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Patent Searching and Data


Matches 451 - 500 out of 3,212

Document Document Title
WO/2000/063186A1
A new process and intermediates for preparing 1,4-benzodiazepines of formula (I) is disclosed: wherein, R?1¿ is H, OH, Br, I, NR?5¿R?6¿, CO¿2?R?7¿, CF¿3?SO¿3?, C¿1-4?alkoxy, or (4,4'-bipiperidinyl) carbonyl; R?2¿ is alkyl, optio...  
WO/2000/063159A1
A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X = O Z = H, =CHAr, =C(OH)COOEt, =NOR; Y = H, NH¿2?, NH¿3??+¿ X¿1??-¿, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X¿1??-¿ =...  
WO/2000/063339A1
The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G?1¿ and G?2¿ are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damas...  
WO/2000/055113A1
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...  
WO/2000/053571A1
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...  
WO/2000/051546A2
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...  
WO/2000/050381A1
The invention concerns a method for preparing 2-aminobenzophenone derivatives as well as the process intermediates, namely 2-nitrobenzophenone derivatives. The invention first concerns a method for preparing a 2-nitrobenzophenone derivat...  
WO1996012697A9
The present invention features compounds of general formulae a), b), c), able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. P...  
WO2000002887B1
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  
WO/2000/044706A1
A process which comprises converting a $g(a)-amino acid ester into the corresponding imine to thereby protect the amino group of the ester, reacting the imine with a halomethyllithium to form an N-protected $g(a)-amino halomethyl ketone,...  
WO/2000/041993A1
Compounds represented by general formula (I) or salts thereof which cause a morphological change in trabecular cells to thereby lower intraocular pressure. In the formula, R?1¿ represents H, lower alkyl, hydroxy, lower alkoxy or halogen...  
WO/2000/038734A1
The present invention concerns a novel family of anthraquinone alkylating agents, their use in the treatment of cancers, methods of manufacture of medicaments for same, and methods of treatment of cancers.  
WO2000002887A3
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  
WO2000000469A3
Novel alkyl ketone compounds having potent cytotoxic activity are described as antitumor agents and are particularly effective against leukemia and breast tumor cells. The compounds of the invention have formula (I), wherein R1-R4, X and...  
WO/2000/034230A1
4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having Formula (I): wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, A and W are as defined in the specification which compounds relaxes smooth muscles.  
WO/2000/027946A1
An organic EL element comprising an anode, a cathode, and one or more organic compound layers sandwiched therebetween, wherein at least one of the organic compound layers comprises an organic compound represented by chemical formula (1),...  
WO/2000/020378A1
The present invention discloses compounds having formula (1) or a pharmaceutically acceptable salt thereof, wherein X represents (2), Y represents O or S. The meaning of R', R'', R''', R?2¿, R?3¿, R?4¿, R?5¿, and R?6¿ are specified ...  
WO/2000/018390A1
A heat shock protein expression inducer containing as the active ingredient a chalcone derivative; another heat shock protein expression inducer which can be selected by a screening method involving the step of using a cell line which ha...  
WO/2000/018724A1
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...  
WO/2000/018721A1
The invention relates to substituted polycyclic aryl and heteroaryl $i(tertiary)-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions an...  
WO/2000/015183A1
The invention relates to agents for dyeing fibres containing keratin, especially human hair, containing 5-arylpenta-2,4-dienylcarbonyl compounds of formula (I) wherein R?1¿ represents a hydrogen atom or a C¿1?-C¿4?-alkyl group and R?2...  
WO1999043636A3
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred...  
WO/2000/009475A1
Amine derivatives represented by general formula (1) or their salts, wherein R?1¿ represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R?3¿ represents C¿1-3? alkyl, hydroxylated C¿1-5? alkyl, C¿1-5? acyl, C¿2-5? alkenyl ...  
WO/2000/005194A1
A process for the preparation of the compound AQ4 of formula (3) or a salt or $i(N)-oxide thereof, includes the step (21-9).  
WO/2000/005195A1
An arylsulfonamide represented by formula [1] is heated in the presence of aluminum chloride to obtain a 2-aminobenzophenone compound represented by formula [2].  
WO/2000/002887A2
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...  
WO1999059527A3
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...  
WO/2000/000469A2
Novel alkyl ketone compounds having potent cytotoxic activity are described as antitumor agents and are particularly effective against leukemia and breast tumor cells. The compounds of the invention have formula (I), wherein R¿1?-R¿4?,...  
WO/1999/065992A1
There is disclosed a compound of formula (I) wherein each of X¿1? and X¿2? are independently NH-A-NR?1¿R?2¿, and wherein A is A C¿2-8? alkylene group and R?1¿ and R?2¿ are independently selected from hydrogen, C¿1-4? alkyl, C¿2-...  
WO/1999/065866A1
A compound is provided having formula (I) wherein: R?1¿ and R?2¿ are independently hydrogen, hydroxy, alkoxy or acyloxy; R?3¿ and R?4¿ are independently oxo, hydroxy or hydrogen; one of R?5¿ or R?6¿ is A-B and the other is hydrogen...  
WO/1999/061410A1
This invention provides compounds of Formula (I) having structure (I) wherein: B and D are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, aryl, heteroaryl, aralkyl of 6-12 carbon atoms,...  
WO/1999/059527A2
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...  
WO1999050223A3
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible alpha -unsaturated alpha -hy...  
WO/1999/053242A1
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be ...  
WO1999026927A3
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders....  
WO/1999/050223A2
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible $g(a)-unsaturated $g(a)-hydr...  
WO/1999/047474A1
This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the $g(m)-halo(triisopropylp...  
WO/1999/043636A2
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred...  
WO/1999/041259A1
A microencapsulated Lewis acid characterized in that the Lewis acid has been supported through coordinate bonds on microcapsules of an organic polymer. The acid is a novel polymer-supported Lewis acid which exceeds the technical limit to...  
WO1999000114A3
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...  
WO/1999/035115A1
A benzyl or benzylidene tetralin or a pharmaceutically acceptable salt of benzyl or benzylidene tetralin represented by general formula (I) in which: a) R?1¿ completes a carbon-carbon double bond with the carbon at position 2, when x is...  
WO/1999/027783A1
Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are als...  
WO/1999/026928A1
Disclosed in a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by structural formula (II) and a starting material represented by structural formula (III). Phenyl Ring A, Phenyl R...  
WO/1999/026927A2
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders....  
WO/1999/025335A1
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apopto...  
WO/1999/021823A1
Intermediates having formulas (A) and (B) wherein B?I¿ is -CH¿2?OH or -CH¿2?OR?P¿, and R?P¿ is an alcohol protecting group; a is 1, 2, or 3; T?I¿ is -OH or (C); Q?I¿ is phenyl, naphthyl or heteroaryl having 1-3 substituents; R?a¿...  
WO/1999/015494A1
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopat...  
WO/1999/011601A1
Iodopropagylamine compounds represented by general formula (1) (wherein R?1¿ and R?2¿ each independently represent a hydrogen atom or a 1-3 C alkyl group, or R?1¿ and R?2¿ combine with each other to form a tetramethylene or pentameth...  
WO/1999/007666A1
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...  
WO/1999/006351A1
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined above (A).  

Matches 451 - 500 out of 3,212