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Matches 701 - 750 out of 7,338

Document Document Title
WO/2005/068415A1
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 ...  
WO/2005/066116A1
Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RAR&g...  
WO/2005/066115A2
Compounds of the formula where the variables have the values described in the specification are antagonists of RAR&gammad retinoid receptors.  
WO/2005/063665A1
The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to i...  
WO/2005/063222A1
An Hsp90 family protein inhibitor which contains as an active ingredient a benzene derivative represented by the following general formula (I), a prodrug thereof, or a pharmacologically acceptable salt of either.  
WO/2005/063018A1
Present invention relates to a haloalkene compound of the formula (I)or its salt: wherein each of X1 and X2 is halogen; Y is alkyl, haloalkyl or phenyl; n is 0 to 5; L is -C(=B)Q, -C(=B)B’Q, -C(=B)N(D)Q, -N(D)Q, -N(D)C(=B)Q, -N(D)C(=B)...  
WO/2005/063840A1
The present invention pertains to non-fugitive amine catalysts wherein the catalyst contains at least one imine and at least one tertiary amine moiety. Such catalysts are suitable for the production of polyurethane products.  
WO/2005/063691A1
The invention relates to a method for the coammoxidation, i.e. for the simultaneous ammoxidation of ketones, especially of cyclic ketones such as cyclododecanone and cyclohexanone. The ammoxidation method of the invention relates to the ...  
WO/2005/063692A1
The invention relates to (hetero)cyclyl carboxanilides of general formula (I), wherein n represents 0, 1, 2, 3, or 4, m represents 1, 2, or 3, Y represents oxygen or sulfur, A represents optionally substituted phenyl or an at least monou...  
WO2005037779A3
The invention relates to medicinally used substances which specifically inhibit peptidases splitting Gly-Pro-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmet...  
WO/2005/061501A2
Processes for preparing 10-amino-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2- a]azepine-2-carboxylates and related compounds are disclosed. The preparation of carboxamide derivatives from these carboxylates is also disclosed. The ...  
WO2005044899A8
A prepolymer, characterized in that it is prepared by the reaction of two compounds A and B which have two or more functional moieties or two or more groups of functional moieties, respectively, and are capable of undergoing a polymeriza...  
WO2005021562A3
Compounds of the formulae (I) and (Ia) where X1 is secondary phosphino; R3 is a hydrocarbon radical having from 1 to 20 C atoms, a heterohydrocarbon radical which has from 2 to 20 atoms and at least one heteroatorn selected from the grou...  
WO2003101938A8
This invention relates to a oxamidination method of carbonyl compounds comprising reacting a liquid-phase reaction system containing carbonyl compounds, ammonia and hydrogen peroxide in the presence of silicon containing catalyst, which ...  
WO2004093207A3
The invention relates to novel mixtures consisting of at least two substances, one substance being used as a matrix material and the other as a material which is capable of emission and contains at least one element having an atomic numb...  
WO/2005/047233A1
Compounds of formula (I), wherein Q is a group Q1, Q2, Q3, Q4, Q5, Q6, Q7 or Q8; A is a bridging member A1, A2, A3, A4 or A5 wherein the bridging members A1 to A5 are linked to the group Q at the end carrying the oxygen atom; B either is...  
WO2004078924A3
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding...  
WO/2005/044782A1
A near-infrared absorbing compound that does not contain antimony and arsenic, excelling in stability, especially heat resistance, light stability and resistance to hot moisture; and, produced with the use of the near-infrared absorbing ...  
WO/2005/044899A1
A prepolymer, characterized in that it is prepared by the reaction of two compounds A and B which have two or more functional moieties or two or more groups of functional moieties, respectively, and are capable of undergoing a polymeriza...  
WO/2005/044781A1
An aromatic polyamine derivative represented by the following formula (1): (1) wherein ring Z represents a monocyclic or polycyclic aromatic ring; Ra, Rb, Rc, and Rd are substituents bonded to the ring Z; and Ra and Rb are the same or di...  
WO/2005/044007A1
A pesticide having stabilized high pesticidal effects for crop plants infected with plant diseases, is presented. The pesticide contains a biphenyl derivative represented by the formula (I) or its salt, as an active ingredient: wherein X...  
WO2003074496A8
The invention relates to compounds of formula (I), where R<1> = R<5>-O-#, R<5>-O-CH2-#, (a), (b), (c), (d) or (e), T= (f), (g), or (h), several methods for production and use thereof for the prevention of harmful organisms and novel inte...  
WO2004022775A8
A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca<2+>, incubating the Ca<2+> depleted bacteria with an agent the antibacterial effect of which shall be determined, r...  
WO/2005/040096A1
A process for the production of asymmetric alkyl compounds which is characterized by comprising the step of mixing a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having an ability to mak...  
WO/2005/037772A2
The invention relates to novel compounds of general formula (I), compositions containing said compounds and to the use thereof for producing pharmaceutical compositions used for human medicine or for veterinary science, and also for cosm...  
WO/2005/037779A2
The invention relates to medicinally used substances which specifically inhibit peptidases splitting Gly-Pro-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmet...  
WO/2005/037773A1
The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia),...  
WO/2005/034940A2
The invention relates to substances, which specifically inhibit both Ala-p-nitroanilide-cleaving peptidases as well as Gly-Pro-p-nitroanilide-cleaving peptidases, for use in the field of medicine. The invention also relates to the use of...  
WO2004062601A3
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...  
WO2004098582A3
The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds ...  
WO/2005/033127A1
The invention relates to a method for the synthesis of the derivative having formula (I) and to the use thereof for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof.  
WO2005019147A3
There are described compounds of formula (I) wherein X1 and X2 are each independently of the other fluorine, chlorine or bromine; A1 and A2 are, for example, a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge; R1 and R2 are, ...  
WO/2005/030193A1
The present invention relates to substituted aryl oximes of formula (I) or a pharmaceutically acceptable salt or ester form thereof wherein R1 is a direct bond to A, C1-C4 alkylene, or -O-C1-C4 alkylene; R2 and R3 are , independently hyd...  
WO/2005/030192A1
The present invention relates to substituted indole oximes and methods of using them.  
WO/2005/030191A1
The present invention relates to indole oxime derivatives of formula (I) wherein: R1 is -OH, -OC1-C8 alkyl, or NH2; R2 and R3 are, independently, hydrogen, C1-C8 alkyl, -CH2-C3-C6 cycloalkyl, -CH2-pyridinyl, phenyl, or benzyl; R4 is hydr...  
WO/2005/030708A1
The inventive method is characterised in that it comprises the following steps consisting in: a) in a reaction medium, reacting (i) an aliphatic ketone having formula R(CO)R', wherein R and R', which may be identical or different, are al...  
WO2005007622A3
[PROBLEMS] To provide (1) an optically active quaternary ammonium salt which, when used as an asymmetric-axis-containing spiro type phase-transfer catalyst for the asymmetric alkylation of a glycine derivative, shows high stereoselectivi...  
WO/2005/028466A1
The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical composit...  
WO2005007611A3
The invention is directed to a process for the preparation of [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1 -ylidene]-methyl-amine of the Formula (I) by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalene-l-one of...  
WO/2005/023831A1
The invention relates to detection of cholesterol ozonation products that are generated by atherosclerotic plaque material, and to methods of detecting vascular conditions that relate to the accumulation and oxidation of cholesterol.  
WO/2005/021562A2
Compounds of the formulae (I) and (Ia) where X1 is secondary phosphino; R3 is a hydrocarbon radical having from 1 to 20 C atoms, a heterohydrocarbon radical which has from 2 to 20 atoms and at least one heteroatorn selected from the grou...  
WO/2005/019151A1
The present invention is directed to a compound of formula I, or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator acti...  
WO/2005/019147A2
There are described compounds of formula (I) wherein X1 and X2 are each independently of the other fluorine, chlorine or bromine; A1 and A2 are, for example, a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge; R1 and R2 are, ...  
WO/2005/016519A1
Catalysts including carbon supports having formed thereon compositions which comprise a transition metal carbide, nitride or carbide-nitride are prepared. The catalysts are useful for catalytic oxidation and dehydrogenation reactions, in...  
WO/2005/014519A1
The invention relates to a process for the preparation of a substituted geminal difluoroalkane, wherein an oxime is converted to the gerninal difluoroalkane using a nitrite and a complex consisting of HF and an organic base, as well as i...  
WO2003099192A8
The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.  
WO2004099122A3
This invention provides estrogen receptor modulators having the structure formula (I): wherein R<1> to R<6> and R<8> are as defined in the specification; or a pharmaceutically acceptable salt thereof.  
WO/2005/011664A1
The present invention provides optionally substituted compounds of the formula (I) or salts thereof; wherein R1 is O or S when double bonded to the ring or is OH, SH, or a protected equivalent, when single bonded to the ring, R2 is hydro...  
WO2004074242A3
Compounds of the formula (I) or (II) wherein R1 is C1-C10haloalkylsulfonyl, halobenzenesulfonyl, C2-C10haloalkanoyl, halobenzoyl; R2 is halogen or C1-C10haloalkyl; Arl is phenyl, biphenylyl, fluorenyl, naphthyl, anthracyl, phenanthryl, o...  
WO/2005/009613A1
An oxidation catalyst for oxidizing a reaction substrate with molecular oxygen, characterized by comprising at least one member selected from the group consisting of specific hydrazyl radicals (e.g., 2,2-diphenyl-1-picrylhydrazyl) and sp...  

Matches 701 - 750 out of 7,338