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Matches 601 - 650 out of 10,129

Document Document Title
WO/2009/007415A3
The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the descrip...  
WO/2009/007696A1
Compounds of formula (I) or formula (II) have dopaminergic activity: wherein: R1 is a carboxyl, carboxyl ester, or carboxamide group; R2 is a group - C(=O)-NR3R4, or -S(=O)2-NR3R4; R3 and R4 are independently selected from hydrogen, opti...  
WO/2009/007259A1
A process for the preparation of indole derivatives of formula (I) which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.  
WO/2009/004643A3
The present invention relates to an improved process for the preparation of (S)- Pregabalin of formula (I) and its intermediates thereof. Particularly, the present invention relates to the process for the preparation (S)-Pregabalin havin...  
WO/2009/004643A2
The present invention relates to an improved process for the preparation of (S)- Pregabalin of formula (I) and its intermediates thereof. Particularly, the present invention relates to the process for the preparation (S)-Pregabalin havin...  
WO/2009/000775A1
The present invention relates to new on bead chemistry to produce compound libraries used in improved screening methods, allowing the direct solution confirmation of on-bead screening hits without compound decoding and resynthesis. More ...  
WO/2008/157740A3
Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 po...  
WO/2008/156817A3
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/156817A8
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/156817A2
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/151992A2
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151992A3
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151785A1
The invention relates to a method for producing a compound which has at least one ether group, at least one ester group, at least one amino group or at least one urethane group, preferably at least one ester group. The method according t...  
WO/2008/151784A1
The invention relates to a method for producing 1,2 propandiol by hydrogenation of glycerol using hydrogen gas, wherein glycerol is reacted with hydrogen to give 1,2 propandiol. This reaction is carried out in at least i reactors R1 to R...  
WO/2008/148747A3
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/148747A2
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/148747A8
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/144635A1
Embodiments of the present disclosure include soil repellent compositions, methods for imparting resistance to soiling on a fibrous substrate, fibrous substrates to which a soil repellent composition has been applied and dried, methods o...  
WO/2008/142100A1
The invention relates to an improved method for producing carbonate-terminated urethanes using isocyanates. The method according to the invention is characterized by high yields with no phenol being produced as a secondary component.  
WO/2008/139467A2
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  
WO/2008/139467A3
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  
WO/2008/138639A1
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorde...  
WO/2008/141097A2
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141097A3
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141097A9
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141099A1
A (-)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.  
WO/2008/137165A1
This invention includes, in part, methods of preparing glycated polypeptide antigens and antibodies that specifically recognize glycated epitopes on polypeptides. The invention also relates, in part, to the preparation and use of antibod...  
WO/2008/135273A1
Urethane and oligourethane derivatives and corresponding uses and methods of producing watermarks using the offset printing technique. The invention relates to compounds having general formula (R-O-CO-NH-X-NH-CO-O-(-A-O-CO-NH-X'-NH-CO-O-...  
WO/2008/134326A1
This invention is a composition comprising a regioisomeric branched aldehyde (2) where Boc is -C(O)OC(CH3)3 and optionally an additional aldehyde of formula (1). The invention is also a method of making the compositions.  
WO/2008/129129A1
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein R is a heterocyclic or heterocyclic carbonyl moiety and R' is a group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted hetero...  
WO/2008/124969A1
The present invention provides a preparation method of rivastigmine and its intermediates. The present invention provides a preparation method of the formula (1) compound by reacting the formula (2) compound with CH3X or CH3CH2X in the p...  
WO/2008/125486A1
The invention relates to a process for the preparation of N-protected α-aminoaldehydes by deacetalization of the acetal functional group of corresponding N-protected α-aminoacetals using formic acid.  
WO/2008/123207A1
[PROBLEMS] To provide a compound useful as a therapeutic agent for chronic renal failure or diabetic neuropathy. [MEANS FOR SOLVING PROBLEMS] Disclosed is an ornithine derivative having an EP4 receptor antagonistic activity. In the compo...  
WO/2008/119804A1
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...  
WO/2008/120475A1
Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic e...  
WO/2008/120573A1
[PROBLEMS] With the purpose of providing an actinic radiation-cured product having high heat resistance and a high refractive index, the invention provides compounds which have specific structures bearing unsaturated groups; resin compos...  
WO/2008/120567A1
Disclosed is a method for collecting an L-biphenylalanine compound salt (2'), which comprises the steps of: hydrolyzing a biphenylalanine ester compound (1) with a protease derived from a microorganism belonging to the genus Bacillus in ...  
WO/2008/111300A1
Disclosed is a novel compound which has a potent FXa inhibition activity and exhibits a sufficient and sustained antithrombotic effect rapidly when administered orally. Specifically disclosed is: a compound represented by the general for...  
WO/2008/110308A3
Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.  
WO/2008/110339A2
The invention relates to a crystalline rivastigmine hydrogentartrate of Form II.  
WO/2008/110308A2
Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.  
WO/2008/110339A3
The invention relates to a crystalline rivastigmine hydrogentartrate of Form II.  
WO/2008/108735A1
The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and d...  
WO/2008/107879A1
Novel derivatives of cannabidiol, having one or two of the hydroxyl groups substituted, exhibiting improved production yield, solubility, stability and bioavailability, are provided. Also provided are pharmaceutical compositions comprisi...  
WO/2008/102680A1
Disclosed is a hyperbranched polymer having a main chain of polyamide structure and a terminal amino group, which does not require a large amount of an organic solvent during production. This hyperbranched polymer has high transparency a...  
WO/2008/100977A3
Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit...  
WO/2008/100977A2
Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit...  
WO/2008/097546A2
Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a...  
WO/2008/095841A2
The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorder...  
WO/2008/095841A3
The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorder...  

Matches 601 - 650 out of 10,129