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WO/2021/107047A1 |
Provided is a method for efficiently producing 4-(aminomethyl)cyclohexane carboxylic acid with a low production cost. According to the present invention, 4-(aminomethyl)cyclohexane carboxylic acid is obtained through synthesis using, a...
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WO/2021/104432A1 |
Provided is a preparation method for an L-ornithine composite salt. The preparation method comprises the following steps: (1) taking an L-ornithine salt solution as a raw material to prepare a free L-ornithine solution by means of a bipo...
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WO/2021/105742A1 |
The present invention relates to an improved process for the preparation of Pregabalin (I), which is simple, economical, efficient, and environment friendly, commercially viable with chemical and chiral purity at least 99.95%.
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WO/2021/098712A1 |
The present invention relates to the technical field of organic synthesis, and specifically to a preparation method for chlorohomoserine alkyl ester. The technical solution in the present invention provides a preparation method for chlor...
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WO/2021/097650A1 |
The invention belongs to the technical field of medicines, and particularly relates to a cocrystal of orlistat and an amino acid, and a pharmaceutical composition comprising the same. The cocrystal formed by orlistat and L-proline, L-leu...
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WO/2021/083459A1 |
The invention relates to a process for the synthesis of DOPA comprising a photolabile protective group and to intermediates for preparing same (I), R being selected from the group that consists of 2-nitrobenzyl,1-(2-nitrophenyl)ethyl, 7-...
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WO/2021/076795A1 |
The present invention describes methods to create chimeric aminoacyl-tRNA synthetases (aaRS) derived from bacteria which show optimal activity and high thermostability. These chimeric aaRSs can be more aggressively engineered to generate...
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WO/2021/076922A1 |
This disclosure features niclosamide compounds (or pharmaceutically acceptable salts and/or co-crystals thereof, e.g., niclosamide), having one or more properties that include, but are not limited to: a particular purity (e.g., a chemica...
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WO/2021/066639A1 |
The present invention provides a tryptophan derivative used in agrochemistry, which has a preventive and corrective antiviral effect against begomovirus in plants, does not display phytotoxicity in field concentrations and is not toxic t...
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WO/2021/067301A1 |
A compound that includes a menthol glycinate. The menthol glycinate includes a menthol connected to a glycine or glycine derivative, via an ester linkage. The groups on the N atom are referred to as R1 and R2, and R1 and R2 are independe...
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WO/2021/052942A1 |
The present invention relates to a process for the solidification of hexyl 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate, DHHB), wherein the process comprises a step (a) of applying a she...
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WO/2021/052271A1 |
A magnolol derivative and a preparation method therefor and an application thereof. The magnolol derivative has a structure represented by formula (1). The magnolol derivative has good water solubility, is colorless and transparent after...
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WO/2021/054421A1 |
Provided are: a crystal of a 1,3,5-triazine derivative or a solvate thereof; and a method for producing the same. The present invention pertains to a crystal of a compound represented by formula (I) or a solvate thereof, and a pharmace...
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WO/2021/052270A1 |
The present invention relates to the field of honokiol derivatives. Disclosed are a honokiol derivative, a preparation method therefor and the use thereof, wherein the derivative has a structure as shown in formula (I). The honokiol deri...
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WO/2021/004973A9 |
The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.
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WO/2021/049876A1 |
Provided is a method for producing L-homoserine, comprising a step of contacting an L-homoserine derivative with a solid acid catalyst.
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WO/2021/034742A1 |
Low primary amine (LPA) polyaspartic esters are provided which comprise a reaction product of an aliphatic diamine and an excess of a Michael addition receptor optionally, in the presence of a C1-C10 alcohol, wherein the low primary amin...
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WO/2021/017645A1 |
The present invention relates to the field of medicine synthesis, relates to a racemic preparation method for preparing a chiral β-amino acid and a derivative thereof, and particularly relates to a racemization method for a sitagliptin ...
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WO/2021/002407A1 |
Provided is a novel production method by which a fluoroalkyl group-containing compound can be efficiently synthesized. This method is for producing a compound represented by general formula (3) (Rf represents a C1-30 alkyl group substi...
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WO/2020/262455A1 |
The present invention provides a means for increasing the solubility of even a poorly soluble amino acid without changing to an expensive peptide and also without changing the pH, and is characterized in that at least two kinds of amino ...
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WO/2020/251812A1 |
Provided is a method of making ethylenediaminetetraacetic acid (EDTA) comprising the steps: (a) providing a reaction mixture (a) comprising ethylenediamine (EDA) and glycolonitrile (GN), wherein reaction mixture (a) comprises 0% to 0.1% ...
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WO/2020/251613A1 |
There is disclosed a process for the production of dodecanedioic acid and 11- aminoundecanoic acid, comprising: (1) reacting castor oil with a primary or secondary amine to form a amide; (2) isomerizing the amide in the presence of a cat...
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WO/2020/247853A1 |
This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulli...
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WO/2020/232597A1 |
The present invention provides a diamine compound, a preparation method therefor, and a thermosetting resin composition. The diamine compound has a structure as represented by structural formula (I). The structure of the diamine compound...
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WO/2020/220963A1 |
The present invention relates to the field of surfactants. Disclosed are a novel photodegradable amphiphilic molecule and synthesis method therefor. The synthesis of the photodegradable amphiphilic molecule has five steps of reactions: (...
