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Matches 251 - 300 out of 1,374

Document Document Title
WO/2001/062735A1
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicat...  
WO/2001/057947A1
The invention relates to amidines of perfluorinated C2-C5 carboxylic acids, which can be used as solvents or components of solvents for conducting salts in electrolytes. Some new amidines are also disclosed.  
WO/2001/055146A1
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...  
WO/2001/055175A2
The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalanin amides of formula (I), in which the anions X are physiologically acceptable anions, and their analogs, which a...  
WO/2001/055095A1
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...  
WO/2001/044164A1
The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia),...  
WO/2001/044172A1
The present invention provides novel compounds of Formula (I), its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or ...  
WO/2001/042198A2
Novel process steps and novel processes for producing unsubstituted and substituted meta- and para- cyano benzoic acid compounds, as well as salts and derivatives thereof, and intermediates therefor which are useful as intermediates for ...  
WO/2001/042199A1
An amidinophenylpyruvic acid derivative represented by the following formula, its analogs and pharmaceutically acceptable salts thereof which have an excellent effect of inhibiting activated blood coagulation factor VII.  
WO/2001/036374A2
The invention relates to bis-basic compounds of the general formula (I): B?1¿-Ar?1¿-X?1¿-Ar?2¿-X?2¿-A-X?3¿-Ar?3¿-X?4¿-Ar?4¿- B?2¿, wherein the groups B?1¿, B?2¿, Ar?1¿, Ar?2¿, Ar?3¿, Ar?4¿, X?1¿, X?2¿, X?3¿, X?4¿ and ...  
WO/2001/036381A1
Hydrazone compounds represented by general formula (1) or salts thereof and novel agricultural chemicals (in particular, insecticides and miticides) containing these compounds as the active ingredient formulae (1), G-1, G-2, G-3, wherein...  
WO/2001/036371A1
There are described new compounds of formula (I) wherein, when n is 0, at least one of the two phenyl rings is substituted; R¿1? and R¿2? are each independently of the other hydrogen, halogen, cyano, nitro, C¿1-4?alkyl, C¿1-4?haloalk...  
WO/2001/030148A1
This invention relates to novel substituted succinic acid metallo-$g(b)-lactamase inhibitors which are useful potentiators of $g(b)-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections...  
WO/2001/027092A2
A process is described for preparing 1-aryltriazolinones of formula (I) useful in the production of commercial herbicides, by: i) carbonylating an amidrazone of formula (A) with one or more carbonylating agent, or ii) condensing a hydraz...  
WO/2001/025186A1
The invention relates to a novel LTB¿4? antagonist, to a method for the production thereof and to its use as a medicament.  
WO/2001/021592A1
The invention provides novel processes for preparing efficiently compounds of general formula (I) (wherein R¿1? and R¿2? are each independently hydrogen, optionally substituted C¿1?-C¿10? alkyl, C¿3?-C¿14? hydrocarbyl bearing an al...  
WO/2001/021582A1
The invention relates to compounds of the formula (I), wherein X, R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meaning indicated in claim 1. The inventive compounds represent inhibitors of the subtype 3 sodium/proton exchanger (NHE-3).  
WO/2001/014320A1
The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention ...  
WO/2001/010823A1
The invention relates to carboxylic acid amides of formula (I), wherein R¿1? to R¿5?, Ar, m and n are defined in Claim 1, their tautomers, their stereoisomers, their mixtures, their prodrugs and their salts, which exhibit valuable prop...  
WO/2001/005753A1
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R?1¿, R?2¿ and R?3¿ have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to...  
WO/2001/005748A1
The current invention discloses novel oligomeric amidino aminocarboxylate derivatves useful as nitric oxide synthase inhibitors.  
WO/2001/000623A1
Method of producing compounds of formula (I), wherein R¿1? is hydrogen or C¿1?-C¿4?-alkyl; R¿2? is hydrogen, C¿1?-C¿8?-alkyl, C¿3?-C¿6?-cycloalkyl, or a radical -N(R¿3?)R¿4?; or R¿2? and R¿6? together are -CH¿2?-CH¿2?-S-; R...  
WO/2000/069813A1
The invention relates to novel substituted N-cyano amidines of general formula (I) in which: R?1¿ represents hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or alkyl aryl, and; R?2¿ represe...  
WO/2000/067751A1
Compounds represented by formula (I): or a pharmaceutically acceptable salt or hydrate thereof, are disclosed. Pharmaceutical compositions and methods of treatment are also included.  
WO/2000/066587A2
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. A...  
