Acyclic or Carbocyclic Compounds

Matches 701 - 750 out of 1,375	< 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 >

Document	Document Title
JP3842132B2	Phenylglycine derivative N-(4-carbamimidoyl-phenyl)-glycine derivatives have the formula:wherein X and R1 to R5 are as defined herein, and includes hydrates or solvates and/or physiologically acceptable salts thereof and/or physiologically acceptable esters ther...
JP3836425B2	Method for producing nitrogen-containing compound A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitutio...
JP3838657B2	Pharmaceutical composition PCT No. PCT/DE94/00756 Sec. 371 Date Feb. 6, 1996 Sec. 102(e) Date Feb. 6, 1996 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01168 PCT Pub. Date Jan. 12, 1995The invention relates to a novel pharmaceutical preparation, containing an active ...
JP3836892B2	SUBSTITUTED CYCLIC AMINE COMPOUND, ITS PRODUCTION AND MEDICINE FOR CIRCULATORY ORGAN CONTAINING THE SAME COMPOUND PURPOSE: To obtain a new substituted cyclic amine compound having a strong and selective serotonin 2 receptor antagonistic effect and useful for prevention and therapy of hypertension, ischemic heart diseases, cerebrovascular diseases, e...
JP2006523223A	Muscarinic agonist The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor
JP3827530B2	Substituted aryl derivatives and substituted heteroaryl derivatives, their preparation and their use as drugs Compounds that prolong thrombin time. Exemplary are:(a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrol idinocarbonyl)-phenyl]-propargylamino}benzamidine,(b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phen yl]-p...
JP3821544B2	FORMAMIDINE COMPOUND AND ULTRAVIOLET ABSORBER COMPRISING SAME To obtain a formamidine compound being normally liquid and lowly viscous and having good compatibility with synthetic polymers. There is provided a formamidine compound represented by formula I, being normally liquid and lowly viscous an...
JP3817263B2	Substituted amidinonaphthyl ester derivative The present invention provide novel substituted amidinonaphthyl ester compounds effective for treatment of thrombosis. The present invention relates to compounds represented by the following formula (I) and pharmaceutically acceptable ac...
JP2006519832A	Methods for selectively removing counterions from compounds and compounds derived from such methods. Methods of selectively removing counterions from compounds are disclosed. Compounds derived from the methods, such as the compound S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine zwitterion with between zero and up to 2 molar equiva...
JP3816543B2	N-ARYLHYDRAZINE DERIVATIVE AS INSECTICIDE AND MITICIDE PURPOSE: To obtain an N-arylhydrazine deriv. controlling insects and mite as harmful organisms and effective in protection from damage and loss caused by the harmful organisms. CONSTITUTION: A compd. represented by formula I {A is CR4 or...
JP3814683B2	AMINO ACID COMPOSITION To prepare an amino acid composition having effects for supplementing the decrease of amino acids in blood due to strong physical exercises, reducing the changes in the concentrations of the amino acids in the blood, improving motor func...
JP2006516671A	Bisaminophenyl-based curing agents and curing accelerators for perfluoroelastomer compositions and amidine-based curing agents and curing accelerators Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based ...
JP2006514824A	Activity-based probe, and how to make and use it The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cys...
JP3770706B2	AMIDINE DERIVATIVE AND MEDICINE CARRIER USING THE SAME AS CONSTITUTING COMPONENT To obtain a new compound useful as a constituting component of a medicine carrier capable of efficiently and safely carrying out transfection of a nucleic acid, a polynucleotide, etc., to a cell and delivery of a medicine, a peptide, etc...
JP3763828B2	METHOD FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING PRECURSOR OF BENZOPYRAN COMPOUND To provide a method for producing a compound useful as an intermediate for synthesizing a precursor of a substituted benzopyran compound so as to synthesize the substituted benzopyran compound with a few steps. The method for producing a...
JP3762790B2	Benzamidine derivatives substituted with amino acid and hydroxy acid derivatives and their use as anticoagulants This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of ...
JP2006045245A	CYANO COMPOUND AND METHOD FOR PRODUCING THE SAME To provide a new phenylcyclohexan-1-ylcarboxylic acid, a pharmaceutical composition containing the compound, the use of the compound in treating allergic and inflammatory diseases and the use of the compound to inhibit the production of ...
JP2006036770A	NOVEL SELECTIVE INHIBITOR TO VIRUS OR BACTERIAL NEURAMINIDASE To selectively inhibit virus (particularly influenza virus), especially glycolytic enzymes like neuraminidase, above all, viral or bacterial neuraminidase.Novel compounds of Formula (III) or Formula (IV) are described. The compounds gene...
JP2006028021A	NEW ORGANIC MOLECULE CATALYST HAVING BINAPHTHOL SKELETON AND METHOD FOR PRODUCING THE SAME AND APPLICATION THEREOF To produce a new organic molecule catalyst which is used for realizing an industrially useful asymmetric reaction and does not contain an organic metal.The new organic molecule catalyst is represented by formula (1) or (2). In addition, ...
JP2006502134A	Compounds with activity at metabolically regulated glutamate receptors The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4, R5, G, M1, M2, M3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared the...
JP2006501160A	Amidine derivatives for the treatment of amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
