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Matches 1 - 50 out of 14,200

Document Document Title
WO/2019/137083A1
Disclosed in the present invention are a one-step process for producing a nylon 5X salt and a prepared high-purity nylon 5X salt. The process comprises: subjecting a lysine fermentation liquid to ion exchange and desorption to obtain a p...  
WO/2019/140038A1
The invention provides branched hydrophobes for the production of surfactants with improved properties over linear hydrophobes. The invention also provides branched C10-12 enals and aldehydes that are oxidized to branched fatty acids or ...  
WO/2019/135189A1
The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as descri...  
WO/2019/136025A1
Described herein are compounds, including pharmaceutically acceptable salts and solvates thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-a...  
WO/2019/131839A1
The present invention provides: a technique that makes it possible to introduce active components, in particular nucleic acids, into cells with excellent efficiency; and cationic lipids, etc. used in the technique. This compound or a sal...  
WO/2019/126859A1
The present invention relates to a compound derived from an amino acid that emits fluorescence that is seen in blue and can be seen in common filters. The present invention also relates to the method for obtaining said compound and the u...  
WO/2019/128918A1
Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in t...  
WO/2019/121946A1
The present invention relates to a zwitterionic pillararene derivative having a structure according to the following general formula (I). Thereby, residue R is a zwitterionic hydrocarbon chain. The invention further relates to uses of su...  
WO/2019/118072A1
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...  
WO/2019/113693A1
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are re...  
WO/2019/111845A1
The present invention addresses the problem of providing a polar compound which exhibits high chemical stability, high ability to align liquid crystal molecules, high solubility in a liquid crystal composition and a high voltage retentio...  
WO/2019/110371A1
The application relates to a process for the synthesis of organic sulfonic acid salts of amino acid esters comprising the steps of (i) reacting at least one lactam with at least 3 carbon atoms in the lactam ring with at least one organic...  
WO/2019/107533A1
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, C...  
WO/2019/108685A1
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein....  
WO/2019/108605A1
The present invention relates to compounds of Formulas I- IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characte...  
WO/2019/102054A1
Non-glycosidic analogues of alpha-galactosylceramide of formula (I), wherein A, Z, Ra, Rb and Rc have the meaning indicated in the description, as NKT cell activators.  
WO/2019/101040A1
The present invention relates to a combination product comprising dicycloplatin, a use of the combination product in preparing a drug for treating and/or preventing pain, inflammation, or a disease related to a virus, and a method for pr...  
WO/2019/089070A1
A method of affecting blood chemistry using a supplement may comprise: measuring a blood glucose level; determining a blood glucose level; and if the blood glucose level exceeds a threshold, administering a supplement comprising lysine, ...  
WO/2019/089069A1
A method of determining a stage of CKD may comprise: measuring a creatinine level; determining a creatinine level; determining a glomerular filtration rate; and determining a stage of CKD.  
WO/2019/080155A1
The present invention relates to a conjugate salt of N,N-dimethylglycine and a metal organic acid, a preparation method therefor, and an application thereof. The conjugate salt of N,N-dimethylglycine and a metal organic acid has the foll...  
WO/2019/080009A1
Disclosed are an N,N-dimethylglycine organic acid polyvalent metal ion compound salt or a solvate thereof, and an application thereof in preparation of novel feed additives and feeds. Also disclosed is a feeding composition comprising th...  
WO/2019/077332A1
The present invention provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein ≃ is selected from a single bond and a double bond, wherein ≃ is 1, 2 or 3, wherein R1, R2, R3, R4, R5, and R6 are each se...  
WO/2019/079759A1
The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or r...  
WO/2019/066412A1
The present invention relates to a method for preparing a glutamate-based surfactant. More specifically, the present invention provides a method for preparing a glutamate-based surfactant, the method being very economical and being capab...  
WO/2019/062665A1
The present invention discloses a linker compound, a polyethylene glycol-linker conjugate and a derivative thereof, and a polyethylene glycol-linker drug conjugate. The linker compound and the polyethylene glycol conjugate and a derivati...  
WO/2019/057951A1
The invention discloses a method for preparation of protected difluoromethylornithine by a difluoromethylation of dibenzaldimine ornithine ester using CHF3 and LiHMDS (lithium bis(trimethylsilyl)amide), which can be converted to a salt o...  
WO/2019/057626A1
The present invention relates to polyaspartic acid ester compositions which contain polyaspartic acid esters with primary amino groups and small amounts of fumaric acid dialkyl esters, to a method for preparing same and the use thereof a...  
WO/2019/057627A1
The present invention relates to a method for purifying polyaspartic acid ester compositions and to the provision of polyaspartic acid ester compositions that contain 0.01 to < 2% by weight fumaric acid dialkyl esters.  
WO/2019/059344A1
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...  
WO/2019/048590A1
The present invention relates to a carbonic acid adduct (CAA) comprising carbonic acid, at least one amine, and optionally at least one salt, said adduct being producible by a method comprising the following steps: a) providing a solutio...  
WO/2019/026004A3
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/037591A1
The present invention relates to a melphalan hydrochloride crystal form, a preparation method therefor and an application thereof. The preparation method is convenient to operate, has a short reaction period, reduces environmental pollut...  
WO/2019/040177A1
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...  
WO/2019/038764A1
The present invention relates to lyso-diacylglyceryltrimethylhomoserine (lyso- DGTS) or derivatives thereof for use in the treatment of atherosclerotic cardiovascular disease, and further provides particular such lyso-DGTS derivatives.  
WO/2019/036028A1
Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G1, G1', G2, G2', G3, L1, L1', L2, L2', X, X', Y and Y' are as defined herein. Use of the compound...  
WO/2019/036008A1
Compounds are provided having the following structure: [Formula should be inserted here] or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compoun...  
WO/2019/036030A1
Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein X, Y, L1, L2, L3, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipi...  
WO/2019/036000A1
Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, L1, L2, G1, G2, G3, a, b, c and d are as d...  
WO/2019/034114A1
Provided is a composition containing L-carnitine-β-hydroxybutyrate wherein the L-carnitine and β-hydroxybutyrate compounds in the molecule exist in the form of an intramolecular salt, and the composition is used for losing weight and p...  
WO/2019/033216A1
There is provided a method for inhibiting growth of a microbial pathogen of a plant. The method includes applying to the plant a combination including a nitrogen-bearing macrocyclic compound which is a singlet oxygen photosensitizer sele...  
WO/2019/031472A1
[Problem] The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. [Solution] The invention provides: a compound represented by formula (I) o...  
WO/2019/030158A1
The present invention relates to cocrystalsof2-[(1R,6R)-6-isopropenyl-3-methylcyclohex- 2-en-1-yl]-5-pentylbenzene-1,3-diol and a zwitterion coformer, processes for their preparation, and their use as a medicament and for the purificatio...  
WO/2019/023791A1
An aqueous formulation comprising levothyroxine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients and methods of using such formulation to treat a subject.  
WO/2019/027459A1
Nitric oxide levels in the blood stream are maintained while delivering, in sustained release, medication or therapeutic agent such as an nsaid (e.g. aspirin). This is accomplished by processing, at room temperature or in a low pressure ...  
WO/2019/026004A2
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/015794A1
The present invention relates to a chemical compound according to general formula (1).  
WO/2019/016354A1
The invention relates to a novel amino acid having a norbornene group and polypeptide comprising the novel amino acid compounds. The invention also relates to a method of producing polypeptides comprising a norbornene group and to the us...  
WO/2019/012545A1
Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic mo...  
WO/2019/014207A1
The present invention relates to a composition comprising a lithium salt of an N-substituted glycine compound and a carrier, wherein the lithium salt of the N-substituted glycine compound is of Formula (I) in which R1, R2, and R3 each ar...  
WO/2019/007944A1
The present invention relates to a methylglycine-N,N-diacetic acid trisodium salt in the form of a crystal, comprising a crystalline modification referred to as crystal type III characterized by the below reflections when analyzed with X...  

Matches 1 - 50 out of 14,200