Acyclic or Carbocyclic Compounds

Matches 351 - 400 out of 1,476	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1998/003473A1	COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES The present invention relates to novel compounds of general formula (I), pharmaceutical compositions containing them, a method of stimulating the release of growth hormone from the pituitary, a method for increasing the rate and extent o...
WO/1997/049667A1	INHIBITORS OF OLEAMIDE HYDROLASE Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of...
WO/1997/047633A1	ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRAL LIGANDS The present invention relates to rigid chiral ligands useful in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed...
WO/1997/044330A1	PROCESS FOR PREPARING BIOLOGICALLY ACTIVE DERIVATIVES OF 1,2,4-TRIAZOL AND INTERMEDIARIES USEFUL IN THIS PROCESS There is disclosed a process for the preparation of fluconazol which is a well-known antifungic agent, as well as pharmaceutically acceptable salts thereof, wherein a new compound having the formula (IV) in which R is H, benzyl, tripheny...
WO/1997/043251A1	COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES Compounds of formula (I), wherein R' is hydrogen or alkyl; A is adamantyl or a mono-, bi- or tricyclic residue optionally unsaturated, a heterocyclic residue and/or substituted by hydroxy, alkanoyloxy, amino, aminoalkyl, halogen, alkyl, ...
WO/1997/040029A1	ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES There are described compounds of formula (I*) wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubsituted or substituted by one or more lower alkoxy radica...
WO/1997/036480A1	COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
WO/1997/033862A1	PESTICIDAL HYDRAZIDE DERIVATIVES A compound of formula (I) wherein R is a) phenyl; phenyl (C1-C4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of halogen, nitro, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 haloalkyl,...
WO/1997/024316A1	METHOD FOR SYNTHESIZING ARYL HYDRAZINE THROUGH REDUCTION OF A DIAZO COMPOUND DERIVATIVE The invention involves a procedure for synthesizing aryl hydrazine through reduction of a diazo derivative. The distinguishing feature of the method is that it involves at least the following step: c) bringing a diazo derivative into con...
WO/1997/023446A1	IMPROVED PROCESS FOR HYDROCYANATION OF DIOLEFINS AND ISOMERIZATION OF NONCONJUGATED 2-ALKYL-3-MONOALKENENITRILES A process for the hydrocyanation of diolefins employing a catalyst comprising the combination of a zero-valent nickel compound and certain bidentate phosphorus compounds, and a process for isomerizing 2-alkyl-3-monoalkenenitrile to form ...
WO/1997/022579A1	PROCESS FOR PREPARATION OF HYDRAZIDES A process for producing a hydrazide of formula (1.0) is disclosed. The process comprises reacting a hydrazone of formula (2.0) or (2.1), wherein said hydrazone is in toluene, with a mixture of Grignard reagents, wherein said Grignard rea...
WO/1997/021432A1	USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is select...
WO/1997/016433A1	PROTEASE INHIBITORS The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, includin...
WO/1997/016177A1	METHOD OF INHIBITING CATHEPSIN K A novel cathepsin K crystalline structure is identified. Also disclosed are methods of identifying inhibitors of this protease and methods of inhibiting cathepsin K using inhibitors with certain structural, physical and spatial character...
WO/1997/015280A1	USE OF AT LEAST ONE NO SYNTHASE INHIBITOR FOR TREATING SENSITIVE SKIN The use of at least one NO synthase inhibitor as the active principle in a cosmetic composition for treating and/or preventing sensitive skin is disclosed. The use of at least one NO synthase inhibitor for preparing a pharmaceutical and ...
WO/1997/012851A1	METHOD FOR INHIBITING POLYMERIZATION OF VINYL COMPOUNDS A method for inhibiting the polymerization of vinyl compounds by using N-nitrosophenylhydroxylamine or salts thereof, wherein further use is made of either a copper salt or a combination of a metal dialkyldithiocarbamate with at least on...
WO/1997/007091A1	FLUOROBUTENIC ACID HYDRAZIDES The invention concerns novel fluorobutenic acid hydrazides of formula (I) in which: Y stands for C=O, C=S or SO2; R1 stands for hydrogen or halogen; and R2 stands for alkyl, alkyl halide, alkoxyalkyl, alkylthioalkyl, cycloalkyl, alkenyl,...
WO/1997/002257A1	HYDRAZINE DERIVATIVES Compounds having structural formula (I) or (II), wherein R is C1-C6 alkoxy or C1-C6 alkyl; R1 is fluorenyl, thienyl, pyridyl or thiazolyl, unsubstituted or substituted by one or more substituents selected from C1-C4 alkoxy, C1-C4 alkyl, ...
WO/1996/041795A1	BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc., and represented by general formula (I), wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower alkyl, etc., R3 ...
WO/1996/036326A1	N-NITROSO-N-SUBSTITUTED HYDROXYLAMINES AS NITRIC OXIDE DONORS Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, a steroid, or a catechola...
WO/1996/033163A1	CHIRAL HYDRAZINE DERIVATIVES Chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id), wherein R1 and R2 are independently C1-C10 alkyl; R3 is H or R4 wherein R4 is a hydroxy protecting group; and Z is H, -CHO, -C(O)OC(CH3)3 or -C(O)OCH2C6H5; are disclo...
WO/1996/032382A1	1-PHENYLPYRAZOLE-3-CARBOXAMIDES ACTING ON NEUROTENSIN RECEPTORS Substituted 1-phenylpyrazole-3-carboxamides of formula (I) are disclosed for use as compounds having high affinity for human neurotensin receptors.
WO/1996/017824A2	COMPOUNDS AND METHODS FOR MONOSACCHARIDE ANALYSIS Compounds and methods are provided for use in monosaccharide analysis. The present invention discloses hydrazino monosaccharide derivatives. Methods for preparing and using hydrazino monosaccharide derivatives for structural analysis of ...
WO/1996/017840A1	HETEROCYCLYL SUBSTITUTED HYDROXYACETAMIDE DERIVATIVES AS FONGICIDES Compounds of formula (I) wherein Q is optionally substituted heterocyclyl; Z is optionally substituted hydroxy or mercapto; E is (i) CO--N(R2), (ii) CS--N(R2) or (iii) C(SR2) = N; W is O, N(R3), optionally substituted methylene or ethyle...
WO/1996/012482A1	HYDROXYETHYL AMINIMIDES This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possesses the structural diversity element G, the quaternary nitrogen possesses structural diversity ...
WO/1996/011905A1	FLUORINATED COMPOUND AND USE THEREOF A fluorinated polyether compound represented by the following general formula (1): X-(Rf1)-(CF2)x-(CH2)y-{CHR-CH2}z1-Y1-Z1 or (1'): Z2-Y2-{CH2-CHR}z2-(CH2)y-(CF2)x-(Rf2)-(CF2)x-(CH2)y-{CHR-CH2 }z3-Y3-Z3, a lubricating oil, and a magnetic...
WO/1996/003982A1	AZAASPARTIC ACID ANALOGS AS INTERLEUKIN-1 BETA CONVERTING ENZYME INHIBITORS Disclosed are compounds, compositions and methods for inhibiting interleukin-1 'beta' protease activity. The compounds, 'alpha'-substituted acetamides are of formula (A), wherein: R2 = H or alkyl; R3 = halo, O(CO)0-1aryl, OPOR4R5; (a), (...
WO/1996/003120A1	INDENE sPLA2 INHIBITORS A class of novel indene-1-functional compounds is disclosed together with the use of such indene compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indene-1-...
WO/1995/033710A1	CARBAMOYL CARBOXYLIC ACID HYDRAZIDES AND THEIR USE AGAINST FUNGI Disclosed are carbamoyl carboxylic acid hydrazides (I) and their salts, wherein: R1 is optionally substitued alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl or an optionally substituted non-aromatic carbo- or hetero...
WO/1995/032184A1	SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS Aminimide- and oxazolone-based molecules, and arrays thereof, having at least two structural diversity elements are made via systematic modular production. A combinatorial library of aminimide- and oxazolone-based molecules is made via s...
WO/1995/032453A1	NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS This subject invention relates to novel dihydrazide compounds of general formula (1), where B and C are the same or different and have general structure (I). A+ and A++ are activity regulating groups, and G- is a negatively charged ion u...
