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WO/2024/079043A1 |
The invention relates to a method of manufacturing a peptide P, which comprises a step of condensing of an alpha amino acid derivative S-am, which has one unprotected alpha amino group or one unprotected alpha imino group, with a protect...
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WO/2024/050715A1 |
Provided in the present application are amide compounds having amino groups on both ends, having general formula (I), in which A and B are independently selected from substituted or unsubstituted C1-C18 alkylene groups, C2-C18 alkenylene...
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WO/2024/041460A1 |
The present invention provides compounds of Formula (I) : wherein all of the variables are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for the...
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WO/2024/038436A1 |
The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-l,4-dihydro-2H-benzo[d][l,3]oxazine-6-car
bonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenz...
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WO/2024/034767A1 |
The present invention relates to a method for producing a chiral nitroso derivative using an organic chiral catalyst compound based on (R,R)-1,2-diphenylethylenediamine (DPEN), and the like. According to the production method, a chiral n...
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WO/2024/000920A1 |
Disclosed in the present invention is a method for preparing a β-trifluoromethylenamine compound on the basis of organic dye catalysis. The present invention belongs to the technical fields of the synthesis of medicines, pesticide produ...
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WO/2023/247968A2 |
The present disclosure relates to modified amino acids which have been modified to modulate their physicochemical properties. The present disclosure further relates to the use of such modified amino acids to provide peptides, in particul...
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WO/2023/165575A1 |
The present invention relates to a new aminoketone compound, and a preparation method therefor and the use thereof. Specifically, the compound of the present invention has a structure as shown in formula (I), wherein the definition of ea...
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WO/2023/153494A1 |
The present invention addresses the problem of providing a new catalyst for selectively generating formamides from urea-based compounds and urethane-based compounds. The present invention pertains to: a complex having a partial structure...
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WO/2023/151157A1 |
A chemical intermediate and a preparation method, belonging to the technical field of dye intermediate synthesis. The chemical intermediate provides a new way for preparing anthraquinone dyes and dye intermediates. The preparation method...
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WO/2023/149559A1 |
[Problem] The present invention provides a catalyst for hydrogenation reactions, the catalyst having excellent catalyst durability and being capable of selectively hydrogenating only some functional groups and/or unsaturated bonds of an ...
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WO/2023/125001A1 |
A cyclic 1,3-diketonediimine compound, and a synthesis method therefor and the use thereof. The cyclic 1,3-diketonediimine compound has a structure as shown in the following general formulas I, II or III, wherein R1-R8 are each independe...
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WO/2023/118482A1 |
The present invention relates to amine synergists comprising the structure element of a substituted 1,3-propanedione and their use in radiation or energy curing by actinic light. The amine synergists of the present invention are particul...
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WO/2023/116940A1 |
The present invention relates to a simple method for modifying a precursor of a β-ketoimine ligand, comprising: reacting an LPhH2 solution with a lithium compound; then adding halogenated hydrocarbon for a C-C bond coupling reaction; an...
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WO/2023/024532A1 |
Disclosed in the present invention is a one-step method for preparing a C-N coupling product using nitroaromatic hydrocarbon and alkyl or phenylboronic acid. The method comprises: adding nitroaromatic hydrocarbon, alkyl or phenylboronic ...
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WO/2023/013974A1 |
The present invention relates to a method for producing novel rucaparib which can achieve an excellent synthesis yield and reproducibility. More particularly, the present invention relates to: a novel production method for synthesizing r...
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WO/2022/193601A1 |
The present invention relates to an aggregation-induced luminescent compound, and a supramolecular polymerized fluorescent nano-material and a preparation method therefor. The preparation method for the supramolecular polymerized fluores...
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WO/2022/092260A1 |
The present invention addresses the problem of providing a cross-coupling reaction method that can use a wide variety of compounds as starting materials, that can substantially not use organic solvent, and that can rapidly provide reacti...
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WO/2022/090762A1 |
The present invention concerns dispiroindenopyridines and dispiroindenopyridazines and derivatives thereof, methods for their preparation, the study and definition of their properties, and their uses. In particular, the present invention...
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WO/2022/089598A1 |
A flavonoid glycoside and organic amine neuroagonist double salt compound, a preparation method therefor, and an application thereof, a pharmaceutical composition containing a therapeutically effective amount of the double salt compound ...
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WO/2022/061920A1 |
A method for preparing 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises subjecting 3'-chloro-2,2,2-trifluoroacetophenone as a raw material to four steps, i.e. nitrification, reduction, chlorination and deamination, so as ...
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WO/2022/061914A1 |
The present application relates to the technical field of chemical pharmacy, and in particular, to a method for preparing 3,5-dihalotrifluoroacetophenone and a derivative thereof. 3-halogen-4-nitrotrifluoroacetophenone is used as a raw m...
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WO/2022/058916A1 |
The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthra...
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WO/2022/026225A1 |
The present invention is a method of making 1,4,5,8-tetrakis(R-phenylamino)anthracene-9,10-dione (where R is H or a hydrocarbyl group) comprising the step of contacting 1,4,5,8-tetrachloroanthraquinone with a mixture of R-anilines compri...
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WO/2021/240331A1 |
The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner using 3,5-d...