WO/2000/066545A1
The invention concerns compounds of general formula (I) wherein: R¿1? represents either a hydrogen atom, or an amino group, or a C¿1?-C¿4? alkyl group, or a C¿1?-C¿6? alkoxycarbonyl group, or a -OH group; R¿2? represents either a C...  
WO/2000/053586A1
The invention relates to the use of formamidine salts of the general formula (I): (NH¿2?-CH=NH¿2?)¿n?H¿x-n?Y, where Y is SO¿4?, x is 2 and n is between 0.1 and 2.0, or Y is PO¿4?, x is 3 and n is between 0.1 and 3.0. The salts obta...  
WO/2000/047554A2
Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubs...  
WO/2000/047553A2
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show se...  
WO/2000/046184A1
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R?1¿ is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R?2¿ and R?3¿, which may be the same or...  
WO/2000/044731A1
The current invention discloses novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors. Compounds of particular interest are defined by Formula (I) wherein X, Y, A, J, R?1¿, R?2¿ R?3¿, R?4¿, R?7¿ and...  
WO/2000/042000A1
The invention concerns a method for preparing an azoiminoether hydrochloride which consists in reacting an azonitrile with an alcohol and hydrochloric acid in an aromatic solvent, wherein the molar ratio R = HCl/azonitrile is > 2 when th...  
WO/2000/041531A2
Compounds having structure (A) are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.  
WO/2000/040529A1
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R?7¿)- wherein R?7¿ is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8¿ or -NR?8¿R?9¿ (wherein R?8¿ is a group -Y?1¿R?10¿ (wherein ...  
WO/2000/040571A1
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated i...  
WO/2000/040548A1
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to arylalkanoyl derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6a) and R(6b) have the meanings indi...  
WO/2000/035858A1
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I), wherein R?1¿, E, X?1¿ to X?4¿ and G?1¿ and G?2¿ are as defined in the description and the claims, as well as hydrates or solvates a...  
WO/2000/035859A1
The invention relates to new substituted aryl and heteroaryl derivatives of the general formula (I) Ar - A - HCR¿1? - X - Y, in which A, Ar, X, Y and R¿1? have the meanings given in claim 1, and to their tautomers, stereoisomers, mixtu...  
WO/2000/031082A1
Novel pyrimidine derivatives of formula (I), as well as possible isomers and mixtures of isomers thereof. The novel compounds have plant-protective properties and are suitable for protecting plants against infestations by phytopathogenic...  
WO/2000/027790A1
A compound of formula (IA) or (IB): in which R?1¿ is R?A¿(CH¿2?)¿n?O(CH¿2?)¿m?, R?A¿(CH¿2?)¿p?, Formula (II) or in which R is a spiro-fused mono- or bi-cyclic ring containing one or two basic nitrogen atoms; and X?1¿ and X?2¿,...  
WO/2000/017156A1
The invention relates to benzamidoxime derivatives of formula (I), whereby the substituents have the following meanings: R?1¿ represents difluoromethyl or trifluoromethyl; R?2¿ represents hydrogen or fluorine; R?3¿ represents C¿1?-CÂ...  
WO/2000/016766A1
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or h...  
WO/2000/006620A2
Various olefins may be polymerized using a catalyst system containing selected $g(a)-diimine, urethane or urea ligands, some of them novel, complexed to nickel, palladium or other selected transition metals. The polymers are useful as mo...  
WO/2000/006555A1
This invention provides a process for preparing compounds of formula (1) wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 ca...  
WO/2000/003975A2
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...  
WO/1999/067203A1
Compounds of general formula (I) wherein A is (a) or (b); Z is (CH¿2?)¿m? or a carbonyl group are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions compris...  
WO/1999/064392A1
A benzamidine derivative represented by formula (I), analogs thereof and pharmaceutically acceptable salts thereof. Because of having an effect of inhibiting activated blood coagulation factor X, these compounds are useful as preventives...  
WO/1999/062968A1
Methods for preparing olefin polymers, and catalysts for preparing olefin polymers are disclosed. The polymers can be prepared by contacting the corresponding monomers with a Group 8-10 transition metal catalyst and a solid support. The ...  
WO/1999/057096A1
The invention relates to novel compounds of formula (I), wherein X, R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meanings cited in Patent Claim No. 1. Said compounds are inhibitors of the coagulation factor Xa and can be used for prophy...  
WO/1999/046240A2
Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors of Formula (I) or a pharmaceutically acceptable salt thereof, wherein all substituents are described in the specification.  

Matches 251 - 300 out of 1,374