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Matches 501 - 550 out of 3,229

Document Document Title
WO/1999/025335A1
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apopto...  
WO/1999/021823A1
Intermediates having formulas (A) and (B) wherein B?I¿ is -CH¿2?OH or -CH¿2?OR?P¿, and R?P¿ is an alcohol protecting group; a is 1, 2, or 3; T?I¿ is -OH or (C); Q?I¿ is phenyl, naphthyl or heteroaryl having 1-3 substituents; R?a¿...  
WO/1999/015494A1
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopat...  
WO/1999/011601A1
Iodopropagylamine compounds represented by general formula (1) (wherein R?1¿ and R?2¿ each independently represent a hydrogen atom or a 1-3 C alkyl group, or R?1¿ and R?2¿ combine with each other to form a tetramethylene or pentameth...  
WO/1999/007666A1
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...  
WO/1999/006351A1
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined above (A).  
WO/1999/002124A2
The invention provides compositions and methods for the direct dyeing of keratinous fibers, with particular regard to human hair on the head. The compositions of the invention contain novel anthraquinone mixtures in which each of the com...  
WO/1999/001418A1
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...  
WO/1999/000114A2
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...  
WO/1998/058913A1
Disclosed are compounds having general formula (A) wherein Ar représents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, -OMe, NO¿2?, CF¿3?, C¿1-4? lower alky...  
WO/1998/058901A1
3-anilino-2-cycloalkenone derivatives represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these: wherein R¿1? represents optionally substituted C¿1-8? alkyl...  
WO/1998/054159A1
The invention relates to non-steroidal gestagens of general formula (I), wherein R?1� and R?2� are the same or different and stand for a hydrogen atom, a C�1?-C�5? alkyl group or a halogen atom, or together with the C atom of the...  
WO/1998/054122A1
The present invention discloses a process for the preparation of a substantially pure compound having formula (4). The process comprises the step of reacting an enolate having formula (A) with a Grignard reagent. The enolate salt is form...  
WO/1998/052906A1
The compounds of formula (I) in which: A represents C�6?-C�10? aryl or an optionally aromatic three- to ten-membered heterocycle; X represents halogen, cyano, C�1?-C�7? alkyl, trifluoromethyl, C�2?-C�7? alkoxy or trifluoromet...  
WO/1998/045249A1
Compounds represented by general formula (I), pharmaceutically acceptable acid addition salts thereof, or hydrates of the same; drugs containing these compounds; medicinal compositions containing these compounds together with pharmaceuti...  
WO/1998/045278A1
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy dro-2H-3,1-benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HI...  
WO/1998/043942A1
The invention relates to novel compounds of Formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7� and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in ...  
WO/1998/043943A1
2-Phenoxyaniline derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R?1� represents a hydrogen atom, an amino group, or an NHCOR?3� group; and R?2� represents a halogen atom, an ami...  
WO/1998/040331A1
A process for the preparation of indanones of formula (II) from indanones of formula (I) or of indanones of formula (IIa) from indanones of formula (Ia) comprises reacting an indanone of formula (I) or (Ia) with a coupling component.  
WO/1998/040416A1
The invention relates to a catalyst system obtained by mixing at least one metallocene, at least one co-catalyst and at least one support which is rendered inert. The invention further relates to a method for producing a free flowing sup...  
WO/1998/038195A1
This invention relates to $g(a)-ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a pro...  
WO1998019512A3
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R<1> is H or C1-6alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-h...  
WO/1998/033763A1
The compound of formula (I), wherein R?1� is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, or polyfluoroalkyl; and one of R?2�, R?3� and R?4� is hydroxyl and the other two are, independently, ...  
WO/1998/033764A1
Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.  
WO/1998/033758A1
A compound of formula (I), wherein R?1� and R?2� each represents a lower alkyl, or R?1� and R?2� may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 1...  
WO/1998/032724A1
Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R�1? and R�2? each represen...  
