| Document |
Document Title |
|
WO/2002/014256A1 |
The present invention relates to a process for the preparation of $g(a)' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylal...
|
|
WO/2002/014267A1 |
The present invention relates to compounds of formula (I) wherein U, V, W, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically accep...
|
|
WO/2002/011883A1 |
The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure (I), wherein R', R' and R'' are organic groups having 1-15 carbon atoms, n = 1-5, and m = 0-4. The present inv...
|
|
WO/2002/010096A1 |
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing cataly...
|
|
WO/2002/008189A1 |
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral ...
|
|
WO/2002/008248A1 |
A method for producing a compound represented by the general formula (VI): (VI) wherein R¿1? represents a hydrogen atom or a linear or branched aliphatic alkyl group having 1 to 4 carbon atoms, R¿2? represents a hydrogen atom or methyl...
|
|
WO/2002/006189A2 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...
|
|
WO/2002/006304A1 |
A process is described for the preparation of dipeptide derivatves having formula (I) characterized by reaction scheme (II).
|
|
WO/2002/004403A1 |
The invention relates to substituted piperazine derivatives of general formula (I), wherein R?1¿ to R?7¿ have the meanings given in claim no. 1, isomers thereof and salts thereof, especially physiologically compatible salts thereof, wh...
|
|
WO/2001/098235A2 |
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...
|
|
WO/2001/096285A1 |
The present invention relates to compound of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof...
|
|
WO/2001/094438A1 |
The invention relates to urethane compounds which release organoleptically active aromatic alcohols; a method for producing said urethane compounds; and the use thereof in cosmetic, glue, paint and plastic compositions, and cleaning prod...
|
|
WO/2001/092210A1 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...
|
|
WO/2001/091897A1 |
This invention relates to a process for the continuous preparation of moderate to high viscosity reaction products requiring moderate to long reaction times (e.g. a polymer(s) including prepolymer(s)), specifically relates to the continu...
|
|
WO/2001/090051A1 |
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R?1¿ to R?5¿ are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologica...
|
|
WO/2001/087837A1 |
1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]
-propan-2-ol, carvedilol, or an acid addition salt thereof, is prepared by alkylating 5-chloromethyl-3-[2-(2-methoxy-phenoxy)-ethyl]-oxazolidin-2-
one (VII) with 4-hydroxy-carb...
|
|
WO/2001/085675A2 |
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having formula (I) wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, R...
|
|
WO/2001/080998A1 |
A reaction vessel (40) represented on Fig.2, and method of identifying a ligand having affinity for a target molecule are disclosed. The reaction vessel (40) includes a first member defining a first chamber (42), the first chamber includ...
|
|
WO/2001/074795A1 |
A process for preparing amic acid esters of the general formula (7) wherein A, R¿1?, R¿3?, and Het are each as defined in the claim, which comprises reacting an amino acid of the general formula (1) with a halocarbonate ester in the pr...
|
|
WO2000050376A9 |
Efficient synthetic methods towards mixed aliphatic carbonates through the three component couplings of aliphatic alcohols, alkyl halides and carbon dioxide in the presence of cesium carbonate and tetrabutylammonium iode (TBAI). Due to t...
|
|
WO/2001/070219A1 |
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide ...
|
|
WO/2001/068591A1 |
This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula (I) wherein R?1¿, R?2¿, and R?3¿ are each independently in each occurrence aryl or heteroaryl, R?4¿ is -COOH or tetr...
|
|
WO/2001/068590A1 |
Process for the preparation of aromatic urethanes consisting in reacting organic carbonates with aromatic amines in reactors operating in continuous, feeding a total quantity of aromatic amines in a percentage, with respect to the weight...
|
|
WO/2001/062706A1 |
The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases usin...
|
|
WO/2001/060786A1 |
A compound of the formula [Ig]; wherein R?1¿ is hydrogen or an amino protective group, R¿2? is hydrogen or hydroxy, and R¿3? and R¿4? are independently N-methyl-methoxycarbonylamino, N-ethyl-methoxycarbonylamino, N-propyl-methoxycarb...
|
|
WO/2001/056978A1 |
The invention relates to positional isomer diethyloctandioldicarbamates and diethyloctandioldiallophanates, to a method for the production thereof and to the use thereof as synthetic building blocks and constituents of adhesives, luting ...
|
|
WO/2001/055081A2 |
Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and ...
