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JP5042422B2 |
Substituted 2-dialkylaminoalkylbiphenyl derivatives, processes for their preparation, pharmaceutical compositions comprising these compounds and methods using these compounds for the preparation of medicaments and for the treatment of di...
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JP5035813B2 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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JP5036298B2 |
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JP5014332B2 |
Nons-teroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds o...
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JP4998889B2 |
To provide a cost-effective and highly-active catalyst for nitro group reduction. The catalyst for nitro group reduction includes: rhodium nanoparticles obtained by reducing amide amine dendrimer-rhodium complex with chain formation of a...
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JP2012517445A |
Disclosed herein are methods of making compounds which are agonists or antagonists of one or more of the individual receptors of the S1P receptor family.
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JP4915696B2 |
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JP4900681B2 |
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JP4889909B2 |
The present invention relates to a process for the preparation of alpha' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylal...
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JP4878189B2 |
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JP4874659B2 |
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JP4829152B2 |
To provide a production method of a new synthetic method of febrifugine (3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazoli
none) and isofebrifugine having very strong activity against tropical malaria parasite by total synthesi...
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JP4825395B2 |
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JP4812913B2 |
A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling compon...
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JP4805967B2 |
The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently C...
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JP4799756B2 |
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JP4795738B2 |
A method for bisformylation an arylamine compound by reacting an arylamine compound with an alkyleneamine in a reaction mixture while refluxing an acid in the reaction mixture.
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JP4793976B2 |
The present invention relates to a production method of optically active hydrazine compound (IV), which includes reacting azo compound (II) with compound (III) in the presence of optically active compound (I). The present invention also ...
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JP4761769B2 |
A process for easily producing an optically active beta -amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available alpha -substituted ketone is reacted...
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JP4744708B2 |
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JP4741199B2 |
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JP4719483B2 |
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JP4706325B2 |
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JP4706320B2 |
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JP2011515441T |
Formula (I) :The inside of [type and A are the following rings:Application as 1, the 4-naphth quinone derivatives, those manufacturing processes, and antimalarial agent of] か chosen.
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JP4663629B2 |
An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (...
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JP4593275B2 |
The invention relates to monoalkylaminoketones of the formula (I), in which R1 and R2 have the meanings indicated.
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JP2010254593A |
To provide a method for safely producing a 2-aminotropone derivative useful as a photobase-generating agent or the like in an industrial scale at a low cost.The method for producing the 2-aminotropone derivative represented by formula (2...
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JP4570740B2 |
Production of arylaminohydroxyanthraquinones (I) by reacting corresponding chlorohydroxyanthraquinones (II) with an amine (III). In the production of arylaminohydroxyanthraquinones of formula (I) by reacting corresponding chlorohydroxyan...
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JP4546242B2 |
and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.
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JP4535342B2 |
The object of the present invention are (3,5-diaminophenyl)(2,4-dihydroxyphenyl)methanone and the acid adducts thereof of formula (I), with 0<=n>=2 and HX denoting an inor-ganic or organic acid, the colorant containing these compounds an...
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JP4525951B2 |
To obtain a solid-phase particle, capable of producing a carboxylic acid, ketone or oxazole derivative with increased carbon content, and useful for solid-phase synthesis or the like. This solid-phase particle has a group shown by the fo...
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JP2010143857A |
To provide a method for purifying carnitine by reducing impurities produced by side reactions, and to provide highly pure carnitine having reduced impurities. The highly pure carnitine can be produced by adding an alcohol solvent to a ca...
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JP4491104B2 |
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JP4490543B2 |
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JP4488162B2 |
Reaction of 1,4-dihydroxyanthraquinone with an aliphatic or aromatic amine to give an N,N/-disubstituted 1,4-diaminoanthraquinone is effected in presence of 2 different solvents, one of which is a dipolar, aprotic solvent with a solubili...
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JP2010520903A |
The substituted phenylamidine has general formula (I). The compound having general formula (I), is new. (I) Y : O, NH or a single bond; R 1> : H, linear or branched 1-12C alkyl, 2-12C alkenyl, 2-12C alkinyl, cyclic 3-8C alkyl, 4-8C alken...
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JP4482783B2 |
An amino group of an alpha -amino acid ester is protected as an imine, and it is then reacted with a halomethyllithium to obtain an N-protected- alpha -aminohalomethylketone. Further, this N-protected- alpha -aminohalomethylketone is tre...
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JP2010111672A |
To provide a new vaporization source of a metal precursor used for chemical vapor deposition (CVD) of group 2 alkaline earth metal-containing oxide films and the like.A group 2 metal-containing polydentate -ketoiminate precursor prepared...
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JP2010508334A |
A compound of the general formula (I) as an active principle for treating cancer, specifically tumors, in particular diseases involving inhibition of metalloproteases, such as Aminopeptidase-N. Pharmaceutical compositions comprising the ...
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JP2009538841A |
The present invention relates to compounds according to formula (1) and/or according to formulae (4) to (10) and their use in organic electroluminescent devices, in particular as a matrix material in phosphorescent devices.
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JP4318753B2 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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JP2009172474A |
To provide a Diels Alder reaction catalyst which contains an -(N-acylamino) acrolein or an -(N,N-diacyl amino) acrolein as a dienophile and is best-suited for an asymmetric Diels Alder reaction.An -phthalimide acrolein (0.25 mmol) is add...
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JP2009137955A |
To provide an improved production method of o-aminophenyl ketones of a key intermediate for producing herbicides.A production method of o-aminophenyl ketones of formula I [wherein, R is a 3-6C alkyl group or a 1-6C haloalkyl group] is pr...
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JP4270524B2 |
There is provided an improved method for the production of o-aminophenyl ketones of formula I wherein R is C3-C6cycloalkyl or C1-C6haloalkyl. There is also provided an effective method for the preparation of the formula I compound o-amin...
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JP2009513596A |
Disclosed is a process for dyeing of keratin-containing fibers comprising treating the fibers with at least one functionalized particle comprising on the surface an organic chromophore which is bound via a bridge member, wherein the part...
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JP4232337B2 |
A 2-aminobenzophenone represented by formula (2) is obtained by heating an arylsulfonamide represented by formula (1) in the presence of aluminum chloride.
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JP4232911B2 |
Process for asymmetric synthesis of benzoxazinone derivatives of formula (VI), comprises: (a) reacting (I) with (VII) or (VIII) in the presence of an acid catalyst to give (II) which is reacted with a mixture of (IX), alkyl lithium and c...
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JP2009502820A |
Compounds of the formula I, in which R, X, R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
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JP4208174B2 |
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