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WO/2011/060302A1 |
The embodiments described herein provide a reduction of an aldehyde or a ketone, such as a Meerwein-Ponnorf-Verley (MPV) reaction of an aldehyde or ketone. In some embodiments, the reaction occurs in the presence of A1[OC(CH3)3]. In some...
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WO/2011/054171A1 |
Tyrosine derivative histone deacetylases inhibitors and preparation methods and applications thereof are disclosed. A kind of powerful histone deacetylases inhibitors, which can effectively treat the diseases of abnormal expression of th...
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WO/2011/054818A2 |
The invention relates to a novel non-crystallizing methacrylate and a method for the production thereof. The invention further relates to a photopolymer formulation comprising the methacrylate of the invention as well as to use of said p...
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WO/2011/048124A1 |
The invention relates to a method for producing urethanes by reacting aromatic amines by with a dialkyl carbonate, characterized in that the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in th...
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WO/2011/048727A1 |
Provided is a ruthenium carbonyl complex represented by general formula (1). (1) RuXY(CO)(L) (In general formula (1), X and Y represent anionic ligands and may be the same as each other or different from each other; and L represents a tr...
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WO/2011/037613A1 |
The present invention relates to salts of 2-(2-((4-(((4-chlorophenyl)(phenyl)-carbamoyloxy)methyl)cycl
ohexyl)methoxy)acetamido)ethanesulfonic acid (Compound 1) and crystalline forms, solvates and hydrates thereof. The present invention ...
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WO/2011/023757A1 |
A process for preparing iodopropargyl compounds of the formula (I) in which R is hydrogen, in each case optionally substituted C1-C20-alkyl, C2-C20-alkenyl, C6-C20-aryl or C3-C20-cycloalkyl, and n is an integer from 1 to 6, characterized...
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WO/2011/021257A1 |
Provided is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative, and a hydroxy compound containing one or more hydroxy compounds. The method comprise...
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WO/2011/022457A1 |
Compounds comprising a lactam moiety, and a urethane or urea functional group are presented. By a preferred synthesis route, they are prepared using at least one polymerizable compound comprising an isocyanate moiety and reacting it with...
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WO/2011/021258A1 |
Provided is a process for the preparation of an N-substituted carbamic acid O-aryl ester derived from a ureido-containing compound. The process comprises a step of preparing an N-substituted carbamic acid O-aryl ester from both a ureido ...
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WO/2010/122682A1 |
High-quality N-alkoxycarbonyl-tert-leucines can be efficiently and stably produced via simple operation by reacting tert-leucine with an N-alkoxycarbonylating agent in an amount of 0.90 to 1.00 time by mole that of tert-leucine in the pr...
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WO/2010/116871A1 |
Disclosed is a process for producing an urethane compound, which comprises reacting a primary amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol with one another in the presence of a catalyst comprising a first meta...
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WO/2010/113458A1 |
Disclosed is a commercially advantageous method for manufacturing a 1,5-benzodiazepine compound. A compound (5) is obtained from a reaction formula and used as an intermediate.
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WO2010110142A1 |
Disclosed is a process for producing a urethane compound, which comprises reacting a primary amine, either urea and/or an N-unsubstituted carbamic acid ester, and an alcohol with one another in the presence of a compound containing a non...
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WO/2010/105768A1 |
The invention is directed to a process for preparing aromatic carbamates which comprises the reaction of an aromatic amine with an organic carbonate in the presence of a catalyst characterized in that Zn4O(OAc)6 is used as catalyst.
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WO/2010/107993A2 |
(R)-Λ/-benzyl-2-(benzyloxycarbonylamino)-3 -methoxypropionamide is an intermediate useful for preparing lacosamide. It can be prepared, for example, by combining (R)-Λ/-benzyl-2-(benzyloxycarbonylamino)-3 -hydroxypropionamide with dime...
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WO/2010/103155A1 |
The invention relates to the production of carbamates in a single reactor (one-pot) using solid catalysts, involving the reaction between at least one nitro compound, an organic carbonate of formula (OR)(OR)C=O, a gas selected from hyd...
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WO/2010/104106A1 |
Disclosed is a method for industrially producing compound (1) and compound (4) to provide an important intermediate for producing an FXa inhibitor. Specifically disclosed is a production method characterized by comprising: a first step o...
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WO/2010/099745A1 |
Preparation methods of rivastigmine tartrate and its intermediate and the intermediate itself are disclosed. More specifically, the intermediate compound [1-(3-benzyloxy-phenyl)-ethyl]-dimethylamine, its preparation method and methods fo...
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WO/2010/100477A2 |
Prodrugs of tapentadol with amino acids or short peptides, pharmaceutical compositions containing such prodrugs and a method for providing pain relief with the tapentadol prodrugs are provided herein. Prodrugs having side chains of valin...
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WO/2010/098193A1 |
Optically active β-aminocarbonyl compounds are obtained by a Mannich reaction of an optically active binaphthol represented by formula (1a), (1b), (2a) or (2b) (in each formula, Ar1 is a phenyl group wherein hydrogen atoms are bound to ...
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WO/2010/090031A1 |
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-
pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for pr...
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WO/2010/073974A1 |
Amides or lactams can be reduced respectively into alcohols or amino alcohols in the presence of an 8(VIII) group transition metal complex, a base and hydrogen gas (H2). By appropriately combining an 8(VIII) group transition metal compl...
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WO/2010/075520A1 |
Allyl 1 {[(α-isobutanoyloxyethoxy)carbonyl] aminomethyl} -1-cyclohexane acetate can be prepared by combining allyl 1-aminomethyl-1-cyclohexane acetate hydrochloride, a polar organic solvent, chloroethyl chloroformate, and an amine base ...
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WO/2010/072798A1 |
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drag substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmet...
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WO/2010/070039A1 |
A continuous process for the production of an aromatic urethane from the reaction of an aromatic amine and an organic carbonate comprising the steps of passing the aromatic amine and the organic carbonate through a fixed bed reactor cont...
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WO/2010/063002A2 |
Gabapentin enacarbil was prepared and purified from intermediates such as 1- haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a C1 to C 10 alcohol or...
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WO/2010/062490A2 |
The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate wh...
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WO/2010/057378A1 |
A method for the preparation of docetaxel of formula 1, comprising: (1) acylating the hydroxyl of compound 2 with compound 3 to obtain compound 4; (2) removing the hydroxyl-protecting group R1 of the obtained compound 4 to obtain compoun...
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WO/2010/047775A2 |
Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
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WO/2010/041739A1 |
The issue is to provide a method to obtain optically active vinyl-cyclopropane carboxylic acid derivatives with high yield and high optical purity using starting materials that are safe and easily acquired at a low cost. An additional is...
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WO/2010/038828A1 |
A novel photobase generator which can sensitively generate a base even by h-ray in place of conventional 2-nitro-4,5-dimethoxybenzyloxycarbonylamine compound photobase generators. Specifically disclosed is an N-(α-aromatic group-substit...
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WO/2010/024762A1 |
A process for stereoselective synthesis of a β-phenylisoserine comprises reacting a carbonyl imine R-C=N-CO-OR1 with a protected α- oxyaldehyde X1O-CH2CHO in the presence of a chiral amine catalyst and oxidizing aldehyde so obtained.
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WO/2010/023892A1 |
Disclosed is a method of efficiently producing N-carboxy amino acid anhydride. The N-carboxy amino acid anhydride production method is characterized by including a process in which an amino acid organic salt compound and a carbonic acid ...
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WO/2010/023535A1 |
Disclosed herein are novel intermediates and process for large scale production of (S)- 3-[(1-dimethylamino) ethyl] phenyl-N-ethyl-N-methyl-carbamate (rivastigmine) or its pharmaceutically acceptable salts employing the novel intermediat...
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WO/2010/020621A1 |
Method for producing urethanes through reaction of aromatic diamines with a dialkyl carbonate, characterized in that the alkyl group of the organic dialkyl carbonate has 2-18 carbon atoms and one or more heteroatoms and the reaction is c...
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WO/2010/017504A1 |
The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods.Formula I
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WO/2010/015935A2 |
Disclosed herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of cinacalcet hydrochloride. Disclosed also herein are novel hydrochloride, oxalate and di-p-toluoyl-L-(+)-tartrate sal...
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WO/2010/013666A1 |
Disclosed is a commercially novel method for producing a carbamate compound by using a carbonic acid ester and an amide compound in the presence of a basic compound, wherein the reaction speed is higher than those in the conventional met...
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WO/2010/008312A1 |
The inventions relates to chemistry and medicine, in particular to antihypertensive agents and to the methods of the production thereof. The aim of said invention is to develop novel 1-alkyl-2-alkylcarbomoyl-glycerin derivatives which co...
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WO/2010/008886A2 |
Gabapentin prodrugs and intermediates thereof are described.
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WO/2010/008522A2 |
Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically su...
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WO/2010/000888A1 |
Procedure for preparing carbamates comprising reaction between at least: an amine or polyamines, an organic carbonate of formula (OR)(OR’)C=O, a catalyst formed at least by a support selected from among at least a metal oxide, a microp...
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WO/2009/147687A2 |
The present patent application relates to an improved process for the separation of enantiomerically pure compounds. Specifically it relates to separation of enantiomerically pure Rivastigmine, Duloxetine, Escitalopram and their intermed...
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WO/2009/139061A1 |
This invention provides a production process which, in producing an isocyanate without using phosgene, is free from various problems as seen in the prior art and can stably produce the isocyanate at a high yield for a long period of time...
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WO/2009/136365A1 |
The present invention relates to a process for the preparation of threo-3,4-epoxy-2- amino-1-substituted butane derivatives represented by general Formula I which comprises reacting compound of Formula III or salt thereof with an active ...
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WO/2009/118341A1 |
The invention relates to a method for producing aldehydes by reacting an α,β-unsaturated carboxylic acid or the salt thereof with carbon monoxide and hydrogen in the presence of a catalyst, said catalyst comprising at least one complex...
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WO/2009/115538A1 |
The object of the invention is a method for producing urethanes through reaction of aromatic amines with a dialkyl carbonate, characterized in that the alkyl radical of the organic dialkyl carbonate has 2-18 carbon atoms and the reaction...
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WO/2009/115537A1 |
The invention provides metal carbamates of the general formula (I) where R1 and R2 are each an alkyl group.
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WO/2009/113608A1 |
Provided is a process by which a urethane (meth)acrylate can be safely produced with satisfactory productivity. The process is a continuous process for urethane (meth)acrylate production which comprises causing a liquid mixture of a comp...
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