| Document |
Document Title |
|
WO/2012/033187A1 |
The present invention pertains to a method for producing optically active 2-aminobutyric acid containing a step for obtaining a diastereometric salt of optically active 2-aminobutyric acid and optically active tartaric acid by combining ...
|
|
WO/2012/033188A1 |
A method for producing an optically active amino acid, said method comprising heating an amino acid and an optically active carboxylic acid together with an aldehyde in an organic solvent, and then adding an amine to the organic solvent ...
|
|
WO/2012/032185A1 |
The invention relates to a method for producing crystalline 5-aminosalicylic acid with a particularly high tap and/or bulk density.
|
|
WO/2012/028721A1 |
The invention refers to a process for the reductive amination of α-keto carboxylic acids catalyzed by transition metal containing compounds.
|
|
WO/2012/025502A1 |
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, ba...
|
|
WO/2012/018095A1 |
The purpose of the present invention is to provide a production process which can synthesize a bicyclo[2.2.2]octylamine derivative represented by general formula (1) or a salt thereof with high efficiency and in a large quantity. The pre...
|
|
WO/2012/010296A1 |
The invention relates to a method for the production of L-carnitine, wherein a chiral β-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X-CH2-CHO, wherein X is selected from CI, Br, I and trim...
|
|
WO/2012/010297A1 |
The invention relates to a method for the production of L-carnitine, wherein a β- lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic...
|
|
WO/2012/002203A1 |
Disclosed is a production method for obtaining an optically active β-aminocarbonyl compound by a Mannich reaction of an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and 1-...
|
|
WO/2011/160730A1 |
The invention relates to a method for producing omega-amino acids or their esters, the method being characterized by the following steps: (a) ozonolysis of unsaturated fatty acids or fatty acid derivatives; (b) reductive amination of the...
|
|
WO/2011/159177A1 |
The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relat...
|
|
WO/2011/158720A1 |
Disclosed is a method for efficiently producing a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate, at low cost. Specifically, a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxyli...
|
|
WO/2011/154333A2 |
The invention relates to a process for preparing crystalline 3,6,9-triaza- 3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula (I) by hydrolysis of di-tert-butyl 3,6,9-triaza-3,6,9-tris(tert- butoxycarbonylmethy...
|
|
WO/2011/152657A2 |
The present invention relates to acetyl-L-carnitine malate, a process for preparing the same, and a pharmaceutical composition comprising the same. The acetyl-L-carnitine malate of the present invention has good stability, solubility, an...
|
|
WO/2011/151517A2 |
The present invention relates to a process for the preparation of a mixture of aspartic acid diethoxy succinate and an amino acid derivative of the general formula (I) wherein n is 1-10, m is 0 or 1, and R is hydrogen or an alkali metal ...
|
|
WO/2011/147254A1 |
Provided are phenylbutyryl curcumin derivatives, their preparation methods, pharmaceutical compositions containing said derivatives and uses thereof for preparing anti-tumor drugs. Said curcumin derivatives are specifically 4-[bis(2-chlo...
|
|
WO/2011/146582A2 |
Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially...
|
|
WO/2011/141160A1 |
The invention relaters to a process for the production of an (S)- or (R)-4- halo-3-hydroxybutyrate, comprising reacting a 4-haloacetoacetate with hydrogen in the presence of a solvent, the solvent being a solvent mixture, which comprises...
|
|
WO/2011/138051A1 |
The subject matter of the invention is a process for synthesizing a saturated long-chain α,ω-amino ester (acid) obtained in a first step by cross-metathesis between an acrylic first compound and a monounsaturated second compound compri...
|
|
WO/2011/127794A1 |
Disclosed are chiral cyclic beta-amino aryl butyric acid derivatives (formula II) which can be used as intermediates for preparing chiral drugs, the preparation methods of such chiral cyclic beta-amino aryl butyric acid derivatives and t...
|
|
WO/2011/128353A1 |
This invention relates to a "one pot" process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yie...
|
|
WO/2011/124934A1 |
Process for the preparation of (S)-(+)-pregabalin (1) that racemic pregabalin (2) was solved in water, reacted with a chiral a-hydroxy-carboxylic acid or a mixture of chiral α-hydroxy-carboxylic acids in desired case in the presence of ...
|
|
WO/2011/117591A2 |
Compounds of formula (I): wherein Ar represents an, optionally substituted, aryl or heteroaryl group, R represents an, optionally substituted, aryl or heteroaryl group, an optionally substituted straight or branched chain C1.10-alkyl, R1...
|
|
WO/2011/117535A1 |
The present invention relates to a method for continuously preparing a betaine aqueous solution, said method including the reaction of an amine with an ω-halocarboxylic acid in the presence of water and a base. Said method is characteri...
