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WO/2024/017221A1 |
A synthesis method for an α-azido ketone containing a tertiary chiral center, the synthesis method comprising: under the action of a squaramide catalyst, reacting a sulfoxonium ylide derivative with an azidation reagent HN3 generated in...
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WO/2023/250318A1 |
Anthraquinone analogs that have anticancer properties are disclosed. Pharmaceutical formulations in forms suitable for the delivery of the compounds to a subject in need thereof are disclosed. Methods of using the compounds for treating ...
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WO/2023/233371A1 |
The present disclosure relates generally to the field of synthetic organic chemistry. More specifically, the disclosure is directed to a continuous flow process for synthesis of azides from alcohols and peroxides, wherein the process com...
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WO/2023/155247A1 |
Provided are a single-molecular-weight amphiphilic fluorene-azobenzene oligomer, a self-assembled fiber, and a preparation method. The present invention diversifies and expands the studies of molecules having a backbone containing fluori...
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WO/2022/263944A1 |
An azido-containing monomer, a polymer containing monomeric units derived from the azido-containing monomer, and various articles containing a substrate and a coating layer of the polymer positioned on the substrate are provided. The azi...
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WO/2022/256738A1 |
Triazenes and methods of producing diazonium species from said traizenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on...
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WO/2022/238696A1 |
The present disclosure describes a novel class of masking agents that can be activated under ionising radiation. The masking agents (which in some cases may be referred to as protecting groups) can be conjugated, linked or bonded to a pa...
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WO/2022/204947A1 |
A preparation method for a linker drug conjugate and an intermediate thereof. Specifically disclosed is a method for preparing a compound of formula (I), wherein R1 is a C1-C6 alkyl, one or more R1-3S(O)2-substituted C1-C6 alkyls, or one...
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WO/2022/191283A1 |
The present invention pertains to a technique for controlling the bonding ratio of an antibody and a modified group to a desired range. More specifically, the present invention pertains to: a compound represented by formula (I) [in the f...
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WO/2021/255737A1 |
The present disclosure pertains to amino cyclohexanone compounds, pharmaceutical compositions containing same and methods of treating depression, pain, inflammation, and other clinical indications.
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WO/2021/133839A1 |
Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N...
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WO/2021/119606A1 |
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diis...
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WO/2021/050660A1 |
Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. However, it can be difficult to form highly substituted phenyl rings suitable for covalent atta...
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WO/2020/260514A1 |
Bis(2-haloacetamido)- compounds for use as linkers to chemically cross-linking multiple thiol groups, and particularly, although not exclusively, the thiol groups of cysteine amino acids in peptide chains are described, along with their ...
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WO/2020/255425A1 |
This anti-HBV agent contains a compound represented by general formula (I) or a compound represented by general formula (II), or a salt thereof.
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WO/2020/237262A1 |
Embodiments are directed to therapeutic, diagnostic, or functional complexes comprising a kethoxal derivative.
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WO/2020/205470A1 |
The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
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WO/2020/163532A1 |
Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits compr...
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WO/2020/146568A1 |
A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclizatio...
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WO/2020/104627A1 |
The invention relates to a method for labeling a target compound with a radiometal by photochemically induced conjugation. Furthermore, a chelating compound for use in said method is provided. The chelating compound is characterized by a...
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WO/2020/043997A1 |
The present invention relates to 1,4-dimethyltetrazenes of formula (la), (Ib) and (le): R1-CH2-N(CH3)-N=N-N(CH3)-CH2-R2 (la) R3-CH2-CH2-N(CH3)-N=N-N(CH3)-CH2-CH2-R4 (Ib) R5-CHOH-CH2-N(CH3)-N=N-N(CH3)-CH2-CHOH-R5 (lc), in which RI, R2, R3...
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WO/2020/006340A1 |
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...
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WO/2020/002634A1 |
The present invention relates to specific nitrogen containing compounds of formulas (I), (II) and (IV) of the present invention, which are suitable to be used in a method to detect alkyne group containing organic compounds by mass spectr...
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WO/2020/004043A1 |
The present invention provides a method which uses an aniline derivative as a starting material, and which is capable of producing an α-azidoaniline derivative or an α, α'-diazide derivative. The present invention comprises a method f...
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WO/2019/240579A1 |
The invention provides a production process for the production of an aromatic epoxide derived compound, the production process comprising: (i) an epoxidation stage comprising: reacting an aromatic compound and a peroxide in the presence ...
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WO/2019/235493A1 |
The present invention provides a method by which a diaminobenzoic acid ester and a benzimidazole derivative are able to be produced more easily with use of lower cost materials. The present invention includes a method for producing a dia...
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WO/2019/184772A1 |
The present invention discloses a gibberellin-like compound, a preparation method therefor, a pharmaceutical composition, uses and an intermediate thereof, wherein the gibberellin-like compound shown in formula (I) has relatively good in...
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WO/2019/155169A1 |
The present invention relates to difunctional biphenyl compounds according to formula (I): in which Alk, Alk' and R are as defined in the description. Said compounds are suitable for use as curing agents for thermosetting resins, particu...
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WO/2019/152801A1 |
The present disclosure features non-canonical or heavy isotope-containing amino acids, where the alpha-amino terminus and/or carboxvlic acid terminus is modified with molecular cages. The molecular cage-modified amino acids are precluded...
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WO/2019/142614A1 |
This container comprises: a container body having formed therein an internal space in which a liquid can be stored; and partitions that divide the internal space into a plurality of liquid storage sections. Holes are formed in the partit...
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WO/2019/037755A1 |
The present invention relates to a compound represented by general formula (I), as well as a racemate, a stereoisomer, a tautomer, a polymorphic substance, and a solvate thereof, or a pharmaceutically acceptable salt thereof. The present...
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WO/2018/179343A1 |
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...
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WO/2018/119101A1 |
A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized mol...
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WO/2018/102517A1 |
Disclosed herein are compositions for use in an energy providing devices and methods of preparing such devices. Also included herein is energy providing devices that comprise a charged compound modified substrate or zwitterion-modified s...
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WO/2017/131097A1 |
Provided is a pharmaceutical composition for the treatment or prevention of a cognitive disease or disorder, the composition comprising a compound represented by formula (1), an enantiomer thereof or diasteriomer thereof, or a pharmaceut...
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WO/2017/131236A1 |
The present invention relates to the nucleic acid complex expressed by formula 1. Formula 1: (In formula 1, X is an oligonucleotide, L1 and L2 each independently represents a sugar ligand, and S1, S2 and S3 each independently represents ...
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WO/2017/089492A1 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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WO/2017/081069A1 |
The present invention relates to tri-functional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) a hydrazone group...
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WO/2017/057461A1 |
A production method for producing an aldehyde compound or a ketone compound by oxidizing a primary or secondary alcohol compound, wherein the alcohol compound has, in the molecule thereof, a group selected from an amino group, an azide g...
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WO/2016/180297A1 |
The present invention relates to the fields of organic chemistry and metal organic chemistry, disclosed are a metal bridge site fused ring compound, and an intermediate, a preparation method and a use thereof, the metal bridge site fused...
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WO/2016/127023A1 |
Neat 4-azidobutylamine and sails of 4-azidobutylamine and processes for producing the same are described herein. Amines represent a large class of organic compounds containing a basic nitrogen atom having a lone pair of electrons and one...
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WO/2016/113764A1 |
The present invention relates to one step room temperature process for the synthesis of azido alcohols from alkenes. More particularly, I2 catalysed a regio and diastereo selective one step room temperature process for the synthesis of 1...
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WO/2016/103283A1 |
The present invention provides bio-based aromatic diisocyanate of formula (I). [Formula should be inserted here] wherein X is –OCH3, Y is selected from -H or –OCH3, and m = 0-12. The present invention further provides a method for pr...
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WO/2016/058056A1 |
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
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WO/2016/007726A1 |
By either forming a triaryl acid halide or a triaryl mixed anhydride and subsequently treating with aqueous sodium azide, triaryl acyl azides are prepared in high yield using inexpensive reagents in a process in which by-products are eas...
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WO/2015/122494A1 |
Provided is a novel compound having an excellent suppression action against arrhythmia including atrial fibrillation and being useful as a pharmaceutical product having a separated antiviral effect. A compound indicated by general formul...
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WO/2015/044177A1 |
The present invention refers to compounds of formula: (formula A), wherein R1 is selected from (formula I), (formula II), (formula (III), (formula IV), (formula V), or (formula B), and wherein R2, R3, R4 and R5 are as defined in the clai...
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WO/2015/043493A1 |
The present invention relates to a 5-formylcytosine specific chemical labeling method and related applications in aspects such as sequencing, detection, imaging, and diagnosis. In the method, a condensation reaction occurs between an act...
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WO/2015/004563A1 |
The present invention provides compounds of formula (1) a process for their preparation, a solution comprising these compounds, a process for the preparation of a device using the solution, devices obtainable by the process and the use o...
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WO/2014/197991A1 |
The present application describes amphiphatic compounds like compound Ila below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated...
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