Acyclic or Carbocyclic Compounds

Matches 151 - 200 out of 679	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >

Document	Document Title
WO/2001/068743A2	POROUS POLYMER/CARRIER SOLID PHASE REACTANTS, METHOD FOR PRODUCING SAME AND THE USE THEREOF Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups ac...
WO/2001/034551A1	HYDROXYEICOSATETRAENOIC ACID ANALOGS AND METHODS OF THEIR USE IN TREATING DRY EYE DISORDERS Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.
WO/2001/028981A1	1-CYCLOHEXENE-1-CARBOXYLIC ACID AND 1-CYCLOHEXENE-1-CARBOXYLATES AS NEURAMINIDASE INHIBITORS The present invention provides compounds of formulae (Ia and Ib) or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenz...
WO/2001/009079A1	2-ALKYL-5-HALOGEN-PENT-4-ENE CARBOXYLIC ACIDS AND THEIR PRODUCTION The invention relates to compounds of formula (I) provided in the form of racemates and enantiomers, preferably compounds of formula (Ia), wherein R¿4? represents C¿1?-C¿6? alkyl; Z represents chlorine, bromine or iodine, and; X repre...
WO/2001/009083A1	PRODUCTION OF N-SUBSTITUTED 2,7-DIALKYL-4-HYDROXY-5-AMINO-8-ARYL-OCTANOYLAMIDES Compounds of formula (I), wherein; R¿5? represents C¿1?-C¿6? alkyl, C¿1?-C¿6? hydroxyalkyl, C¿1?-C¿6? alkoxy-C¿1?-C¿6? alkyl, C¿1?-C¿6? alkanoyloxy-C¿1?-C¿6? alkyl, C¿1?-C¿6? aminoalkyl, C¿1?-C¿6? alkylamino-C¿1?-C¿6? ...
WO/2001/001261A2	NETWORKED VEHICLE COMMUNICATIONS SYSTEM COMPRISING A FRONT-END UNIT, A TERMINAL THAT CAN BE OPERATED BY A USER, AND A CORRESPONDING APPLICATION The invention relates to a vehicle communications system comprising a databus and at least one front-end unit which is connected thereto and which has a user interface framework unit, and comprising at least one terminal which can be ope...
WO/2000/075101A1	EXCITATORY AMINO ACID RECEPTOR MODULATORS Compounds of formula (I) in which R?1¿ is halo-C¿1-10? alkyl; halo-C¿2-10? alkenyl; or (CH¿2?)¿n?Y in which n is 1 or 2 and Y is OH, CN, N¿3?, OR?3¿, SH, S(O)¿p?R?4¿, S(O)¿3?H, NH¿2?, NHR?5¿, NR?6¿R?7¿, NHCOR?8¿, NO¿2?, C...
WO/2000/068184A1	AROMATIC AMIDES Aromatic and heteroaromatic amides of formula (I) where R?1¿, R?2¿ and R?3¿ can be alkyl, X is alkylene, and R?4¿ is an unsubstituted or substituted aromatic or heteroaromatic group such as naphthyl or fluorenyl, are CNS agents usefu...
WO/2000/066522A1	GLUCOCORTICOID RECEPTOR MODULATORS The present invention provides non-steroidal compounds of formula (I) which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides p...
WO/2000/058270A2	HSV PRIMASE INHIBITORS The invention provides compounds of formula (1) that are active against the HSV primase enzyme: wherein R¿1? is hydroxy or amino; R¿2? is hydrogen, halo, (C¿1-4?)alkyl or (C¿1-4?)alkoxy; R¿3? is hydrogen, halo, (C¿1-4?)alkyl, (C¿1...
WO/2000/058275A1	PHOTOSENSITIVE COMPOUND AND PHOTOSENSITIVE COMPOSITION A water-soluble photosensitive compound which is represented by formula (1) or (2) and in which the photosensitive group gives an ultraviolet absorption spectrum having an absorption maximum wavelength of 305 nm or shorter; and a photose...
WO/2000/032200A1	CANNABIMIMETIC LIPID AMIDES AS USEFUL MEDICATIONS Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The imp...
WO/2000/028983A1	NOVEL 4-DEDIMETHY LAMINOTETRA CYCLINE DERIVATIVES The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted at the 7,8, and/or 9 positions and methods for preparing the 4-dedimethylamino tetracycline compounds. Other tetracycl...
WO2000006525A9	SYNTHESIS OF COMBINATORIAL LIBRARIES OF COMPOUNDS REMINISCENT OF NATURAL PRODUCTS The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in th...
WO/2000/015603A1	BENZENE DERIVATIVES AND MEDICINAL USE THEREOF Benzene derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof; and AP-1 activation inhibitors, NF-kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease pr...
WO/2000/009463A1	STEREOSELECTIVE RING OPENING REACTIONS The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile, selected from the group consisting of water, alcohols, carboxylic acids, and thiols, an...
WO/2000/003975A2	ARYL VINYL ETHER DERIVATIVES AND THEIR USE AS HERBICIDES The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...
WO/2000/001383A1	ANGIOGENESIS INHIBITORS RGD mimetics which combine a nitroaryl moiety with an arylether/$g(a)-aminoacid/guanidine framework exhibit activity as antagonists toward various integrins and as inhibitors of angiogenesis.
WO/1999/056699A2	MAIN-GROUP METAL-BASED ASYMMETRIC CATALYSTS AND APPLICATIONS THEREOF The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive $g(p)-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples o...
WO/1999/055664A1	PREPARATION OF CARBOCYCLIC COMPOUNDS The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves...
WO/1999/036384A1	ALKENYLDIARYLMETHANE NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITORS Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.
WO/1999/033781A1	SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS Compounds represented by formulae (I, II or III), wherein U is CH, O, or S; Z is -C(R¿2?)(R¿3?), -CH-N(R¿2?)(R¿3?), C(R¿3?)[(CH¿2?)nR¿2?], CH-C(R¿3?)(R¿8?)(CH¿2?)nR¿2?, C[(CH¿2?)nR¿2?]-[CH(R¿3?)(R¿8?)], C[(R¿3?)][CH[(CH¿...
WO/1999/033493A1	POLYAMIDE OLIGOMERS The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, $i(etc). The oligomer-lipid conjugates can be used to form liposomes, virusomes, micelles, $i(etc.)...
WO/1999/031047A1	CYCLOHEXENE CARBOXYLATES AS NEURAMINIDASE INHIBITORS Novel compounds of Formula (I) are described. R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are described in this specification. Synthetic intermediates and pharmaceutical compositions comprising the inhibitors of the invention are also de...
WO/1999/027890A2	A PROCESS FOR THE PREPARATION OF RING-OPENED EPOTHILONE INTERMEDIATES WHICH ARE USEFUL FOR THE PREPARATION OF EPOTHILONE ANALOGS The present invention relates to a process to produce ring opened epothilones and the novel ring opened epothilones produced therefrom.
WO/1999/014185A1	COMPOUNDS CONTAINING SIX-MEMBERED RINGS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
WO/1999/009006A1	SYNTHESIS OF CLASTO-LACTACYSTIN $g(b)-LACTONE AND ANALOGS THEREOF The present invention is directed to an improved synthesis of $i(clasto)-lactacystin-$g(b)-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthe...
WO/1999/008501A2	NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmac...
WO/1999/006353A1	ARYLOXYANILINE DERIVATIVES Aryloxyaniline derivatives represented by the general formula (I), wherein Ar?1¿ and Ar?2¿ represent each a substituted or unsubstituted phenyl, pyridyl, or naphthyl group; R?1¿ represents a hydrogen atom, an alkyl group or the like; ...
WO/1998/058916A1	NEW $g(b)-AMINO AND $g(b)-AZIDOCARBOXYLIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS, The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin rece...
WO/1998/051655A1	EXCITATORY AMINO ACID RECEPTOR MODULATORS Compounds of formula (I) in which R?1� and R?2� are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.
WO/1998/043942A1	NOVEL COMPOUNDS, THEIR USE AND PREPARATION The invention relates to novel compounds of Formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7� and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in ...
WO/1998/022441A2	N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE AND/OR ITS SYNTHESIS Disclosed are compounds which inhibit $g(b)-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits...
WO/1998/007685A1	PREPARATION OF CYCLOHEXENE CARBOXYLATE DERIVATIVES The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neura...
WO/1998/005627A1	BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, afte...
