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Document Title |
JP3842132B2 |
N-(4-carbamimidoyl-phenyl)-glycine derivatives have the formula:wherein X and R1 to R5 are as defined herein, and includes hydrates or solvates and/or physiologically acceptable salts thereof and/or physiologically acceptable esters ther...
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JP3836425B2 |
A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitutio...
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JP3838657B2 |
PCT No. PCT/DE94/00756 Sec. 371 Date Feb. 6, 1996 Sec. 102(e) Date Feb. 6, 1996 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01168 PCT Pub. Date Jan. 12, 1995The invention relates to a novel pharmaceutical preparation, containing an active ...
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JP3836892B2 |
PURPOSE: To obtain a new substituted cyclic amine compound having a strong and selective serotonin 2 receptor antagonistic effect and useful for prevention and therapy of hypertension, ischemic heart diseases, cerebrovascular diseases, e...
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JP2006523223A |
The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor
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JP3827530B2 |
Compounds that prolong thrombin time. Exemplary are:(a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrol
idinocarbonyl)-phenyl]-propargylamino}benzamidine,(b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phen
yl]-p...
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JP3821544B2 |
To obtain a formamidine compound being normally liquid and lowly viscous and having good compatibility with synthetic polymers. There is provided a formamidine compound represented by formula I, being normally liquid and lowly viscous an...
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JP3817263B2 |
The present invention provide novel substituted amidinonaphthyl ester compounds effective for treatment of thrombosis. The present invention relates to compounds represented by the following formula (I) and pharmaceutically acceptable ac...
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JP2006519832A |
Methods of selectively removing counterions from compounds are disclosed. Compounds derived from the methods, such as the compound S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine zwitterion with between zero and up to 2 molar equiva...
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JP3816543B2 |
PURPOSE: To obtain an N-arylhydrazine deriv. controlling insects and mite as harmful organisms and effective in protection from damage and loss caused by the harmful organisms. CONSTITUTION: A compd. represented by formula I {A is CR4 or...
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JP3814683B2 |
To prepare an amino acid composition having effects for supplementing the decrease of amino acids in blood due to strong physical exercises, reducing the changes in the concentrations of the amino acids in the blood, improving motor func...
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JP2006516671A |
Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based ...
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JP2006514824A |
The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cys...
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JP3770706B2 |
To obtain a new compound useful as a constituting component of a medicine carrier capable of efficiently and safely carrying out transfection of a nucleic acid, a polynucleotide, etc., to a cell and delivery of a medicine, a peptide, etc...
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JP3763828B2 |
To provide a method for producing a compound useful as an intermediate for synthesizing a precursor of a substituted benzopyran compound so as to synthesize the substituted benzopyran compound with a few steps. The method for producing a...
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JP3762790B2 |
This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of ...
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JP2006045245A |
To provide a new phenylcyclohexan-1-ylcarboxylic acid, a pharmaceutical composition containing the compound, the use of the compound in treating allergic and inflammatory diseases and the use of the compound to inhibit the production of ...
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JP2006036770A |
To selectively inhibit virus (particularly influenza virus), especially glycolytic enzymes like neuraminidase, above all, viral or bacterial neuraminidase.Novel compounds of Formula (III) or Formula (IV) are described. The compounds gene...
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JP2006028021A |
To produce a new organic molecule catalyst which is used for realizing an industrially useful asymmetric reaction and does not contain an organic metal.The new organic molecule catalyst is represented by formula (1) or (2). In addition, ...
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JP2006502134A |
The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4, R5, G, M1, M2, M3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared the...
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JP2006501160A |
The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
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JP2005538950A |
Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition o...
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JP3727334B2 |
Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to member...
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JP2005535710A |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists,...
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JP2005535570A |
The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates...
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JP3712208B2 |
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen o...
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JP3704649B2 |
Compounds of the formula Iin whichY is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen,Z is a group a)R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at m...
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JP2005529934A |
A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations...
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JP2005263809A |
To provide a method for protecting important agronomic crops from harmful and damaging action caused by noxious organisms of insects and ticks.The N-aryl hydrazine derivative is represented by formula I [for example, 2,2-dimethyl propion...
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JP2005525413A |
The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
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JP2005524706A |
Compounds of the formula (R5)m-(R6A)-2-(R4)-1-[N-C(R1)N(R2)(R3)]benzene and their agriculturally suitable salts, are disclosed which are useful as fungicides, wherein R1 is H, OH, SH, SO3H, CN, -OR7 or -SR7; C1-C10 alkyl, C2-C10 alkenyl,...
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JP3676236B2 |
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims, as well as hydrates or solvates and physiologica...
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JP2005519994A |
The invention relates to novel substituted aryl and heteroaryl derivatives of general formula (I), in which A, Ar, n, X, Y1, Y2, Y3, Y4, R1, and R5 are defined as per claim 1, to their prodrugs, tautomers, stereoisomers, mixtures and sal...
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JP2005519866A |
The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
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JP2005516062A |
The present invention relates to compounds of formula (I):
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JP2005126332A |
To provide a means for producing high-purity formamidine acetate in high yield by an economical and simple method.A method for production is carried out as follows. A reaction is made to proceed under refluxing conditions when the formam...
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JP2005514332A |
The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhi...
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JPWO2003027060A1 |
Provided are a compound represented by the following general formula (1), which has a higher selectivity for a smooth muscle muscarinic receptor than a cardiac muscarinic receptor and has a strong antagonistic effect, and a salt and hydr...
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JP2005509606A |
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic co...
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JP2005508874A |
Substituted N-acylaniline derivatives of general formula wherein R<1 >to R<5>, A, X, Y, and Z are as defined herein, and the tautomers, prodrugs, and derivatives thereof which contain, instead of a carboxy group, a group which is negativ...
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JP2005508307A |
There are provided novel compounds of formula (I), wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes...
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JP2005507380A |
This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- a...
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JP2005504827A |
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R1, R2, R3, R4, R5, R6, R8, R9 and X are defined herein. The compounds are useful for treating autoimmune and other diseas...
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JP2005504053A |
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
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JP3614711B2 |
To obtain a new compound useful for a production intermediate compound of a selective inhibitor for an inducible nitric-oxide synthase. This compound is expressed by formula I (Q is H or a carboxy protecting group; Q' is a protecting gro...
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JP3611517B2 |
A new family of aminoamidine derivatives is claimed, which are oil soluble and have good filtering properties for UV-A and UV-B radiation and thus protection from solar irradiation. Cosmetic compositions for external use, particularly fo...
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JP2005500259A |
Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase ...
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JP2004359609A |
To provide a method by which cyclopropylcarbamidine hydrochloride can economically and industrially advantageously be produced in a favorable yield.The production method for cyclopropylcarbamidine hydrochloride represented by formula (II...
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JP2004535379A |
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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JP2004535362A5 |
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