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JP6270180B2 |
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JP2017226676A |
To provide processes for making compounds useful as inhibitors of ATR kinase.The present invention relates to compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules, and processes ...
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JPWO2016140189A1 |
An object of the present invention is to provide a novel method for producing an optically active α-fluoroamino acid compound or a salt thereof. In particular, it is an object of the present invention to easily produce an α-fluoroamino...
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JP6212045B2 |
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds u...
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JP6195409B2 |
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JP6180936B2 |
Phenyl substituted bicyclooctane-1,3-dione derivative (I) and its isomers comprising 3-hydroxy-2-phenyl-4,5,6,6a-tetrahydro-3aH-pentalen-1-one derivative (IIa) and (IIb), and 2-phenyl-tetrahydro-pentalene-1,3-dione derivative (IIc), are ...
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JP6176259B2 |
A novel method for producing a stereoselective epoxyketone compound is provided. A method for producing an epoxyketone compound represented by the formula (1), as represented by the following scheme, whereby it is possible to obtain an e...
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JP2017521476A |
The carbamate functional material is produced by reacting the carbamate compound with the hydroxy functional material using zirconium acetylacetonate as a catalyst.
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JP2017132793A |
To provide a novel process for the synthesis of R-biphenylalaninol and its intermediates useful in the synthesis of pharmaceutically active compounds.The present invention provides a process for obtaining a compound of formula I by Boc-p...
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JP6173702B2 |
The present invention relates to a method for hydrogenating an imine to an optically active amine using a ruthenium metal complex represented by Formula (1) RuXYAB(1) such as RuBr 2 [(...
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JP6166939B2 |
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JP2017519038A |
The carbamate functional material is produced by reacting the carbamate compound with the hydroxy functional material using titanium (IV) alkoxide as a catalyst.
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JP6162887B2 |
The invention relates to novel carbodiimides having terminal urea and/or urethane groups, methods for the preparation thereof and use thereof as stabilizers in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene ter...
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JP6162795B2 |
The invention relates to compounds of the formula to a process for making same and to the use of the products in the solid phase peptide synthesis. The compounds of formula I are versatile peptide intermediates for the solid phase peptid...
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JP6159801B2 |
The present invention relates to a reaction method comprising a step of supplying a liquid containing at least one raw material compound and a low-boiling compound having a standard boiling point lower than a standard boiling point of th...
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JP6150179B2 |
This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalan...
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JP2017514832A |
The present invention is based on the formula Ia:The present invention relates to a method for preparing a JAK1 inhibitor having the above and a new form of the inhibitor.
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JP2017513930A |
The present invention18The present invention relates to a method for producing an organic compound containing an F atom.18The F-containing compound may be useful as a PET ligand for use in diagnostics and / or scanning. The method of the...
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JP2017095478A |
To provide substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions.In one embodiment, a substituted saccharide amide compound comprises a hydrophobic gro...
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JP6140768B2 |
A method for producing a carbonyl compound of the present invention comprises a step (X) of reacting a specific compound having a urea bond with a carbonic acid derivative having a carbonyl group (-C(=O)-) under heating at a temperature ...
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JP6140405B2 |
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JP6120215B2 |
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JP2017510553A |
The present disclosure provides a method for the preparation of compounds of the formula, which are selective delayed sodium current inhibitors. The disclosure also provides compounds that are synthetic intermediates. The present disclos...
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JP6112011B2 |
The present invention provides a production method of peptide, which includes the following step (1). (1) removing N-terminal Fmoc group of N-Fmoc C-protected amino acid or N-Fmoc C-protected peptide wherein a C-terminal carboxy group is...
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JP6106452B2 |
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JPWO2015037460A1 |
A step of reacting an optically active biphenylalanine represented by the formula [I] with a reducing agent to obtain an optically active biphenylalaninol represented by the formula [II]; and a step represented by the formula [II] obtain...
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JPWO2014200094A1 |
[Abstract] PROBLEM TO BE SOLVED: To provide a novel method for producing a stereoselective optically active alcohol compound. An industrially useful production method capable of producing an optically active alcohol compound represented ...
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JPWO2014157612A1 |
Providing a method for efficiently producing (1S, 4S, 5S) -4-bromo-6-oxabicyclo [3.2.1] octane-7-one (1), which is important as an intermediate compound for producing FXa inhibitory compounds. The challenge is to do. Treatment of the (R)...
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JP6067700B2 |
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JP2017014131A |
To provide an industrially advantageous manufacturing method of 3-isobutyl aniline useful as a manufacturing intermediate of an agricultural acaricide.There is provided a method of manufacturing 3-isobutyl aniline or salts thereof by rea...
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JP2017014109A |
To provide a method to manufacture optically active 2,6-dimethyl tylosin derivative with high optics purity useful as a medicinal intermediate product easily and efficiently.By separating and removing 2,6-dimethyl tylosin derivative with...
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JP6061399B2 |
As shown by the following formula (1), after methyl laurate (2 mmol) and water (8 mL) are added to an ammonium pyrosulfate catalyst (5 mol%), a hydrolysis reaction of methyl laurate is carried out by heating for 24 hours at 60°C while s...
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JP6059799B2 |
Xylylene dicarbamate contains impurities represented by formulas (1) to (4) below at a ratio of less than 100 ppm as a total amount thereof on a mass basis. (In the above-described formulas (1) to (4), R represents a monovalent hydrocarb...
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JP6055084B2 |
A method for producing an isocyanate, comprising: a carbamation step of generating an N-substituted carbamate from an organic primary amine, urea and an organic hydroxy compound according to a carbamation reaction, and then recovering a ...
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JP6049804B2 |
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18 F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of comp...
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JP6046154B2 |
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a n...
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JP2016204286A |
To provide a method for producing a carbamate compound that can efficiently recover ammonia and an organic hydroxy compound after carbamation reaction and can stably perform the operation.The method for producing a carbamate compound by ...
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JP6034802B2 |
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and ...
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JP2016536367A |
The present invention is a manufacturing method of the new carbamate intermediate of formula II, and the new carbamate intermediate of formula II, And it is related with the converting method to the salt which can be permitted as 3- [(R ...
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JP6021918B2 |
The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II...
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JP2016188196A |
To provide a method for producing a urethane compound, with which a compound having a cyclic carbonate group is made to efficiently react with an amine compound, and a urethane compound can be obtained with good yield.There is provided a...
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JP6018578B2 |
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging p...
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JP6014512B2 |
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JP2016532705A |
In the present invention, equation (1) {in equation, a is an integer of 1 to 10, more preferably 1 to 3; b is an integer of 0 to 7; Z is a terminal group, and Y is two. With respect to the peptide modifier compound or salt thereof, which...
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JP6005340B2 |
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JP6002133B2 |
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, ba...
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JP2016528271A |
The present invention relates to a novel synthetic pathway for R-biphenylalaninol and intermediates used in this synthetic pathway. The methods and intermediate compounds of the present invention are useful in the synthesis of pharmaceut...
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JP2016160212A |
To use arylboronic acid with a chemical structure more simpler than that of the conventional one in a method for producing carboxylic acid amide.Provided is a method for producing carboxylic acid amide capable of obtaining carboxylic aci...
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JP2016160213A |
To provide a convenient and high diastereo/enantioselective synthesis method for optically active α,β-diaminonitrile.The present invention provides an asymmetric catalytic production method for optically active α,β-diaminonitrile by ...
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JP5963140B2 |
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