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Matches 1 - 50 out of 2,353

Document Document Title
WO/2018/115421A1
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).  
WO/2018/098401A1
The present invention describes compositions, including pharmaceutical compositions, comprising an agent that binds members of the TNFRSF and a benzamide compound and methods for use thereof, for example in the treatment of cancer. In so...  
WO/2018/089651A1
The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the treatment of various diseases, disorders, or conditions related to HDAC6.  
WO/2018/081858A1
The present invention relates to new desferrioxamine B analogues that are useful for iron-chelation therapy, to their preparation including intermediates, and to compositions including the compounds. The present invention also relates to...  
WO/2018/060354A1
The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them, wherein meanings of the substituents are indicated in the description. Such compounds for use in the treatment of cancer and ot...  
WO/2018/053080A1
Acute kidney injury (AKI) is often associated with damage to remote organs, such as lungs or heart. AKI induces kidney tubular necrosis as well as NETosis, programmed neutrophil death leading to neutrophil extracellular traps (NETs). His...  
WO/2018/015292A1
The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cance...  
WO/2018/015493A1
A metal complex has the general formula (I), in which: R-Z is a HDAC inhibitor in which Z a terminal hydroxamate group; M is a redox active metal; n+ is the positive charge on the complex cation; Bn- is a balancing counterion; Z binds to...  
WO/2018/015595A3
The present invention relates to a family of compounds which are effective against parasites of the genus Leishmania, preferably caused by L. infantum, L. major or L. tropica, and which have low toxicity, even at high doses of the compou...  
WO/2018/011811A3
A pharmaceutical composition and a method of treating, reducing or preventing vascular, cardiovascular arterial or valve calcification in a subject in need comprising administering to the subject an effective amount of an agent that prev...  
WO/2017/217553A1
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] An oxime compound represented by formula (1) and an herbicide containing the same. (In formula (1): B represents B-1 or the like; Q represents ...  
WO/2017/204144A1
Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal o...  
WO/2017/201441A1
The present invention provides a method of imaging a subject's lung which comprises contacting the subject's lung with a matrix metalloproteinase inhibitor labeled with a radioisotope under conditions such that the inhibitor binds to mat...  
WO/2017/199028A1
A method of preparing an active agent or a salt thereof from a prodrug first compound (1) comprising a propargyl group connected to an oxygen that is directly or indirectly connected to the active agent is provided, wherein the bond betw...  
WO/2017/195216A1
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and...  
WO/2017/195216A4
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and...  
WO/2017/181811A1
Disclosed are an opctahydroanthracene compound as represented by formula (I) or (II), a preparation method for same, and uses of same, which provides great therapeutic effects for tumors and neurodegenerative diseases and is prepared mai...  
WO/2017/182433A1
The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin β and/or α, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially su...  
WO/2017/170884A1
Provided are: a novel method for producing a hydroxamic acid derivative, which uses, as an intermediate, a compound represented by general formula [12] (wherein R1 represents a methyl group, etc.; R2 represents a methyl group, etc.; and ...  
WO/2017/152237A1
The present invention relates to new Desferrioxamine B-based compounds that are useful for iron-chelation therapy, to their preparation, and to compositions including the compounds. The present invention also relates to the use of the co...  
WO/2017/118822A3
The present invention relates to the design of new molecules, referred to as "multi-target" molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDAC) and as inhibitors of tubulin polymerisation...  
WO/2017/118822A2
The present invention relates to the design of new molecules, referred to as "multi-target" molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDAC) and as inhibitors of tubulin polymerisation...  
WO/2017/105449A1
Embodiments of the present disclosure describe methods of synthesis of amidines, amidine-metal complexes, thin metal films formed using amidine-metal complexes on semiconductor devices, and semiconductor devices and systems with thin met...  
