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WO/2002/000609A2 |
Formula (I) compounds are described where the groups are as defined in the description, as well as processes for their preparation and their use as medicaments, particularly for the preparation of medicaments with phosphodiesterase IV in...
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WO/2001/098251A1 |
New compounds of formula (I) are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
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WO/2001/096278A2 |
Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P?1¿ and P?2¿ are ea...
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WO/2001/094357A1 |
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...
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WO/2001/092202A1 |
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/2001/089504A1 |
Excellent 12-lipoxygenase inhibitors containing as the active ingredient tropolone derivatives of the general formula (1) or salts thereof. In said formula wherein R?1¿ is hydrogen or optionally substituted C¿3-10? alkenyl; R?2¿ is hy...
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WO/2001/078713A1 |
Compounds of general formula (I). wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings B, C and E being aliphatic whereas ring D may...
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WO/2001/070675A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
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WO/2001/068654A2 |
A diverse set of tubulin binding ligands have been discovered which are structural by characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for m...
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WO/2001/064208A1 |
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/2001/062257A2 |
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective ...
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WO/2001/062705A2 |
A compound of the formula (I) wherein X¿1? is bond or -O(CH¿2?)¿m?- (in which m is an integral number of 1, 2 or 3); X¿2? is bond, -(CH¿2?)¿n?-, etc. (in which n is an integral number of 1, 2 or 3); R¿1? is hydrogen or amino prote...
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WO/2001/060781A2 |
For use in the inhibition of retinoic acid metabolism, diphenyl compounds of formula (I).
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WO/2001/049651A2 |
The invention relates to aminomethyl-phenyl-cyclohexanone derivatives, to methods for the production thereof, to the use of aminomethyl-phenyl-cyclohexanone derivatives for producing medicaments, and to medicaments containing aminomethyl...
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WO/2001/046125A2 |
Substituted phenantheren-9, 10-diones in accord with structural diagram (I), compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In ...
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WO/2001/044190A1 |
Use of compound of Formula (I): at least one of R?1¿, R?2¿, R?5¿ and R?6¿ is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R?7¿)¿n?X-Y wherein R?7¿ is ...
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WO/2001/042243A2 |
Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or ...
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WO/2001/042189A1 |
A compound of general formula (I), wherein R¿1? represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C¿1?-C¿3?)alkyl, (C¿2?-C¿3?)olefinic group, (C¿1?-C¿3?)alkoxy, (CÂ...
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WO/2001/034557A1 |
A process for the production of optically active cyclic enaminone derivatives, characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to thereby obtain an optical isomer mixture ...
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WO/2001/030865A1 |
Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones.
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WO/2001/028977A1 |
Parkinson's disease is treated with a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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WO/2001/014313A1 |
A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonit...
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WO/2001/010816A2 |
The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.
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WO/2001/008685A1 |
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present inve...
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WO/2001/005744A1 |
The present invention relates to compounds of formula (I) wherein R¿1? represents one or more, similar or different substituents; R¿2? represents hydrogen, hydroxy, halogen, alkyl, alkoxy, alkylthio, or cyano; R¿3? represents on...
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WO/2001/005745A1 |
The present invention relates to compounds of formula (I) wherein R¿1? and R¿2? independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amin...
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WO/2001/005743A1 |
The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.
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WO/2001/005749A1 |
The present invention relates to compounds of formula (I) wherein R¿1?, R¿2? and R¿3? independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trif...
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WO/2001/005746A1 |
The present invention relates to a compound of general formula (I) wherein R¿1?, R¿2?, and R¿3? represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, ...
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WO/2001/004247A1 |
There is provided a process for producing particles of amine reaction product by means of a carrier having a melting point of less than 30 °C, optionally followed by a coating step. Processed amine reaction products and finished composi...
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WO/2001/004248A1 |
There is provided a process for producing particles of amine reaction product by means of an acid carrier. Processed amine reaction products and finished compositions incorporating such processed product are also herein provided.
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WO/2001/004105A1 |
The invention concerns novel methods for preparing enantiopure compounds of formula (I) wherein X represents a halogen atom, its additive salts with mineral or organic acids, or its salts with optically active organic acids. The inventio...
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WO/2001/002376A1 |
The present invention relates to amino-alkyl derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and met...
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WO/2000/073292A1 |
The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl st...
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WO/2000/066522A1 |
The present invention provides non-steroidal compounds of formula (I) which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides p...
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WO/2000/066537A1 |
The present invention is directed to compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein X is hydrogen, C1, Br, I, NO¿2?, NR?3¿R?4¿ or -L-Ch; Y is hydrogen, -CH¿2?OR?5¿, -CH¿2?NCH¿3?R?1¿, NO¿2?, NR?3¿...
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WO/2000/066541A1 |
Intermediates for the preparation of phenylalkanoic acid amides having excellent germicidal effects; a process for the preparation of the intermediates; and a process for preparing starting compounds for the preparation of the intermedia...
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WO/2000/063186A1 |
A new process and intermediates for preparing 1,4-benzodiazepines of formula (I) is disclosed: wherein, R?1¿ is H, OH, Br, I, NR?5¿R?6¿, CO¿2?R?7¿, CF¿3?SO¿3?, C¿1-4?alkoxy, or (4,4'-bipiperidinyl) carbonyl; R?2¿ is alkyl, optio...
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WO/2000/063159A1 |
A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X = O Z = H, =CHAr, =C(OH)COOEt, =NOR; Y = H, NH¿2?, NH¿3??+¿ X¿1??-¿, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X¿1??-¿ =...
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WO/2000/063339A1 |
The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G?1¿ and G?2¿ are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damas...
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WO/2000/055113A1 |
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...
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WO/2000/053571A1 |
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...
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WO/2000/051546A2 |
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...
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WO/2000/050381A1 |
The invention concerns a method for preparing 2-aminobenzophenone derivatives as well as the process intermediates, namely 2-nitrobenzophenone derivatives. The invention first concerns a method for preparing a 2-nitrobenzophenone derivat...
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WO1996012697A9 |
The present invention features compounds of general formulae a), b), c), able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. P...
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WO2000002887B1 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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WO/2000/044706A1 |
A process which comprises converting a $g(a)-amino acid ester into the corresponding imine to thereby protect the amino group of the ester, reacting the imine with a halomethyllithium to form an N-protected $g(a)-amino halomethyl ketone,...
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WO/2000/041993A1 |
Compounds represented by general formula (I) or salts thereof which cause a morphological change in trabecular cells to thereby lower intraocular pressure. In the formula, R?1¿ represents H, lower alkyl, hydroxy, lower alkoxy or halogen...
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WO/2000/038734A1 |
The present invention concerns a novel family of anthraquinone alkylating agents, their use in the treatment of cancers, methods of manufacture of medicaments for same, and methods of treatment of cancers.
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WO/2000/034230A1 |
4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having Formula (I): wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, A and W are as defined in the specification which compounds relaxes smooth muscles.
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