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Matches 1 - 50 out of 14,246

Document Document Title
WO/2019/193607A1
The present invention relates to an improved process for the preparation of 3-isobutyl glutaric acid compound of formula-1 which is used as the key intermediate in the preparation of Pregabalin compound of formula-A. The present inventio...  
WO/2019/190823A1
The application relates to pharmaceutically acceptable salts of [3-(4- {2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lH-imidazol-4-yl}-p henoxy) -propyl]-diethylamine (Azeliragon) useful in the treatment of RAGE mediated diseases such as Alzh...  
WO/2019/184663A1
Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat trea...  
WO/2019/189110A1
A photosensitive resin composition, a cured film, a laminate, a method for manufacturing a cured film, and a semiconductor device, in which: a heterocycle-containing polymer precursor, a thermal base generator, and a radically polymeriza...  
WO/2019/184991A1
The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and th...  
WO/2019/175169A1
The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R1 R2N- CHR3-COOM or formula (II) R1 R2N-CHR3CHR3-COOM, in particular N,N- dimethyl glycinate salt, and th...  
WO/2019/175897A1
The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tau...  
WO/2019/108685A8
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein....  
WO/2019/168269A1
The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using ...  
WO/2019/168866A1
Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods,...  
WO/2019/166537A1
The present invention describes novel chelators (multidentate ligands) and precompounds for complexation of radiometals and non-radioactive counterparts, for use in radiopharmacy. The invention includes a process and a kit involving such...  
WO/2019/162469A1
The present invention relates to novel surface active compounds based on polyhydroxy acids. The compounds are of formula (I), where X represents hydrogen or a cation; n is 4 and Y represents a group of formula (II) or formula (III), wher...  
WO/2019/161526A1
Provided is a one-pot method for preparing twin dicarboxylic acid diamine complex platinum (II) derivatives, the method does not comprise the separation of intermediate carboplatin or carboplatin analogue. Compared with the prior art, ac...  
WO/2019/154797A1
Cleaning solution comprising a) one or more surfactant(s) according to Formula (I), wherein R1 is a linear, branched, or cyclic, saturated or unsaturated aliphatic group having from 3 to 7 carbon atoms or an aryl group having 6 or 7 carb...  
WO/2019/157426A1
The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermedia...  
WO/2019/154151A1
The present invention relates to an intermediate compound of formula II-1 or formula II-2 or a salt thereof, and a preparation method therefor. The present invention further relates to a process for synthesizing a compound of formula I b...  
WO/2019/148827A1
Provided by the present invention are a self-aligning material, a self-aligning liquid crystal material, and a method for manufacturing a liquid crystal panel. The self-aligning material of the present invention can align liquid crystal ...  
WO/2019/150323A1
Ionic liquids of creatine comprising a creatine anion and a cation., as well as their means of manufacture. Examples of the ionic liquids of creatine are choline creatinate, betaine ethyl ester creatinate and agmatine creatinate are desc...  
WO/2019/141246A1
The present disclosure relates to compounds useful in the treatment, imaging, and/or diagnosis of Epstein-Barr virus (EBV)-positive cells, such as cancer.  
WO/2019/137083A1
Disclosed in the present invention are a one-step process for producing a nylon 5X salt and a prepared high-purity nylon 5X salt. The process comprises: subjecting a lysine fermentation liquid to ion exchange and desorption to obtain a p...  
WO/2019/140038A1
The invention provides branched hydrophobes for the production of surfactants with improved properties over linear hydrophobes. The invention also provides branched C10-12 enals and aldehydes that are oxidized to branched fatty acids or ...  
WO/2019/135189A1
The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as descri...  
WO/2019/136025A1
Described herein are compounds, including pharmaceutically acceptable salts and solvates thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-a...  
WO/2019/131839A1
The present invention provides: a technique that makes it possible to introduce active components, in particular nucleic acids, into cells with excellent efficiency; and cationic lipids, etc. used in the technique. This compound or a sal...  
WO/2019/126859A1
The present invention relates to a compound derived from an amino acid that emits fluorescence that is seen in blue and can be seen in common filters. The present invention also relates to the method for obtaining said compound and the u...  
