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Matches 1 - 50 out of 15,787

Document Document Title
WO/2019/193846A1
Provided is a novel production method for a compound. This production method for a compound (1) represented by the following general formula (1) (in the formula, R1 and R2 are independent of each other and are a fluorine atom or an organ...  
WO/2019/192614A1
The described invention relates to sarecycline, related compounds, intermediates and salts thereof and processes for preparing the same.  
WO/2019/185877A1
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...  
WO/2019/188508A1
Provided is a compound capable of thickening a fluidic organic substance to a desired viscosity, and uniformly stabilizing the compositional makeup thereof. The compound according to the present invention is represented by formula (1). I...  
WO/2019/189277A1
A method for producing an amide compound, said method comprising a step for contacting optionally treated microbial cells containing nitrile hydratase with a nitrile compound in an aqueous medium in a first reactor to give a liquid react...  
WO/2019/179436A1
The present invention relates to the field of pharmaceutical chemistry. Disclosed are an acid amide compound and use thereof in the treatment of cancers. Disclosed is use of an acid amide compound represented by formula (I), or its cryst...  
WO/2019/170791A1
The invention discloses a method for the preparation of 2-chloro acetoacetic acid amide or ester by a reaction of acetoacetic acid amide or ester with trichloroisocyanuric acid in the presence of amylene and in the solvent acetone.  
WO/2019/162289A1
The present invention is directed to compounds of the general formula (I) and salts thereof wherein X- is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1...  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/159596A1
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...  
WO/2019/146508A1
A method for producing 2-chloroacetoacetamide, characterized in that acetoacetamide and trichloroisocyanuric acid are reacted in an ethanol solvent (wherein the amount of trichloroisocyanuric acid is 0.30–0.38 mol, inclusive, times the...  
WO/2019/136782A1
Disclosed is a tri-cationic viscoelastic surfactant, a preparation method therefor, an application thereof, and a clean fracturing fluid. The invention utilizes N,N'-dimethyl-1,3-propanediamine and epichlorohydrin to prepare an intermedi...  
WO/2019/138362A1
The field of this invention relates to a novel process, suitable for industrial scale manufacture, for the preparation of 4-(4-aminophenyl)morpholin-3-one of Formula (I), the key intermediate of rivaroxaban according to the scheme. In th...  
WO/2019/127649A1
Disclosed is a self-aligned liquid crystal adjuvant, comprising an adjuvant I as shown in formula 1 and an adjuvant II as shown in formula 2. Further disclosed is a self-aligned liquid crystal mixture comprising the above self-aligned li...  
WO/2019/127994A1
The present invention relates to a sacubitril sodium salt as represented by formula IV, a eutectic of sacubitril free acid and acetic acid, a crystal form of the eutectic and a preparation method for the crystal form, and a method for us...  
WO/2019/128872A1
Disclosed are a pyrazole amide compound-benzamide compound of general formula (I) having a pesticidal activity, and an intermediate of general formula (II) used for preparing the compound of general formula (I), wherein R1 is selected fr...  
WO/2019/125930A1
Disclosed is a composition including a carbonyl-substituted alkene including a dicarbonyl compound having an alkylene group between the carbonyl groups. At least one carbonyl group of the dicarbonyl compound includes an amide group. Anot...  
WO/2019/123125A1
The present disclosure relates to a process for the manufacturing of a compound comprising a (meth)acryloyl group, wherein the process comprises the steps of: a) providing a multi-screw extruder comprising a reaction chamber; b) providin...  
WO/2019/120235A1
The present invention relates to a class of phenylcarboxylic acid derivatives, a preparation method therefor and a use thereof, more specifically relating to a class of phenylcarboxylic acid derivatives as shown in formula I, a preparati...  
WO/2019/113435A1
The disclosure provides a process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2019/110499A1
The invention relates to a process for preparing at least one di- or polyformamide comprising at least two -NHCHO groups by reacting at least one primary di- or polyamine with carbon dioxide in the presence of hydrogen and at least one c...  
WO/2019/108542A1
Processes for preparing acetylated amphetamine derivatives and, in particular, processes for preparing L-lysine-D-amphetamine dimesylate from D-amphetamine salts.  
WO/2019/097539A1
The present invention discloses cost-effective, industrially efficient and safe process synthesis of levomilnacipran that is devoid of 1-phenyl-1- diethylaminocarbonyl-2- chloromethylcyclopropane.  
WO/2019/096325A1
The present invention relates to a bisamide complex, and a method for quickly detecting organophosphate and carbamate pesticides. The complex prepared in the present invention can effectively detect trace quantities of organophosphate an...  
WO/2019/091975A1
The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.  
WO/2019/081972A1
Preparation of a salt of 4-nitrophenyl ethylamine with (R)-mandelic acid and its use for the synthesis of mirabegron is disclosed. 4-Nitrophenyl ethylamine (1) is prepared by reduction of 4-nitrobenzyl cyanide (7) in a solvent with the u...  