WO/1997/038977A1	AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Compounds of formula (I) wherein R represents (i) phenyl, benzothiazolyl or a six-membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms, which phenyl, benzo ring of the benzothiazolyl or heterocyclic aromatic ring is optio...
WO/1997/030710A1	NON-ACIDIC CYCLOPENTANE HEPTANOIC ACID, 2-CYCLOALKYL OR ARYLALKYL DERIVATIVES AS THERAPEUTIC AGENTS The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl...
WO/1996/040621A1	METHODS AND COMPOUNDS FOR DIAGNOSING CORONARY ARTERY DISEASE The present invention relates generally to methods of diagnosis, evaluation and treatment of coronary artery disease in mammals using substituted catecholamines and compounds therefore. It also relates to the preparation, use and adminis...
WO/1996/037628A1	PREPARATION OF HYDROXY COMPOUNDS BY BIOCONVERSION WITH DIOXYGENASE A process for preparing a compound of formula (3) in which R2 is -H; which comprises the steps: (i) conversion of a compound of formula (1) into a compound of formula (2) using a dioxygenase enzyme; (ii) conversion of the compound of for...
WO/1996/033971A1	PHOTOACTIVATABLE POLYMERS FOR PRODUCING PATTERNED BIOMOLECULAR ASSEMBLIES The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.
WO/1996/028402A1	STEREOSELECTIVE RING OPENING REACTIONS The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catal...
WO/1996/026933A1	NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
WO/1996/024579A1	15-DEOXYSPERGUALIN ANALOGS, THERAPEUTICAL USE THEREOF, AND METHOD FOR PREPARING SAME Compounds selected from the group consisting of (i) products of formula (I), wherein R is a hydrogen atom, an OH group, an OCH3 group or a CH2OH group, *C, when R is not a hydrogen atom, is an asymmetrical carbon atom having configuratio...
WO/1996/022962A1	BUTYRYL-TYROSINYL SPERMINE, ANALOGS THEREOF AND METHODS OF PREPARING AND USING SAME The present invention provides a compound having structure (I) wherein R1 is a saturated or unsaturated linear or branched chain alkyl group, or a cholestanyl group; wherein R2 ia s 2-indolyl, 3-indolyl, 4-indolyl, 5-indolyl, 4-hydroxyph...
WO/1996/017832A1	NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES Novel substituted alicyclic fused ring 2,3-quinoxalinediones, pharmaceutical compositions containing the same and the method of using the same, for the blockade of glutamate receptors, including either or both N-methyl-D-aspartate (NMDA)...
WO/1995/025710A1	ELECTROPHILIC SUBSTITUTION OF TRIPHENYLENE-BASED DISCOTIC LIQUID CRYSTALS A triphenylene such as hexa-'beta'-substituted hexyloxytriphenylene is 'alpha'-substituted by an electrophile in mixed polar cosolvents according to the reaction scheme (a).
WO/1995/024379A1	BENZAMIDE ANALOGS, USEFUL AS PARP (ADP-RIBOSYLTRANSFERASE, ADPRT) DNA REPAIR ENZYME INHIBITORS A range of 3-oxybenzamide compounds (I) and related quinazolinone compounds (II) are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can pr...
WO/1995/013059A1	FARNESYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have formula (I), wherein R1 represents farnesyl, geranyl or geranyl-geranyl; Z represents C-R2 or N; R2...
WO/1995/007266A1	SUBSTITUTED LACTIC-ACID DERIVATIVES WITH AN ORGANIC N-GROUP IN THE BETA POSITION, THEIR PREPARATION AND THEIR USE AS HERBICIDES AND ANTIDOTES The invention concerns substituted lactic-acid derivatives, containing an organic nitrogen group in the beta position, of general formula (I) in which the substituents R2 to R5 and X are as defined in the description and N is one of the ...
WO/1995/007302A1	GANGLIOSIDE GM3 DERIVATIVE HAVING FLUORINATED CERAMIDE MOIETY A ganglioside GM3 derivative having a fluorinated ceramide moiety, represented by general formula (I), wherein R represents alkyl or fluoroalkyl; m represents an integer of 2 or above; and n represents an integer of 0 to 7, provided m is...

Matches 151 - 200 out of 679	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >