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Matches 701 - 750 out of 10,220

Document Document Title
WO/2008/039367A1
The present invention concerns methods of synthesis of trans-tert-butyl-2- aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce 2-azido-N-tosylcyclopentananiine; reducing the 2-...  
WO/2008/037433A1
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...  
WO/2008/037503A2
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...  
WO/2008/037503A3
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...  
WO/2008/033328A3
The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a m...  
WO/2008/034119A3
The present invention provides polymeric delivery systems including hindered ester moieties. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.  
WO/2008/028845A1
The instant invention relates to a composition comprising a) an organic material which is susceptible to oxidative, thermal or light-induced degra- dation, and b) at least one compound of the formula (I) wherein the general symbols are a...  
WO/2008/026678A1
Disclosed is a process for producing an optically active succinic acid imide derivative (3) which is a key intermediate for the production of ranirestat. The derivative (3) can be produced readily by treating a succinic acid diester deri...  
WO/2008/022976A1
Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. The alkylcarbamic acid aryl ester of Formula (I), KDS-4103, is a FAAH inhibitor. Described herein is a process for t...  
WO/2008/022938A1
The present invention relates to compounds of the general Formula (I) wherein (A) is a 5 or 6-membered aromatic or heteroaromatic ring; R1 is cycloalkyl or is aryl or heteroaryl, wherein at least one ring is aromatic in nature, unsubstit...  
WO/2008/020452A1
The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1 = R2 = H or R1 =...  
WO/2008/015240A1
The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinso...  
WO/2008/013860A3
Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharm...  
WO/2008/013269A1
Disclosed is an isoquinuclidine derivative which enables to easily synthesize oseltamivir or an analogue thereof. Specifically disclosed is an isoquinuclidine derivative represented by the formula (1) below or a mirror image structure of...  
WO/2008/013860A2
Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharm...  
WO/2008/010897A3
Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R1-NH2 in the presence of a carboxylic acid and a method for preparing a compound of Formula 2 by contacting a compound of Formula 4 wit...  
WO/2008/009897A1
The invention relates to the preparation of pregabalin and its opposite enantiomer, or a pharmaceutically-acceptable salt of either thereof, and to the intermediates used for their preparation.  
WO/2008/007670A1
A process for the production of a compound having a primary, secondary or tertiary aminomethyl-aromatic ring, characterized in that a fluoroboron compound represented by the formula (I): Ra(Rb)N-CH2-BF3M (I) or a dimmer thereof or a solv...  
WO/2008/004798A1
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity a...  
WO/2008/004798A8
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity a...  
WO/2008/003079A1
This invention is related to compositions and methods pertaining to PNA oligomers comprising one or more guanidinium moieties.  
WO/2007/147163A2
A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subjec...  
WO/2007/147163A3
A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subjec...  
WO/2007/141423A1
The invention concerns phenoxy-isobutyric acid derivatives of general formula (I) wherein: R1 and R2 are H, an alkyl group, or a -OR group where R is an alkyl, or R1 and R2 together form a hydrocarbon ring of 3 to 6 carbon atoms; R3 is H...  
WO/2007/134971A1
The invention relates to benzoyl-substituted alanines of formula (I), in which the variables R1 to R13 are defined as cited in the description, and to their agriculturally useful salts. The invention also relates to methods and intermedi...  
WO/2007/136323A1
The present invention relates to a process for the production of a compound of formula (I) comprising a reduction of the carboxyl and cyanide groups of a compound of formula (III), followed by resolvation of the racemic product into the ...  
WO/2007/132277A1
The compounds of the general Formula (I), wherein R1 is aryl or alkyl; R2 represents alkyl; R3 represents alkyl or aralkyl, are valuable pharmaceutical intermediates, which can be prepared by reacting a compound of the general Formula (I...  
WO/2007/131336A1
This invention relates to iodonium salts, acetal copolymers and polymer binders comprising functional groups capable of undergoing cationic or radical polymerization, their method of preparation and their use in the preparation of coatin...  
WO/2007/125196A1
This invention relates to compounds with the formula (I) given below or one of their pharmaceutically acceptable salts, as a medicine; Formula (I) of pharmaceutical compositions comprising one or more compounds with Formula (I) as active...  
