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Patent Searching and Data


Matches 401 - 450 out of 3,207

Document Document Title
WO/2002/002516A2
The present invention is a series of novel and effective inhibitors of integrase, an essential in the life cycle of retroviruses. These compounds were designed to have a restricted conformation for the determination of the integrase bind...  
WO/2002/002507A1
The invention relates to an oxidative colouring agent for keratin fibres, in particular hair, based on a developing agent-coupling agent combination, which contains as a developing agent, at least one 2-hydroxy-5-amino-biphenyl derivativ...  
WO/2002/000586A1
The present invention relates to propanedione derivatives represented by general formular (A), and their use as UV-absorbent. Wherein R?1¿ is substituted aromatic ring, optionally substituted heteroaromatic ring, or optionally substitut...  
WO/2002/000609A2
Formula (I) compounds are described where the groups are as defined in the description, as well as processes for their preparation and their use as medicaments, particularly for the preparation of medicaments with phosphodiesterase IV in...  
WO/2001/098251A1
New compounds of formula (I) are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.  
WO/2001/098265A2
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO/2001/096278A2
Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P?1¿ and P?2¿ are ea...  
WO/2001/094357A1
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...  
WO/2001/092202A1
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).  
WO/2001/089504A1
Excellent 12-lipoxygenase inhibitors containing as the active ingredient tropolone derivatives of the general formula (1) or salts thereof. In said formula wherein R?1¿ is hydrogen or optionally substituted C¿3-10? alkenyl; R?2¿ is hy...  
WO/2001/078713A1
Compounds of general formula (I). wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings B, C and E being aliphatic whereas ring D may...  
WO/2001/070675A2
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2001062705A8
A compound of the formula (I) wherein X1 is bond or -O(CH2)m- (in which m is an integral number of 1, 2 or 3); X2 is bond, -(CH2)n-, etc. (in which n is an integral number of 1, 2 or 3); R1 is hydrogen or amino protective group; R2 is hy...  
WO/2001/068654A2
A diverse set of tubulin binding ligands have been discovered which are structural by characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for m...  
WO/2001/064208A1
This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).  
WO/2001/062257A2
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective ...  
WO/2001/062705A2
A compound of the formula (I) wherein X¿1? is bond or -O(CH¿2?)¿m?- (in which m is an integral number of 1, 2 or 3); X¿2? is bond, -(CH¿2?)¿n?-, etc. (in which n is an integral number of 1, 2 or 3); R¿1? is hydrogen or amino prote...  
WO2001010816A3  
WO/2001/060781A2
For use in the inhibition of retinoic acid metabolism, diphenyl compounds of formula (I).  
WO/2001/049651A2
The invention relates to aminomethyl-phenyl-cyclohexanone derivatives, to methods for the production thereof, to the use of aminomethyl-phenyl-cyclohexanone derivatives for producing medicaments, and to medicaments containing aminomethyl...  
WO/2001/047866A1
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.  
WO/2001/046125A2
Substituted phenantheren-9, 10-diones in accord with structural diagram (I), compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In ...  
WO/2001/044190A1
Use of compound of Formula (I): at least one of R?1¿, R?2¿, R?5¿ and R?6¿ is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R?7¿)¿n?X-Y wherein R?7¿ is ...  
WO/2001/042243A2
Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or ...  
WO/2001/042189A1
A compound of general formula (I), wherein R¿1? represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C¿1?-C¿3?)alkyl, (C¿2?-C¿3?)olefinic group, (C¿1?-C¿3?)alkoxy, (C...  
WO/2001/040188A1
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF¿3?; Z is H, OH, OR¿1?, halogen, or CF¿3?; X¿1? and X¿2? are independently C or N; and A is as defined in the application; exhibiting anti-tum...  
WO/2001/034557A1
A process for the production of optically active cyclic enaminone derivatives, characterized by aminating one of the carbonyl groups of a cyclic 1,3-diketone derivative having a symmetry plane to thereby obtain an optical isomer mixture ...  
WO/2001/030865A1
Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones.  
WO/2001/028977A1
Parkinson's disease is treated with a compound of Formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2001/014313A1
A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonit...  
WO/2001/010816A2
The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.  
WO/2001/008685A1
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present inve...  
WO/2001/005744A1
The present invention relates to compounds of formula (I) wherein R¿1? represents one or more, similar or different substituents; R¿2? represents hydrogen, hydroxy, halogen, alkyl, alkoxy, alkylthio, or cyano; R¿3? represents on...  
WO/2001/005745A1
The present invention relates to compounds of formula (I) wherein R¿1? and R¿2? independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amin...  
WO/2001/005743A1
The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.  
WO/2001/005749A1
The present invention relates to compounds of formula (I) wherein R¿1?, R¿2? and R¿3? independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trif...  
WO/2001/005746A1
The present invention relates to a compound of general formula (I) wherein R¿1?, R¿2?, and R¿3? represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, ...  
WO/2001/004247A1
There is provided a process for producing particles of amine reaction product by means of a carrier having a melting point of less than 30 °C, optionally followed by a coating step. Processed amine reaction products and finished composi...  
WO/2001/004248A1
There is provided a process for producing particles of amine reaction product by means of an acid carrier. Processed amine reaction products and finished compositions incorporating such processed product are also herein provided.  
WO/2001/004105A1
The invention concerns novel methods for preparing enantiopure compounds of formula (I) wherein X represents a halogen atom, its additive salts with mineral or organic acids, or its salts with optically active organic acids. The inventio...  
WO/2001/002376A1
The present invention relates to amino-alkyl derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and met...  
WO2000051546A3
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...  
WO/2000/073292A1
The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl st...  
WO/2000/066522A1
The present invention provides non-steroidal compounds of formula (I) which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides p...  
WO/2000/066537A1
The present invention is directed to compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein X is hydrogen, C1, Br, I, NO¿2?, NR?3¿R?4¿ or -L-Ch; Y is hydrogen, -CH¿2?OR?5¿, -CH¿2?NCH¿3?R?1¿, NO¿2?, NR?3¿...  
WO/2000/066541A1
Intermediates for the preparation of phenylalkanoic acid amides having excellent germicidal effects; a process for the preparation of the intermediates; and a process for preparing starting compounds for the preparation of the intermedia...  
WO/2000/063186A1
A new process and intermediates for preparing 1,4-benzodiazepines of formula (I) is disclosed: wherein, R?1¿ is H, OH, Br, I, NR?5¿R?6¿, CO¿2?R?7¿, CF¿3?SO¿3?, C¿1-4?alkoxy, or (4,4'-bipiperidinyl) carbonyl; R?2¿ is alkyl, optio...  
WO/2000/063159A1
A description is given here of novel solid and stable derivatives of (-)-verbenone having formula (I) wherein, when X = O Z = H, =CHAr, =C(OH)COOEt, =NOR; Y = H, NH¿2?, NH¿3??+¿ X¿1??-¿, NHCOAr, NHCOR, NHCONHR, NHCONHAr; X¿1??-¿ =...  
WO/2000/063339A1
The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G?1¿ and G?2¿ are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damas...  
WO/2000/055113A1
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...  

Matches 401 - 450 out of 3,207