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Matches 1 - 50 out of 3,414

Document Document Title
WO/2018/050795A1
The present invention relates to a process for preparing a carotenoid mono-ester of the formula (I), including the stereoisomers of formula (I), wherein, R1 is e.g. hydrogen, C1-C20-alkyl, C2-C20-alkenyl, C4-C20-alkdienyl, C6-C20-alktrie...  
WO/2018/043658A1
Provided is an economically efficient method by which a carbamic acid ester is able to be produced with high yield and high selectivity. In a method for producing a carbamic acid ester according to the present invention, an amine, carbon...  
WO/2018/038130A1
Provided are a chemical reaction device able to promote a chemical reaction, and a method for producing same. The chemical reaction device has an optical electric field confinement/chemical reaction container structure obtained by integr...  
WO/2018/038426A1
The present invention relates to: a novel acid addition salt of an optically active diamine derivative; and a preparation method therefor. The diamine derivative acid addition salt of the present invention can prepare edoxaban with high ...  
WO/2018/032359A1
Provided are an ethyl carbamate hapten combination, artificial antigen combination, and method for preparing same and application of same. The ethyl carbamate artificial antigen combination has the molecular structure as shown in formula...  
WO/2018/033866A1
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...  
WO/2018/024828A1
A process for the preparation of N-(dialkylaminoalkyl)-carbamic acid esters, in particular (propyl N-[3-(dimethylamino)propyl] carbamate) comprising an oxidative carbonylation reaction of a compound of general structure (II) wherein each...  
WO/2018/007919A1
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...  
WO/2017/214539A1
The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.  
WO/2017/211145A1
The present invention discloses a micro/nanomaterial, a product thereof with a surface covalently modified with a hydrophilic material, and a manufacturing method. The surface of the micro/nanomaterial comprises a carboxyl group or poten...  
WO/2017/206692A1
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions and/or organic amine B cations; m ...  
WO/2017/206693A1
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions, hydrazine ions and/or organic ami...  
WO/2017/204144A1
Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal o...  
WO/2017/195147A1
The present invention relates to process for preparation of ledipasvir of formula (1) and its novel intermediates. The process involves reacting a compound of formula (4) with compound of formula (5) to yield a compound of formula (3), d...  
WO/2017/191332A3
A process of forming compounds of formula (I) comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.  
WO/2017/175238A1
: The invention discloses a novel process for highly chemoselective reactions of substituted anilines without any detectable reaction at aromatic amino group. The invention also relates to a novel process for preparation of neostigmine m...  
WO/2017/170934A1
The present invention pertains to an acetylacetone derivative which is useful in trapping metal elements by complex formation, and a simple and highly versatile synthesis method therefor. More specifically, the present invention pertains...  
WO/2017/155120A1
The present invention addresses the problem of providing a long life catalyst which can be produced simply and inexpensively, which exhibits high activity, and in which metal leakage is suppressed. Provided is a catalyst according to sev...  
WO/2017/137343A1
A method for the production of carbamate compounds comprises the steps of: A) reacting an organic primary amine with an organic halogen compound in the presence of a quaternary organic ammonium carbonate and/or bicarbonate, thereby obtai...  
WO/2017/133620A1
The present invention relates to a synthesis process of suvorexant, and a preparation method of novel compounds represented by formulas II, III, IV or V, or a salt or intermediate thereof for preparing the suvorexant. The preparation met...  
WO/2017/100750A1
An adhesive comprising an allyl (urethane) silane, where the allyl (urethane) silane comprises at least one allyl-functional group and one silane-functional group connected through a urethane linkage. Preferably, the allyl(urethane) sila...  
WO/2017/098975A1
A method for producing methyl (2Z)-3-(1,1'-biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]- prop-2-enoate, comprising the steps of: reacting 4-phenylbenzaldehyde with glycine in the presence of sodium hydroxide or potassium hydroxide to pr...  
WO/2017/070418A1
Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.  
WO/2017/059759A1
A process is provided for preparation of (R)-N-Boc biphenyl alaninol.It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 ...  
WO/2017/043626A1
Provided is a method for producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative, which is a compound useful as an intermediate for a medicine, in a simple manner and with high efficiency. 4-carbamoyl-2,6-dimethylb...  
WO/2017/020835A1
An antibiotic for inhibiting a drug-resistant microorganism. The antibiotic is Fmoc-Ala-OPfp, which is not toxic to human cells and can effectively inhibit a drug-resistant microorganism.  
WO/2017/019791A1
Provided is a process for preparing (S)-Pregabalin  
WO/2016/199688A1
Tert-Butyl[(2R)-1-(biphenyl-4-yl)-3-hydroxypropan-2-yl]carba mate can be produced by a step for obtaining a protic acid salt of a compound shown by formula [C]: by reacting a compound shown by formula [A]: with an alcohol shown by formul...  
WO/2016/192150A1
A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic peptide lipids are dispersed in water, a cationic liposome with a particle size...  
WO/2016/193474A1
Reaction product containing amidoamine groups, containing one or more species of the general formula (I) (R1-X)p-Z1-(XH)y where p + y = w and w is an integer from 1 to 10, p is an integer from 1 to 10, y is an integer from 0 to 9, and X ...  
WO/2016/184160A1
The present invention relates to a chiral spiro phosphorus-nitrogen-sulphur (P-N-S) tridentate ligand, and a preparation method and application thereof. The P-N-S tridentate ligand is a compound represented by formula I or formula II, a ...  
WO/2016/180275A1
Disclosed are AHU-377 intermediates and a method for preparing AHU-377 and AHU-377 intermediates. The above-mentioned method for preparing AHU-377 uses a chiral glycidyl benzyl ether as the starting raw material. Intermediate compound (3...  
WO/2016/177761A1
The present invention relates to a process for the preparation of an isocyanate compound comprising the steps of: a) Reacting an amine compound A having at least one primary amino group with CO2 and an organotin compound S having at leas...  
WO/2016/176636A1
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.  
WO/2016/150823A1
Described is a method of preparing a carbamate-functional material. The method comprises reacting a carbamate compound with a hydroxy-functional material using a zinc catalyst. Also described are carbamate-functional materials prepared b...  
WO/2016/150953A1
The present invention relates to a process for synthesis of 4,5,6,7- tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to ob...  
WO/2016/147204A1
The present invention discloses an improved catalyst free process for synthesis of alkyl carbamates in an integrated system comprising a tubular reactor and a striper. The process comprises reacting urea and an alcohol in said tubular re...  
WO/2016/140189A1
The purpose of the present invention is to provide a novel method for producing an optically active α-fluoro amino acid compound or a salt thereof. More specifically, the purpose is to produce an α-fluoro amino acid compound or a salt ...  
WO/2016/123707A1
The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in par...  
WO/2016/119757A1
The present invention relates to a method for preparing a 2-[1-cycloalkylethyl] phenol derivative, i.e. a method for preparing a compound as shown in formula (I) and an isomer thereof, and an intermediate, and the method has the advantag...  
WO/2016/114670A1
The invention pertains to the synthesis of carbamate and urea compounds. In particular the invention is directed to the synthesis of carbamate and urea compounds which may be used in the production of compounds that are used to stabilize...  
WO/2016/083475A1
The invention relates to an electrochemical process for preparing bis-O-alkyl-carbamates from primary amines with C02 as carbonyl source and at least one alkyl halide with at least 3 C-atoms in the alkyl group as alkylating agent.  
WO/2016/075605A1
The present invention provides a process for the preparation of crystalline anhydrous compound of Formula (X), Further, the present invention relates to the use of compound of Formula (X) preparation of Raltegravir (I) or its pharmaceuti...  
WO/2016/055015A1
Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: under the existence of transition metal catalyst of chiral phosphine ligand and hydrogen, conducting asymmetrical reduction ammonification reaction...  
WO/2016/047644A1
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copp...  
WO/2016/026459A1
The present invention relates to an isopropyl phenol derivative and a preparation method thereof, and in particular relates to a method for preparing compounds shown by formulae (I) and (IV), and their intermediates, and to their interme...  
WO/2016/019630A1
Disclosed is a method for synthesizing 1,3-disubstituted allene with high optical activity, namely a method for preparing 1,3-disubstituted allene with high optical activity in one step of functionalizing terminal alkyne, aldehyde and ch...  
WO/2016/015596A1
A process of preparing 2, 3-disubstituted-5-oxopyran compounds, comprising cyclizing a compound in the presence of a base and an organic solvent is provided.  
WO/2016/002918A1
 Provided is a novel method for producing an indole compound or salt thereof having an ITK-inhibiting effect and being useful in the treatment or prevention of inflammatory diseases and the like. A method for producing N-[2-(6,6-dimeth...  
WO/2015/195656A3
Methods of making compounds of Formula (I) are disclosed.  

Matches 1 - 50 out of 3,414