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Matches 1 - 50 out of 10,290

Document Document Title
WO/2019/197232A1
The invention relates to a multi-stage process for producing 2,6-dialkylphenyl acetic acids of general formula (I) by reacting 2,6-dialkyl bromobenzenes with (1) magnesium, (2) a formamide, (3) an acid, (4) hydrogenation of the benzaldeh...  
WO/2019/198023A1
Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invent...  
WO/2019/196263A1
The present invention relates to the field of pharmaceutical synthesis, in particular to a method for preparing a hexahydrofuro-furanol derivative, an intermediate thereof and a preparation method therefor. The preparation method compris...  
WO/2019/199863A1
Provided are compounds, or pharmaceutically acceptable salts thereof, which are useful for inhibiting FOXM1, inhibiting cancer growth, and/or treating cancer. In particular, these compounds and their corresponding quaternary ammonium sal...  
WO/2019/191624A1
The present invention includes substituted 3,3'-bis(phenoxymethyl)-1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (H...  
WO/2019/190172A1
The present invention is to provide a compound represented by the formula 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same, which can be used for preventing or treating obesity or meta...  
WO/2019/181714A1
A compound according to the present invention is characterized by being represented by formula wherein: R1 represents an oxygen atom or a sulfur atom; and each of R2-R6 independently represents a hydrogen atom, an alkyl group having 1-6 ...  
WO/2019/175352A1
The current invention relates to long α-ω di-functional linear molecules as building blocks closing the gap between small molecules and polymers, or in a polycondensated form, in the production of oligomers and/or polymers, surfactants...  
WO/2019/175897A1
The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tau...  
WO/2019/169402A1
Apparatus and a method for cleaning accumulated sediment from storm drain conduits and other large-diameter conduits. A nozzle assembly is arranged to deliver a high-volume flow of water at a pressure high enough to loosen sediment from ...  
WO/2019/166578A1
The present invention relates to the field of catalytic hydrogenation and to the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands and optionally a diamine liga...  
WO/2019/087069A3
The present disclosure provides impurities of pimavanserin tartrate, processes for the preparation of the disclosed impurities, and the use of the disclosed impurities as reference standards in a chromatographic method for analyzing the ...  
WO/2019/162121A1
The invention relates to a method for the continuous separation by distillation of mixtures containing morpholine (MO), monoaminodiglycol (ADG), ammonia, water and methoxyethanol (MOE), obtained by reacting diethylene glycol (DEG) with a...  
WO/2019/153216A1
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), Ar is an aryl group, a heteroaryl group, or an aryl or heteroaryl group substituted by one or mo...  
WO/2019/155169A1
The present invention relates to difunctional biphenyl compounds according to formula (I): in which Alk, Alk' and R are as defined in the description. Said compounds are suitable for use as curing agents for thermosetting resins, particu...  
WO/2019/088800A3
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/137724A1
The present invention relates to ureylene additives, a method for their preparation, a use of said ureylene additives favorably as additive in metal or metal alloy deposition composition, preferably in a copper or copper alloy deposition...  
WO/2019/127920A1
A liquid phase spherical carrier as represented by formula I, a preparation method therefor and use thereof. R is a functional group, preferably a group having hydroxyl, amino, carboxyl or halogen. The liquid phase synthesis carrier can ...  
WO/2019/088800A9
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/107533A1
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, C...  
WO/2019/106084A1
Disclosed is a continuous process for the oxidation of tertiary amines to provide an amine oxide composition.The process involves mixing a tertiary amine and an aqueous oxidizing agent in a spinning disk reactor and (1) diluting and/or d...  
WO/2019/103989A1
Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gau...  
WO/2019/103639A1
The invention relates to the field of protecting metals from corrosion in the oil and gas industry during the production, storage, and transport of hydrocarbons, and can be used for protecting parts of engines that run on a hydrocarbon f...  
WO/2019/088800A2
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/076904A1
The application relates to compounds of formula (I) that show great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activi...  
WO/2019/071348A1
There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying exci...  
WO/2019/018785A3
Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AIPs) comprising endocannabinoid and FABP motifs covalently linked to a b...  
WO/2019/066337A1
The present specification relates to a compound represented by chemical formula (1), a coating composition comprising the compound represented by chemical formula (1), an organic light-emitting diode using same, and a method for preparin...  
WO/2019/066338A1
The present specification relates to a coating composition, an organic light-emitting diode using same and a method for preparing same. The coating composition comprises: a compound represented by chemical formula (1); and an ionic compo...  
WO/2019/063952A1
The invention relates to a new method for the synthesis of unsymmetrical tertiary amines using alcohol and an imine, and to new tertiary amines.  
WO/2019/016511A3
The present invention relates to new crystalline forms of vilanterol trifenatate, processes for their preparation, and their use in a pharmaceutical composition for the treatment of respiratory diseases, particularly for the treatment of...  
WO/2019/053494A1
The present invention relates to a process of preparation of O-Desmethyl tramadol through potassium hydroxide mediated demethylation of Tramadol under phase transfer conditions.  
WO/2019/051222A1
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl...  
WO/2019/051416A1
The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-...  
WO/2019/035775A1
A method for the preparation of tapentadol in the form of a base or its hydrogen chloride, which involves the preparation of a salt (III) from a mixture of diastereomers (II) by means of crystallization-induced asymmetric transformation ...  
WO/2019/032743A1
The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.  
WO/2019/024924A1
The present invention relates to an amine compound for inhibiting semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitors and use thereof in medicine, and further relates to a pharmaceutical com...  
WO/2019/022251A1
A (poly)amine compound represented by formula (0): (in formula (0), RX represents a C1-70 2nA-valent group or a single bond; R1A each independently represent an optionally substituted C1-30 alkyl group, an optionally substituted C6-30 ar...  
WO/2019/020026A1
Disclosed are a difluoromethoxy diphenylethane and trans-stilbene derivatives, and a preparation method therefor and the use thereof. The present invention conducts a chemical structure modification with a difluoromethoxy group at the 4'...  
WO/2019/018785A2
Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AIPs) comprising endocannabinoid and FABP motifs covalently linked to a b...  
WO/2019/016512A1
The present invention relates to an amorphous form of vilanterol trifenatate, processes for its preparation and its use in pharmaceutical formulations for the treatment of respiratory diseases, particularly for the treatment of asthma an...  
WO/2019/016511A2
The present invention relates to new crystalline forms of vilanterol trifenatate, processes for their preparation, and their use in a pharmaceutical composition for the treatment of respiratory diseases, particularly for the treatment of...  
WO/2019/013299A1
The present invention provides a thermally conductive material that has excellent thermal conductivity. The present invention also provides: a device that is provided with a thermally conductive layer that includes the thermally conducti...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2019/001473A1
Provided are a dendritic polyglycol derivative, a preparation method therefor, and an application thereof. The dendritic polyglycol derivative has a structure of formula (I), a plurality of terminal functional groups, and better water so...  
WO/2018/230848A1
The present specification relates to a compound in chemical formula (1), a coating composition comprising the compound in chemical formula (1), an organic light-emitting device using same and a method for preparing same.  
WO/2018/223347A1
Disclosed is a method for synthesizing an N-alkylaminophenyl alkyl ether, wherein the N-alkylaminophenyl alkyl ether is prepared by subjecting a nitrophenyl alkyl ether to hydrogenation reduction and alkylation, or wherein same may also ...  
WO/2018/219204A1
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...  
WO/2018/211844A1
This compound is represented by general formula (1). In general formula (1), R1 and R2 are each independently an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aryl group having 6 to 14 carbon atom...  

Matches 1 - 50 out of 10,290