|
|
WO/2011/116686A1 |
Sitagliptin intermediate compounds of formula (f), preparation methods and uses thereof are provided. The compounds of formula (f) are prepared by the following steps: compounds of formula (a) are subjected to electrophilic reaction with...
|
|
WO/2011/113486A1 |
The present invention refers to a process for the synthesis of a D-(-)-p-hydroxyphenylglycine (HPG) ester in crystal form, by crystallizing D-HPG ester from a solution containing dissolved D-HPG ester to obtain a suspension comprising D-...
|
|
WO/2011/113822A1 |
The present invention relates to a method for producing aminocarboxylates starting from amines using a reaction sequence of ethoxylation to form amino alcohols and subsequent oxidative dehydrogenation to form the corresponding aminocarbo...
|
|
WO/2011/110556A1 |
A process is described for the preparation of intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)- 1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.
|
|
WO/2011/102584A1 |
The present invention relates to novel metal dialkyl glycine using modified glycine and a manufacturing method thereof, wherein the metal dialkyl glycine is stable in water, is easy to store, and has thermal stability.
|
|
WO/2011/102388A1 |
Provided is a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
which is useful as an intermediate for synthesizing a therapeutic agent for hepatitis C, and also provided is a novel method for produ...
|
|
WO/2011/101599A1 |
The aim of the invention is to provide a method for preparing carboxylic acid derivatives by aromatic nucleophilic substitution, in which a carboxylic acid derivative having a single carboxyl functional group, or one of the salts thereof...
|
|
WO/2011/101336A1 |
The invention relates to a method for producing ether carboxylates.
|
|
WO/2011/101604A1 |
The present invention relates to a method for preparing aromatic carboxylic acid derivatives by nucleophilic aromatic substitution, which involves reacting an aromatic carboxylic acid derivative supporting only one carboxyl function, or ...
|
|
WO/2011/101287A1 |
The invention relates to a method for producing ether carboxylates.
|
|
WO/2011/098386A1 |
The present invention relates to a novel a process for the preparation of a compound of formula (I) which process comprises adding 1 to 2 mol of sodium hypochlorite with a concentration of 8% to 15% by weight to a suspension of the compo...
|
|
WO/2011/088797A1 |
Disclosed are intermediates for the manufacture of neutral endopeptidase (NEP) inhibitors or prodrugs thereof, and preparation method thereof. In particular, the said NEP inhibitors comprise a γ-amino-δ-biphenyl-α-methylalkanoic acid,...
|
|
WO/2011/086565A1 |
A process for preparation of enantiomerically enriched and/or racemic γ-amino acids, particularly those useful for preparing γ-amino acids that exhibit binding affinity to the human α2δ calcium channel subunit, including pregabalin a...
|
|
WO/2011/077463A1 |
Processes for preparing pregabalin and its intermediate such as 3-(carbamoylmethyl)-5-methylhexanoic acid are provided. The process for preparing pregabalin mainly comprises reacting 3-(carbamoylmethyl)-5-methylhexanoic acid with (+)-phe...
|
|
WO/2011/073236A1 |
The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparat...
|
|
WO/2011/073409A1 |
The present invention generally refers to a process for the preparation of L- thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agen...
|
|
WO/2011/070028A1 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
|
|
WO/2011/069915A1 |
The present invention provides a method for producing a composition for external use containing a physiologically acceptable salt of a tranexamate as an active ingredient, which is dispersed in the composition in the state of fine partic...
|
|
WO/2011/062139A1 |
Provided is a three-step method for manufacturing optically active 3-tert-butoxycarbonylamino-2-fluoro-1-propanol. The provided method can dramatically reduce the amount of a palladium catalyst used and can complete the reaction in one c...
|
|
WO/2011/060903A1 |
Subject of the invention is a method for the production of L-carnitine, comprising the steps of (a) providing a solution comprising at least 5% (w/w) carnitine in a first solvent, wherein the carnitine is a mixture of D- and L-carnitine,...
|
|
WO/2011/061935A1 |
Disclosed is a process for producing a 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxyl
ic acid derivative represented by formula (I) or a salt thereof, the process including a step of transforming a compound represented by f...
|
|
WO/2011/061341A1 |
The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given tempera...
|
|
WO/2011/054874A1 |
The present invention relates to a novel method for the production of 2- amino-6-ethylbenzoic acid wherein7-amino-3-methylphtalide or 7-amino-3- hydroxy-3-methylphtalide is reduced to 2-amino-6-ethylbenzoic acid in water or in a mixture ...
|
|
WO/2011/051071A1 |
The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.
|
|
WO/2011/048535A1 |
The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently r...
|
|
WO/2011/045266A1 |
The invention relates to a method for producing a powder containing one or more complexing agent salts of the general formula (I), starting from an aqueous solution, containing the one or more complexing agent salts at a concentration of...
|
