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Matches 1 - 50 out of 21,693

Document Document Title
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2019/007239A1
A fluidized-bed catalyst suitable for producing haloarylnitrile, and preparation and application thereof. The catalyst comprises an active ingredient and a carrier. The active ingredient is a complex consisting of VPaCrbAcMdOx by atomic ...  
WO/2019/006359A1
The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorde...  
WO/2019/004254A1
A compound represented by the general formula which is an excellent light-emitting material. In the general formula, R1 to R5 represent a hydrogen atom or a substituent, provided that: one of R1 to R5 represents a cyano group; one to thr...  
WO/2018/235798A1
A method for producing a compound, which comprises a reaction step wherein a fluidized bed reactor that comprises an internal space in which a catalyst is contained in a flowable manner, a first supply port through which a starting mater...  
WO/2018/234139A1
2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)a cetamides for combating phytopathogenic fungi The present invention relates the compounds of the formula I and their N-oxides and agriculturally acceptable salts thereof, and t...  
WO/2018/235323A1
This method for producing a reaction-generating gas comprises a reaction step for feeding a starting gas for a fluidized bed gas-phase reaction in the presence of a catalyst, the reaction step including a shutdown step in which, when at ...  
WO/2018/234346A1
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.  
WO/2018/232298A1
The present invention provides a compound having the structure: and use of the compound for inhibiting the growth of or killing a fungus  
WO/2018/225854A1
A method for producing an unsaturated nitrile, the method having a reaction step for producing a corresponding unsaturated nitrile by subjecting a hydrocarbon to a gas phase ammoxidation reaction in the presence of a catalyst within an i...  
WO/2018/219204A1
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...  
WO/2018/215070A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/215610A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/214519A1
Provided are a process and a device for preparing an environmentally-friendly insulating gas perfluoroalkylnitrile. The device comprises a first tank reactor, a second tank reactor, and a fixed bed reactor. A condensing and collecting de...  
WO/2018/210631A1
The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to fu...  
WO/2018/211858A1
This catalyst for ammoxidation comprises catalyst particles that contain molybdenum, bismuth and iron, while having a hollow particle percentage of 23% or less. A method for producing this catalyst for ammoxidation comprises: a step for ...  
WO/2018/192665A1
The invention primarily relates to the use of 4-ethyl-octene-2-nitrile and/or 4-ethyl-octene-3-nitrile as a fragrance. The invention also relates to novel fragrance compositions comprising 4-ethyl-octene-2/3-nitrile, to perfumed articles...  
WO/2018/187717A1
This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purp...  
WO/2018/179482A1
The purpose of the present invention is to provide an organic electroluminescence element which has a long life and emits blue light having high color purity. A dibenzo[c, g]fluorene compound including a specific substitution group of th...  
WO/2018/174253A1
[Problem] To provide a fluorescent probe with which it is possible to selectively detect GSTP1 activity. [Solution] A nitrobenzene derivative represented by general formula (1) [in the formula, the symbols are defined as in the specifica...  
WO/2018/175025A1
The present disclosure provides a resin blend. The resin blend includes at least one diluent containing a single phthalonitrile functional group and at least one diphthalonitrile resin. Also provided are prepregs including the resin blen...  
WO/2018/171305A1
The present application discloses a process and an industrialized production device for co-production of environmentally friendly insulating gases. The co-production process comprises: 1) conducting a contact reaction of oxygen and HFP i...  
WO/2018/169023A1
The complex crystal according to the present disclosure has a structure in which supramolecule units each including two or more types of molecules are arrayed. Each of the supramolecule units contains, as the molecules, a cyanoacrylic ac...  
WO/2018/169022A1
The complex crystal according to the present disclosure has a structure in which supramolecule units, each including two or more types of molecules, and guest molecules for which the supramolecule units are hosts are arrayed. Each of the...  
WO/2018/158131A1
The invention relates to a method for the production of fluoroalkyl nitriles and of the corresponding fluoroalkyl tetrazoles, proceeding from fluorinated carboxylic acid amides.  
