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Matches 501 - 550 out of 3,275

Document Document Title
WO1999059527A3
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...  
WO/2000/000469A2
Novel alkyl ketone compounds having potent cytotoxic activity are described as antitumor agents and are particularly effective against leukemia and breast tumor cells. The compounds of the invention have formula (I), wherein R¿1?-R¿4?,...  
WO/1999/065992A1
There is disclosed a compound of formula (I) wherein each of X¿1? and X¿2? are independently NH-A-NR?1¿R?2¿, and wherein A is A C¿2-8? alkylene group and R?1¿ and R?2¿ are independently selected from hydrogen, C¿1-4? alkyl, C¿2-...  
WO/1999/065866A1
A compound is provided having formula (I) wherein: R?1¿ and R?2¿ are independently hydrogen, hydroxy, alkoxy or acyloxy; R?3¿ and R?4¿ are independently oxo, hydroxy or hydrogen; one of R?5¿ or R?6¿ is A-B and the other is hydrogen...  
WO/1999/061410A1
This invention provides compounds of Formula (I) having structure (I) wherein: B and D are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, aryl, heteroaryl, aralkyl of 6-12 carbon atoms,...  
WO/1999/059527A2
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...  
WO1999050223A3
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible alpha -unsaturated alpha -hy...  
WO/1999/053242A1
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be ...  
WO1999026927A3
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders....  
WO/1999/050223A2
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible $g(a)-unsaturated $g(a)-hydr...  
WO/1999/047474A1
This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the $g(m)-halo(triisopropylp...  
WO/1999/043636A2
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred...  
WO/1999/041259A1
A microencapsulated Lewis acid characterized in that the Lewis acid has been supported through coordinate bonds on microcapsules of an organic polymer. The acid is a novel polymer-supported Lewis acid which exceeds the technical limit to...  
WO1999000114A3
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...  
WO/1999/035115A1
A benzyl or benzylidene tetralin or a pharmaceutically acceptable salt of benzyl or benzylidene tetralin represented by general formula (I) in which: a) R?1¿ completes a carbon-carbon double bond with the carbon at position 2, when x is...  
WO/1999/027783A1
Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are als...  
WO/1999/026928A1
Disclosed in a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by structural formula (II) and a starting material represented by structural formula (III). Phenyl Ring A, Phenyl R...  
WO/1999/026927A2
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders....  
WO/1999/025335A1
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apopto...  
WO/1999/021823A1
Intermediates having formulas (A) and (B) wherein B?I¿ is -CH¿2?OH or -CH¿2?OR?P¿, and R?P¿ is an alcohol protecting group; a is 1, 2, or 3; T?I¿ is -OH or (C); Q?I¿ is phenyl, naphthyl or heteroaryl having 1-3 substituents; R?a¿...  
WO/1999/015494A1
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopat...  
WO/1999/011601A1
Iodopropagylamine compounds represented by general formula (1) (wherein R?1¿ and R?2¿ each independently represent a hydrogen atom or a 1-3 C alkyl group, or R?1¿ and R?2¿ combine with each other to form a tetramethylene or pentameth...  
WO/1999/007666A1
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...  
WO/1999/006351A1
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined above (A).  
WO/1999/002124A2
The invention provides compositions and methods for the direct dyeing of keratinous fibers, with particular regard to human hair on the head. The compositions of the invention contain novel anthraquinone mixtures in which each of the com...  
WO/1999/001418A1
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...  
WO/1999/000114A2
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...  
WO/1998/058913A1
Disclosed are compounds having general formula (A) wherein Ar représents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, -OMe, NO¿2?, CF¿3?, C¿1-4? lower alky...  
WO/1998/058901A1
3-anilino-2-cycloalkenone derivatives represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these: wherein R¿1? represents optionally substituted C¿1-8? alkyl...  
WO/1998/054159A1
The invention relates to non-steroidal gestagens of general formula (I), wherein R?1� and R?2� are the same or different and stand for a hydrogen atom, a C�1?-C�5? alkyl group or a halogen atom, or together with the C atom of the...  
WO/1998/054122A1
The present invention discloses a process for the preparation of a substantially pure compound having formula (4). The process comprises the step of reacting an enolate having formula (A) with a Grignard reagent. The enolate salt is form...  
WO/1998/052906A1
The compounds of formula (I) in which: A represents C�6?-C�10? aryl or an optionally aromatic three- to ten-membered heterocycle; X represents halogen, cyano, C�1?-C�7? alkyl, trifluoromethyl, C�2?-C�7? alkoxy or trifluoromet...  
WO/1998/045249A1
Compounds represented by general formula (I), pharmaceutically acceptable acid addition salts thereof, or hydrates of the same; drugs containing these compounds; medicinal compositions containing these compounds together with pharmaceuti...  
WO/1998/045278A1
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy dro-2H-3,1-benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HI...  
WO/1998/043942A1
The invention relates to novel compounds of Formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7� and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in ...  
WO/1998/043943A1
2-Phenoxyaniline derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R?1� represents a hydrogen atom, an amino group, or an NHCOR?3� group; and R?2� represents a halogen atom, an ami...  
WO/1998/040331A1
A process for the preparation of indanones of formula (II) from indanones of formula (I) or of indanones of formula (IIa) from indanones of formula (Ia) comprises reacting an indanone of formula (I) or (Ia) with a coupling component.  
WO/1998/040416A1
The invention relates to a catalyst system obtained by mixing at least one metallocene, at least one co-catalyst and at least one support which is rendered inert. The invention further relates to a method for producing a free flowing sup...  
WO/1998/038195A1
This invention relates to $g(a)-ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a pro...  
WO1998019512A3
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R<1> is H or C1-6alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-h...  
WO/1998/033763A1
The compound of formula (I), wherein R?1� is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, or polyfluoroalkyl; and one of R?2�, R?3� and R?4� is hydroxyl and the other two are, independently, ...  
WO/1998/033764A1
Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.  
WO/1998/033758A1
A compound of formula (I), wherein R?1� and R?2� each represents a lower alkyl, or R?1� and R?2� may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 1...  
WO/1998/032724A1
Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R�1? and R�2? each represen...  
WO/1998/032756A1
The invention relates to novel substituted aminoalkylidenamino triazines of formula (I), wherein R?1� represents the grouping A-Z, wherein A represents optionally substituted straight-chain or branched alkane diyl, which contains oxyge...  
WO/1998/032730A1
The compounds of the present invention are represented by general formula (I) in which formula R�1? and R�2? stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halog...  
WO/1998/030609A1
Selected olefins such as ethylene and $g(a)-olefins are polymerized by nickel [II] complexes of certain monoanionic ligands. The polyolefins are useful in many applications such as molding resins, film, fibers and others. Also described ...  
WO1998011046A3  
WO/1998/019512A2
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R?1� is H or C�1-6?alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent ...  
WO/1998/017267A1
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...  

Matches 501 - 550 out of 3,275