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Matches 601 - 650 out of 10,203

Document Document Title
WO/2009/071957A2
The invention relates to novel compounds of general formula (I) with neurogenic or non-neurogenic anti-inflammatory, analgetic as well as tumour inhibiting effects as well as the salts and metal complexes of these compounds. In the above...  
WO/2009/057199A1
A compound represented by the following general formula (I), which is converted into retinoid after being absorbed in vivo, or its salt or ester: wherein R1 to R5 represent each a hydrogen atom, an alkyl group or a trialkylsilyl group; X...  
WO/2009/053443A3
This invention provides new indane compounds, their use for the treatment or prevention of melatoninergic disorders and its compositions.  
WO/2009/053443A2
This invention provides new indane compounds, their use for the treatment or prevention of melatoninergic disorders and its compositions.  
WO/2009/054240A1
Hexamethylphosphoramide (HMPA) is added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The reaction vessel is purged with oxygen, and is stirred at 80°C for 5 days under 7 atmospheres of oxygen...  
WO/2009/050587A1
The present invention relates to a process of preparing a compound of Formula I: (I) Formula I Wherein R1 is defined in the specification. Compounds of Formula I are useful for treating disorders of the central nervous system, including ...  
WO/2009/050365A3
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and the salts thereof. The invention is characterised in that it includes a step comprising the peptide coupling of 4 ...  
WO/2009/050365A2
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and the salts thereof. The invention is characterised in that it includes a step comprising the peptide coupling of 4 ...  
WO/2009/044707A1
Disclosed is a nitrotriazole derivative represented by the general formula (I) below. This nitrotriazole derivative is a compound useful as a synthesis reagent for synthesizing a carbamate, a carbonate and a thiocarbonate, which are usef...  
WO/2009/042574A1
The invention relates to a dental composition comprising a monomer or mixture of monomers represented by the following structure (1) with 1 ,2Rindependently selected from H, alkyl (e.g. CH3 C2H5), and Phenyl, 3,4R independently selected ...  
WO/2009/034308A2
There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A), wherein R' is selected from the group consisting of hydrogen, -C(O)OA, -C(O)CX3, - OH C(O)NH2, -C(O)-NHOH or (a). Ther...  
WO/2009/034308A3
There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A), wherein R' is selected from the group consisting of hydrogen, -C(O)OA, -C(O)CX3, - OH C(O)NH2, -C(O)-NHOH or (a). Ther...  
WO/2009/029717A1
The compound of formula (I) is a water-stable, long acting ß2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like.  
WO/2009/028707A1
It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the...  
WO/2009/023964A1
The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said...  
WO/2009/018939A1
The present invention relates to a process for heterogeneously catalyzed partial esterification of (meth)acrylic acid with oxyalkylated polyols, wherein the oxyalkylated polyols have at least 3 free hydroxyl groups, and wherein the catal...  
WO/2009/018389A1
Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein relates to the transdermal or topical admi...  
WO/2009/016879A1
It is intended to provide a process for producing an optically active N-(halopropyl)amino acid derivative. This method comprises: the step wherein an optically active alanine ester represented by the formula (I) or its salt (hereinafter ...  
WO/2009/018389A4
Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein relates to the transdermal or topical admi...  
WO/2009/013915A1
An inhibitor of plasminogen activator inhibitor-1 (PAI-1). A medicinal composition having an effect of inhibiting the PAI-1 activity and being efficacious in preventing or treating various diseases for the onset of which the PAI-1 activi...  
WO/2009/013915A8
An inhibitor of plasminogen activator inhibitor-1 (PAI-1). A medicinal composition having an effect of inhibiting the PAI-1 activity and being efficacious in preventing or treating various diseases for the onset of which the PAI-1 activi...  
WO/2009/007415A2
The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the descrip...  
WO/2009/007415A3
The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the descrip...  
WO/2009/007696A1
Compounds of formula (I) or formula (II) have dopaminergic activity: wherein: R1 is a carboxyl, carboxyl ester, or carboxamide group; R2 is a group - C(=O)-NR3R4, or -S(=O)2-NR3R4; R3 and R4 are independently selected from hydrogen, opti...  
WO/2009/007259A1
A process for the preparation of indole derivatives of formula (I) which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.  
WO/2009/004643A3
The present invention relates to an improved process for the preparation of (S)- Pregabalin of formula (I) and its intermediates thereof. Particularly, the present invention relates to the process for the preparation (S)-Pregabalin havin...  
WO/2009/004643A2
The present invention relates to an improved process for the preparation of (S)- Pregabalin of formula (I) and its intermediates thereof. Particularly, the present invention relates to the process for the preparation (S)-Pregabalin havin...  
WO/2009/000775A1
The present invention relates to new on bead chemistry to produce compound libraries used in improved screening methods, allowing the direct solution confirmation of on-bead screening hits without compound decoding and resynthesis. More ...  
WO/2008/157740A3
Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 po...  
WO/2008/156817A3
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/156817A8
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/156817A2
Described are compounds that bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compound...  
WO/2008/151992A2
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151992A3
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino ]-8-methyl-8H- pyrid...  
WO/2008/151785A1
The invention relates to a method for producing a compound which has at least one ether group, at least one ester group, at least one amino group or at least one urethane group, preferably at least one ester group. The method according t...  
WO/2008/151784A1
The invention relates to a method for producing 1,2 propandiol by hydrogenation of glycerol using hydrogen gas, wherein glycerol is reacted with hydrogen to give 1,2 propandiol. This reaction is carried out in at least i reactors R1 to R...  
WO/2008/148747A3
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/148747A2
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/148747A8
This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.  
WO/2008/144635A1
Embodiments of the present disclosure include soil repellent compositions, methods for imparting resistance to soiling on a fibrous substrate, fibrous substrates to which a soil repellent composition has been applied and dried, methods o...  
WO/2008/142100A1
The invention relates to an improved method for producing carbonate-terminated urethanes using isocyanates. The method according to the invention is characterized by high yields with no phenol being produced as a secondary component.  
WO/2008/139467A2
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  
WO/2008/139467A3
The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N'-disucci...  
WO/2008/138639A1
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorde...  
WO/2008/141097A2
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141097A3
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141097A9
A (-)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.  
WO/2008/141099A1
A (-)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.  
WO/2008/137165A1
This invention includes, in part, methods of preparing glycated polypeptide antigens and antibodies that specifically recognize glycated epitopes on polypeptides. The invention also relates, in part, to the preparation and use of antibod...  
WO/2008/135273A1
Urethane and oligourethane derivatives and corresponding uses and methods of producing watermarks using the offset printing technique. The invention relates to compounds having general formula (R-O-CO-NH-X-NH-CO-O-(-A-O-CO-NH-X'-NH-CO-O-...  

Matches 601 - 650 out of 10,203