WO/2018/159834A1
Provided are a donor-acceptor type compound having a novel structure and an application of the donor-acceptor type compound. This enamine compound is represented by general formula (1) (in the formula: R1 represents an electron-accepting...  
WO/2018/152949A1
The present invention relates to a method for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one, and belongs to the field of chemical synthesis. The method of the present invention uses the steps of alkylation, reduction, cy...  
WO/2018/151633A1
The present invention relates to a method for producing a compound of formula I, where B is, independently, hydrogen or [see appropriate figure], wherein no more than one B is hydrogen; D is NR1 or O; R1 is H, R, C1-C4 alkyl, unsubstitut...  
WO/2018/145653A1
The present invention relates to the technical field of chemical medicine and relates to a compound represented by formula (I) or formula (II) and a preparation method therefor, the compound being a biaryl derivative and having retinoid-...  
WO/2018/148158A1
The present disclosure relates generally to catalyst materials and processes for making and using them. More particularly, the present disclosure relates to molybdenum, bismuth and iron-containing metal oxide catalyst materials useful, f...  
WO/2018/144869A1
Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.  
WO/2018/144870A1
Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).  
WO/2018/144620A1
Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating d...  
WO/2018/137260A1
Disclosed in the present application is a method for preparing a compound I, which is characterized in being prepared and obtained by reacting starting materials which comprise a compound II, which contains a carbon-carbon double bond, a...  
WO/2018/138369A1
The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3,R4, R5, R6, R7 and X ha...  
WO/2018/134278A1
The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.  
WO/2018/129609A1
Compounds of formula (II) are useful in modulating voltage-gated sodium channel activity. Their preparation and use for reducing the severity of convulsant activity in a subject, for example in the treatment of epilepsy, is presented.  
WO/2018/120880A1
The present invention provides an insecticidal compound having an ether bond structure. The structural formula of the compound is as shown in formula A, wherein R1 is methyl, halogen atom, cyano group, or trifluoromethyl; R2 and R3 are H...  
WO/2018/121051A1
Disclosed is a preparation method for methyl 3-cyano-4-isopropoxybenzoate: step one, preparing methyl 3-aldehyde-4-hydroxybenzoate from methyl paraben; step two, preparing methyl 3-cyano-4-hydroxybenzonate from methyl 3-aldehyde-4-hydrox...  
WO/2018/121050A1
Disclosed in the present invention is a preparation method for 3-cyano-4-hydroxybenzoic acid methyl ester, comprising: step 1: preparing methyl 4-hydroxybenzoate into methyl 3-formyl-4-hydroxybenzoate; and step 2: preparing the methyl 3-...  
WO/2018/114464A1
This invention relates to a process for preparing electron deficient olefins, such as 2-cyanoacrylates, using an acid catalyzed two-step process including a transesterification reaction followed by a Knoevenagel condensation reaction.  
WO/2018/114458A1
This invention relates to a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an acid catalyzed Knoevenagel condensation reaction.  
WO/2018/110669A1
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and meth...  
WO/2018/105572A1
The present invention is a method for producing ε-caprolactam via adipamide that serves as an intermediate. This method for producing ε-caprolactam is characterized by comprising a lactamization step wherein adipamide produced from a s...  
WO/2018/096176A1
A precursor compound of a fragrant aldehyde is provided, as well as a method of forming such a compound, a kit comprising said compound, and certain uses thereof. The precursor compound has formula (I), wherein A is a hydrocarbon residue...  
WO/2018/098270A1
The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferativ...  
WO/2018/087767A1
The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.  
WO/2018/083053A1
The present invention relates to fluoranthenyl-amine compounds according to a formula (I). Said compounds are suitable for use in electronic devices. The invention also relates to a method for producing said compounds, and to electronic ...  
WO/2018/078053A1
The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formu...  
WO/2018/074046A1
A purification method for acrylonitrile which comprises a purification step in which an acrylonitrile solution comprising acrylonitrile, hydrogen cyanide, and water is distilled, wherein the purification step comprises: a first step, whi...  

Matches 1 - 50 out of 21,693