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Matches 1 - 50 out of 2,899

Document Document Title
WO/2018/177383A1
The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a...  
WO/2018/178693A1
A quaternary ammonium salt of formula (I): wherein X is a linking group; Y is O, NH or NR1 wherein R1 is H or an optionally substituted hydrocarbyl group; Q+ is a moiety that includes a quaternary ammonium cation; A- is an anion; R2 is a...  
WO/2018/168205A1
Provided are: a polymerizable compound represented by formula (1), which has adequate polymerizability, a high voltage holding ratio, and high solubility in liquid-crystal compositions; a polymerizable composition comprising the compound...  
WO/2018/150906A1
This liquid crystal display device 10 is provided with: a pair of substrates which have conductive films 14, 15, respectively; a liquid crystal layer 12 which is arranged between the pair of substrates and contains liquid crystals; and a...  
WO/2018/143923A1
The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.  
WO/2018/104677A1
The subject of the invention is a process for continuously producing a (meth)acrylic ester by transesterification reaction between a light C1-C4 alkyl (meth)acrylate and a heavy alcohol in the presence of a catalyst, characterized in tha...  
WO/2018/087753A1
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their int...  
WO/2018/087064A1
The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained...  
WO/2018/084579A1
The present invention relates to a modifier represented by chemical formula 1, a method for preparing same, a high- modification rate modified conjugated diene-based polymer comprising a functional group derived from the modifier, and a ...  
WO/2018/084625A1
The present invention relates to a novel method for preparing (S)-N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride.  
WO/2018/078053A1
The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formu...  
WO/2017/183835A1
The present invention relates to a method for preparing a D-4,4'-biphenylalanine alkyl ester or an L-4,4'-biphenylalanine alkyl ester by optically splitting a DL-4,4'-biphenylalanine alkyl ester using a chiral diaroyl tartaric acid as an...  
WO/2017/181118A1
The present invention provides methods for producing cannabinoid prodrugs. Also described are pharmaceutically acceptable compositions of the prodrugs and a system for the large-scale production of the prodrugs.  
WO/2017/176974A1
The present disclosure relates to a series of biodegradable amino-ester lipid-like nanoparticles. In some embodiments, the biodegradable amino-ester lipid-like nanoparticles are used in methods for the delivery of nucleic acids.  
WO/2017/164363A1
The present invention provides a liquid softener composition, which is capable of controlling generation of a sulfur-like odor while continuously realizing the fragrance intended in design and which has excellent storage stability at a l...  
WO/2017/141911A1
The present invention relates to (2E)-N-[2-(dimethylamino)ethyl]-2-hexadecenamide, 2-(diethylamino)ethyl (2E)-2-hexadecenoate, or pharmaceutically acceptable salts thereof. In addition to activating signal transmission via the MAP kinase...  
WO/2017/142028A1
A metal-supported macromolecule and a use thereof as a catalyst, said metal-supported macromolecule being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is bond...  
WO/2017/136976A1
The present invention discloses an ionic liquid having a methanofullerene carboxylate as an anion, and a preparation method thereof. The ionic liquid is comprised of the methanofullerene carboxylate anion and a quaternary ammonium cation...  
WO/2017/122730A1
[Problem] To provide a novel diamine that produces a film having excellent flexibility and transparency and also having low retardation characteristics. [Solution] Disclosed are: a diamine characterized by being represented by formula (1...  
WO/2017/117528A1
Compounds are provided having the following structure (I) or (II): or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, L, X, L, G1, G2, Z, a1, a2 and n are independently as defined herein for each ...  
WO/2017/106138A1
Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infecti...  
WO/2017/075531A1
Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of l...  
WO/2017/041139A1
The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.  
WO/2017/033128A1
The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.  
WO/2017/033611A1
[Problem] The present invention addresses the problem of producing a polyfunctional (meth)acrylate with high yield by carrying out a transesterification reaction between a specific monofunctional (meth)acrylate and a polyhydric alcohol. ...  
WO/2017/023067A3
The present invention relates to a fluorene derivative, and a photopolymerization initiator and a photoresist composition containing the same. The fluorene derivative according to the present invention has an advantage of being capable o...  
WO/2017/023067A2
The present invention relates to a fluorene derivative, and a photopolymerization initiator and a photoresist composition containing the same. The fluorene derivative according to the present invention has an advantage of being capable o...  
WO/2016/176330A1
The present invention relates to compositions and methods for inducing adaptive immune response in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule enc...  
WO/2016/161826A1
The present invention relates to a method for preparing 4-isopropylamino-1-butanol. By using cheap and easily available tetrahydrofuran and acetic acid solution of hydrogen bromide as initial raw materials, a novel intermediate compound ...  
WO/2016/155468A1
Disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteris...  
WO/2016/148444A1
The present invention relates to a novel desfesoterodine derivative or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a novel desfesoterodine derivative or a pharmaceutically acceptable sa...  
WO/2016/124837A1
The invention relates to a method for producing a (meth)acrylic ester with improved productivity, by transesterification of a light alkyl (meth)acrylate with a heavy alcohol. The method of the invention includes the recycling of noble pr...  
WO/2016/125623A1
Provided is a method for producing 2-aminoethylmethacrylate hydrochloride that, according to one embodiment, includes a step (A) for reacting a ketimine compound of 2-aminoethylmethacrylate with water and hydrogen chloride and obtaining ...  
WO/2016/125257A1
A fluorine-containing ether monocarboxylic acid aminoalkyl ester represented by the general formula CnF2n+1O[CF(CF3)CF2O]aCF(CF3)COO(CH2)bNR1R2 (here, R1 is a hydrogen atom or C1 to C12 alkyl group, aryl group or aralkyl group, preferabl...  
WO/2016/121370A1
[Problem] To provide a feature capable of limiting reduction in the water absorbency of fiber products while conferring softness. [Solution] The present invention relates to one kind of compound represented by general formula (1) or a mi...  
WO/2016/114312A1
The purpose of the present invention is to provide a simple and efficient method for treating a tin compound in a reaction mixture. Provided is a method for carrying out a reaction, using stannous chloride, on a compound A as a raw mater...  
WO/2016/114308A1
Provided is a novel method for producing an aromatic amine compound by reducing an aromatic nitro compound starting material using stannous chloride, the method whereby an Sn compound included in the reaction liquid is easily and efficie...  
WO/2016/093205A1
Provided is an industrial method for producing a cationic lipid with which it is possible to efficiently obtain a high-purity cationic lipid without requiring special equipment. A cationic lipid represented by formula (1) and a tetraalky...  
WO/2016/060564A8
The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at ...  
WO/2016/060564A1
The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at ...  
WO/2016/052953A1
The present specification relates to a (meth)acrylate compound, and a copolymer and a homopolymer comprising a repeating unit derived from the compound.  
WO/2016/044951A1
The invention relates to compositions and methods useful for enhancing hair growth and promoting skin regeneration. Particularly, the invention provides topical compositions including trimebutine, salts, or active metabolites thereof, fo...  
WO/2016/041508A1
Provided is a method for preparing an oxazolidinone compound and an intermediate thereof. Specifically, two segments are coupled to prepare the oxazolidinone compound by the Suzuki reaction. The method has a simple process, a short react...  
WO/2016/037053A1
This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic l...  
WO/2016/028959A1
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V) and/or a salt thereof, wherein R1 is OH or OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as ...  
WO/2016/028910A1
A link between ApoE4 allele and sirtuins expression level is identified that is believed to be associated with elevated risk for the promotion of processing of amyloid precursor protein (APP) by the non-amyloidogenic pathway in a mammal ...  
WO/2016/020406A1
The present invention relates to a process for the preparation of a compound of formula (Ila') and (II) Further, the present invention relates to a compound of formula (Ila') and to a compound of formula (II) as well as all intermediates...  
WO/2016/020405A1
The present invention relates to a process for the preparation of a compound of formula (A), Further, the present invention relates to the respective compound (A) as such and to its use in the preparation of antifungal agent.  
WO/2016/019121A2
Amines and amine derivatives that improve the buffering range, and / or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form...  
WO/2016/019121A3
Amines and amine derivatives that improve the buffering range, and / or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form...  

Matches 1 - 50 out of 2,899