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Matches 1 - 50 out of 10,820

Document Document Title
WO/2019/171093A2
The invention relates to a robust and reproducible process for the preparation of polymorph form B of treprostinil diethanolamine salt, comprising the following steps: a. treprostinil is dissolved in methanol, b. to the solution of step ...  
WO/2019/166578A1
The present invention relates to the field of catalytic hydrogenation and to the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands and optionally a diamine liga...  
WO/2019/162121A1
The invention relates to a method for the continuous separation by distillation of mixtures containing morpholine (MO), monoaminodiglycol (ADG), ammonia, water and methoxyethanol (MOE), obtained by reacting diethylene glycol (DEG) with a...  
WO/2019/154647A1
The invention relates to a method for continuously producing C2-C4 mono-alkanolamines by reacting a corresponding C2-C4 alkylene oxide with a molar excess of ammonia (NH3), wherein aqueous ammonia is used, in the liquid phase and in the ...  
WO/2019/154436A1
Disclosed is a preparation method for a racemic adrenaline as represented by formula 2. The method comprises the following steps: compound 1 is directly racemized in an acidic solution to produce compound 2, the acid solution comprising ...  
WO/2019/088800A3
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/141343A1
The invention relates to esterquats which can be obtained by reacting di- or trialkanolamines with a mixture of fatty acids and polycarboxylic acids, and the esters obtained in this manner are then quaternized with an alkylating agent, w...  
WO/2019/138216A1
The present invention relates to the field of catalytic hydrogenation and, more particularly, to methods of manganese-catalysed hydrogenation of esters to alcohols. Advantageously, where the esters are chiral, the hydrogenations proceed ...  
WO/2019/127920A1
A liquid phase spherical carrier as represented by formula I, a preparation method therefor and use thereof. R is a functional group, preferably a group having hydroxyl, amino, carboxyl or halogen. The liquid phase synthesis carrier can ...  
WO/2019/129710A1
The disclosure provides methods for making a quaternary ammonium compound, such as comprising: providing an amine composition comprising an amine of the formula R[CONH(CH2)n]zN(R1)(R2), wherein z is 0-1, n is 2-5, R is C10-C22 alkyi or C...  
WO/2019/119293A1
The present invention concerns new cationic quaternary ammonium compounds which exhibit excellent adsorption properties on negatively charged surfaces. These ones can notably be obtained firstly by reacting an internal ketone with a twin...  
WO/2019/117446A1
The present invention relates to a method for producing a 2-octylglycine ester having optical activity from a racemic 2-octyl-DL-glycine ester and, more particularly, to a method for producing a 2-octyl-L-glycine ester or a 2-octyl-D-gly...  
WO/2019/109610A1
Disclosed are an aqueous agent and powder of a Gemini-type shale inhibitor for water-based drilling fluids, preparation methods therefor, and an inhibitor. After adding the Gemini-type shale inhibitor for water-based drilling fluids to a...  
WO/2019/088800A9
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/106084A1
Disclosed is a continuous process for the oxidation of tertiary amines to provide an amine oxide composition.The process involves mixing a tertiary amine and an aqueous oxidizing agent in a spinning disk reactor and (1) diluting and/or d...  
WO/2019/105324A1
Disclosed is a method for preparing salicylamide acetate. The method comprises the steps of: (1) carrying out amino protection on salicylaldehyde having a structure represented by formula 1 to obtain a compound having a structure represe...  
WO/2019/088800A2
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/079871A1
The present invention relates to a two-step method of alkoxylation of a polymer composition with at least one alkylene oxide. Said polymer composition comprises at least one amine-derived polymer and at least one polyalkoxylate. The alko...  
WO/2019/081285A1
The invention relates to a method for producing ethyleneamines and/or alkanolamines, having the following steps: 1) reacting MEG with ammonia in the presence of hydrogen and an amination catalyst; and 2) separating hydrogen and ammonia f...  
WO/2019/081283A1
The invention relates to a method for purifying a mixture containing MEG, MEA, EDA and DETA, as well as low-boiling components having a boiling point lower than or the same as that of PIP, and high-boiling components having a boiling poi...  
WO/2019/068578A1
The present invention relates to a process for preparing dimethylaminoalkyi (meth)acrylates from alkyl (meth)acrylate and dimethylaminoalkanol. It likewise relates to the use of a catalyst system comprising a solution of a lithium alkoxi...  
WO/2019/063952A1
The invention relates to a new method for the synthesis of unsymmetrical tertiary amines using alcohol and an imine, and to new tertiary amines.  
WO/2019/055498A1
The present invention provides enzymes that have been optimized by implementation of Protein Repair One Stop Shop (PROSS), an algorithm that generates protein design(s) for enhanced stability without changing either enzymatic properties ...  
WO/2019/041961A1
Provided are a transparent nucleating agent, a preparation method therefor and the use thereof, wherein the transparent nucleating agent comprises a compound represented by formula (1) and a derivative thereof; the method comprises: brin...  
WO/2019/035775A1
A method for the preparation of tapentadol in the form of a base or its hydrogen chloride, which involves the preparation of a salt (III) from a mixture of diastereomers (II) by means of crystallization-induced asymmetric transformation ...  
WO/2019/020889A1
The present invention relates to the production of (meth)acrylic esters according to a continuous process by transesterification, and in particular to the purification of a crude reaction mixture comprising a C4-C12 (meth)acrylic ester w...  
WO/2019/020466A1
Process for the hydrolysis or alcoholysis of a ketal or acetal compound wherein a ketal or acetal compound comprising at least one ketal or acetal group and at least one amino group is reacted with carbon dioxide and water oran alcohol.  
