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WO/1993/013048A1 |
High molecular weight buffering compositions and polymeric buffering compositions incorporating such compositions are described. The compositions are useful in applications where lower molecular weight buffers are unsatisfactory because ...
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WO/1993/008288A1 |
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecula...
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WO/1993/004148A1 |
A novel compound comprises a chemical compound comprising or including a cyclic ring system such as an aromatic ring system, the compound carrying at least two substituents of the general formula -A-NR1R2 below on the ring system where A...
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WO/1993/004373A1 |
Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more Ca?2+¿ receptors. Novel compou...
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WO/1993/002041A1 |
New ester-containing quaternary ammonium salts are provided having advantageous utility as charge control agents in electrostatographic toners and developers. The salts have the structure (I) wherein R1 is alkyl or aryl, R2 is alkyl or a...
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WO/1993/000313A2 |
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an eff...
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WO/1993/000325A1 |
Described is the use, for the treatment of illnesses, of esters of fatty acids with amino alcohols of the formula I, in which R?1¿ to R?7¿ are as defined in the description.
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WO/1993/000326A1 |
Described are compounds of the formula: R?1¿-X-Y-NR?2¿R?3¿, plus their salts with physiologically tolerable acids and their C¿1-2?-trialkylammonium salts. These compounds are suitable for use in the treatment of illnesses.
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WO/1992/020646A1 |
The invention relates to organic chemistry and more especially to therapeutic chemistry. It concerns, in particular, novel quaternary ammonium salts of general formula (I), in which Hal is a halogen atom other than fluorine, R and R1, th...
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WO/1992/019585A1 |
A triphenylalkene derivative represented by general formula (1), a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical composition thereof having a tumor inhibitory action and an osteoporosis curing activity. In ...
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WO/1992/016493A1 |
Esters are disclosed of citric acid or acetylcitric acid anhydride with compounds containing at least 3 OH groups selected in the group formed by polyglycerine, sucrocarboxylic acids, alkylglucosides, derivates of oligosaccharides, amino...
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WO/1992/015593A1 |
The imidazopyridines compounds of the present invention are serotonergic 5-HT3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT3 receptors is beneficial. Therapy is indicated for, bu...
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WO/1992/015555A2 |
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are pa...
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WO/1992/015553A1 |
A trialkylamine derivative represented by general formula (1) or a pharmacologically acceptable salt thereof, wherein R1 and R2 may be the same or different from each other and each represents lower alkyl; R3, R4 and R5 may be the same o...
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WO/1992/009673A1 |
The reaction products of (1) anhydrides and/or poly-acids and (2) aminoalcohols or aminoalcohols/amides with long chain hydrocarbyl groups attached improve the low-temperature properties of distillate fuel when added thereto.
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WO/1992/008837A2 |
The invention pertains to biodegradable fabric softeners based on selected amines which, in protonated form, exhibit an unexpectedly favourable softening action. The selected amines essentially contain ester-groups, and preferably are di...
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WO/1992/002481A1 |
Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity ligands to the sigma binding-sites cont...
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WO/1992/001671A1 |
A heterocycle-substituted benzene derivative represented by general formula (I) wherein R represents C¿3? to C¿8? cycloalkyl, X represents halogen, and Z represents (Ia) or (Ib) provided that the cycloalkyl may be substituted with C¿1...
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WO/1991/019693A1 |
Novel compounds selected from the group consisting of: (A) compounds of formula I(1), wherein: one of R?1� and R?2� represents the group (a) and the other represents hydrogen or R?7�CO-; R?5� represents C�1? to C�6?-alkyl or ...
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WO/1991/017974A1 |
Quaternerised esters with textile softening and hydrophilising properties are obtained by the reaction of mono-unsaturated fatty acids containing at least 40 mol % trans-configured double bonds or their esters with alkanol amines followe...
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WO/1991/015482A1 |
Compounds of either general formulae (I) and (II), wherein R1 represents C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-8)alkyl, C2-8 alkenyl, or C1-6 alkyl substituted phenyl group; R3 represents a hydrogen atom or a substituent R4 or ...
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WO/1991/014178A1 |
The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents a...
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WO/1991/013080A1 |
Pseudonucleosides and pseudonucleotides are useful in the synthesis of oligomers which contain these components as a means to derivatize the resulting oligonucleotide. In general, these pseudonucleotide components are of formula (1), whe...
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WO/1991/011512A1 |
An antibody molecule or molecule containing antibody combining site portions (catalytic molecule) that catalytically hydrolyzes a preselected carboxylic acid amide or ester bond of a reactant ligand, methods of making and using the catal...
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WO/1991/010665A1 |
This invention relates to a method of producing carboxetanocin G represented by formula (II), or carboxetanocin A represented by formula (9), each expected as an antiviral agent, and cyclobutane derivatives as the intermediates therefor ...
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WO/1991/010430A1 |
There are provided novel esters of 2-arylmethyl-1-naphthol derivatives useful as anti-inflammatory agents. Also provided are pharmaceutical compositions containing these compounds and methods of using the compounds to treat inflammatory ...
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WO/1991/009594A1 |
The invention relates to methods for the treatment of schizophrenia or other psychoses by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment....
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WO/1991/003457A1 |
This invention provides multistep process embodiments for the production of novel esters which exhibit nonlinear optical response. A process embodiment is illustrated by the reaction of a Schiff base with a substituted acetic acid to for...
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WO/1991/003512A1 |
Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA2 and preventing oxidation. In particular, each compound has ...
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WO/1991/001295A1 |
In a process for preparing quaternary ammonium compounds with an aminoester function which are used as textile softeners, fatty acids are esterified with alkanolamine. The compounds so obtained are alkylated and can be used as readily bi...
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WO/1991/001301A1 |
The effects of acne and psoriasis are relieved by applying either topically or by oral administration, a compound having structure(I), wherein R�1?, R�2?, R??3?, R�4?, and R�5? are independently selected from the group consisting...
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WO/1990/015056A1 |
Novel compounds are provided of formula (I), or a pharmaceutically acceptable salt, ester or amide thereof, wherein A is O, S, CHR2, CR2 or C when n is 0 and A and R6 taken together form a nitrogen-containing 5-, 6- or 7-membered ring, a...
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WO/1990/014331A1 |
D-propoxyphene can be prepared by reacting d-oxyphene and propionic anhydride. Preferably, an excess of propionic anhydride is used. The reaction easily proceeds at temperatures of 70 to 80°C and produces yields exceeding 95 percent of ...
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WO/1990/012788A2 |
Acetalically protected, enantiomer-pure $g(a)-arylalkane carboxylic acids of general formula (I), in which A, B, C, and D denote hydrogen or a methyl group in any combination, m and n denote the numbers 0, 1 or 2, where the sum of m and ...
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WO/1990/010628A1 |
Novel aryloxy alkyl amine derivatives of the general formula (I), in which A is a benzole or thiophene ring; R and R¿1? are, mutually independently, hydrogen, alkyl, halogen CF¿3? or alkoxy; R¿2? is alkyl, cycloalkyl, alkenyl, alkinyl...
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WO/1990/008130A1 |
The compounds of formula (I), wherein R1 is a C18-24 alkenyl containing at least two double bonds, X is O, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is metal, and R2 is a side chain of a natural amino acid at alpha-positi...
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WO/1990/004918A2 |
Quaternary amine-containing ether lipid analogs of the formula R1-X-R2-N+(R3)(R4)(R5) Z- are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to ...
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WO/1989/012070A1 |
Salts of glycosaminoglycans (heparin, its fractions or fragments ''supersulfatated'', dermatan sulfate, heparan sulfate, modifed heparins) with cations of formula (I), wherein R1, R2, R3 and R4 represent for instance H, alkyl, cycloalkyl...
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WO/1989/009765A1 |
This invention relates to novel compositions of matter and their methods of preparation, which compositions are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters....
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WO/1989/009204A1 |
Quaternary ammonium compounds with a possibly long-chained carboxylate or sulfonate or sulphate anion, process for preparing these compounds and for their use as fabric softeners. Said quaternary ammonium compounds contain only one or tw...
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WO/1989/007589A1 |
Process for preparing aqueous solutions of unsaturated quaternary ammonium salts according to the formula H2C=CH-C(O)-A-R3-N+(R1)(R2)(R), X-, in which A is an oxygen atom or an NH group, R3 is a linear or branched alkyl radical, with 1 t...
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WO/1989/007588A1 |
Process for preparing aqueous solutions of unsaturated quaternary ammonium salts in accordance with formula H2C=C(R3)-C(O)-A-R4-N+(R1)(R2)(R), X- from at least one (meth)acrylic monomer (II) having the formula H2C=C(R3)-C(O)-A-R4-N(R1)(R...
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WO/1989/007099A1 |
Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor (''PAF''). Also disclosed are methods of synthesizing and usin...
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WO/1988/007582A1 |
This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel meth...
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WO/1988/006580A1 |
Aryl-substituted tert.-alkylenamines, have the formula (I), where R is an alkyl group with 1-6 C-atoms, or the total residue (a) represents the heterocyclic residues (b), (c), (d), (e), or (f), where R5 is hydrogen, methyl, phenyl, 4-chl...
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WO/1988/006152A1 |
A process for preparing unsaturated quaternary ammonium salts, which comprises treating a cationic vinyl monomer represented by general formula (1) with an alkyl or aralkyl halide to prepare an unsaturated quaternary ammonium salt repres...
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WO/1987/005603A1 |
A compound having formula (I), wherein R1 is the esterification residue of an alcohol (R1-OH) having from 1 to 8 carbon atoms; R2 is a substituted or unsubstituted aryl, cycloalkyl or alkyl group having from 1 to 8 carbon atoms; R3 is H ...
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WO/1987/004153A1 |
2,3-Dihydro-1H-phenalene-2-amino compounds of formula (I), some of which are new, e.g., 2,3-dihydro-2-(N,N-di-n-propylamino)-1H-phenalen-5-ol, and pharmaceutically acceptable salts of such compounds have been found to be useful anti-psyc...
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WO/1986/002637A1 |
Benzoic acid derivatives represented by general formula (I), (wherein R1 and R2 may be the same or different and each represents hydrogen or lower alkyl or, when taken together with the adjacent nitrogen atom, R1 and R2 form a 5- or 6-me...
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WO/1986/002636A1 |
Benzoic acid derivatives represented by general formula (I) (wherein R1 represents lower alkyl, R2 represents optionally protected carboxy, and X represents halogen) or salts thereof, particularly those wherein R2 represents a carboxy gr...
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