WO/2017/091552A1
Collector compositions C for mineral flotation, which include at least one of a hydroxamic acid A, and/or a salt S of a hydroxamic acid A solubilized in a water-soluble organic solvent L, and processes for using same for recovering sulfi...  
WO/2017/079821A1
There is described herein use of a compound of formula (I) below to make cyclic peptides.  
WO/2017/064701A1
The present invention provides methods for total chemical synthesis of Resolvin E1 (Rv E1).  
WO/2017/040564A1
Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a periph...  
WO/2017/025727A1
The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I)  
WO/2017/024996A1
Provided are a hydroxy amidine derivative, a preparation method and a use in medicine thereof. In particular, provided are the hydroxy amidine derivative as shown by general formula (I), the preparation method thereof and a pharmaceutica...  
WO/2017/008101A1
An aminopeptidase inhibitor compound comprising a biaryl, hydroxamic acid based core of formula: wherein X is a 5 or 6-membered ring, and including pharmaceutically acceptable salts and solvates thereof.  
WO/2017/004964A1
The present invention provides a novel preparation method of a 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid as a drug for preventing muscular dystrophy and an intermediate compound. The preparation method has a reasonable prod...  
WO/2016/184561A1
Novel inhibitors of the enzyme autotaxin are described. The inhibitors contain one or two zinc-binding groups at the appropriate distance, Also described are uses thereof, such as for the inhibition of autotaxin activity and the treatmen...  
WO/2016/168058A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2016/168483A1
Compounds of formula I are provided Formula (I) R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen...  
WO/2016/149099A1
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.  
WO/2016/141492A1
Genes exhibiting specific mutational and/or transcriptional patterns in mixed-lineage leukemia- rearranged acute myeloid leukemia (MLL leukemia) relative to other types of AMLs are disclosed. The use of these mutational and/or transcript...  
WO/2016/135062A1
The present invention discloses the efficient preparation of 2-substituted-4-amido-1,2,3-triazoles.  
WO/2016/032768A1
The present invention provides a novel method for treating cancer that comprises administering a compound represented by formula (I) and/or a chemotherapeutic agent to a subject. The present invention further provides a novel kit that co...  
WO/2016/020369A1
The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and metho...  
WO/2015/188085A1
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse a...  
WO/2015/158244A1
A hydroxamic acid compound as indicated in formula (I), and a use thereof in preparing medications for inhibiting cancer cell proliferation and/or treating cancers. The substituents A-D are as defined in the description. The hydroxamic a...  
WO/2015/100363A1
The present invention provides hydroxamic acids of the formula described herein, that have activity toward inhibiting histone deacetylases, and in particular HDAC6. Also contemplated are pharmaceutical compositions and methods of use of ...  
WO/2015/056798A1
The present invention addresses the problem of providing a novel compound which is useful as a pharmaceutical product, and which has high antibacterial activity with regard to gram-negative bacteria such as pseudomonas aeruginosa and wit...  
WO/2015/056799A1
The present invention addresses the problem of providing a novel compound which is useful as a pharmaceutical product, and which has high antibacterial activity with regard to gram-negative bacteria such as pseudomonas aeruginosa and wit...  
WO/2015/056800A1
The present invention addresses the problem of providing a novel compound which is useful as a pharmaceutical product, and which has high antibacterial activity with regard to gram-negative bacteria such as pseudomonas aeruginosa and wit...  
WO/2015/058106A1
Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): w...  
WO/2015/014230A1
The present invention relates to a matrix metalloproteinase inhibitor and a use thereof. In particular, the matrix metalloproteinase inhibitor has a structure as shown in formula (I) or a pharmaceutically acceptable salt thereof, and can...  
WO/2015/013187A1
The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neuro...  
WO/2015/013187A8
The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neuro...  
WO/2015/007870A1
The present invention relates to new compounds for treating, preventing or inhibiting a parasitic disease, preferably toxoplasmosis in a subject, the method for preparing thereof.  

Matches 1 - 50 out of 2,353