thereof, comprising O-demethylating venlafaxine by treatment with 2- (diethylamino) ethanethiol free base or its hydrochloride salt.
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WO/2008/087736A1 |
A process for producing an aromatic amine compound having an aralkyloxy or heteroaralkyloxy group, in which under mild conditions, through convenient procedure, an aromatic nitro compound having an aralkyloxy or heteroaralkyloxy group is...
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WO/2008/083708A1 |
The present invention relates to an improved process for the preparation of essentially pure Venlafaxine Hydrochloride. Particularly, the process for the preparation of Venlafaxine Hydrochloride comprises the following steps: i) Preparat...
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WO/2008/080287A1 |
A L-carnitine calcium fumarate and its preparation and applications are disclosed in present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the...
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WO/2008/077799A2 |
A method of making an amino-alkylenediol and intermediate compounds useful in the method is disclosed. The method includes preparing a first intermediate compound comprising an aminoalkylene diol wherein a protecting group is linked to t...
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WO/2008/077560A1 |
Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is hydrogen, C1-6alkyl or aryl-substituted C1-6alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6alkoxy, or salts thereof are prepa...
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WO/2008/072773A1 |
Disclosed is a production method comprising the steps (A)-(E) below, which enables to commercially and safely produce (1R,2R)-2-amino-1-cyclopentanol or a hydrochloride thereof.
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WO/2008/070909A1 |
The present invention relates to a process for obtaining the R-enantiomer of salbutamol from a mixture of the enantiomers of salbutamol by a crystallization of said R-enantiomer as its salt with R-ibuprofen from a solution or slurry of a...
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WO/2008/067857A1 |
The invention provides a process for preparing polyetheramines of the formula (1) R2(NR1R3)n in which n is a number from 1 to 20, R2 represents an organic radical that contains between 2 and 600 oxalkylene groups, and R1 and R3 are alike...
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WO/2008/068444A1 |
The subject of the invention is a method for the synthesis of (meth)acrylic esters by transesterification in the presence of a catalyst corresponding to the formula [(R'O)3TiO]xR'' in which R' is a linear or branched alkyl radical having...
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WO/2008/068927A1 |
Equipment for the production of amines which is constituted of a reactor (11) for conducting the reaction of a mono(lower alkyl)amine (raw material (I)) with an alkylene oxide (raw material (II)), a distillation column (14) for separatin...
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WO/2008/061466A1 |
Disclosed are synthetic methods of formula (V) compounds: wherein R1-R7 are same or different and respectively selected from hydrogen and C1-4 alkyl; and n is an integer of 1-4. Said methods can be carried out as one-pot processes. Synth...
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WO/2008/062138A1 |
The invention relates to an in situ or one-pot method for preparing compounds of the formula (I). The method provides a compound of the formula (I) and comprises: a) hydrogenation of a nitrile function of the compound of the formula (II)...
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WO/2008/062473A1 |
The present invention relates to the process for preparing Atomoxetine hydrochloride which is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is chemically known as (-)-iV-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydroch...
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WO/2008/059525A2 |
A novel single step process for the synthesis of venlafaxine of formula I and N-desmethylvenlafaxine of formula II from 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile [cyano-intermediate] of formula V V comprising reacting 2-(1-...
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WO/2008/056808A1 |
Disclosed is a polyimide which is obtained by reacting a tetracarboxylic acid component with a diamine component containing a diamine compound represented by the following general formula (1). (In the formula, A represents a biphenylene ...
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WO/2008/058111A2 |
Provided are methods of preparing halohydroxypropyltrialkylammonium halides.
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WO/2008/053652A1 |
A process for producing 1-hydroxy-4-aminoadamantane shown below. wherein R1 and R2 independently represent a hydrogen, a halogen, a carboxy, a nitro, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylsulfonyl...
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WO/2008/047382A2 |
The present invention relates to a process for the preparation of 4-[2-[[3-(4-hydroxyphenyl)-1- rnethylpropyl]amino]ethyl]-1,2-benzenediol, a compound of formula (I), and its pharmaceutically acceptable salts. The compound of formula (I)...
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WO/2008/048988A2 |
This invention relates to novel macromolecular compositions having oxidation inhibition characteristics that are exhibited when added to organic material normally susceptible to oxidative degradation in the presence of air or oxygen, suc...
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WO/2008/048990A2 |
This invention relates to processes for the production of reaction mixtures, which have oxidation inhibition characteristics, using sterically hindered 4-alkoxymethyl-2,6-dihydrocarbylphenol and aromatic amines or heterocyclic compounds.
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WO/2008/037590A1 |
The invention relates to a method for the continuous separation by distillation of mixtures that contain morpholine (MO), monoaminodiglycol (ADG), ammonia and water, obtained by reacting diethyleneglycol (DEG) with ammonia. The method ac...
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WO/2008/038146A2 |
The invention relates generally to an improved process for manufacturing venlafaxine base and/or salts thereof.
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WO/2008/037659A1 |
The invention relates to a method for producing electronic grade 2,2'-aminoethoxyethanol by reacting diethylene glycol with ammonia in a reactor in the presence of a catalyst, thereby obtaining a reaction mixture. A crude 2,2'-aminoethox...
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WO/2008/038619A1 |
Disclosed is a method for producing a DAM at high productivity and high purity while keeping safety, by adjusting the gas composition in a gas phase in a reactor to a value falling within the predetermined range. Specifically disclosed i...
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WO/2008/038618A1 |
Disclosed is a method for producing a DAM at high productivity and high purity by cooling a reaction solution efficiently to control the increase in temperature in a reactor. Also disclosed is a production apparatus suitable for the meth...
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WO/2008/038637A1 |
Disclosed is a clean, simple, and general-purpose method for producing a free amine from a salt of an amine having 1 to 10 carbon atoms which may have a substituent with an acid, which does not need to use water or any organic solvent, a...
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WO/2008/035358A2 |
This invention relates to a new process for preparation of enantiomerically pure dapoxetine or an acid addition salt thereof i.e. S(+)-N,N-dimethyl-2-[2-(naphthalenyl oxy)ethyl]benzenemethanamine hydrochoride, a potent serotonin re-uptak...
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WO/2008/035796A1 |
Disclosed is a method for producing a high-purity quaternary ammonium salt, which is characterized in that (1) an oxide or hydroxide of a group 1, 2, 12 or 13 metal is added into a quaternary ammonium salt which contains a protonic acid ...
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WO/2008/028586A1 |
The invention relates to a method for producing alkylene oxide addition products by reaction of compounds having a nucleophilic center with alkylene oxides in a reactor having a large inner surface. The invention is characterized in that...
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WO/2008/028587A1 |
The invention relates to a method for producing alkylene oxide addition products. The method according to the invention is characterized by (a) contacting ethylene and/or propylene with an oxidizing agent in a first structured reactor ("...
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WO/2008/026227A2 |
Provided is the process for the preparation of Atomoxetine hydrochloride by the condensation of N,N-dimethyl 3-phenyl-3-chloropropyl amine acid addition salt with o- cresol in presence of a phase transfer catalyst and base followed by de...
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WO/2008/022541A1 |
Disclosed are a series of esters containing 2,6-diisopropylphenyl and tert-amine, the water-soluble derivatives thereof (II) through reaction with acid, and preparation method thereof. The method uses 2,6-diisopropylphenol (I) as a raw m...
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