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WO/2021/234697A1 |
The present invention pertains to compositions and methods for treating inflammation in a subject in need thereof using hydroxynorketamine (HNK), a salt thereof, a stereoisomer thereof, or a combination thereof.
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WO/2021/233805A1 |
The present invention relates to a process for purifying 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester providing a high purity and low phthalic acid dialkyl ester content.
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WO/2021/208951A1 |
Disclosed is a β-diketone cerium (IV) compound of formula (I). The compound has a wide absorption band, is suitable for near ultraviolet-visible region curing as a photoinitiator, and has a high sensitiveness, while also having the adva...
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WO/2021/071033A9 |
The present invention relates to a method for preparing diethylamino hydroxybenzoyl hexyl benzoate and, specifically, to: a method for preparing diethylamino hydroxybenzoyl hexyl benzoate, which has a simple preparation process and can b...
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WO/2021/189528A1 |
Disclosed are a thermally activated delayed fluorescent material and a synthesis method therefor, and an electroluminescent device. The thermally activated delayed fluorescent material is a target compound synthesized by reaction of an e...
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WO/2021/138443A1 |
Methods and compositions for modifying the course and severity of neuropsychiatric disorders. The method includes administering a composition to a subject suffering from a neuropsychiatric disorder, wherein the composition includes a sub...
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WO/2020/251015A1 |
Provided is a method for producing a substance related to 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione that is suitable for industrial production. The present disclosure provides: a method for producing two production intermediates for 2...
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WO/2020/237748A1 |
Provided in the present application is a method for preparing a compound having a long-acting therapeutic effect. The compound may be used to prepare antidepressant, anesthetic and analgesic drugs, as well as drugs for cognitive function...
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WO/2020/215388A1 |
Provided are a deep red light thermally activated delayed fluorescence material, a preparation method therefor, and an electroluminescent device. The deep red light thermally activated delayed fluorescence (TADF) material comprises a com...
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WO/2020/212510A1 |
The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymme...
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WO/2020/212157A1 |
The invention concerns a new, efficient process for the preparation of enantiomerically pure norepinephrine (also known as noradrenaline), or an addition salt thereof, using a catalytic hydrogenation system under hydrogen donor transfer....
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WO/2020/212890A1 |
Disclosed herein is a method for synthesizing levomethadone hydrochloride including producing (R)-2-(dimethylamino)propan-1-ol by reducing Ν,Ν-dimethyl-D-alanine using borax, forming (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochlori...
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WO/2020/187155A1 |
Use of an apocynin dimer analogue derivative in preparing a medicament or a health care product for preventing and treating Parkinson's disease. The structure of the apocynin dimer analogue derivative is as shown in formula I. The apocyn...
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WO/2020/171400A1 |
The present invention pertains to: a water-soluble naphthoquinone derivative composition and a method for producing same; a water-soluble composition for controlling harmful algae; a method for controlling large-scale harmful algae; and ...
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WO/2020/037372A1 |
A method of detecting the presence of an NBOMe in a sample which comprises of contacting the sample with an activated p-quinone such as 2,3,5,6-tetrachloro-1,4-benzoquinone (TCBQ) and an aldehyde, for example acetaldehyde, and optionally...
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WO/2020/002338A1 |
A process for the continuous production of a reaction product of a diazo‐compound and a substrate in a multi‐stage flow reactor is disclosed.
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WO/2019/243369A1 |
The present invention relates to compounds of formula (I) that are able to generate oct-2-en-4-one and thus to provide a long-lasting or substantive strawberry odor to the environment. Moreover, the present invention relates to a method ...
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WO/2019/236557A1 |
A process for the preparation of (2R,6R)-hydroxynorketamine is provided. The process requires no chromatography purification and affords the (2R,6R)-hydroxynorketamine in eight steps with a 26% overall yield and greater than 97% purity.
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WO/2019/223015A1 |
Disclosed are a precursor for a blue anthraquinone active disperse dye and a preparation method therefor. A parent body structure of the precursor is of an anthraquinone structure, has an amino capable of being reacted with an active gro...
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WO/2019/223016A1 |
Provided are a blue anthraquinone active disperse dye suitable for use in a supercritical CO2 fluid dyeing process and a preparation method therefor. A parent structure of the active disperse dye is of an anthraquinone structure, and als...
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WO/2019/219942A1 |
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...
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WO/2019/199518A1 |
Processes are disclosed for synthesizing an α-amino acid or α-amino acid derivative, from a starting compound having a carbonyl functional group (C=O), with hydroxy-substituted carbon atoms at alpha (α) and beta (β) positions, relati...
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WO/2019/122204A1 |
Disclosed are processes for the manufacture of pyrazole compounds of formula (I) and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically activ...
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WO/2019/047846A1 |
Derivatives of hypocrellin with peri-position and 2-position simultaneously substituted by amino groups and a preparation method and application thereof are disclosed. The structural formula of the derivatives is as shown in the formulae...
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WO/2019/035775A1 |
A method for the preparation of tapentadol in the form of a base or its hydrogen chloride, which involves the preparation of a salt (III) from a mixture of diastereomers (II) by means of crystallization-induced asymmetric transformation ...
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