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WO/2001/032605A1 |
Disclosed herein is a method for making compounds having structural formulae (I) of (II) wherein: X is (a) phenyl; lower phenylalkoxy; phenoxy; or benzyl; or (b) one substituent from group (a) and one or more substituents selected from C...
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WO/2001/032599A1 |
Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II) wherein: X is a) phenyl; lower phenylalkoxy, phenoxy; or benzyl; or b) one subtituent from group a) and one or more substituen...
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WO/2001/027073A1 |
The present invention relates to a continuous process of preparing N-alkyl-nitratoethylamines and a production plant for carrying out a continuous process of preparing such N-alkyl-nitratoethylamines.
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WO/2001/014412A1 |
The present invention relates generally to new compositions of matter and methods of using such compositions of matter for investigational or therapeutic purposes, and more particularly to compositions that a) mimic $g(b)-strands, b) blo...
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WO/2001/012604A1 |
Use of compounds of general formula (I) or salts thereof as phytopathogenic fungicides wherein the various radicals and substituents are as defined in the description, pesticidal compositions containing them and method for combatting pes...
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WO/2001/007020A2 |
The invention relates to the use of carboxylic acid amides of general formula (I) for inhibiting telomerase, wherein A, B and R¿1? to R¿5? are defined as per claim (1). The invention also relates to novel carboxylic acid amides of gene...
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WO/2001/005753A1 |
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R?1¿, R?2¿ and R?3¿ have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to...
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WO/2001/002351A2 |
The invention concerns a method for preparing a hydroxylated arylhydrazine using intermediates of general formula (II) wherein: A, X¿2?, Y¿1?, Y¿2? and n are as defined in Claim 1. The invention also concerns a method for obtaining in...
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WO/2001/000623A1 |
Method of producing compounds of formula (I), wherein R¿1? is hydrogen or C¿1?-C¿4?-alkyl; R¿2? is hydrogen, C¿1?-C¿8?-alkyl, C¿3?-C¿6?-cycloalkyl, or a radical -N(R¿3?)R¿4?; or R¿2? and R¿6? together are -CH¿2?-CH¿2?-S-; R...
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WO/2000/078846A1 |
Degradable cross-linkers which are used to form polymer networks which degrade under aqueous conditions are described. These cross-linkers comprise a monodispersed central polyacid, monodispersed monomeric or monodispersed oligomeric deg...
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WO/2000/078711A1 |
N-Nitrosohydroxylamine compounds exhibiting minimal or no degradation are disclosed. The N-nitrosohydroxylamines can be stabilized in the presence of a compound capable of removing water from the environment.
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WO/2000/071502A1 |
Hydrazide derivatives represented by general formula (I) which have an inhibitory effect on apo B-associated lipoprotein secretion: wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿ and R?9¿ represent each H, etc.; the ring...
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WO/2000/069805A1 |
The invention relates to processes for the preparation of compounds of formula (I), wherein R?1¿ and R?2¿ each independently represent a halogen atom.
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WO/2000/069810A1 |
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or preventio...
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WO2000046235B1 |
The invention relates to novel betulinic acid derivatives of structural formula having modifications at C2, C3, C17, C20 and/or C29 positions, said derivatives being useful as inhibitors of tumor/cancer cells; process for preparation of ...
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WO/2000/053583A1 |
The present invention comprises small molecular weight, non-peptidic inhibitors of formula (I) of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
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WO/2000/048988A1 |
Compounds of formula (1) and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, are effective inhibitors of the binding of VCAM-1 to VLA-4 $i(in vivo) and are useful in treating ...
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WO/2000/046210A2 |
The invention relates to a process for the preparation of a compound of formula (I): wherein W, R?1¿, R?2¿ and R?3¿ are as defined in the description.
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WO/2000/041798A1 |
A direct fixation of NO¿2? and N¿2?O¿4? at room temperature and atmospheric pressure is described using bis(diorganoamino)magnesium compounds formed from reactions between donor-solvent free diorganomagnesium compounds and primary or ...
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WO/2000/039055A1 |
Novel polyaromatic hydrocarbon quenching reagents of Formula (I), wherein: P is a polyaromatic hydrocarbon of low chemical reactivity which is soluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that ...
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WO/2000/037478A1 |
The invention relates to novel ligands and complexes for the homogeneous catalytic enantioselective hydrogenation. The invention specifically concerns the ligands of general formula (I). Another aspect of the invention relates to the com...
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WO/2000/027813A1 |
A compound of formula (I) wherein R is H or -N=N-2-carboxyphenyl; A is (CH¿2?)¿n? or -CH=CH-, wherein n is an integer from 0 to 10, or A may also be -CH(COOH)- when R is -N=N-2-carboxyphenyl; and X is a radical selected from the group ...