JP2005538950A	Synthesis of 2-alkylcysteine, 2- (hydroxylated phenyl) -4-alkylthiazolin-4-carboxylic acid and their derivatives Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition o...
JP3727334B2	Compounds with selectivity for retinoid X receptor Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to member...
JP2005535710A	Aryl and heteroaryl compounds and methods of regulating coagulation This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists,...
JP2005535570A	New pyrimidone derivative The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates...
JP3712208B2	A novel intermediate for the production of antihistamine 4-diphenylmethyl / diphenylmethoxypiperidine derivatives The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen o...
JP3704649B2	Their use as O-benzyloxime ether derivatives and pest control agents Compounds of the formula Iin whichY is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen,Z is a group a)R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at m...
JP2005529934A	Process of preparing xanthine phosphodiesterase V inhibitor and its precursor A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations...
JP2005263809A	N-ARYL HYDRAZINE DERIVATIVE AS INSECTICIDE AND ACARICIDE To provide a method for protecting important agronomic crops from harmful and damaging action caused by noxious organisms of insects and ticks.The N-aryl hydrazine derivative is represented by formula I [for example, 2,2-dimethyl propion...
JP2005525413A	Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
JP2005524706A	Amidinyl phenyl compounds, their use as fungicides and fungicides Compounds of the formula (R5)m-(R6A)-2-(R4)-1-[N-C(R1)N(R2)(R3)]benzene and their agriculturally suitable salts, are disclosed which are useful as fungicides, wherein R1 is H, OH, SH, SO3H, CN, -OR7 or -SR7; C1-C10 alkyl, C2-C10 alkenyl,...
JP3676236B2	Phenylglycine derivative The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims, as well as hydrates or solvates and physiologica...
JP2005519994A	Substituted aryl and heteroaryl derivatives, their formulas and use as pharmaceutical compositions The invention relates to novel substituted aryl and heteroaryl derivatives of general formula (I), in which A, Ar, n, X, Y1, Y2, Y3, Y4, R1, and R5 are defined as per claim 1, to their prodrugs, tautomers, stereoisomers, mixtures and sal...
JP2005519866A	6-membered heterocyclic compound useful for selection inhibition of coagulation cascade The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
JP2005516062A	A novel compound that inhibits factor X activity The present invention relates to compounds of formula (I):
JP2005126332A	METHOD FOR PRODUCING FORMAMIDINE ACETATE To provide a means for producing high-purity formamidine acetate in high yield by an economical and simple method.A method for production is carried out as follows. A reaction is made to proceed under refluxing conditions when the formam...
JP2005514332A	A 6-membered unsaturated heterocyclic compound useful for selective inhibition of the coagulation cascade The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhi...
JPWO2003027060A1	Diphenylbutane amide derivative Provided are a compound represented by the following general formula (1), which has a higher selectivity for a smooth muscle muscarinic receptor than a cardiac muscarinic receptor and has a strong antagonistic effect, and a salt and hydr...
JP2005509606A	A prodrug of substituted polycyclic compounds useful for selectively inhibiting the blood clot cascade The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic co...
JP2005508874A	Substituted N-acyl-aniline derivatives, their preparation and use as pharmaceutical compositions Substituted N-acylaniline derivatives of general formula wherein R<1 >to R<5>, A, X, Y, and Z are as defined herein, and the tautomers, prodrugs, and derivatives thereof which contain, instead of a carboxy group, a group which is negativ...
JP2005508307A	Their use as aryl heteroalkylamine derivatives and nitric oxide synthase inhibitors There are provided novel compounds of formula (I), wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes...
JP2005507380A	HIV inhibitory pyrimidine derivative This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- a...
JP2005504827A	Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R1, R2, R3, R4, R5, R6, R8, R9 and X are defined herein. The compounds are useful for treating autoimmune and other diseas...
JP2005504053A	Amidine derivatives for the treatment of amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
JP3614711B2	INTERMEDIATE FOR ENZYME INHIBITOR To obtain a new compound useful for a production intermediate compound of a selective inhibitor for an inducible nitric-oxide synthase. This compound is expressed by formula I (Q is H or a carboxy protecting group; Q' is a protecting gro...
JP3611517B2	Compositions for photoprotective cosmetics containing aminoamidine derivatives and their uses A new family of aminoamidine derivatives is claimed, which are oil soluble and have good filtering properties for UV-A and UV-B radiation and thus protection from solar irradiation. Cosmetic compositions for external use, particularly fo...
JP2005500259A	Drugs and methods for treating cancer Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase ...
JP2004359609A	METHOD FOR PRODUCTION OF CYCLOPROPYLCARBAMIDINE HYDROCHLORIDE To provide a method by which cyclopropylcarbamidine hydrochloride can economically and industrially advantageously be produced in a favorable yield.The production method for cyclopropylcarbamidine hydrochloride represented by formula (II...
JP2004535379A	Bifunctional energized reverse acyl composition Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
JP2004535362A5	No Title Available

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