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Matches 451 - 500 out of 3,275

Document Document Title
WO/2001/044190A1
Use of compound of Formula (I): at least one of R?1¿, R?2¿, R?5¿ and R?6¿ is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R?7¿)¿n?X-Y wherein R?7¿ is ...  
WO/2001/042243A2
Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or ...  
WO/2001/042189A1
A compound of general formula (I), wherein R¿1? represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C¿1?-C¿3?)alkyl, (C¿2?-C¿3?)olefinic group, (C¿1?-C¿3?)alkoxy, (C...  
WO/2001/040188A1
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF¿3?; Z is H, OH, OR¿1?, halogen, or CF¿3?; X¿1? and X¿2? are independently C or N; and A is as defined in the application; exhibiting anti-tum...  
WO/2001/034557A1
A process for the production of optically active cyclic enaminone derivatives, characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to thereby obtain an optical isomer mixture ...  
WO/2001/030865A1
Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones.  
WO/2001/028977A1
Parkinson's disease is treated with a compound of Formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2001/014313A1
A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonit...  
WO/2001/010816A2
The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.  
WO/2001/008685A1
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present inve...  
WO/2001/005744A1
The present invention relates to compounds of formula (I) wherein R¿1? represents one or more, similar or different substituents; R¿2? represents hydrogen, hydroxy, halogen, alkyl, alkoxy, alkylthio, or cyano; R¿3? represents on...  
WO/2001/005745A1
The present invention relates to compounds of formula (I) wherein R¿1? and R¿2? independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amin...  
WO/2001/005743A1
The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.  
WO/2001/005749A1
The present invention relates to compounds of formula (I) wherein R¿1?, R¿2? and R¿3? independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trif...  
WO/2001/005746A1
The present invention relates to a compound of general formula (I) wherein R¿1?, R¿2?, and R¿3? represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, ...  
WO/2001/004247A1
There is provided a process for producing particles of amine reaction product by means of a carrier having a melting point of less than 30 °C, optionally followed by a coating step. Processed amine reaction products and finished composi...  
WO/2001/004248A1
There is provided a process for producing particles of amine reaction product by means of an acid carrier. Processed amine reaction products and finished compositions incorporating such processed product are also herein provided.  
WO/2001/004105A1
The invention concerns novel methods for preparing enantiopure compounds of formula (I) wherein X represents a halogen atom, its additive salts with mineral or organic acids, or its salts with optically active organic acids. The inventio...  
WO/2001/002376A1
The present invention relates to amino-alkyl derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and met...  
WO2000051546A3
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...  
WO/2000/073292A1
The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl st...  
WO/2000/066522A1
The present invention provides non-steroidal compounds of formula (I) which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides p...  
WO/2000/066537A1
The present invention is directed to compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein X is hydrogen, C1, Br, I, NO¿2?, NR?3¿R?4¿ or -L-Ch; Y is hydrogen, -CH¿2?OR?5¿, -CH¿2?NCH¿3?R?1¿, NO¿2?, NR?3¿...  
WO/2000/066541A1
Intermediates for the preparation of phenylalkanoic acid amides having excellent germicidal effects; a process for the preparation of the intermediates; and a process for preparing starting compounds for the preparation of the intermedia...  
WO/2000/063186A1
A new process and intermediates for preparing 1,4-benzodiazepines of formula (I) is disclosed: wherein, R?1¿ is H, OH, Br, I, NR?5¿R?6¿, CO¿2?R?7¿, CF¿3?SO¿3?, C¿1-4?alkoxy, or (4,4'-bipiperidinyl) carbonyl; R?2¿ is alkyl, optio...  
WO/2000/063159A1
A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X = O Z = H, =CHAr, =C(OH)COOEt, =NOR; Y = H, NH¿2?, NH¿3??+¿ X¿1??-¿, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X¿1??-¿ =...  
WO/2000/063339A1
The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G?1¿ and G?2¿ are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damas...  
WO/2000/055113A1
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...  
WO/2000/053571A1
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...  
WO/2000/051546A2
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...  
WO/2000/050381A1
The invention concerns a method for preparing 2-aminobenzophenone derivatives as well as the process intermediates, namely 2-nitrobenzophenone derivatives. The invention first concerns a method for preparing a 2-nitrobenzophenone derivat...  
WO1996012697A9
The present invention features compounds of general formulae a), b), c), able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. P...  
WO2000002887B1
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  
WO/2000/044706A1
A process which comprises converting a $g(a)-amino acid ester into the corresponding imine to thereby protect the amino group of the ester, reacting the imine with a halomethyllithium to form an N-protected $g(a)-amino halomethyl ketone,...  
WO/2000/041993A1
Compounds represented by general formula (I) or salts thereof which cause a morphological change in trabecular cells to thereby lower intraocular pressure. In the formula, R?1¿ represents H, lower alkyl, hydroxy, lower alkoxy or halogen...  
WO/2000/038734A1
The present invention concerns a novel family of anthraquinone alkylating agents, their use in the treatment of cancers, methods of manufacture of medicaments for same, and methods of treatment of cancers.  
WO2000002887A3
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  
WO2000000469A3
Novel alkyl ketone compounds having potent cytotoxic activity are described as antitumor agents and are particularly effective against leukemia and breast tumor cells. The compounds of the invention have formula (I), wherein R1-R4, X and...  
WO/2000/034230A1
4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having Formula (I): wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, A and W are as defined in the specification which compounds relaxes smooth muscles.  
WO/2000/027946A1
An organic EL element comprising an anode, a cathode, and one or more organic compound layers sandwiched therebetween, wherein at least one of the organic compound layers comprises an organic compound represented by chemical formula (1),...  
WO/2000/020378A1
The present invention discloses compounds having formula (1) or a pharmaceutically acceptable salt thereof, wherein X represents (2), Y represents O or S. The meaning of R', R'', R''', R?2¿, R?3¿, R?4¿, R?5¿, and R?6¿ are specified ...  
WO/2000/018390A1
A heat shock protein expression inducer containing as the active ingredient a chalcone derivative; another heat shock protein expression inducer which can be selected by a screening method involving the step of using a cell line which ha...  
WO/2000/018724A1
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...  
WO/2000/018721A1
The invention relates to substituted polycyclic aryl and heteroaryl $i(tertiary)-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions an...  
WO/2000/015183A1
The invention relates to agents for dyeing fibres containing keratin, especially human hair, containing 5-arylpenta-2,4-dienylcarbonyl compounds of formula (I) wherein R?1¿ represents a hydrogen atom or a C¿1?-C¿4?-alkyl group and R?2...  
WO1999043636A3
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred...  
WO/2000/009475A1
Amine derivatives represented by general formula (1) or their salts, wherein R?1¿ represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R?3¿ represents C¿1-3? alkyl, hydroxylated C¿1-5? alkyl, C¿1-5? acyl, C¿2-5? alkenyl ...  
WO/2000/005194A1
A process for the preparation of the compound AQ4 of formula (3) or a salt or $i(N)-oxide thereof, includes the step (21-9).  
WO/2000/005195A1
An arylsulfonamide represented by formula [1] is heated in the presence of aluminum chloride to obtain a 2-aminobenzophenone compound represented by formula [2].  
WO/2000/002887A2
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  

Matches 451 - 500 out of 3,275