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Matches 1 - 50 out of 14,030

Document Document Title
WO/2018/177383A1
The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a...  
WO/2018/176150A1
Novel methods for isolating fish roe/egg extracts, notably a coagulum and a sediment extract, enriched in phospholipids and omega-3 fatty acids are described. Novel compositions comprising omega-3 polyunsaturated fatty acids and micronut...  
WO/2018/174826A1
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B ...  
WO/2018/170322A1
Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate ("Compound 1"), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoat e ("Compound 2"),(3)...  
WO/2018/170306A1
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...  
WO/2018/165120A1
Methods of treating obesity symptoms, metabolic disorders or lipodystropy by administering carboxyalkylethers, in particular 6,6'-oxybis-(2,2'-dimethylhexanoic acid) or an ester, hydrate or salt thereof.  
WO/2018/164662A1
A resveratrol ester has the following structure: (I). R1, R2 and R3 are H or (II). Each R4 is independently a carbon chain of 2 to 4 carbon atoms comprising a terminal carboxylic acid moiety, a carbon chain of 1 to 5 carbon atoms compris...  
WO/2018/157842A1
The present invention provides a use of 2-(substituted phenylamino)benzoic acid FTO inhibitor in treating leukemia.  
WO/2018/157843A1
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix)...  
WO/2018/153876A1
Process for making solid methylglycine diacetate (MGDA) alkali metal salt (a), said process comprising the steps of (A) providing a 35 to 60% by weight aqueous solution of said MGDA salt having a temperature in the range of from 50 to 90...  
WO/2018/150906A1
This liquid crystal display device 10 is provided with: a pair of substrates which have conductive films 14, 15, respectively; a liquid crystal layer 12 which is arranged between the pair of substrates and contains liquid crystals; and a...  
WO/2018/145553A1
The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I), compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatricdisorder (e....  
WO/2018/148380A1
Methods of treating a seizure disorder with (1S,3S)-3-amino-4-(difluoromethylidene)cyclopentane-1-carbox ylic acid, or (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxyl ic acid (KT-II-115), or a pharmaceutically acceptable sal...  
WO/2018/139311A1
[Problem] To provide a novel diamine compound with which it is possible to synthesize a polyimide compound having high solubility in organic solvents and high melt moldability. [Solution] This diamine compound is characterized by being r...  
WO/2018/132066A1
Disclosed are compounds having the following formula: (I) wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of -2; or R is a quaternary amine having the following formula...  
WO/2018/116203A1
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...  
WO/2018/115434A1
The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate · glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providin...  
WO/2018/118838A1
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the en...  
WO/2018/107158A1
This present disclosure is directed to compounds of formula (I): where r, q, R1a, R1b, R1c, R1d, R1e, R2, R3, R4a, R5a, R5b, R6a, R6b, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceu...  
WO/2018/101329A1
The purpose of the present invention is to develop a therapeutic agent for inflammatory diseases such as inflammatory bowel disease and NASH, said therapeutic agent having few adverse effects and high efficacy. The present invention prov...  
WO/2018/096504A1
Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 a...  
WO/2018/097431A1
The present invention provides a composition for protecting the skin from heavy metals and formaldehyde, comprising at least one selected from the group consisting of trientine or trientine derivative of Formula (1), cyclen or cyclen der...  
WO/2018/090963A1
The invention provides a method for preparing a lisinopril intermediate, comprising: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting...  
WO/2018/090670A1
The present invention relates to a method for preparing a droxidopa intermediate (2S,3R)-3-(3,4-dibenzyloxyphenyl)-2-dibenzylamino-3-hydroxyp ropionate, comprising carrying out asymmetric hydrogenation to 3-(3,4-dibenzyloxyphenyl)-2-dibe...  
WO/2018/087753A1
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their int...  
WO/2018/087064A1
The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained...  
WO/2018/086053A1
The present invention discloses a γ-aminobutyric acid semihydrate crystal. The formula of the crystal is C4H9NO2·0.5H2O. The present invention further discloses a preparation method for the γ-aminobutyric acid semihydrate crystal, whe...  