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WO/2000/027800A1 |
CCR-3 receptor antagonists and novel methods for their use are provided.
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WO/2000/027835A1 |
CCR-3 receptor antagonists and novel methods for their use are provided.
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WO/2000/027821A1 |
The invention relates to a method for producing substituted hydroxypyrazoles and new intermediate products. It relates in particular to a method for producing compounds of formula (I) in which R?1¿ is hydrogen, an aliphatic group with b...
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WO/2000/027843A1 |
CCR-3 receptor antagonists and novel methods for their use are provided.
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WO/2000/024697A1 |
Aldehyde derivatives of polyethylene glycols and methods of making thereof are disclosed. These aldehyde derivatives can be used to make polyethylene glycol-hydrazines, polyethylene glycol-thiols, polyethylene glycol amines, and branched...
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WO/2000/020382A1 |
Novel compounds are provided having the structural formula R[-N(NO¿2?)-L-R?1¿]¿n? wherein R, L, R?1¿ and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing a...
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WO/2000/020381A1 |
A method of purifying a compound of forumla (I) where R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkylthio, haloalkylthio, alkoxy, haloalkoxy, alkylsulphonyl or haloalkylsulp...
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WO/2000/016766A1 |
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or h...
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WO/2000/011039A2 |
An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenchin...
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WO/2000/003975A2 |
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...
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WO/2000/003973A1 |
The invention relates to compounds of formula (I), wherein X, Y, Z, R?1¿ and R?2¿ have the meanings cited in claim 1, and to the salts and solvates thereof. Said compounds can be used as integrin inhibitors, especially in the prophylax...
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WO/1999/046238A1 |
A hydrazide fixed to a resin represented by formula (1): P-Q-CO-NH-NH¿2? wherein P represents a main chain of a polymer constituting the resin and Q represents a hydrocarbon side chain optionally substituted with a substituent which may...
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WO1998034632A9 |
Carrier compounds and compositions which are useful in the delivery of active agents are provided. The carrier compound can be an amino acid derivative, and the active agent can be a peptide, mucopolysaccharide, carbohydrate, or lipid. M...
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WO/1999/043643A2 |
A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition met...
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WO/1999/037600A1 |
The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).
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WO/1999/031070A1 |
The invention relates to substituted phenylpyrazolones of formula (I) in which the substituents have the following meanings: Y represents halogen, alkyl, halogen alkyl or alkoxyl; n represents 0, 1 or 2, whereby the radical Y can be diff...
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WO/1999/026584A2 |
Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agen...
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WO/1999/019296A1 |
Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and...
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WO/1999/001428A1 |
Hydrazine derivatives of formula (I) wherein Y signifies CO or SO¿2?; R?1¿ signifies lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R?2¿ signifies lower alkyl, halo-lower alkyl, a...
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WO/1999/001421A1 |
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of formula (I) where R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, and R¿6? are hydrogen or substituent groups such as alkyl, and where R¿7? is hydrogen or an organic radical, a...
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WO/1998/056849A1 |
Polyester polyols which contain at least one dihydrazide linkage -C(=O)-NHNH-C(=O)- reduce the incidence of scorching when used as a reactant in the manufacture of polyurethane foam. Also disclosed are compounds of structures (2) D-HN(-N...
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WO/1998/049152A1 |
Compounds of formula (I), wherein R?l� is an aromatic or a heteroaromatic ring; R?2� and R?3� are H, C�1?-C�8?alkyl, aryl, arylC�1?-C�8?alkyl, or heteroaryl; R?4� is an aromatic or a heteroaromatic ring or an amine; W, X,...
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WO/1998/046342A2 |
A description is given of an extrusion process for the preparation of a low-dust stabiliser, using a subcooled melt as granulation liquid, as well as of amorphous modifications of different stabilisers, including 2,2'-methylenebis(4-[1,1...
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WO/1998/029383A1 |
The invention concerns 2-benzoyl-cyclohexan-1,3-diones of formula (I), in which R?1�, R?2� stand for hydrogen, nitro, halogen, cyano, rhodano, alkyl, halogen alkyl, alkoxyalkyl, alkenyl, alkinyl, -OR?5�, -OCOR?6�, -OSO�2?R?6�...
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WO/1998/019996A1 |
The invention is directed to nitric oxide (NO) donor compounds (such as those of formulae 1-4) and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, whe...
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WO/1998/017267A1 |
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...
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WO/1998/015521A1 |
The invention relates to new compound derived from pentaerythritol of the general formula (I), (XIV), (XVI), (XIX) and (XXIII), the subtituents of which have the meaning given in the description, which can be used as pharmaceutical activ...
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WO/1998/008496A1 |
A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and therefore delivers nitric oxide to the specific...
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