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Matches 1 - 50 out of 3,202

Document Document Title
WO/2018/173058A1
The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).  
WO/2018/167264A1
The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.  
WO/2018/159834A1
Provided are a donor-acceptor type compound having a novel structure and an application of the donor-acceptor type compound. This enamine compound is represented by general formula (1) (in the formula: R1 represents an electron-accepting...  
WO/2018/153212A1
The present invention relates to the technical field of medicinal chemistry, and in particular relates to colchicine derivatives (I), a preparation method therefor, and pharmaceutical compositions comprising the compounds. Pharmacodynami...  
WO/2018/136792A1
The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.  
WO/2018/109192A1
The present invention relates to novel cationic azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair...  
WO/2018/103239A1
Disclosed is a preparation method for a compound shown by formula (E), a Velpatasvir intermediate shown by formula (K) and an analogue thereof. The method of the present invention uses inexpensive and easily available materials, and a si...  
WO/2018/102488A1
The present invention features methods, compositions, and kits for the treatment of all forms of emotional and painful symptoms related to the menstrual cycle, including symptoms characteristic of menstrual cycle-related disorders, such ...  
WO/2018/100556A1
Several compounds have been discovered that modulate signal transduction through the PD-1 receptor. In certain embodiments, the compounds promote or induce an activating signal through the PD-1 receptor that activates a T cell. The compo...  
WO/2018/076107A1
In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof minocycline, or a functional derivative thereof, and hydroxychloroquine, or a fun...  
WO/2018/076108A1
ABSTRACT In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof one or more compounds described herein. In a specific example, the neuro...  
WO/2018/074411A1
Provided is an efficient and economical method for producing a nitrogen-containing compound. In this method for producing a compound represented by the formula R3C(O)CH=CHNR1R2, a six-fold molar excess of a compound represented by the fo...  
WO/2018/053221A1
Disclosed are novel ketamine prodrugs, pharmaceutical preparations containing such prodrugs of ketamine and methods of treating, bipolar depression, neuropathic and chronic pain, including complex regional pain synthetic pain syndrome (C...  
WO/2018/025259A1
Naphthoquinone compounds that induce the formation of reactive oxygen species (ROS) are disclosed. Process of preparing the naphthoquinone compounds are also disclosed. Uses of the compounds for treating a disease or disorder are also di...  
WO/2018/013682A1
Covalent organic frameworks (COFs) usually crystallize as insoluble powders and their processing for suitable devices has been thought to be limited. Here, it is demonstrated that COFs can be mechanically pressed into shaped objects havi...  
WO/2017/220969A1
The present invention provides di-substituted acetalanthraquinone- based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of ...  
WO/2017/205795A1
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.  
WO/2017/198812A3
Process for the manufacture of 2-substituted-5-(1-methylthio)alkylpyridines and a process for the manufacture of agriculturally or pharmaceutically active substances comprising the process for the manufacture of 2-substituted-5-(1- methy...  
WO/2017/184752A1
The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococc...  
WO/2017/180589A1
The present disclosure provides compounds of Formula I and/or Formula II, or pharmaceutically acceptable salts thereof: wherein D is deuterium and each deuterium has deuterium enrichment of no less than about 10%, compositions containing...  
WO/2017/165878A1
The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine ...  
WO/2017/149052A1
The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a pr...  
WO/2017/145022A1
Described herein are UV-absorbing vinylic monomers conjugated to 2-aminobenzophenone derivatives and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and violet radiation with waveleng...  
WO/2017/147386A1
The present disclosure is directed to, e.g., 3-substituted, 5-amine-substituted-cyclohex-2-en-1-one compounds, and method of treatment and making associated with the same compounds.  
WO/2017/138838A1
The invention relates to salts and hydrates of arylcycloalkylamine derivatives of general formula (I) and formula (II), where in formula (I), R1 and R2 signify H, a linear or branched alkyl (C1, C4), a linear or branched alkoxy (C1, C4),...  
WO/2017/138363A1
The present invention provides an organic photoelectric conversion element (1) which comprises an electron collecting electrode (13), a hole collecting electrode (14), and a photoelectric conversion part arranged between the electron col...  
WO/2017/129759A1
The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.  
WO/2017/101791A1
Disclosed are a compound and a use thereof in preparing a drug, and in particular, provided in the present invention are: the compound as shown in formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitroxide, a ...  
WO/2017/087607A1
Compounds are provided as chemokine inhibitors having the structure: Formula (A).  
WO/2017/087388A1
Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by admini...  
WO/2017/082144A1
The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The present invention also provides: a composition which includes the compound represented by formula (I), or...  
WO/2017/081590A1
The present invention provides a process for preparing omarigliptin.  
WO/2017/077550A1
The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).  
WO/2017/078332A1
The present invention relates to a method for forming a three-dimensional object. According to the present invention, when the three-dimensional object is manufactured by an inkjet method, a support can be removed without damage to a str...  
WO/2017/067497A3
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups s...  
WO/2017/067497A9
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups s...  
WO/2017/067634A1
The invention relates to the use of hydrophilic compounds of formula (I) as photopolymerization initiators of polymerizable substance mixtures, which contain unsaturated compounds, or to the photochemical cross-linking of linear polymers...  
WO/2017/057460A1
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...  
WO/2017/054112A1
The present invention relates to a method of preparing a 3-fluoroalkyl-1-methylpyrazole-4-carboxylic acid comprising the following steps: Step 1, performing a condensation reaction on the fluoroacetyl halide derivative shown in formula I...  
WO/2017/043175A1
Provided is a near-infrared absorbing curable composition which is capable of forming a cured film that has excellent infrared light shielding properties and visible light transparency, while exhibiting excellent heat resistance and ligh...  
WO/2017/035665A1
The present application is directed to transdermal formulations for the delivery of doxycycline compounds to a subject for the treatment of doxycycline-responsive diseases. In particular, the transdermal formulation is an emulsion compri...  
WO/2017/035224A1
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are ...  
WO/2016/207252A1
A method of preparing a compound represented by general formula (3) : Formula (3). R1 and R2 are each independently an alkyl group. The method includes reacting a compound represented by general formula (2) : Formula (2) with an alkylami...  
WO/2016/202254A1
Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is ...  
WO/2016/197730A1
The present invention relates to an organic electroluminescent material, which has a structure as represented by formula (I). Compounds as represented by formula (I) have highly stable electron acceptor groups and electron donor groups, ...  
WO/2016/180984A1
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. Th...  
WO/2016/150208A1
Disclosed are a pharmaceutical composition and dosage form containing a glaucocalyxin A derivative as represented by the formula (I) or salt thereof, and a preparation method and use of said composition and dosage form; the anti-autoimmu...  
WO/2016/150206A1
Disclosed is a glaucocalyxin A derivative -- dimethylamino glaucocalyxin A hydrochloride salt -- and two crystalline forms thereof. The dimethylamino glaucocalyxin A hydrochloride salt provided by the present invention has good water sol...  
WO/2016/150207A1
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fig...  
WO/2016/152886A1
The present invention provides a novel method for producing pyrazole derivatives useful as intermediates of pharmaceuticals and agricultural chemicals, as well as novel intermediate compounds in this method. The present invention pertain...  

Matches 1 - 50 out of 3,202