WO/2018/082096A1
Provided are a new γ-propalanine crystal form and a preparation method therefor. The method comprises steps of: S1: adding a crude γ-propalanine into water to prepare a γ-propalanine solution having an initial concentration of 0.5 to ...  
WO/2018/085578A1
The present disclosure provides combinations of a VLA-4 inhibitor and an agent which interacts with a chemokine receptor, and methods of use thereof. In some embodiments, the disclosed combinations may be used in a method of mobilizing h...  
WO/2018/078053A1
The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formu...  
WO/2018/081372A1
Embodiments of the present disclosure provide for methods of treating cancer (e.g., leukemia), pharmaceutical compositions for treating cancer, methods of modulating cancer progression and development, and the like.  
WO/2018/080869A1
Methods of making polyamides from renewable materials, such as natural oils, are generally disclosed herein. In some embodiments, the polyamides are nylon-10. In some such embodiments, nylon-10 is made by polymerizing 10-aminodecanoic ac...  
WO/2018/068757A1
New anticancer and anti-obesity agents based on the cyclic peptide compounds are disclosed, and its preparation and application method for treating cancer and obesity diseases are also disclosed.  
WO/2018/067401A1
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a hig...  
WO/2018/064755A1
A transfection reagent composition comprising: 30-60MOL% of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL% structural lipid; a sterol and 0.1 to about 10MOL% of a stabilizing agent is provided. The reagent is pa...  
WO/2018/059279A1
Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw ...  
WO/2018/059427A1
Disclosed is a method for preparing 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl )ethoxy)phenyl)propanoic acid. In the method 9-carbazole ethanol mesylate and methyl 2-[2-(4-fluorobenzoyl)phenyl)amino]-3-(4-hydroxyphenyl)...  
WO/2018/062984A3
The present invention relates to an improved method for the synthesis of dendron-based chromatography resins. The method comprises incorporating dendrons, molecules having a branched structure, into the chromatography resin. In a second ...  
WO/2018/057290A1
The invention relates to a method for synthesizing amino acids or amino acid derivatives involving cross metathesis of functionalized olefins and a tandem amination-reduction process. Amino acids and amino acid derivatives present many i...  
WO/2018/050795A1
The present invention relates to a process for preparing a carotenoid mono-ester of the formula (I), including the stereoisomers of formula (I), wherein, R1 is e.g. hydrogen, C1-C20-alkyl, C2-C20-alkenyl, C4-C20-alkdienyl, C6-C20-alktrie...  
WO/2018/050046A1
Disclosed are a fused tricyclic γ-amino acid derivative and a medical use thereof, in particular, the present invention relates to a fused cyclic γ-amino acid derivative as shown in general formula (I), or a stereoisomer, solvate, meta...  
WO/2018/048882A1
The present invention provides a composition comprising the compound having the structure: Formula or a salt of the compound; 4-amino-2- [19F] -fluorobenzoic acid or a salt of 4-amino-2- [19F] -fluorobenzoic acid; and at least one accept...  
WO/2018/044987A1
The present disclosure relates to thiopicolinamides of Formula I and their use as fungicides.  
WO/2018/044991A1
This disclosure relates to thiopicolinamides of Formula I and their use as fungicides.  
WO/2018/041804A1
The present invention relates to a process for preparing 3-(2-hydroxybenzoyloxy)-4-(trimethylammonio)butyrobetaine hydrochloride of the formula (I), wherein the process comprises the reaction of 3-hydroxy-4-(trimethylammonio)butyrobetain...  
WO/2018/035610A1
The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging: (Formula (I)).  
WO/2018/037115A1
The present invention provides an aqueous composition comprising a silicon complex. The composition comprises (i) a monomeric organosilanolate that comprises 1 to 3 oxygen atoms per silicon atom, said organosilanolate being of formula (R...  
WO/2018/033883A2
The invention provides for a synthesised ester intermediate of formula 1. Formula 1 Wherein and wherein R may be a saturated or unsaturated fatty acid (C12-C20).  
WO/2018/025892A1
The purpose of the present invention is to provide a novel polymerizable triptycene derivative compound, which has a structure in which three benzene rings arranged around barrelene having a triptycene skeleton are capable of balanced ro...  
WO/2018/023116A1
Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify β-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable ...  

Matches 1 - 50 out of 14,030