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Matches 601 - 650 out of 3,236

Document Document Title
WO/1995/003270A1
The invention relates to new N,N,N',N'-tetra-substituted-1,2-ethanediamine compounds of general formula (I), wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p-F-C6H4-CH) group and R is a benzyl group opti...  
WO/1995/000476A1
Novel beta-aminovinyl ketones of general formula (VI), wherein R1 is, in particular, an alkenyl, alkynyl, cycloalkyl or cycloalkenyl group; R2 is, in particular, an electron attracting substituent such as nitro, acyl, ester, alkylthio, c...  
WO/1995/000468A1
The present invention provides novel fluorenone derivatives represented by formula (A) (wherein Ra-Rg are defined in the specification), and a method for repairing and protecting central or peripheral nerve degeneration comprising use of...  
WO/1995/000131A1
The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical compo...  
WO/1994/029255A1
Compounds of general formula (I), stereoisomers and pharmaceutically acceptable salts thereof, wherein each of Z and Z' are independently H or F; Q is (a), CH(OH), (b); X is H, Br, Cl, F or CF3; Y is H, Br, Cl, F, OH, OR5, OC(O)R4, N3, C...  
WO/1994/029277A1
A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein Ar is an optionally substituted aryl or heteroaryl ring selected from phenyl, naphthyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, imidazolyl, thienyl, oxa...  
WO/1994/027965A1
The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or phenyl(C1-4)al...  
WO/1994/027947A1
This invention relates to substituted phenylcyclopropane derivatives, which carry various substituents on the cyclopropane ring, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for their...  
WO/1994/017018A1
A fullerene derivate has formula (I), in which the symbols and indexes have the following meaning: F is a fullerene residue having the formula (C20+2m), in which m equals 1 to 50; R1 to R8 are the same or different and represent H, CO2R9...  
WO/1994/015258A1
A polymer has at least one photoactive site and more than one perfluorocyclobutane group. New monomers containing photoactive sites or photoactive precursors and at least one perfluorovinyl group are useful for making such polymers. Proc...  
WO/1994/014754A1
An anilinium salt compound represented by general formula (I) and a cationic polymerization initiator containing at least one said compound, wherein R1 represents hydrogen, alkyl, etc.; R2 represents alkyl, etc.; R3 represents alkyl subs...  
WO/1994/008943A1
A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substitut...  
WO/1994/005619A1
An optically active compound represented by general formula (I), a mixture thereof, and a carcinostatic and osteogenesis promoter each containing the same as the active ingredient, wherein Y represents hydrogen or halogen; A represents h...  
WO/1994/004485A1
Ligands and compositions for gallium-68 PET heart imaging are disclosed. The ligands form stable complexes with Ga-68. Variation of pendant substituents permits organ targeting with perfusion characteristics akin to a potassium mimic. Ma...  
WO/1994/002442A1
Novel compounds of general formula (I), wherein R1 is selected from alkyl, alkoxy, alkenyloxy, arylalkoxy, alkylthio and alkenylthio; R2 is selected from halogen, hydroxy, alkyl, alkoxy, alkenyloxy, alkylthio, alkenylthio, alkylamino, tr...  
WO/1994/001474A1
A polymerizable monomer represented by general formula (1), a polymer thereof, a process for producing the same, and the use of the polymer, wherein R1 represents hydrogen, methyl, chloro or cyano; R2 represents C1-C4 alkylene; R3 repres...  
WO/1994/000420A1
Inhibitors of leukotriene A4 hydrolase are disclosed, as are processes for making and using the same. A contemplated inhibitor has a structure corresponding to formula (I), wherein the depicted -NH2 group is in the (S) configuration; -W ...  
WO/1993/024446A1
A compound having anthelmintic and/or nematocidal activity, having general formula (I) or (II); wherein X and Y which may be the same or different, each represents a heteroatom; R¿1?, R¿3? and R¿4?, which may be the same or different,...  
WO/1993/023364A1
Novel 2,5 dihydroxybenzylamine derivatives of general formula (I), their preparation and pharmaceutical compositions containing same. In general formula (I), one of the symbols R1 or R2 denots a hydrogen or halo atom or a hydroxy, alkoxy...  
WO/1993/022279A1
Diamine derivatives of formula (I), wherein n = 0-8; R1 is hydrogen or a C1-3 alkyl residue; each of R2, R3, R4, R5 and R6 is hydrogen, a C1-6 alkyl residue, branched C4-12 alkyl or alkenyl; R2 and R3 together may form a C3-8 ring option...  
WO/1993/022259A1
The invention relates to a process for producing 1,4-bisaryl-butane-1,4-diones having general formula (I) where R and R' independently denote substituted or unsubstituted aromatic or heteroaromatic groups and polymers thereof from 1,4-bi...  
WO/1993/017671A1
Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic $g(a),$g(b)-unsaturated ketones, are used for the preparatio...  
WO/1993/017678A1
Enaminones which display anticonvulsant activity having formula (I) wherein R is from the group consisting of COOCH3 and COOC2H5; R1 is from the group consisting of H and CH3; R2 is from the group consisting of H and CH3; and R3 is from ...  
