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Matches 251 - 300 out of 3,496

Document Document Title
WO/2010/024762A1
A process for stereoselective synthesis of a β-phenylisoserine comprises reacting a carbonyl imine R-C=N-CO-OR1 with a protected α- oxyaldehyde X1O-CH2CHO in the presence of a chiral amine catalyst and oxidizing aldehyde so obtained.  
WO/2010/023892A1
Disclosed is a method of efficiently producing N-carboxy amino acid anhydride. The N-carboxy amino acid anhydride production method is characterized by including a process in which an amino acid organic salt compound and a carbonic acid ...  
WO/2010/023535A1
Disclosed herein are novel intermediates and process for large scale production of (S)- 3-[(1-dimethylamino) ethyl] phenyl-N-ethyl-N-methyl-carbamate (rivastigmine) or its pharmaceutically acceptable salts employing the novel intermediat...  
WO/2010/020621A1
Method for producing urethanes through reaction of aromatic diamines with a dialkyl carbonate, characterized in that the alkyl group of the organic dialkyl carbonate has 2-18 carbon atoms and one or more heteroatoms and the reaction is c...  
WO/2010/017504A1
The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods.Formula I  
WO/2010/015935A2
Disclosed herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of cinacalcet hydrochloride. Disclosed also herein are novel hydrochloride, oxalate and di-p-toluoyl-L-(+)-tartrate sal...  
WO/2010/015935A3
Disclosed herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of cinacalcet hydrochloride. Disclosed also herein are novel hydrochloride, oxalate and di-p-toluoyl-L-(+)-tartrate sal...  
WO/2010/013666A1
Disclosed is a commercially novel method for producing a carbamate compound by using a carbonic acid ester and an amide compound in the presence of a basic compound, wherein the reaction speed is higher than those in the conventional met...  
WO/2010/008312A1
The inventions relates to chemistry and medicine, in particular to antihypertensive agents and to the methods of the production thereof. The aim of said invention is to develop novel 1-alkyl-2-alkylcarbomoyl-glycerin derivatives which co...  
WO/2010/008886A2
Gabapentin prodrugs and intermediates thereof are described.  
WO/2010/008522A3
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically su...  
WO/2010/008522A2
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically su...  
WO/2010/008886A3
Gabapentin prodrugs and intermediates thereof are described.  
WO/2010/000888A1
Procedure for preparing carbamates comprising reaction between at least: an amine or polyamines, an organic carbonate of formula (OR)(OR’)C=O, a catalyst formed at least by a support selected from among at least a metal oxide, a microp...  
WO/2009/147687A3
The present patent application relates to an improved process for the separation of enantiomerically pure compounds. Specifically it relates to separation of enantiomerically pure Rivastigmine, Duloxetine, Escitalopram and their intermed...  
WO/2009/147687A2
The present patent application relates to an improved process for the separation of enantiomerically pure compounds. Specifically it relates to separation of enantiomerically pure Rivastigmine, Duloxetine, Escitalopram and their intermed...  
WO/2009/139061A1
This invention provides a production process which, in producing an isocyanate without using phosgene, is free from various problems as seen in the prior art and can stably produce the isocyanate at a high yield for a long period of time...  
WO/2009/136365A1
The present invention relates to a process for the preparation of threo-3,4-epoxy-2- amino-1-substituted butane derivatives represented by general Formula I which comprises reacting compound of Formula III or salt thereof with an active ...  
WO/2009/118341A1
The invention relates to a method for producing aldehydes by reacting an α,β-unsaturated carboxylic acid or the salt thereof with carbon monoxide and hydrogen in the presence of a catalyst, said catalyst comprising at least one complex...  
WO/2009/115537A8
The invention provides metal carbamates of the general formula (I) where R1 and R2 are each an alkyl group.  
WO/2009/115538A1
The object of the invention is a method for producing urethanes through reaction of aromatic amines with a dialkyl carbonate, characterized in that the alkyl radical of the organic dialkyl carbonate has 2-18 carbon atoms and the reaction...  
WO/2009/115537A1
The invention provides metal carbamates of the general formula (I) where R1 and R2 are each an alkyl group.  
WO/2009/113608A1
Provided is a process by which a urethane (meth)acrylate can be safely produced with satisfactory productivity. The process is a continuous process for urethane (meth)acrylate production which comprises causing a liquid mixture of a comp...  
WO/2009/108484A1
The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a nov...  
WO/2009/102556A3
Processes for the alcoholysis, inclusive of transesterification and/or disproportionation, of reactants are disclosed. The alcoholysis process may include feeding reactants and a trace amount of soluble organometallic compound to a react...  
WO/2009/102556A8
Processes for the alcoholysis, inclusive of transesterification and/or disproportionation, of reactants are disclosed. The alcoholysis process may include feeding reactants and a trace amount of soluble organometallic compound to a react...  
WO/2009/098327A1
Method for producing fluorinated carbamates that comprises the reaction between an amine or polyamine and a fluorinated carbonate in the presence of a catalyst in the presence of basic heterogeneous catalysts. The method may also compris...  
WO/2009/096545A1
A diurethane compound R2(SO2)m(CH2)nOCONH-R1-NHCOO(CH2)n(SO2)mR2 is produced by a method in which a diamine compound H2NR1NH2 is reacted with a chloroformate compound ClCOO(CH2)n(SO2)mR2 or by a method in which a diisocyanate compound OC...  
WO/2009/095164A1
The invention relates to a method for producing urethanes by the oxidative carbonylation of amino compounds in the presence of carbon monoxide, oxygen and organic compounds carrying hydroxyl groups, characterized in that the carbonylatio...  
WO/2009/094563A2
A crystalline form of Ca-salts of (3S) -aminomethyl-5-hexanoic acids and methods of preparing a crystalline form of a (3S) -aminomethyl-5-hexanoic acid and methods of using a crystalline form of a (3S) -aminomethyl-5-hexanoic acid are pr...  
WO/2009/094569A3
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.  
WO/2009/094563A3
A crystalline form of Ca-salts of (3S) -aminomethyl-5-hexanoic acids and methods of preparing a crystalline form of a (3S) -aminomethyl-5-hexanoic acid and methods of using a crystalline form of a (3S) -aminomethyl-5-hexanoic acid are pr...  
WO/2009/094569A2
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.  
WO/2009/090251A2
The invention relates to a process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according ...  
WO/2009/090251A3
The invention relates to a process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according ...  
WO/2009/078396A1
The object is to provide a method for improving the yield in the radioactive fluorination in the process for producing a radioactive-fluorine-labeled organic compound. Provided is a method for labeling a compound represented by the formu...  
WO/2009/075291A1
Disclosed is a novel optically active dinickel complex. Also disclosed is a method for producing a novel optically active amine by an asymmetric Mannich reaction using the optically active dinickel complex as a catalyst. Specifically dis...  
WO/2009/054240A1
Hexamethylphosphoramide (HMPA) is added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The reaction vessel is purged with oxygen, and is stirred at 80°C for 5 days under 7 atmospheres of oxygen...  
WO/2009/050587A1
The present invention relates to a process of preparing a compound of Formula I: (I) Formula I Wherein R1 is defined in the specification. Compounds of Formula I are useful for treating disorders of the central nervous system, including ...  
WO/2009/044707A1
Disclosed is a nitrotriazole derivative represented by the general formula (I) below. This nitrotriazole derivative is a compound useful as a synthesis reagent for synthesizing a carbamate, a carbonate and a thiocarbonate, which are usef...  
WO/2009/018939A1
The present invention relates to a process for heterogeneously catalyzed partial esterification of (meth)acrylic acid with oxyalkylated polyols, wherein the oxyalkylated polyols have at least 3 free hydroxyl groups, and wherein the catal...  
WO/2009/016879A1
It is intended to provide a process for producing an optically active N-(halopropyl)amino acid derivative. This method comprises: the step wherein an optically active alanine ester represented by the formula (I) or its salt (hereinafter ...  
WO/2009/013062A1
Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO2 in the presence of ionic liquids and optionally in the presence of a base.  
WO/2008/151992A2
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151992A3
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151785A1
The invention relates to a method for producing a compound which has at least one ether group, at least one ester group, at least one amino group or at least one urethane group, preferably at least one ester group. The method according t...  
WO/2008/151784A1
The invention relates to a method for producing 1,2 propandiol by hydrogenation of glycerol using hydrogen gas, wherein glycerol is reacted with hydrogen to give 1,2 propandiol. This reaction is carried out in at least i reactors R1 to R...  
WO/2008/142100A1
The invention relates to an improved method for producing carbonate-terminated urethanes using isocyanates. The method according to the invention is characterized by high yields with no phenol being produced as a secondary component.  
WO/2008/139467A2
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  
WO/2008/139467A3
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  

Matches 251 - 300 out of 3,496