WO/1998/032756A1
The invention relates to novel substituted aminoalkylidenamino triazines of formula (I), wherein R?1� represents the grouping A-Z, wherein A represents optionally substituted straight-chain or branched alkane diyl, which contains oxyge...  
WO/1998/032730A1
The compounds of the present invention are represented by general formula (I) in which formula R�1? and R�2? stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halog...  
WO/1998/030609A1
Selected olefins such as ethylene and $g(a)-olefins are polymerized by nickel [II] complexes of certain monoanionic ligands. The polyolefins are useful in many applications such as molding resins, film, fibers and others. Also described ...  
WO1998011046A3  
WO/1998/019512A2
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R?1� is H or C�1-6?alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent ...  
WO/1998/017267A1
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...  
WO/1998/013331A1
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...  
WO/1998/011046A2
This invention relates to processes for the preparation of aryl-$g(b)-diketones and aryl-pyrimidine ketones. In addition, this invention relates to the preparation of aryl-$g(b)-triketones and dimethyl aminomethylene $g(b)-diketones, whi...  
WO/1998/006692A1
Cyano and carboxy derivatives of substituted styrenes of formula (I), in which Y is -COZ, -C$m(Z)N, or lower alkyl of 1 to 5 carbon atoms; Z is -OH, -NR?6�R?6�, -R?7�, or -OR?7�; X, R?1�, R?2�, R?3�, R?4�, R?5�, R?6�,...  
WO/1998/005623A1
A process for the preparation of meta-substituted arylalkanoic acids starting from m-aryl-olefins followed by the Claisen rearrangement and an oxidative cleavage of the formed compound.  
WO/1998/002413A1
The compounds of formula (I) wherein R�1?, R�2?, R�3? and A are as defined herein are useful, via potassium channel modulation, in the treatment of disorders associated with smooth muscle contraction. Such disorders include, but ar...  
WO/1998/000390A1
Disclosed are racemates and optically active isomers of substituted aminobutyl derivatives of cyclohexylphenylglycolic acid, including esters, amides and keto isosteres, which possess smooth muscle spaxmolytic properties with reduced ant...  
WO/1997/049433A1
Compounds of formula (A), wherein R1, R2, R3, Y and Z are organic substituents, are useful in the diagnosis of amyloidosis; some of the compounds of formula (A) are novel. Processes for their preparation, and pharmaceutical compositions ...  
WO/1997/045397A1
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase...  
WO/1997/045551A1
A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.  
WO/1997/043244A1
The invention relates to an improved process for the separation of racemic 2-)o-chlorophenyl)-2-methyl aminocyclohexanone (ketamine).  
WO1997019675A3  
WO/1997/033855A1
The invention relates to cinnamylidene camphor derivatives of the formula (1) in which the diene system is in the configuration Z,Z; Z,E; E,Z or E, E and R1 is H, CH3, R2 is C1-C6 alkyl, C1-C6 alkoxy, halogen, NR3H, NR32, R3 is C1-C4 alk...  
WO/1997/031904A1
The invention concerns compounds of formula (I) and their salts which are suitable as herbicides and plant growth regulators, R1 to R6, Y1, Y2, Y3, m and n being defined as in claim 1. These compounds can be prepared in similar manner to...  
WO/1997/028136A1
The invention relates to 4-benzoylisoxazole derivatives of formula (Ia), 5-phenylisoxazole derivatives of formula (Ib) and 2-cyano-1,3-dione derivatives of formula (Ic), wherein R1, R2, R3, X and n are as defined in the description, and ...  
WO/1997/021684A1
The therapeutical use of tricyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), for treating diseases related to venous function deficiency and/or inflammatory oedema, is disclosed. In general for...  
WO/1997/021432A1
The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is select...  
WO/1997/020805A1
Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in fo...  
WO/1997/020806A1
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity as described, wherein in formul...  

Matches 501 - 550 out of 3,229