WO/1993/016969A1
A process is provided for the catalytic perfluoroalkylation of aromatic compounds, wherein a perfluoroalkyl iodide or mixture of iodides is reacted with an aromatic compound in the presence of an aqueous base, such as an alkali metal hyd...  
WO/1993/015607A1
Ion pairs of hypericin and its analogues and derivatives are prepared by acidifying hypericin to its free acid form and reacting with a predetermined quantity of an organic or inorganic base at a pH below about 11.5. The compounds are us...  
WO/1993/013052A1
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having formula (I-a) or (I-b). Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and processes of preparing said compounds ...  
WO/1993/013099A1
Heterocyclic compound of the formula: R1-A-CO-X-Y-R2, in which R1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, R2 is optionally substituted aralkyl, X is optionally substituted arylene, Y is -O- or (a), wherein R6 is hydrogen...  
WO/1993/004099A1
Rigid-rod macromonomers, and methods for preparing such macromonomers, having a polyaromatic backbone, solubilizing side groups, and reactive end groups are provided. The macromonomers are chemically incorporated into polymer systems to ...  
WO/1993/004098A1
Rigid-rod macromonomers, and methods for preparing such macromonomers, having a polyaromatic backbone, solubilizing side groups, and reactive side groups are provided. The macromonomers are chemically incorporated into polymer systems to...  
WO/1993/004373A1
Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more Ca?2+¿ receptors. Novel compou...  
WO1993000313A3  
WO/1993/000313A2
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an eff...  
WO1992018564A3  
WO/1992/019586A1
Disclosed is a process for the preparation of 1-amino-4-bromoanthraquinones by the bromination of the corresponding 1-aminoanthraquinone wherein a 1-amino-anthraquinone is contacted with elemental bromine in the presence of a carboxylic ...  
WO/1992/018564A2
A method of manufacturing 3-amino-2-cyclohexene-1-one by hydrogenating m-phenylenediamene to produce a novel intermediate salt of 3-amino-2-cyclohexene-1-imine followed by hydrolysis to produce 3-amino-2-cyclohexene-1-one. The novel inte...  
WO/1992/015319A1
The invention relates to HIV protease inhibitors wherein the compounds have a 2,4-dihydroxy isostere wherein the hydroxyl group in the 2-position is further substituted to create a tertiary alcohol. Also disclosed are pharmaceutically ac...  
WO/1992/014726A1
Substituted pyridylpyrimidines have formula (I), in which A and Ar have the meaning given in the test of the description. Also disclosed are their preparation, their use and new initial products. The compounds having formula (I) may be p...  
WO/1992/013833A1
A herbicide compound of formula (I) wherein R is halogen, C1-C2 alkyl, C1-C2 alkoxy, nitro; cyano; C1-C2 haloalkyl, or RaSOn- wherein n is 0 or 2 and Ra is C1-C2 alkyl; R1 is hydrogen or C1-C4 alkyl; R2 is hydrogen or C1-C4 alkyl; or R1 ...  
WO/1992/013827A1
A process for producing compounds represented by general formulae (III) and (IV), which are useful as intermediates for the production of amino acid derivatives which have a renin inhibitory activity and are useful as a hypotensive, ster...  
WO/1992/010466A1
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes. They have general formula (I), w...  
WO/1992/007558A1
The present invention provides novel substituted anthraquinones having formula (I), wherein R¿1? and R¿2? are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR¿3?R¿4?, Cl, Br, I, F, alky...  
WO/1992/007557A1
The present invention provides novel substituted anthraquinones having formula ($g(a)), wherein R¿1? and R¿2? are independently H, C¿1?-C¿10? alkyl, aryl, arylalkyl, alkylaryl, or R¿1? and R¿2? taken together with the adjacent nitr...  
WO1991018866A3  
WO/1992/006670A1
The object of the present invention are hair colorants containing at least one 1,4-bis-[(dihydroxyalkyl)amino]-anthrachinone of the general formula (I) in which R?1¿ and R?2¿ may be the same or different and mutually independently be a...  
WO/1992/005143A1
The present invention is concerned with compounds of formula (I), wherein R1 is hydrogen, hydroxy, C1-4 alkyl, halo (e.g., chloro), carbamoyl, aminosulfonyl, C1-4 alkylsulfonylamino or C1-4 alkyl(C1-4 alkylsulfonyl)amino; R2 is hydrogen,...  
WO/1992/004328A1
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by compounds of formula (1.0) and their pharmaceutically acceptable salts and solvates. Pharm...  
WO/1992/004309A1
15,16-Seco-19-nor progestins are provided which display elevated progestational activity with a minimum of ancillary hormonal activity. Processes for the preparation of the novel progestins are provided as are methods of use. A preferred...  
WO/1992/003488A1
The fluorinated quinoline polymers comprising repeating units of one or more quinoline groups wherein at least a portion of the repeating units include a group selected from hexafluoroisopropylidene (6F) and 1-aryl-2,2,2-trifluoroethylid...  
WO/1992/002484A1
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes, aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class and from polyacetates, diaminobe...  
WO/1992/002480A1
5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods...  

Matches 601 - 650 out of 3,236