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WO/2002/008197A1 |
The invention relates to novel biphenyl carboxamides of formula (I), wherein A, R, Z, X, Y, m and n have the meanings given in the description, to multiple methods for producing these substances, to their use for combating unwanted micro...
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WO/2001/049651A2 |
The invention relates to aminomethyl-phenyl-cyclohexanone derivatives, to methods for the production thereof, to the use of aminomethyl-phenyl-cyclohexanone derivatives for producing medicaments, and to medicaments containing aminomethyl...
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WO/2001/044190A1 |
Use of compound of Formula (I): at least one of R?1¿, R?2¿, R?5¿ and R?6¿ is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R?7¿)¿n?X-Y wherein R?7¿ is ...
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WO/2001/034557A1 |
A process for the production of optically active cyclic enaminone derivatives, characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to thereby obtain an optical isomer mixture ...
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WO/2001/014313A1 |
A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonit...
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WO/2001/010816A2 |
The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.
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WO/2001/005743A1 |
The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.
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WO/2001/004247A1 |
There is provided a process for producing particles of amine reaction product by means of a carrier having a melting point of less than 30 °C, optionally followed by a coating step. Processed amine reaction products and finished composi...
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WO/2001/004248A1 |
There is provided a process for producing particles of amine reaction product by means of an acid carrier. Processed amine reaction products and finished compositions incorporating such processed product are also herein provided.
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WO/2000/066541A1 |
Intermediates for the preparation of phenylalkanoic acid amides having excellent germicidal effects; a process for the preparation of the intermediates; and a process for preparing starting compounds for the preparation of the intermedia...
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WO/2000/059875A2 |
Derivatives of aryl and heterocyclic ureido and aryl and heterocyclic carboxamido phenoxy isobutyric acids have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproduc...
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WO/2000/055113A1 |
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...
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WO/2000/053571A1 |
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...
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WO/2000/050381A1 |
The invention concerns a method for preparing 2-aminobenzophenone derivatives as well as the process intermediates, namely 2-nitrobenzophenone derivatives. The invention first concerns a method for preparing a 2-nitrobenzophenone derivat...
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WO2000002887B1 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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WO/2000/044706A1 |
A process which comprises converting a $g(a)-amino acid ester into the corresponding imine to thereby protect the amino group of the ester, reacting the imine with a halomethyllithium to form an N-protected $g(a)-amino halomethyl ketone,...
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WO/2000/024710A1 |
The compounds of formula (1), wherein R and R¿2? are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the infla...
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WO/2000/018722A2 |
The present invention relates to new derivatives of 6-(4-phenylbutoxy)hexylamine having the general formula (I) wherein R¿1? is CHO, or CHOR¿3?OR¿4?, wherein R¿3? and R¿4? are independently C¿1?-C¿6? alkyl, aralkyl or can form cyc...
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WO/2000/009475A1 |
Amine derivatives represented by general formula (1) or their salts, wherein R?1¿ represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R?3¿ represents C¿1-3? alkyl, hydroxylated C¿1-5? alkyl, C¿1-5? acyl, C¿2-5? alkenyl ...
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WO/2000/005194A1 |
A process for the preparation of the compound AQ4 of formula (3) or a salt or $i(N)-oxide thereof, includes the step (21-9).
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WO/2000/005195A1 |
An arylsulfonamide represented by formula [1] is heated in the presence of aluminum chloride to obtain a 2-aminobenzophenone compound represented by formula [2].
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WO/1999/065866A1 |
A compound is provided having formula (I) wherein: R?1¿ and R?2¿ are independently hydrogen, hydroxy, alkoxy or acyloxy; R?3¿ and R?4¿ are independently oxo, hydroxy or hydrogen; one of R?5¿ or R?6¿ is A-B and the other is hydrogen...
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WO/1999/050223A2 |
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible $g(a)-unsaturated $g(a)-hydr...
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WO/1999/047474A1 |
This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the $g(m)-halo(triisopropylp...
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WO/1999/026928A1 |
Disclosed in a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by structural formula (II) and a starting material represented by structural formula (III). Phenyl Ring A, Phenyl R...
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WO/1999/021823A1 |
Intermediates having formulas (A) and (B) wherein B?I¿ is -CH¿2?OH or -CH¿2?OR?P¿, and R?P¿ is an alcohol protecting group; a is 1, 2, or 3; T?I¿ is -OH or (C); Q?I¿ is phenyl, naphthyl or heteroaryl having 1-3 substituents; R?a¿...
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WO/1999/007666A1 |
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...
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WO/1999/006351A1 |
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined above (A).
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WO/1999/001418A1 |
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...
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WO/1998/054122A1 |
The present invention discloses a process for the preparation of a substantially pure compound having formula (4). The process comprises the step of reacting an enolate having formula (A) with a Grignard reagent. The enolate salt is form...
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WO/1998/045278A1 |
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy
dro-2H-3,1-benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HI...
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WO/1998/043942A1 |
The invention relates to novel compounds of Formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7� and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in ...
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WO/1998/040331A1 |
A process for the preparation of indanones of formula (II) from indanones of formula (I) or of indanones of formula (IIa) from indanones of formula (Ia) comprises reacting an indanone of formula (I) or (Ia) with a coupling component.
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WO/1998/038195A1 |
This invention relates to $g(a)-ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a pro...
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WO/1998/032724A1 |
Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R�1? and R�2? each represen...
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WO/1998/013331A1 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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WO/1998/002413A1 |
The compounds of formula (I) wherein R�1?, R�2?, R�3? and A are as defined herein are useful, via potassium channel modulation, in the treatment of disorders associated with smooth muscle contraction. Such disorders include, but ar...
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WO/1997/043244A1 |
The invention relates to an improved process for the separation of racemic 2-)o-chlorophenyl)-2-methyl aminocyclohexanone (ketamine).
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WO/1997/020805A1 |
Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in fo...
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WO/1997/020806A1 |
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity as described, wherein in formul...
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WO/1997/020802A1 |
Indame dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity are described.
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WO/1997/019681A1 |
The invention concerns perfluoro-lower-alkyl derivatives of amino acids. A new synthetic route is provided for preparing 'alpha'-aminotrifluoromethylketones, by converting 'alpha'-amino acids to oxazolidin-5-ones which are then reacted w...
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WO/1997/018190A1 |
N-Protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates of formula ...
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WO/1996/022275A1 |
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a c...
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WO/1996/021355A1 |
Pesticidal compounds having general formula (I) or a salt thereof is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R independently represents a halogen atom or a nitro, cyano, hydroxyl, alky...
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WO/1996/021354A1 |
Pesticidal as a pesticide against whitefly, Lepidoptera and certain fungi is provided of compound of general formula (I) or a salt thereof is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R ...
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WO/1996/011894A1 |
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two substances, one of them a liquid in which the racemic mixture to be separated is present, the other containing a chir...
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WO/1996/005161A1 |
A process is disclosed for preparing aromatic aldehydes having the general formula (I), in which R1, R2, R3, R4 and R5 stand for hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, aryl, hydroxy, C1-C4 alkoxy, phenoxy, C7-C12 alkylphenyl, C7-C12 ph...
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WO/1995/014653A1 |
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide of cyanohydrin from a...
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WO/1994/011336A1 |
An improved process for the preparation of highly diastereomerically enriched substituted 1,2,3-aminodiols is described which involves reaction of an amino aldehyde to afford a cyanohydrin and subsequent construction in a stereochemicall...
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