WO/2019/077104A1
The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a strai...  
WO/2019/072864A1
The present invention pertains to a process for the preparation of polymorph form X of agomelatine, which comprises providing agomelatine, and crystallizing agomelatine in the presence of at least one of an acid and a salt thereof, and t...  
WO/2019/074158A1
The present invention relates to a novel pseudoceramide compound and a use thereof. The pseudoceramide of the present invention has anti-oxidizing, anti-inflammatory, whitening, and moisturizing effects, is economical through a simple sy...  
WO/2019/066644A1
The invention relates to the field of medicinal chemistry, more in particular to methods for providing highly pure, pharmaceutical grade synthetic Palmitoylethanolamine (PEA), to pure PEA preparations obtainable thereby, and the uses the...  
WO/2019/044946A1
A method for producing a compound represented by formula (C), the method comprising a step for converting a compound represented by formula (B) (wherein R1 represents an amino group protected by a protecting group) by intramolecular cycl...  
WO/2019/042086A1
The present invention discloses a method and a device for purifying 2-nitro-4-acetamidoanisole and a product purified thereby. The 2-nitro-4-acetamidoanisole is prepared by using p-acetaminoanisole as a raw material to perform mixed acid...  
WO/2019/038638A1
Disclosed herein, in part, are processes of large scale purification of a L- dopamide pharmaceutically acceptable salt and processes of making a purified pharmaceutically acceptable L-dopamide and pharmaceutically acceptable L-dopamide s...  
WO/2019/035453A1
Provided is a catalyst represented by general formula (1). In general formula (1), R1-R14 each independently represent a hydrogen atom or a substituent.  
WO/2019/028198A1
Methods may include quantifying the concentration of residual free amine and/or free carboxylic acid in a product mixture prepared from a reaction of a multireactive species and a fatty reagent; verifying that the concentration for the f...  
WO/2019/022203A1
The present invention provides: an aromatic amine compound capable of satisfactorily forming a cured product having exceptional alkali resistance by reaction with an epoxy compound; a curing agent for an epoxy compound, the curing agent ...  
WO/2019/010016A1
There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yie...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/002042A1
The present invention relates to a method for preparing substituted 4-aminoindane derivatives of the general formula (I) by rearrangement of compounds of the formula (II) in HF, wherein R1, R2, R3, R4, and R5 have the definitions as spec...  
WO/2018/233562A1
The present invention relates to an intermediate for preparing oseltamivir and an isomer thereof. The intermediate of the present invention is prepared by means of neighboring group participation at room temperature under the conditions ...  
WO/2018/228546A1
Disclosed is a highly efficient contrast agent synthesizing method, comprising the following steps: (I) preparing an intermediate mixture of a compound represented by formula (II) and a compound represented by formula (I) and/or formula ...  
WO/2018/220646A1
The present invention relates to an improved process for the preparation of (2S)-2- [(4R)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl] butanamide compound of formula- 1, its intermediates, novel salt compounds of intermediates of the compoun...  
WO/2018/221604A1
The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine, which is a production intermediate of the pyrimidine compound; a phenylethyl...  
WO/2018/214980A1
The present invention provides a novel aromatic amide as a Kv2.1 inhibitor and a preparation method, pharmaceutical composition, and use thereof. In particular, the present invention relates to an aromatic amide derivative shown in gener...  
WO/2018/210274A1
Provided is a novel, mild, highly effective, and economic process for co-producing formamide and monofunctional or polyfunctional acrylamide compounds.  
WO/2018/212216A1
Provided is a method for producing an optically active isomer, the method including an asymmetry induction step in which an asymmetry-inducing agent is caused to act on chiral molecules having an enantiomeric-excess half-life period less...  
WO/2018/205299A1
Disclosed are a 4,5-disubstituted-1-hydro-pyrrole(2,3-f)quinolone-2,7,9-tric arboxylate compound, an analogue of same or a derivative of same, the structure thereof is as represented by formula I: where R1 and R4 respectively are indepen...  
WO/2018/206879A1
Process for the synthesis of N-acyl derivatives of amino acids and oligopeptides, without the use of solvents or acid chloride. The invention also relates to cosmetic compositions containing same.  
WO/2018/206239A1
A poly-lysine derivative obtained by a process comprising the steps of (a) heating an aqueous lysine solution to boiling (b) increasing temperature of the aqueous lysine solution to a reaction temperature in the range of about 105°C to ...  
WO/2018/207120A1
The present invention is directed towards a process for the preparation of 4- fluoro-2-methoxy-5-nitroaniline (I) or salts thereof, wherein, 4-fluoro-2-methoxy aniline (III) is protected to obtain N-protected-(4-fiuoro-2-methoxy)aniline ...  

Matches 1 - 50 out of 15,787