WO/2019/020488A1
Process for the preparation of a compound of formula (I) with R1 and R2 independently from each other representing hydrogen or a C1-to C10 alkyl group by a two-step process wherein the first step is an amination of the compound of formul...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/001549A1
A multi-arm single molecular weight polyethylene glycol and an active derivative thereof, used for drug modification, effectively improving the solubility, stability, and immunogenicity of drugs; improving the absorption of the drugs in ...  
WO/2019/001473A1
Provided are a dendritic polyglycol derivative, a preparation method therefor, and an application thereof. The dendritic polyglycol derivative has a structure of formula (I), a plurality of terminal functional groups, and better water so...  
WO/2018/234294A1
The present invention relates to a fabric softener active composition comprising: a component (a), said component being at least one or a mixture of quaternary mono-, di- or tri-ester ammonium compounds; a component (b), said component b...  
WO/2018/228981A1
The invention relates to a process for the preparation of a compound represented by formula (I) wherein X is selected from the group consisting of -H, -halogen, linear or branched C1-C7 alkyl group, linear or branched C1-C5 alkoxy group,...  
WO/2018/224315A1
The invention relates to a method for producing alkanolamines and/or ethyleneamines in the liquid phase by reacting ethylene glycol and/or monoethanolamine with ammonia in the presence of an amination catalyst which contains one or more ...  
WO/2018/224316A1
The invention relates to a method for producing alkanolamines and/or ethyleneamines in the liquid phase, by reacting ethylene glycol and/or monoethanolamine with ammonia in the presence of an amination catalyst containing Co, Ru and Sn.  
WO/2018/224321A1
The invention relates to a method for producing alkanolamines and/or ethyleneamines in the liquid phase, by reacting ethylene glycol and/or monoethanolamine with ammonia in the presence of an amination catalyst obtained by reducing a cat...  
WO/2018/223347A1
Disclosed is a method for synthesizing an N-alkylaminophenyl alkyl ether, wherein the N-alkylaminophenyl alkyl ether is prepared by subjecting a nitrophenyl alkyl ether to hydrogenation reduction and alkylation, or wherein same may also ...  
WO/2018/214877A1
Disclosed is a crystal form of dezocine. The X-ray powder diffraction (XRD) pattern thereof is determined using Cu/K-α1, and has a diffraction peak at the 2θ value of 9.1±0.2 and 12.2±0.2, and the height% of these diffraction peaks a...  
WO/2018/209665A1
A preparation method for a nano-nickel-based catalyst with a confinement structure and hexahedral morphology. According to the method, a nickel-aluminum hydrotalcite precursor of an organic carbon chain intercalation is synthesized first...  
WO/2018/205108A1
Provided is a method for the alcoholysis of an amide. The method comprises subjecting an amide-containing compound to alcoholysis under alkaline conditions using an epoxy compound as an accelerator. The method described above is easy to ...  
WO/2018/202765A1
The present invention relates to a process for the conversion of ethylene oxide to 2-aminoethanol and/or ethane-1,2-diamine and/or linear polyethylenimines of the formula H2N- (CH2CH2NH)n-CH2CH2-NH2 wherein n≥ 1 comprising (i) providin...  
WO/2018/195956A1
Provided is a method for preparing a single crystal of an anhydrous halogenated choline or a derivative thereof, comprising the steps of: (1) proportionally weighing the halogenated choline or a derivative thereof, an alcohol or ether co...  
WO/2018/199166A1
The purpose of the present invention is to provide: compounds having a TrkA inhibiting effect, or pharmacologically acceptable salts thereof, or solvates of these; pharmaceutical compositions characterized by containing these as an activ...  
WO/2018/172026A1
The invention relates to a process for synthesizing an aqueous N,N-dimethyl glucamine solution, characterized in that a formaldehyde solution is metered into an N-methyl glucamine solution in the presence of a metal catalyst at hydrogen ...  
WO/2018/172025A1
The invention relates to a method for preparing aqueous solutions of N,N-dimethylglucamine, characterized by first preparing an adduct of N-methylglucamine and formaldehyde in water at temperatures of between 15°C and 40°C, and subsequ...  
WO/2018/174442A1
The present invention relates to a compound for treating diseases caused by a coronavirus infection. The compound exhibits excellent inhibitory activity against coronaviruses, and is useful as a pharmaceutical composition for preventing ...  
WO/2018/148113A1
The present invention is directed to 13C and/or 2H isotope enhanced ambroxol ("isotope enhanced ambroxol") and its use in the treatment of autophagy infections, especially mycobacterial and other infections, disease states and/or conditi...  
WO/2018/146529A1
The present invention relates to a high yield process of preparation of, [1-[2-(Dimethylamino)-1- (4-hydroxyphenyl)ethyl]-cyclohexanol]through potassium hydroxide mediated demethylation of [1-[2-(Dimethyl amino-1-(4-methoxyphenyl) ethyl ...  
WO/2018/144101A1
Described herein are labeling agents, specifically [11C]fluoroform, [11C]difluoromethane, [11C]fluoromethyl iodide, [11C]fluoromethyl bromide, [11C]fluoromethyl chloride, [11C]fluoromethyl trifluoromethansulfonate, [11C]difluoromethyl io...  
WO/2018/135506A1
The purpose of the present invention is to provide a ruthenium complex which is capable of serving as a reduction catalyst that is applicable to an industrial production. According to the present invention, ketones, aldehydes, esters or ...  

Matches 1 - 50 out of 10,820