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WO/2020/215895A1 |
The present invention relates to the technical field of medicine, and relates to derivatives represented by formula 1 and formula 2 in which a carboxylic acid group is introduced into the structure of ginkgolide B by means of a hydroxyl ...
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WO/2020/212399A1 |
The present invention relates to a method for the preparation of the preparation of ethyl (2S, 3S)-3-aminobicyclo [2.2.2] octane-2 -carboxylate from the β-keto ester (II) via a chiral transfer hydrogenation reaction in the presence of a...
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WO/2020/212585A1 |
This invention relates to a process for producing cyanoacetates using aspartic acid as a precursor.
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WO/2020/206367A1 |
Disclosed are methods for preparing deuterated analogs of D-serine and compounds useful for preparing deuterated analogs of D-serine.
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WO/2020/197875A1 |
The disclosure provides processes for preparing a compound of formula I, comprising reacting a compound of formula II with an aqueous acid in a solvent and at a temperature sufficient for at least about 48 hours to produce a compound of ...
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WO/2020/187256A1 |
Provided is a method for preparing β-alanine, the method comprising: preparing a β-alanine product from a reactant containing fumaric acid and aqueous ammonia in the presence of a catalyst, wherein the catalyst contains a catalyst comp...
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WO/2020/179817A1 |
[Problem] To provide a purification method that enables purification of a diamine compound to which none of purification methods by distillation, sublimation, or recrystallization are applicable, and that, as another purpose of the metho...
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WO/2020/169700A1 |
The present invention relates to two-component clear coat systems containing polyaspartic acid ester with primary amino groups and small amounts of fumaric acid dialkyl esters, to a method for preparing same and the use thereof for produ...
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WO/2020/167829A1 |
The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical...
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WO/2020/154891A1 |
The present invention provides a hydrolysis method of tert-butyl ester used in a gadolinium contrast agent. The hydrolysis method comprises the following steps: hydrolyzing the tert-butyl ester by using a catalyst; a preparation method f...
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WO/2020/155733A1 |
A central venous catheter, a preparation method therefor and a medical device comprising same. The central venous catheter comprises: a tube body and a coating layer formed on a surface of the tube body; the coating layer is formed by a ...
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WO/2020/144030A1 |
The present invention relates to a process for the synthesis of organosulfate salts of amino acid esters comprising the steps of reacting at least one lactam with at least 3 carbon atoms in the lactam ring with sulfuric acidin an aqueous...
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WO/2020/145627A1 |
Provided is a method for preparing glufosinate, comprising the steps of: preparing a first intermediate compound by reacting L-homoserine in the presence of a first acid catalyst; preparing a second intermediate compound by reacting the ...
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WO/2020/141141A1 |
The invention relates to novel cocrystals of (R)-Baclofen and processes for preparation thereof, and in particular to cocrystals of (R)-Baclofen with cinnamic acid, benzoic acid, salicylic acid and ferulic acid. It also refers to pharmac...
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WO/2020/140309A1 |
The present invention provides a method for preparing a 3-hydroxybutyrate amino acid salt compound, comprising: (1) adding ethyl 3-hydroxybutyrate or methyl 3-hydroxybutyrate into a reaction vessel, taking water as a solvent, adding a ba...
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WO/2020/134137A1 |
The present application relates to the field of drug synthesis, and disclosed thereby is a method for synthesizing R-3-chloroalanine methyl ester hydrochloride, comprising the following steps: 1) allowing d-serine to react with paraforma...
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WO/2020/127349A1 |
The present invention relates to a crumbly phase composition containing on total weight of the composition (i) 70 – 87 wt% of organic compounds and salts thereof containing 85 to 100 wt% on total organic compounds and salts thereof of ...
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WO/2020/095983A1 |
It was discovered that a cyclic sulfamidate could be produced by reacting an aminoacid derivative with a cyclization reagent. In addition, it was discovered that an O-substituted serine derivative could be produced by reacting the cyclic...
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WO/2020/070508A1 |
An amorphous form of a chelating agent is provided, in particular wherein the chelating agent comprises ethylenediaminetetraacetic acid/edetic acid (EDTA), diethylenetriaminepentaacetic acid/pentetic acid (DTPA), nitrilotriacetic acid (N...
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WO/2020/031201A1 |
The present invention relates to highly pure 6-aminohexanoic acid of formula-1 which is free of organic volatile impurities, caprolactam impurity and improved process for its preparation thereof. The present invention also relates to an ...
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WO/2020/029762A1 |
A preparation method for a fused tricyclic γ-amino acid derivative and an intermediate thereof, and a method for preparing an intermediate of the fused tricyclic γ-amino acid derivative. The fused tricyclic γ-amino acid derivative has...
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WO/2020/024763A1 |
Provided are a photocurable hydrophilic polymer, a coating composition based thereon, a hydrophilic lubricant coating, and a product. The photocurable hydrophilic polymer is formed by the copolymerization of a polymerizable photosensitiv...
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WO/2020/021077A1 |
The present invention relates to processes for the preparation of polymorphic form D2 of robenacoxib and to pharmaceutical formulations thereof. The polymorphic form of robenacoxib obtained by the processes of the present invention is ch...
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WO/2020/007774A1 |
The present invention relates to a process to prepare esters of an amino carboxylic acid of the formula (I) wherein R is an alkyl group containing 5 to 16 carbon atoms that may be branched or linear, k is a value of 1 to 3, m is an integ...
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WO/2020/006340A1 |
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...
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