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JP4297814B2 |
A compound of formula (I) wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is...
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JP4282981B2 |
This invention relates to a method for the production of a sphingoid base according to formulacomprising the steps of(1) dissolving a starting compound according to formula III or a salt thereof in a substantially inert solvent,(2) prote...
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JP2009132621A |
To provide a method for efficiently producing 3-amino-2-hydroxyhexanoic acid cyclopropylamide, suitable for industrial production, to provide an intermediate compound useful for the production method, and to provide a method for producin...
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JP2009091331A |
To provide a method for efficiently preparing an optically active fluoromalonic ester.The method for preparing an optically active fluoromalonic ester comprises using a DBFOX-Ph/Lewis acid complex as a catalyst.
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JP4250529B2 |
A process is provided for preparing chirally pure S-enantiomers of alpha-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organometallic reage...
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JP2009512642A |
The Staudinger reaction can be used for activation of prodrugs or pro-imaging probes. The invention relates to a method of preparing and activating prodrugs or pro-imaging probes by using the Staudinger reaction and to kits for medical i...
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JP4234917B2 |
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
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JP2009506136A |
A series of AB-type amphiphilic dendritic polyesters have been prepared divergently, in which two hybrids were coupled via the copper(1)-catalyzed triazole formation.
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JP4191263B2 |
Compounds of the formula in which R<1> and R<2> are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.
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JP4187274B2 |
The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers,...
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JP2008273948A |
To provide inhibition of viruses (especially influenza virus), especially, inhibition of glycolytic enzymes such as neuraminidase, and, especially, viral or bacterial neuraminidase inhibitors, to provide a method for synthesizing the inh...
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JP4173678B2 |
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JP4157770B2 |
The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury causedby radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound...
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JP2008163016A |
To provide a method for producing a cis-1,4-cyclohexanediamine monoamide derivative useful as MCH (melanin-concentrating hormone) 1 receptor antagonist, being inexpensive and suitable for mass production and to provide an efficient dimet...
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JP4106454B2 |
The present invention relates to a phytandiol amine derivative represented by the following formula (I) and compositions for treating acne comprising the same: wherein each of Y and Z is OH with the proviso that X is NH2, each of X and Z...
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JP4102022B2 |
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydro...
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JP2008515978A |
One aspect of this disclosure relates generally to lipid compounds that exert diverse effects in the endocannabinoid system, such as regulating CB1 and CB2 receptor or moderating other bio-macromolecules within the endocannabinoid system...
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JP2008081489A |
To provide a compound useful as an intermediate for the production of oseltamivir phosphate and provide a method for producing the compound.The invention provides a compound expressed by general formula (I) (R1 is an isocyanate group or ...
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JP4068639B2 |
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inh...
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JP2008507498A |
Compounds of formula I are useful in treatment of diseases associated with the deposition of beta-amyloid in the brain.
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JP2008050360A |
To provide a method for synthesizing a heterocyclic organic compound combinational library synthesized on a solid phase starting substance, and to provide for assaying biologically activity with the library.The library of heterocyclic or...
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JP2008013556A |
To provide a new compound having pharmacological characteristics relating to melatoninergic receptors.The compound is represented by formula (I) (wherein, R1 represents a group R4 or NHR4, wherein R4 is defined specifically; R2 represent...
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JP4036440B2 |
The present invention provides a novel photosensitive compound having an azido group suitable for exposure to light of a short wavelength; a photosensitive resin containing the photosensitive compound; and a photosensitive composition co...
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JP2007332160A |
To obtain various hemiasterlin derivatives and to develop a synthesis theory for testing the therapeutic usefulness. The present invention provides compounds having formula (I) and additionally provides methods for the synthesis thereof ...
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JP2007534702A |
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and...
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JP2007302694A |
To provide a new labeling agent composed of a3H-labeled compound of an isocarbacyclin derivative useful e.g. as a probe of a cerebrospinal prostacyclin receptor. The agent is a3H-labeled isocarbacyclin derivative expressed by formula (I)...
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JP4010562B2 |
The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst...
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JP2007532505A |
In the first step, a bifunctional alkane with two different denuclearizing groups is reacted with an azide to separate one denuclearizing group into a monofunctional azidoalcan, and in the second step, one. A method for producing an azid...
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JP2007530417A |
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contac...
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JPWO2005075639A1 |
To provide a method for producing a glycopeptide in which a sugar chain can be easily introduced. In the present invention, an amino acid having a protected group for introducing a sugar chain is introduced into a protein by a 4-base cod...
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JP3986065B2 |
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JP3972377B2 |
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JP2007521338A |
Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The...
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JP3918956B2 |
To obtain a new 1-azidoindan-2-ol derivative useful as an intermediate for producing variety of physiologically active substances, etc. This new 1-azidoindan-2-ol derivative comprises both trans-1- azidoindan-2-ol derivative of formula I...
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JP3914065B2 |
To provide a new compound that inhibits retrovirus proteases, especially proteases of human immunodeficiency virus(HIV), a composition for treating retrovirus infection, especially for treating HIV infection, a production method of the c...
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JP2007106759A |
To provide a method for industrially producing an intermediate for a compound exhibiting activated blood coagulation factor Xa inhibitory activity and useful as a prophylactic or curative agent for thrombotic diseases.A compound represen...
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JP3901945B2 |
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides phar...
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JP3876341B2 |
PURPOSE: To provide novel heterotrifunctional compounds as photoaffinity labelling of biomolecules which have water-soluble groups before and after labelling of biomolecule and whose solubility is kept so that the labelling molecules pro...
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JP2007500245A |
This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
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JP3864199B2 |
To provide a method for efficiently producing an intermediate for synthesizing a phosphazene base using an organic catalyst less harmful to the environment without using harmful heavy metals. H-Si, C-Si, O-Si and N-Si bonds of an organic...
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JP3856816B2 |
A compound of formula (I) wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is...
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JP3837876B2 |
To provide the subject new compound, excellent in heat resistance, capable of introducing a protecting group of hydroxyl group capable of being deprotected under mild conditions and useful for protecting hydroxyl group in various compoun...
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JP2006232845A |
To provide an HIV protease inhibitor useful for treating or preventing AIDS.The retroviral protease-inhibiting compound is represented by general formula (A). Preferably, in the formula, R1 is a thiazolyl or oxazolyl which may be substit...
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JP2006507232T5 |
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JP3812969B2 |
To obtain the subject new compound having a specific molecular structure, exhibiting an action on the inhibition of a retrovirus protease, and useful for the therapy of retrovirus infection, especially human immunodeficiency virus(HIV) i...
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JP3799643B2 |
To obtain a new phenol compound useful as an alkali soluble low molecular weight additive to a photo sensitive resin composition, an intermediate for a photosensitive ingredient, etc. This compound is a pentaphenol compound expressed by ...
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JP3787848B2 |
PURPOSE: To obtain a composite propellant, containing a high-energy binder, capable of maintaining physical properties such as strength in a high-temperature region and improving physical properties such as elongation versus stress in a ...
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JP3780036B2 |
To obtain a new compound good in stability in blood, exhibiting a good cell proliferation-inhibiting effect against cells in a low concentration and useful as a carcinostatic agent. A compound of formula I [R1 is a 3-10C alkyl; R2 is an ...
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JP3781821B2 |
To obtain solid fuel for a gas generating agent having an easily controllable high pressure index by using a specified copolymer and a specified polymer in combination. A base is composed of a copolymer (A) of 3,3-bis(azidomethyl)oxetane...
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JP3762868B2 |
The invention provides compounds of the formula 1 that are active against the HSV primase enzyme:whereinR1 is hydroxy or amino;R2 is hydrogen, halo, (C1-4)alkyl or (C1-4)alkoxy; R3 is hydrogen, halo, (C1-4)alkyl, (C1-4)alkoxy, amino or a...
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