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JP6033767B2 |
According to the invention there is provided a compound of Formula (I) in which: A is a C 2-8 alkylene group; R 1 , R 2 , R 3 , and R 4 are independently selected from hydrogen, C 1-4 alkyl, C 2-4 dihydroxyalkyl in which the carbon atom ...
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JP2016183191A |
To provide anthraquinone analogs and methods of making and using thereof.Rhein analogs that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or ...
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JP2016108332A |
To provide a method for producing an amino compound by reduction reaction of an azide compound with high yields, by a method showing consideration for the environment, conveniently and efficiently.The present invention provides a method ...
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JP5934305B2 |
The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositi...
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JP5925234B2 |
The present invention addresses the problem of providing a photoelectric conversion material that excels in heat resistance and vapor-deposition stability, a photoelectric conversion element using the photoelectric conversion material, a...
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JP5901534B2 |
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-on
e ...
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JP5866339B2 |
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JP5854345B2 |
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JP5856211B2 |
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceut...
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JP2016501869A |
In the present invention, α- (3,5-dimethoxybenzylidene) -α'-hydrogen group methylene cyclic ketone having the composition of formula (I) or (II) (where R is an aryl group or an alkyl group) As a method for producing the same, cyclic ke...
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JP2016501832A |
The present invention is a compound of formula (I).In the formula, X, Y, and R1~ R4Provides a compound and a salt thereof, which have any of the values defined herein, and a composition comprising the compound or salt. This compound is u...
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JP2015536962A |
The present invention is a compound of formula (I). [Chemical 1](I) and methods for preparing them, pharmaceutical compositions containing them, and these for treating and / or preventing cancer, hematological malignancies, proliferative...
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JP5829520B2 |
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halo...
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JP2015209402A |
To provide an alicyclic amine compound capable of being used as an intermediate of medicine, an intermediate material for industrial products, and an additive; and to provide a method for producing the same.This invention relates to: an ...
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JP2015189679A |
To provide a purification method capable of enhancing yield of sublimation purification of an organic compound used for a photoelectric conversion element having enhanced light response speed and an organic electroluminescent element hav...
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JP5786621B2 |
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JP2015527322A |
Rain analogs that exhibit antiproliferative activity, especially against cancer cells, are described herein. In some embodiments, the compound contains a flat or planar ring system. Such a ring works by promoting non-covalent binding of ...
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JP5775178B2 |
A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine.
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JP5773877B2 |
Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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JP2015145392A |
To provide compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using the compounds and compositions.This invention r...
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JP5763599B2 |
The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, -NR8R9 or -S-R16, A' is -O-, -NH- or -NR8-, X and Y are each indepe...
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JP5758844B2 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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JP5725299B2 |
1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
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JP2015091801A |
To provide a material for an organic electronic element that shows very excellent film formation properties and is easy to dissolve in organic solvent.This invention relates to a compound represented by, for example, the following formul...
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JP2015091842A |
To provide an amine derivative useful for treatment of eye diseases and disorders, e.g. age-related macular degeneration and Stargardt Disease, and a pharmaceutical composition using the same.There are provided an amine derivative repres...
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JP5711724B2 |
The invention provides bupropion analogue compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and...
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JP5699286B2 |
Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, acetyl, or methoxycarbonyl; R2s are each independently...
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JP2015501316A |
The present invention provides compounds useful for the treatment of hepatitis C virus (HCV) infections. This compound has the formula (1) [formulation] or a salt thereof, an N-oxide, a metamutant or a steric isomer, in which A is CH or ...
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JP2014210715A |
To provide a new hydrophilic and neutral compound having ultraviolet A wave (UVA) absorbing properties and a method for producing the same, and to provide an ultraviolet absorber and a skin external preparation using the same.There is pr...
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JP2014196287A |
To provide alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds, which are useful for treating neurodegenerative diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's ...
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JP2014185149A |
To provide a biaryl phosphodiesterase-4 (PDE4) inhibitor useful for treatment and prevention of stroke, myocardial infarction, cardiovascular inflammatory diseases and central nervous system disorders.There is provided a biaryl compound ...
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JP5599974B2 |
The present invention relates to processes for the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-b
enzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-±'-[[[6-(4...
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JP2014174554A |
To provide a photosensitive resin composition and a spacer produced by using the composition.The photosensitive resin composition comprises an alkali-soluble resin, a photocurable monomer, a photopolymerization initiator, an amino acetop...
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JP2014172847A |
To provide an industrially advantageous method for producing a corresponding aromatic amine compound from an aromatic nitro compound.There are provided: a method for producing an aromatic amine compound which comprises a step of hydrogen...
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JP2014523899A |
The manufacturing method of an amino pro pin including the process to which metal acetylide, amine, and a carbonyl content compound are made to react, or enemy non is provided under existence of a transition metal catalyst. The manufactu...
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JP2014169312A |
To provide intermediates useful in producing tetrahydroisoquinolines, particularly 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-
7-yl]pyridazin-3-amine useful in the treatment of depression and other conditions.Intermediat...
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JP5591714B2 |
Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the tr...
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JP5560715B2 |
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JP5548182B2 |
A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling compon...
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JP5543150B2 |
To provide a catalyst for selectively and economically hydrogenating only a nitro group even when the nitro group, a carbon-carbon double bond, a halogen atom bonded to an aromatic ring, and groups such as an aromatic ketonic carbonyl gr...
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JP5529591B2 |
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JP5520966B2 |
The present invention relates to enaminocarbonyl compounds with the formula I. The present invention also relates to the use of compounds with the formula I for the modification of the taste of a product and/or preparation for oral admin...
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JP5514218B2 |
A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]p
ropan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
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JP5508738B2 |
Producing ketone compounds (I), comprises reacting alpha-oxocarboxylate compounds (II) with aryl bromide compounds (III) in the presence of two transition metals or compounds as catalyst. Producing ketone compounds of formula (R-C(=O)-R1...
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JP5508402B2 |
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JP5481739B2 |
To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt thereof: wherein A represents a phenyl group or...
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JP5480386B2 |
An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction co...
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JP2014508717A |
Compositions, uses, kits and methods for reducing hinge or compulsive eating are described herein. Methods may include administering an effective combination of a dosage of a bupropion or a pharmaceutically acceptable salt thereof, and a...
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JP5432526B2 |
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for t...
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JP5391372B2 |
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