WO/1995/030682A1	ANTITUMOR INDOLOPYPROLOCARBAZOLE DERIVATIVE A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 represent each OH, R1 being present at the 1- or 2-position while R2 being present at the 10- or 11-position, provided when R1...
WO/1995/024381A1	CYANO COMPOUNDS AND PREPARATIONS THEREOF This invention relates to compounds of formula (I) which are useful as PDE IV inhibitors and for treating diseases related thereto.
WO/1995/022520A1	SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS A compound of structure (I), wherein, when R8 = H: R1 = alkyl, cycloalkyl, arylalkyl, aryl; R2 = cycloalkyl, aryl, C3-C10 alkyl; X, Y = O, S(O)n, NH; Z = CH2OH, NHSO2R3, CHO, CO2R3, CONHR4R5, CN, COR6, H, halo, NHCN, NHCONR4R5, CONR4OR5,...
WO/1995/018972A1	SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE-BASED MOLECULES HAVING SELECTED PROPERTIES A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diver...
WO/1995/018623A1	OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES Novel compounds and libraries of compounds based on nitrogen atoms that are joined together with spanner groups include "letters", i.e. functional groups, that are attached to the nitrogen atoms, to the spanner groups or to both the nitr...
WO/1995/018186A1	MODULAR DESIGN AND SYNTHESIS OF AMINIMIDE CONTAINING MOLECULES The design and synthesis of novel aminimide-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
WO/1995/007269A1	POLAR-SUBSTITUTED HYDROCARBONS The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A)m-V where W, A, B, A, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...
WO/1995/000472A1	1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS The invention concerns acid derivatives of the formula (I): R1-CON(R2)-N(R3)CO-X1-Q-X2-G, and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof; wherein R1 represents...
WO/1994/029267A1	ARYLACETAMIDES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS FUNGICIDES Compounds of formula (I), in which A is an optionally substituted aryl group; A' is an optionally substituted aryl group; B is a carbonyl group or a methylene group which is substituted by optionally substituted hydroxy and an optional f...
WO/1994/017074A1	PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, w...
WO/1994/011334A1	SUBSTITUTED ORTHO-ETHENYL-PHENYL ACETIC ACID DERIVATIVES Compounds of general formula (I) in which the index and the constituents have the meanings below: n: 0, 1, 2, 3 or 4; X: CHOCH3, CHCH3 or NOCH3; Y: O or NH; R1: nitro, cyano, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio...
WO/1994/010148A1	ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl; which inhibits lipoxygenase enzyme activity and l...
WO/1994/006280A1	INHIBITORS OF METAZOAN PARASITE PROTEASES Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. These compositions and methods have particular utility in the treatment of schistosom...
WO/1994/005643A1	NEOPENTYL DIFLUOROAMINO COMPOUNDS FOR USE IN ENERGETIC FORMULATIONS This invention relates to novel neopentyl difluoroamino compounds which are useful as plasticizers and oxidizers in energetic formulations, such as propellants, explosives, and gasifiers. These neopentyl difluoroamino compounds can be pr...
WO/1994/005153A1	HERBICIDAL BENZENE COMPOUNDS Herbicidal compositions and method of use involving effective amounts of substituted benzene compounds to control the growth of undesired vegetation.
WO/1994/001771A1	UNIVERSAL STANDARD REAGENTS, METHOD OF PREPARING SAME AND USE THEREOF A universal standard chemical reagent for quantitative visual and spectrometric analysis of compounds having reactive functional groups, including mixtures and homologs of said compounds, said reagent comprising a compound of the general...
WO/1994/001102A1	AMINIMIDE-CONTAINING MOLECULES AND MATERIALS AS MOLECULAR RECOGNITION AGENTS The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogniti...
WO/1993/023024A1	DIAMINES IN THE TREATMENT OF ARRHYTHMIA A method for the treatment of arrhythmia in human or non-human mammals, which method comprises the administration of an effective, non-toxic amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof and/or a pharm...
WO/1993/022273A1	INHIBITION OF THE FORMATION OF NITROSAMINES Reaction of amine-containing substrates with hydrogen peroxide can suffer from certain problems, especially in the presence of transition metals. These problems include both in situ generation of impurities and particularly nitrosamines,...

Matches 351 - 400 out of 1,476	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >