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Matches 1 - 50 out of 3,459

Document Document Title
WO/2019/009317A1
Provided are: a novel compound usable as an organic tag which has a high stability under acidic conditions in peptide synthesis, etc.; and a method for highly efficiently producing a peptide wherein the compound is used as an organic tag.  
WO/2019/004114A1
Provided is a production method for efficiently synthesizing a compound (1-2) which is an important intermediate in production of edoxaban. The method comprises dripping a compound (1-1) into a solution A that is obtained by causing a re...  
WO/2019/002540A1
The present invention relates to a method for producing an object in an additive manufacturing process from a precursor and comprises the following steps: I) depositing a layer of a radically cross-linkable construction material, which c...  
WO/2018/219212A1
The present invention provides an antibacterial hydrophilic compound. The antibacterial hydrophilic compound can react with a C-H group by means of a photoinitiation hydrogen abstraction group in the structural formula thereof and thus b...  
WO/2018/216036A1
The present invention discloses a process for the synthesis of aromatic carbamates from amine with dialkyl carbonate in the presence of binary or ternary mixed metal oxide catalyst. The present invention further discloses the yield of sa...  
WO/2018/212206A1
This isocyanate production method is characterized by having: a carbamation step for reacting a carbonic acid ester, an inorganic acid salt of an amino acid derivative, and a basic compound with one another, and obtaining a reaction mixt...  
WO/2018/210711A1
The present invention relates to silica-based heterogeneous zinc compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce carbamates. The catalysts have the formula [SiO2]-CH2-CHR-X-COOZn[Y],...  
WO/2018/212176A1
[Problem] To provide a photopolymerization sensitizer which gives a practically sufficient photocuring rate without arousing the problem wherein additives including a photopolymerization sensitizer bleed out to the surface during photocu...  
WO/2018/207120A1
The present invention is directed towards a process for the preparation of 4- fluoro-2-methoxy-5-nitroaniline (I) or salts thereof, wherein, 4-fluoro-2-methoxy aniline (III) is protected to obtain N-protected-(4-fiuoro-2-methoxy)aniline ...  
WO/2018/199147A1
Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence o...  
WO/2018/187667A1
The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produ...  
WO/2018/182102A1
One embodiment of the present invention provides: a metal selenide-supported (MSe2) catalyst for preparing urethane, comprising a solid support and a metal selenide (MSe2) adsorbed and supported on the surface of the solid support; a pre...  
WO/2018/181710A1
A monomer useful as a dental material, a composition, a dental material, and a kit are provided. This monomer for a dental material contains a compound in which a core part (X) and a specific terminal group (Y2) are bonded together direc...  
WO/2018/160306A1
The present disclosure generally relates to hydroxyalkylurethanes obtained from the reaction of amines and alkylene carbonates and their use in gas hydrate inhibitor compositions to effectively inhibit gas hydrate formation in a crude hy...  
WO/2018/141751A1
The invention relates to an economical, single-stage method for producing n-substituted aromatic hydroxylamine of formula (I) R-N(OH)-C(=O)-(O) R1 (I), using hydrogen, by catalytic hydrogenation using optionally modified hydrogenation ca...  
WO/2018/133703A1
The present invention relates to crystal forms of R228060 hydrochloride and a preparation method and use thereof. The crystal forms CS1 and CS2 of R228060 hydrochloride provided by the present invention have good stabilities, high solubi...  
WO/2018/096484A1
The current invention offers a process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid by a reaction of tert-Leucine with di-tert-butyl-dicarbonate, the process comprising (i) contacting the tert-Leucine with di-tert-butyl-d...  
WO/2018/073124A1
The invention relates to the preparation of fluorosubstituted fluoroformate from halosubstituted haloformate by reaction with at least one fluorinating agent in the presence of a catalyst. The further preparation of fluorosubstituted (fl...  
WO/2018/050795A1
The present invention relates to a process for preparing a carotenoid mono-ester of the formula (I), including the stereoisomers of formula (I), wherein, R1 is e.g. hydrogen, C1-C20-alkyl, C2-C20-alkenyl, C4-C20-alkdienyl, C6-C20-alktrie...  
WO/2018/043658A1
Provided is an economically efficient method by which a carbamic acid ester is able to be produced with high yield and high selectivity. In a method for producing a carbamic acid ester according to the present invention, an amine, carbon...  
WO/2018/038130A1
Provided are a chemical reaction device able to promote a chemical reaction, and a method for producing same. The chemical reaction device has an optical electric field confinement/chemical reaction container structure obtained by integr...  
WO/2018/038426A1
The present invention relates to: a novel acid addition salt of an optically active diamine derivative; and a preparation method therefor. The diamine derivative acid addition salt of the present invention can prepare edoxaban with high ...  
WO/2018/032359A1
Provided are an ethyl carbamate hapten combination, artificial antigen combination, and method for preparing same and application of same. The ethyl carbamate artificial antigen combination has the molecular structure as shown in formula...  
WO/2018/033866A1
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...  
WO/2018/024828A1
A process for the preparation of N-(dialkylaminoalkyl)-carbamic acid esters, in particular (propyl N-[3-(dimethylamino)propyl] carbamate) comprising an oxidative carbonylation reaction of a compound of general structure (II) wherein each...  
WO/2018/007919A1
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...  
WO/2017/214539A1
The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.  
WO/2017/211145A1
The present invention discloses a micro/nanomaterial, a product thereof with a surface covalently modified with a hydrophilic material, and a manufacturing method. The surface of the micro/nanomaterial comprises a carboxyl group or poten...  
WO/2017/206692A1
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions and/or organic amine B cations; m ...  
WO/2017/206693A1
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions, hydrazine ions and/or organic ami...  
WO/2017/204144A1
Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal o...  
WO/2017/195147A1
The present invention relates to process for preparation of ledipasvir of formula (1) and its novel intermediates. The process involves reacting a compound of formula (4) with compound of formula (5) to yield a compound of formula (3), d...  
WO/2017/191332A3
A process of forming compounds of formula (I) comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.  
WO/2017/175238A1
: The invention discloses a novel process for highly chemoselective reactions of substituted anilines without any detectable reaction at aromatic amino group. The invention also relates to a novel process for preparation of neostigmine m...  
WO/2017/170934A1
The present invention pertains to an acetylacetone derivative which is useful in trapping metal elements by complex formation, and a simple and highly versatile synthesis method therefor. More specifically, the present invention pertains...  
WO/2017/155120A1
The present invention addresses the problem of providing a long life catalyst which can be produced simply and inexpensively, which exhibits high activity, and in which metal leakage is suppressed. Provided is a catalyst according to sev...  
WO/2017/137343A1
A method for the production of carbamate compounds comprises the steps of: A) reacting an organic primary amine with an organic halogen compound in the presence of a quaternary organic ammonium carbonate and/or bicarbonate, thereby obtai...  
WO/2017/133620A1
The present invention relates to a synthesis process of suvorexant, and a preparation method of novel compounds represented by formulas II, III, IV or V, or a salt or intermediate thereof for preparing the suvorexant. The preparation met...  
WO/2017/100750A1
An adhesive comprising an allyl (urethane) silane, where the allyl (urethane) silane comprises at least one allyl-functional group and one silane-functional group connected through a urethane linkage. Preferably, the allyl(urethane) sila...  
WO/2017/098975A1
A method for producing methyl (2Z)-3-(1,1'-biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]- prop-2-enoate, comprising the steps of: reacting 4-phenylbenzaldehyde with glycine in the presence of sodium hydroxide or potassium hydroxide to pr...  
WO/2017/070418A1
Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.  
WO/2017/059759A1
A process is provided for preparation of (R)-N-Boc biphenyl alaninol.It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 ...  
WO/2017/043626A1
Provided is a method for producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative, which is a compound useful as an intermediate for a medicine, in a simple manner and with high efficiency. 4-carbamoyl-2,6-dimethylb...  
WO/2017/020835A1
An antibiotic for inhibiting a drug-resistant microorganism. The antibiotic is Fmoc-Ala-OPfp, which is not toxic to human cells and can effectively inhibit a drug-resistant microorganism.  
WO/2017/019791A1
Provided is a process for preparing (S)-Pregabalin  
WO/2016/199688A1
Tert-Butyl[(2R)-1-(biphenyl-4-yl)-3-hydroxypropan-2-yl]carba mate can be produced by a step for obtaining a protic acid salt of a compound shown by formula [C]: by reacting a compound shown by formula [A]: with an alcohol shown by formul...  
WO/2016/192150A1
A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic peptide lipids are dispersed in water, a cationic liposome with a particle size...  
WO/2016/193474A1
Reaction product containing amidoamine groups, containing one or more species of the general formula (I) (R1-X)p-Z1-(XH)y where p + y = w and w is an integer from 1 to 10, p is an integer from 1 to 10, y is an integer from 0 to 9, and X ...  
WO/2016/184160A1
The present invention relates to a chiral spiro phosphorus-nitrogen-sulphur (P-N-S) tridentate ligand, and a preparation method and application thereof. The P-N-S tridentate ligand is a compound represented by formula I or formula II, a ...  
WO/2016/180275A1
Disclosed are AHU-377 intermediates and a method for preparing AHU-377 and AHU-377 intermediates. The above-mentioned method for preparing AHU-377 uses a chiral glycidyl benzyl ether as the starting raw material. Intermediate compound (3...  

Matches 1 - 50 out of 3,459