WO/2019/128918A1
Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in t...  
WO/2019/121946A1
The present invention relates to a zwitterionic pillararene derivative having a structure according to the following general formula (I). Thereby, residue R is a zwitterionic hydrocarbon chain. The invention further relates to uses of su...  
WO/2019/118072A1
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...  
WO/2019/113693A1
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are re...  
WO/2019/111845A1
The present invention addresses the problem of providing a polar compound which exhibits high chemical stability, high ability to align liquid crystal molecules, high solubility in a liquid crystal composition and a high voltage retentio...  
WO/2019/110371A1
The application relates to a process for the synthesis of organic sulfonic acid salts of amino acid esters comprising the steps of (i) reacting at least one lactam with at least 3 carbon atoms in the lactam ring with at least one organic...  
WO/2019/107533A1
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, C...  
WO/2019/108685A1
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein....  
WO/2019/108605A1
The present invention relates to compounds of Formulas I- IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characte...  
WO/2019/102054A1
Non-glycosidic analogues of alpha-galactosylceramide of formula (I), wherein A, Z, Ra, Rb and Rc have the meaning indicated in the description, as NKT cell activators.  
WO/2019/101040A1
The present invention relates to a combination product comprising dicycloplatin, a use of the combination product in preparing a drug for treating and/or preventing pain, inflammation, or a disease related to a virus, and a method for pr...  
WO/2019/089070A1
A method of affecting blood chemistry using a supplement may comprise: measuring a blood glucose level; determining a blood glucose level; and if the blood glucose level exceeds a threshold, administering a supplement comprising lysine, ...  
WO/2019/089069A1
A method of determining a stage of CKD may comprise: measuring a creatinine level; determining a creatinine level; determining a glomerular filtration rate; and determining a stage of CKD.  
WO/2019/080155A1
The present invention relates to a conjugate salt of N,N-dimethylglycine and a metal organic acid, a preparation method therefor, and an application thereof. The conjugate salt of N,N-dimethylglycine and a metal organic acid has the foll...  
WO/2019/080009A1
Disclosed are an N,N-dimethylglycine organic acid polyvalent metal ion compound salt or a solvate thereof, and an application thereof in preparation of novel feed additives and feeds. Also disclosed is a feeding composition comprising th...  
WO/2019/077332A1
The present invention provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein ≃ is selected from a single bond and a double bond, wherein ≃ is 1, 2 or 3, wherein R1, R2, R3, R4, R5, and R6 are each se...  
WO/2019/079759A1
The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or r...  
WO/2019/066412A1
The present invention relates to a method for preparing a glutamate-based surfactant. More specifically, the present invention provides a method for preparing a glutamate-based surfactant, the method being very economical and being capab...  
WO/2019/062665A1
The present invention discloses a linker compound, a polyethylene glycol-linker conjugate and a derivative thereof, and a polyethylene glycol-linker drug conjugate. The linker compound and the polyethylene glycol conjugate and a derivati...  
WO/2019/057951A1
The invention discloses a method for preparation of protected difluoromethylornithine by a difluoromethylation of dibenzaldimine ornithine ester using CHF3 and LiHMDS (lithium bis(trimethylsilyl)amide), which can be converted to a salt o...  
WO/2019/057626A1
The present invention relates to polyaspartic acid ester compositions which contain polyaspartic acid esters with primary amino groups and small amounts of fumaric acid dialkyl esters, to a method for preparing same and the use thereof a...  
WO/2019/057627A1
The present invention relates to a method for purifying polyaspartic acid ester compositions and to the provision of polyaspartic acid ester compositions that contain 0.01 to < 2% by weight fumaric acid dialkyl esters.  
WO/2019/059344A1
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...  
WO/2019/048590A1
The present invention relates to a carbonic acid adduct (CAA) comprising carbonic acid, at least one amine, and optionally at least one salt, said adduct being producible by a method comprising the following steps: a) providing a solutio...  
WO/2019/026004A3
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  

Matches 1 - 50 out of 14,246