|
|
WO/2001/055097A1 |
This invention relates to an improved synthesis of 5-(N-[(S)-N-{N,N-bis(2-chloroethyl)amino}phenoxycarbonyl)-$g
(g)-glutamyl]amino)isophthalic acid (also named ZD9063P), a prodrug used in Antibody Directed Enzyme Prodrug Therapy (ADEPT),...
|
|
WO/2001/051457A2 |
The invention relates to a method for producing compounds of formula (I) wherein the radicals R?1¿ and R?2¿ have the meanings given in the description and in the claims, which can be used on a large scale.
|
|
WO/2001/047871A2 |
Process for the synthesis of polyurethane derivatives from aromatic polyamine compounds. The method involves reaction of an aromatic polyamine compound with CO and O¿2? in the presence of a catalyst comprising a Group VIII or lanthanide...
|
|
WO/2001/047870A2 |
A process for the preparation of an aromatic polycarbamate which comprises reacting an aromatic polyamine, urea and an alcohol, characterised in that the alcohol is an alkoxylated monoalcohol.
|
|
WO/2001/046120A1 |
The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitro
benzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol....
|
|
WO/2001/044165A1 |
Processes for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives (I), in particular, optically active compounds, which are useful as materials for producing drugs such as proteases. A process for producing the compou...
|
|
WO/2001/040163A1 |
Disclosed is a method for preparing a t-butoxycarbonylated amine compound and, more particularly, a method for preparing a t-butoxycarbonylated amine compound where an amine compound is reacted with a t-butylchloroformate in an aqueous o...
|
|
WO/2001/036375A1 |
This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I): wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pan...
|
|
WO/2001/027074A1 |
The invention relates to novel processes for preparing differentially protected lysine derivatives via a novel p-anisaldehyde Schiff base intermediate and the intermediate prepared therein.
|
|
WO/2001/017952A1 |
3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) including the opposite enantiomers thereof, wherein R?1¿ is either COOX, wherein X is alk...
|
|
WO/2001/010799A1 |
A method for preparing an N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.
|
|
WO/2001/005747A1 |
A nitrile compound is prepared by treating a solid supported amide to dehydrate it and cleave it from the support in one operation. The preparation involves acetylation of the amide compound in the presence of a base at a temperature of ...
|
|
WO/2001/000570A1 |
Problem: To provide intermediates for the synthesis of benzimidazole compounds having an excellent antihyperglycemic activity or salts thereof and a process for the preparation thereof. Means for solutions: A process for the preparation ...
|
|
WO/2001/000634A1 |
A method for making a vinyl carbonate represented by the formula (I): CH¿2?=CHOC(O)X¿1?R¿1?, wherein X¿1? is oxygen or sulfur and R¿1? is a substituted or an unsubstituted aliphatic alkyl, aryl, aryl alkyl, olefinic, vinyl, or cyclo...
|
|
WO/2001/000558A1 |
The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.
|
|
WO/2001/001569A2 |
The invention relates to a process for preparing (-)-(1S,4R) N protected 4-amino-2-cylcopentene-1-carboxylate esters represented by formula (I) wherein R¿1? and R¿2? are as described within the specification.
|
|
WO/2000/069944A1 |
Polymerizable urethane acid compounds are provided. Preferred compounds additionally comprise a hydroxy functionality. These compounds are made by reaction of hydroxy functional acid compounds with isocyanates.
|
|
WO/2000/055126A2 |
The present invention relates to novel $i(N)-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and $i(N)-oxides thereof, their uses as therapeutic agents and the methods of their making.
|
|
WO/2000/055113A1 |
A process of reacting an N-protected $g(a)-amino acid ester with a dihalomethyllithium to thereby obtain an $g(a)-amino dihalomethyl ketone derivative. This process is suitable for industrial production and enables economical and efficie...
|
|
WO/2000/055125A2 |
The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
|
|
WO/2000/055124A2 |
The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and $i(N)-oxides thereof; their uses as therapeutic agents and the methods of their making.
|
|
WO/2000/053575A1 |
An optically active $g(b)-amino acid ester derivative can be efficiently prepared on an industrial scale by reacting a $g(a)-amino acid ester derivative with a base and a dihalomethane to prepare a $g(a)-amino-$g(a)',$g(a)'-dihaloketone ...
|
|
WO/2000/053571A1 |
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...
|
