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WO/2008/046889A1 |
The invention relates to an insect- and mite-repelling agent, characterized by a content of at least one substituted, enantiomer-enriched α-,ω-amino alcohol derivative of formula (1) wherein X represents hydrogen, COR11 or R13, R13 rep...
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WO/2008/045391A2 |
The present invention relates to a novel crystal of (S)-(+)-2-(2-chlorophenyl)-2- hydroxy-ethyl carbamate, pharmaceutical compositions comprising this crystal and, and methods of making and using this crystal.
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WO/2008/044731A1 |
Disclosed is a compound represented by the general formula (I) below, which has a plasminogen activator inhibitor-1 (PAI-1) inhibitory activity, a salt thereof, or a hydrate or solvate of any of them. (I) (In the formula, R1 represents a...
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WO/2008/043798A1 |
A process for the preparation of for the preparation of β-amino aldehydes and derivatives thereof, in particular β-amino acids and Υ-amino alcohols, by reacting carbamate-protected imines and unmodified aldehydes in the presence of an...
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WO/2008/039367A1 |
The present invention concerns methods of synthesis of trans-tert-butyl-2- aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce 2-azido-N-tosylcyclopentananiine; reducing the 2-...
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WO/2008/037433A1 |
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...
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WO/2008/037503A2 |
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...
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WO/2008/028845A1 |
The instant invention relates to a composition comprising a) an organic material which is susceptible to oxidative, thermal or light-induced degra- dation, and b) at least one compound of the formula (I) wherein the general symbols are a...
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WO/2008/026678A1 |
Disclosed is a process for producing an optically active succinic acid imide derivative (3) which is a key intermediate for the production of ranirestat. The derivative (3) can be produced readily by treating a succinic acid diester deri...
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WO/2008/022976A1 |
Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. The alkylcarbamic acid aryl ester of Formula (I), KDS-4103, is a FAAH inhibitor. Described herein is a process for t...
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WO/2008/022938A1 |
The present invention relates to compounds of the general Formula (I) wherein (A) is a 5 or 6-membered aromatic or heteroaromatic ring; R1 is cycloalkyl or is aryl or heteroaryl, wherein at least one ring is aromatic in nature, unsubstit...
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WO/2008/020452A1 |
The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1 = R2 = H or R1 =...
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WO/2008/015240A1 |
The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinso...
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WO/2008/013269A1 |
Disclosed is an isoquinuclidine derivative which enables to easily synthesize oseltamivir or an analogue thereof. Specifically disclosed is an isoquinuclidine derivative represented by the formula (1) below or a mirror image structure of...
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WO/2008/013860A2 |
Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharm...
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WO/2008/009897A1 |
The invention relates to the preparation of pregabalin and its opposite enantiomer, or a pharmaceutically-acceptable salt of either thereof, and to the intermediates used for their preparation.
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WO/2008/007670A1 |
A process for the production of a compound having a primary, secondary or tertiary aminomethyl-aromatic ring, characterized in that a fluoroboron compound represented by the formula (I): Ra(Rb)N-CH2-BF3M (I) or a dimmer thereof or a solv...
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WO/2008/004798A1 |
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity a...
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WO/2008/003079A1 |
This invention is related to compositions and methods pertaining to PNA oligomers comprising one or more guanidinium moieties.
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WO/2007/147163A2 |
A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subjec...
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WO/2007/141423A1 |
The invention concerns phenoxy-isobutyric acid derivatives of general formula (I) wherein: R1 and R2 are H, an alkyl group, or a -OR group where R is an alkyl, or R1 and R2 together form a hydrocarbon ring of 3 to 6 carbon atoms; R3 is H...
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WO/2007/134971A1 |
The invention relates to benzoyl-substituted alanines of formula (I), in which the variables R1 to R13 are defined as cited in the description, and to their agriculturally useful salts. The invention also relates to methods and intermedi...
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WO/2007/136323A1 |
The present invention relates to a process for the production of a compound of formula (I) comprising a reduction of the carboxyl and cyanide groups of a compound of formula (III), followed by resolvation of the racemic product into the ...
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WO/2007/132277A1 |
The compounds of the general Formula (I), wherein R1 is aryl or alkyl; R2 represents alkyl; R3 represents alkyl or aralkyl, are valuable pharmaceutical intermediates, which can be prepared by reacting a compound of the general Formula (I...
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WO/2007/131336A1 |
This invention relates to iodonium salts, acetal copolymers and polymer binders comprising functional groups capable of undergoing cationic or radical polymerization, their method of preparation and their use in the preparation of coatin...
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WO/2007/125196A1 |
This invention relates to compounds with the formula (I) given below or one of their pharmaceutically acceptable salts, as a medicine; Formula (I) of pharmaceutical compositions comprising one or more compounds with Formula (I) as active...
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WO/2007/112618A1 |
The present invention provided a kind of vinyloximinoether-containing methyl carbamate derivatives represented by the general formula (I), wherein R1, R2and R3 are, independently, alkyl, R4 and R5 are, independently, hydrogen or alkyl, R...
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WO/2007/111024A1 |
An ethylenediamine derivative having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and...
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WO/2007/110836A1 |
Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.
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WO/2007/112358A1 |
The present invention provides a method for the synthesis of ß2-amino acids. The method also provides methods yielding a-substituted ß-amino aldehydes and ß-substituted γ-amino alcohols. The present method according to this invention...
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WO/2007/105050A1 |
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain oth...
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WO/2007/099385A1 |
The present invention relates to dipeptidyl peptidase IV (DPP-IV) inhibitors of formula (1), pharmaceutical compositions containing them, processes for their preparation, and methods for treating disorders mediated by DPP-IV inhibition, ...
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WO/2007/098573A1 |
A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein R1 and R2 independently are hydrogen or a C1-6 alkyl; R3 and R4 are the same or different and each is a C1-6 alkyl; or R3 and R4 together with t...
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WO/2007/100080A1 |
[PROBLEMS] To provide a method by which the benzyl position in an -O-benzyl group formed by introducing benzyl, benzyloxymethyl, or the like as a hydroxy-protecting group is efficiently and industrially deuterized. [MEANS FOR SOLVING PRO...
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WO/2007/099843A1 |
A novel process for producing antiviral drug oseltamivir phosphate (trade mark: Tamiflu) without using shikimic acid as a raw material; and a novel raw material or intermediate for use in the production process. It is a compound represen...
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WO/2007/097406A1 |
Disclosed is a method for converting a carbon cluster into a hydrophilic carbon cluster without greatly changing the characteristics of the carbon cluster. Also disclosed are a hydrophilic carbon cluster having a structure wherein a subs...
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WO/2007/097254A1 |
Disclosed is an isodipeptide represented by the formula (1) below, which is useful as a synthesis unit used for an efficient synthesis process of a peptide or the like. (1) (In the formula, A represents an acid residue of an N-protecting...
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WO/2007/096193A2 |
The present invention provides a process for the preparation of a 11C of 18F- labelled carbamate comprising reacting a primary or secondary amine or an anion thereof with carbon dioxide and a compound of formula RX or R1X, wherein X repr...
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WO/2007/090434A1 |
The invention relates to compounds of the formula (I) in which A1, A2, R1, R2, R3, R4, R5 and X have the definition specified in the description, to processes and intermediates for preparing them and to their use for controlling pests.
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WO/2007/089669A2 |
The present invention provides improved synthetic methods for the preparation of compounds (I) that modulate proliferation or differentiation in a cell or tissue.
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WO/2007/080430A1 |
The present invention relates to a process for the preparation of a carbamoyl chloride RR’N-CO-Cl (I).
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WO/2007/080885A1 |
Disclosed is a novel cycloalkanecarboxamide derivative having a selective cathepsin K inhibitory activity. Also disclosed is a method for producing such a cycloalkanecarboxamide derivative. Specifically disclosed is a cycloalkanecarboxam...
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WO/2007/074789A1 |
Disclosed is a novel process intermediate represented by the general formula (1) or (2): wherein X represents a halogen atom, a cyano group or the like; Y represents a halogen atom, a cyano group or the like; R1 represents a C1-C6 haloal...
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WO/2007/076306A1 |
Compounds of Formula I are useful in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders. wherein: A and R1 to R8 are defined in the specification.
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WO/2007/073168A1 |
The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound (3,4-dichloro-phenyl)-carbamic acid 2-isobutoxycarbonylam...
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WO/2007/071452A1 |
This invention provides compounds having the structural formula: wherein:- R1 is an acyl or sulfonyl group, - R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic mon...
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WO/2007/072689A1 |
This invention provides a novel ethylenically unsaturated bond-containing compound having satisfactorily high sensitivity also in scanning exposure to a laser beam in an ultraviolet to near infrared wavelength region and having good cure...
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WO/2007/072089A1 |
The present invention relates to new mGluR5 receptor subtype preferring ligands of formula (I): (I) wherein R1 and R2 represent independently a substituent selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl and cyano; X is a CHR6 ...
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WO/2007/068929A1 |
Compounds of formula (I) have muscarinic M3 receptor modulating activity; formula (I) wherein R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, or a group, -Z-Y-R5, or a group -Z-NR9R10, or a group -Z-N(R9)C...
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WO/2007/062335A2 |
The invention is directed to the succinate salt of trans-4-aminocyclohexyl (1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetr
amenthyl-9-oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA). Compound IA is useful...
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