WO/2007/112618A1
The present invention provided a kind of vinyloximinoether-containing methyl carbamate derivatives represented by the general formula (I), wherein R1, R2and R3 are, independently, alkyl, R4 and R5 are, independently, hydrogen or alkyl, R...  
WO/2007/111024A1
An ethylenediamine derivative having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and...  
WO/2007/110836A1
Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.  
WO/2007/112358A1
The present invention provides a method for the synthesis of ß2-amino acids. The method also provides methods yielding a-substituted ß-amino aldehydes and ß-substituted γ-amino alcohols. The present method according to this invention...  
WO/2007/107828A3
The invention relates to compounds of Formula (1 ) and to intermediates in the preparation of, compositions containing and uses of such derivatives. The compounds according to the present invention are β2 adrenergic receptor agonists an...  
WO/2007/105050A1
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain oth...  
WO/2007/099385A1
The present invention relates to dipeptidyl peptidase IV (DPP-IV) inhibitors of formula (1), pharmaceutical compositions containing them, processes for their preparation, and methods for treating disorders mediated by DPP-IV inhibition, ...  
WO/2007/098573A1
A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein R1 and R2 independently are hydrogen or a C1-6 alkyl; R3 and R4 are the same or different and each is a C1-6 alkyl; or R3 and R4 together with t...  
WO/2007/100080A1
[PROBLEMS] To provide a method by which the benzyl position in an -O-benzyl group formed by introducing benzyl, benzyloxymethyl, or the like as a hydroxy-protecting group is efficiently and industrially deuterized. [MEANS FOR SOLVING PRO...  
WO/2007/099843A1
A novel process for producing antiviral drug oseltamivir phosphate (trade mark: Tamiflu) without using shikimic acid as a raw material; and a novel raw material or intermediate for use in the production process. It is a compound represen...  
WO/2007/096193A3
The present invention provides a process for the preparation of a 11C of 18F- labelled carbamate comprising reacting a primary or secondary amine or an anion thereof with carbon dioxide and a compound of formula RX or R1X, wherein X repr...  
WO/2007/097406A1
Disclosed is a method for converting a carbon cluster into a hydrophilic carbon cluster without greatly changing the characteristics of the carbon cluster. Also disclosed are a hydrophilic carbon cluster having a structure wherein a subs...  
WO/2007/097254A1
Disclosed is an isodipeptide represented by the formula (1) below, which is useful as a synthesis unit used for an efficient synthesis process of a peptide or the like. (1) (In the formula, A represents an acid residue of an N-protecting...  
WO/2007/096193A2
The present invention provides a process for the preparation of a 11C of 18F- labelled carbamate comprising reacting a primary or secondary amine or an anion thereof with carbon dioxide and a compound of formula RX or R1X, wherein X repr...  
WO2006084688A8
Compounds of the formula (I): Wherein R1, R2, X and N are as defined in the specification; E is N, CH; A1 and A" are terminal groups as defined in the specification. The compounds have utility as HIV-I protease inhibitors.  
WO/2007/090434A1
The invention relates to compounds of the formula (I) in which A1, A2, R1, R2, R3, R4, R5 and X have the definition specified in the description, to processes and intermediates for preparing them and to their use for controlling pests.  
WO/2007/089669A3
The present invention provides improved synthetic methods for the preparation of compounds (I) that modulate proliferation or differentiation in a cell or tissue.  
WO/2007/089669A2
The present invention provides improved synthetic methods for the preparation of compounds (I) that modulate proliferation or differentiation in a cell or tissue.  
WO/2007/080430A1
The present invention relates to a process for the preparation of a carbamoyl chloride RR’N-CO-Cl (I).  
WO/2007/080885A1
Disclosed is a novel cycloalkanecarboxamide derivative having a selective cathepsin K inhibitory activity. Also disclosed is a method for producing such a cycloalkanecarboxamide derivative. Specifically disclosed is a cycloalkanecarboxam...  
WO/2007/074789A1
Disclosed is a novel process intermediate represented by the general formula (1) or (2): wherein X represents a halogen atom, a cyano group or the like; Y represents a halogen atom, a cyano group or the like; R1 represents a C1-C6 haloal...  

Matches 701 - 750 out of 10,220